5UBP


Conserved Protein Domain Family
SAC3_GANP

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pfam03399: SAC3_GANP 
SAC3/GANP family
This family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins. The family includes the yeast nuclear export factor Sac3, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localization of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle.
Statistics
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PSSM-Id: 397460
Aligned: 126 rows
Threshold Bit Score: 201.21
Threshold Setting Gi: 209880329
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5UBP_A       130 GTCLDMCPTFERSRRNVEYTVYSYEK----NQPNDKKASRTKALKVFARpa-aAAAPPLPSDVRPPHILVKTLDYIVDNL 204
XP_025758746  74 GTCQTMCPAQELRDREAQNRLHHFEMlpgtEKDRRPKGDPSRAVKEYSRpa-aGKDSTKPSDLRPPPVLLKTVNYLINDI 152 Nile tilapia
6_pfamImport   1 GTCQTMCPARELRDRQLQSRLHRFEVsagtEGDRRPKGDPLRVVKEYSRpa-aGKDLTNPADLRPAAVLLKTVCYLVDDI 79 
XP_004068394  59 gtcqtMCPVQELQDRVAQNRLHHFEMvpgtEKDRRPKGDPLRAVKEYARpa-aGKDATNPTDLRPPAVLLKTVHYLINEI 137 Japanese medaka
XP_005795812  58 ASCQTMCPAQELWNRESQNRLHCFEVvpgtESFRKPKGDPLRAVKEYSRpa-aGKDVTKPSYLRPPDVLLKTVCYLIDEI 136 southern platyfish
EMP25815     367 GTCPGMCPLGELAQRERQGWLHRLEL-----REGTRQGDPARVVKEYSRpa-aGKELPRPQELRPAPVLLATVHYLLGQV 440 Green sea turtle
XP_008122120  21 GTCPGMCPASEFDRRKCQRRLHRLEL----GPSPSCQPDASLAVKEYSRpa-aGKPPPRPEELRPPPVLLDTVRHLL-SL 94  green anole
EDM12574      91 GLCPDMCPAAERARRERERRLHRLEVep-gGCGNAPRADPRRTVKEYSRpa-aGKPRPPPSLLRPPPVLLATVRYLAGEV 168 Norway rat
XP_023415519   9 GTCSDMCPAAERAQREKERRLHRFEVvp-gCRGDQPRADLQRA-REGVQspaaGKPRPSPSQLRPPRVLLAAVRYLAGEV 86  African savanna...
TNM88061     394 GSCLTMCSVGELRERERQKRLHRFEMmpgtERDRLPRGDPLRAVKEYTRpa-aGKDSTNPAELRPAEVLLKTVCYLIDDI 472 Takifugu bimacu...
5UBP_A       205 LT-----TLPESEGFLWDRMRSIRQDFTYQNYSGPEA-VDCNERIVRIHLLILHIMVKSNVE--FSLQQELEQLHKSLIT 276
XP_025758746 153 AAapslyPWTEVYTFVFDRLRAVKQDMIIQRMSGLDC-VVILERTVRFLIYASYRLCGEPLRl-YDPRINDTHLQEYLSW 230 Nile tilapia
6_pfamImport  80 VAsphlhPWTEAYSFAFDRLRGVKQDMIIQRVSGSTC-VAILERTVRFLIYASYRLCGEPLRl-YDPRINDTHLQENLSW 157
XP_004068394 138 AAtpsrhPWTEVYGFVFDRLRSVKQDMIIQRVSGSEC-AALLEPIVRFLIYASYRLCGEPLRl-YDPRINDTHLQEYLSW 215 Japanese medaka
XP_005795812 137 AGstslhPWTEVYSFVFDRLRSVKQDMIIQRLSGKDC-VAILELTVRFHIYASYRLCGEPLRi-FDPRINDTHLQEYLNW 214 southern platyfish
EMP25815     441 APra-dlPPPEVHAFISDRLRAVHQDATLQRLRGAPC-VALLERSLGYLLHAGYQLCREPPAr-FDPHLHRTQLQECFSW 517 Green sea turtle
XP_008122120  95 DDga-kgDEAERCAFVTDRLRAVRLDLTLQRLTSRPCaIPILERALVFLLHAGSRLHAQPDSr-FDAHLHREQVQESFAA 172 green anole
EDM12574     169 ADrt-dvSCAEVASFVADRLRAVRLDLSLQGVDDAEA-AAVLEPALATLLVVVARMRPEETRgvADPVLLQTQVQEGFGS 246 Norway rat
XP_023415519  87 AEra-daSRAEVASFVADRLRAVRLDLALQSAGDAEA-AVVLETALATLLAVVARLGPDAARgaVDPGLLQAQVQEGFGS 164 African savanna...
TNM88061     473 AAssrphPWTEVYSFVFDRLRGVKQDMIIQRISGLNC-VAILERMVRFLIYSSYRLCGEPPHl-YNPCINDTHLQENLTW 550 Takifugu bimacu...
5UBP_A       277 LSEI-------------YDDVRSSGg--TCPNEAEFRAYA---LLSKI--------RD---------------PQYDENI 315
XP_025758746 231 LLDC-------------YMTKTg-----PHPNQEEFQSLS---LLYNL--------GS---------------ARAMQHT 266 Nile tilapia
6_pfamImport 158 LLDC-------------YGAGAg-----PHANQDELQALDnccLLISLflfssppsGS---------------ARATQHV 204
XP_004068394 216 LLDC-------------YTADGg-----PNPNQEEFQALG---LLYNL--------DS---------------MRARQHA 251 Japanese medaka
XP_005795812 215 LFDC-------------YKTGTg-----PYPNQEEFQTLG---LLYNL--------GS---------------SPATQDV 250 southern platyfish
EMP25815     518 LRRC-------------YRDSC-------HHGEPAFQALF---LLYNL--------GF---------------PEALRQV 551 Green sea turtle
XP_008122120 173 LRRA-------------YRQGQAKDqgvAAASEPRFQALF---LLYNL--------GS---------------PAALGQV 213 green anole
EDM12574     247 LRRC-------------YARGKa-----PHPRQAAFQGLF---LLYNL--------GS---------------VEALQEV 282 Norway rat
XP_023415519 165 LRRCyargagphprqaaF------------------QGLF---LLYNL--------GEsgtgggaelrdwgppCGGFARD 215 African savanna...
TNM88061     551 LLDC-------------YAREKg-----PYPNQEEFYALG---LLYNL--------GL---------------VRPAQHI 586 Takifugu bimacu...
5UBP_A       316 QRLPKHIFQDKLVQMALCFRRVISNsaytergfvktenclNFYARFFQLMQspSLPLLMGFFLQMHLTDIRFYALRALSH 395
XP_025758746 267 MQLPLRLRSTPNIKLALSINQAFLE---------------RNPVRLLRLAQ--KLNFLQTCALHRHLLTCRQDLLLIYSH 329 Nile tilapia
6_pfamImport 205 MGLPSRLRSSPAITLALSINRAFLE---------------RNPVRLLRLAR--RLNFLQSCALHRHLVTCGRDLLLIYSH 267
XP_004068394 252 MELPQQLRTSSSVTLAMSIGQAFLE---------------RNPVRLLRLAG--GLSFLQTCALHRHLVACRRDLLLIYSH 314 Japanese medaka
XP_005795812 251 LELPERLRQTPSLKLALAINQAFLE---------------GNHVHLLRLVQ--KLDFLQTCALHRHLVTCRRHLLLIYSH 313 southern platyfish
EMP25815     552 LQLPDPVRASPELRTALAVNWAYLE---------------RNWARFFRLVQ--ALPYLPICALHRHLGPARRLALLTFSH 614 Green sea turtle
XP_008122120 214 LHLPKGSRTSPDIVLALAIHWAFLE---------------RNFARFFRLAS--ALPYLPSCALQPHLVAARRQALATFSH 276 green anole
EDM12574     283 LQLPAALRACPPLQTALAVDSAFRE---------------DNYARLFRLLR--TLPYLQSCAVQEHIGYARRKALSRLSR 345 Norway rat
XP_023415519 216 LQLPATLRAARPCAQP-GVDSAFRE---------------GNTARLFRLLR--TLSYLPSCAVCGHXGpCRRRALARLAR 277 African savanna...
TNM88061     587 LELPKGLRSSPTITLALSINRAFLE---------------RNPVCVLRLAQ--RLDFLQSCALHRHLVACRRDLLLIYSH 649 Takifugu bimacu...
5UBP_A       396 TLn-kKHKPIPFIYLENMLLFNNRQEIIEFCNYYSIEIIN 434
XP_025758746 330 GYs-sRNCRFPLDRLAKLLFLDA-SLTAQLCRSYGVEVNK 367 Nile tilapia
6_pfamImport 268 GFs-sRNCRFPLDEVAQLLSLDA-SLAARLCQAHGVAVNR 305
XP_004068394 315 GFs-sRNCRFPLDRLARLLHLDS-ALAAQLCQLCGLRVDL 352 Japanese medaka
XP_005795812 314 GYh-sRNCRFPLDRLAQLLSLEP-SLTAELCQVYGIEVNQ 351 southern platyfish
EMP25815     615 GFs-tRNCRCPLAWLARLLAVDGPEEMAELCRHHGLMVLD 653 Green sea turtle
XP_008122120 277 GFs-aRNCRYPLARLARMLALGGAEEAAQLCRAHGLTVVD 315 green anole
EDM12574     346 ALstpRGQTLPLDFIVHLLALDGLQEAQDLCQAHGLTLDK 385 Norway rat
XP_023415519 278 ALstpKGQTLPLGFLVHLLALDGPEEARDLCQAHGLPLDG 317 African savanna elephant
TNM88061     650 GYn-sRNCRFPLDRLAQLLCLDA-SHAAQLCRAYGLEVTQ 687 Takifugu bimaculatus
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