8OX4,7VGH,6LCP


Conserved Protein Domain Family
CDC50

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pfam03381: CDC50 (This model is not part of the current CDD release)
LEM3 (ligand-effect modulator 3) family / CDC50 family
Members of this family have been predicted to contain transmembrane helices. The family member LEM3 is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells. The products of genes YNR048w, YNL323w and YCR094w (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants may be due to inactivation of CDC39. The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.
Statistics
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PSSM-Id: 515546
Aligned: 283 rows
Threshold Bit Score: 156.183
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8OX4_B        74 VTSN-------NIREIEIDYT--------------------------GTEPSSPCnkc----------------lspDVT 104 human
XP_003722734  55 RANA-------SAVDITVRYDhq-----------------------qQCSFGYNNtgafry-----------easpgDVW 93 
Q38DJ5        44 FCNR-------NAKEASFRYDne----------------------ptKCTEETFSlig----------------gqgTGK 78  Trypanosoma brucei
Q4DU99        49 LMNK-------QAKEVTVRYDhi-----------------------hRCTITHNTgafiy-------------egnnMTF 85  Trypanosoma cruzi
Q4CMM3        54 KASD-------SVFELSIRYD-------------------------------ETNnyqyrvgpddkyphkfrfnnsnFST 95  Trypanosoma cruzi
XP_001463565 168 VKGR-------EYHIVEQEYShihqyqyvpsnssvninhgilqftadGVTHAQGT----------------------RTW 218
Q382L6        80 ITCN-------GHYEVRGNYQhihkyqyipsdpkvninegirsfyvgNEVHRQGT----------------------RTR 130 Trypanosoma brucei
Q4DQA4        70 LASD-------RFYEVRQAYNeihryqyiptnpavninqgirsftvgNKTYKQGT----------------------RTR 120 Trypanosoma cruzi
CBJ31365      10 SCASeqrllerTVVEFKRRYDgdnv-------------------dveGCKITEG------------------------NQ 46 
XP_001562722 172 VKGR-------QQHIIEQEYShihqyqyvpsntsvninqgilqftadGVTHAQGT----------------------RTW 222
8OX4_B       105 pcf--ctINFTLEKSFEGNVFMYYGLSNFYQNHRRYVKSRDDSQLNGDS-SAllnPSk-eCEPYrr-------nE----- 168 human
XP_003722734  94 qtgcvtdVPFRVDKHLKAPVYVYYGLENFYQNHRRFSNSKSDAQLAGQRvSAa--AIasaTSPLtypgelrhtaDqginl 171
Q38DJ5        79 rtvcethFEFVLAETLRQPVYFYYGLTKMYQNHRRYTNSRSGKQLMGADv-----RSetdANPFvipgdtmdntNkpief 153 Trypanosoma brucei
Q4DU99        86 ktgcmteVSFDITEKLKAPVYLYYELTRFYQNHRRYSISRNDEQLAGKAv-----RYlpdTSPLaipgdiygisGtpiky 160 Trypanosoma cruzi
Q4CMM3        96 gah--vsRNFTLLKSLASPIYLQYALVGFYQNYRRYAFSRDLAQREGNAy-----LVsaaCEPFrfpgeyqnrkI----- 163 Trypanosoma cruzi
XP_001463565 219 -------LEINISHRMKAPVYMYYKIANMHQNHRDFHNGRSNSQLRGKS-KId--KAy-lCKPYtypgfrsdegDtpiti 287
Q382L6       131 -------VSFKLEKPMKKPVYLYYTLGNFHQNFRAFHEGRSLDMLRGHR-SIi--GSypeCQPYerpgtinkaeKtevkv 200 Trypanosoma brucei
Q4DQA4       121 -------VMLEVRETLKAPVYLYYTLGNFFQNFRDYHNGASRNLLRGTE-RRs--GRykeCEPFqkpgflndalGkevhv 190 Trypanosoma cruzi
CBJ31365      47 gtt--csVQIEVDEFMKPPIYVYYELNNYFQNHRRYVKSRSSLQLLGEAv-----EPdenCEPLerttv----------- 108
XP_001562722 223 -------LEINISRGILAPVYMYYKISNMHQNHRDFHRGRSNSQLRGKS-TId--KTy-tCQPYtypgfrnnkgEtpiti 291
8OX4_B       169 -------------DKPIAPCGAIANSMFNDTLe---------------lFLIGND---------SY-------------- 197 human
XP_003722734 172 lg-----tflhysDFVYVPAGLIPWSMFNDTFtlyri--------thheAAAVTApsl----rlICngsafsr-----ft 229
Q38DJ5       154 gg-----rnhtykDFVYVPVGLVAWSMFNDTFtlfrk--------ekngSNPGEVlic----ngTDfsrhtnk------p 210 Trypanosoma brucei
Q4DU99       161 vd----gsdlrykDFLYVPAGLIAWSIFNDTFtlyte--------atngGTSRKLicn----atDFskgnnl-------p 217 Trypanosoma cruzi
Q4CMM3       164 -------------LGIYFPCGSIAWSLFNDSFslyrl--------sdasKSTINSqdf---enaKLicdggafd----aa 215 Trypanosoma cruzi
XP_001463565 288 tdvtgtqvtrparYFTYNPCGIAPWSKFNDTFilyrkltpaevvqanisGVPVLHggvdsttpvTLicngtdfglrgepl 367
Q382L6       201 vvdg-envtlkyeEFLYNPCGIAPWSMFNDTFvlyrsrdvssaqndsvkLDEGAElic----ntSDfgptgep------l 269 Trypanosoma brucei
Q4DQA4       191 dvdg-kihvmhygDFIYNPCGMAPWSMFNDTFvlyrvvn---pktgnapSAADLVmic----nsSDfgprgep------l 256 Trypanosoma cruzi
CBJ31365     109 ----------ggeiMDLNPCGLIANSMFNDIIqlt------------tegV----------------------------- 137
XP_001562722 292 tdatgrqvtrparYFTYNPCGIAPWSKFNDTFvlyrkltpaevlqasisGVPVLHggvdgttpvELicngtdfglkgepl 371
8OX4_B       198 -----PIPiaL-KKKGIAWWTDKnV--------------KFRnP------------------------------------ 221 human
XP_003722734 230 nepldGAG--RcHKKGIAWTSDVeF--------------KYKkPhfpppssp---------------------------- 265
Q38DJ5       211 lhrsvSHN--HcDKNGIAWESDIkK--------------KFLePkwdgsgp----------------------------- 245 Trypanosoma brucei
Q4DU99       218 lngseSKN--McVKKGIAWDTDVeY--------------KFKaPdleaknr----------------------------- 252 Trypanosoma cruzi
Q4CMM3       216 gkslnEKN--LcIKKGIALSSDVrLfhpltdgkkdsavwRFGg------------------------------------- 256 Trypanosoma cruzi
XP_001463565 368 sgsvtKNH--C-SKMGISWKADReI--------------RFRnItlredwwslyy------------------------- 405
Q382L6       270 yqsktPNK--C-KKKGISWPADEkI--------------RFRpLerdkklwslry------------------------- 307 Trypanosoma brucei
Q4DQA4       257 gqsasPNH--C-HKKGITWKADEeI--------------RYKpLqpqlkwwslry------------------------- 294 Trypanosoma cruzi
CBJ31365     138 -------T--M-SEKDISWESDReT--------------RFKqPpgftfaecsadtscsdclggskysscgdhtdestgt 193
XP_001562722 372 dgsvaVNR--C-SKMGISWKADRnI--------------RFHnMtlredwwslyy------------------------- 409
8OX4_B       222 -----------PGG--DNleerfKGTTKPVnwlkpvymld--------sdpdnngfiNEDFIVWMRTAALPTFRKLYRLi 280 human
XP_003722734 266 ---rpvwsapkWAYeaADg----DVNPNPPsrmpsdnayfnegwyadepghripvttDEDLMVWARVASLPKFRKLYRVi 338
Q38DJ5       246 -----vwtaprSEY------------GKPSiesndtyfnngwy--ageeghmipvvtDEDFMVWMRASPLPNVRKLYRIi 306 Trypanosoma brucei
Q4DU99       253 -----fwtaakELYt--------GKVPTPElsnddffnkgwy---agelghaipvttDEDFMVWMRPASLPSFRKLHRVi 316 Trypanosoma cruzi
Q4CMM3       257 ---------------------------DPAandpyqkegyyy----eepghpipsnvDEDYIVWSSLSYMKDFTKKYRIi 305 Trypanosoma cruzi
XP_001463565 406 pypttneylrnGWYlhEPg----HALPDPS---------------------------DYDLHVWMRASFTSNFRKLYRIi 454
Q382L6       308 phkndnvyltnGWYadEPg----HRLTDPE---------------------------DYDMQVWIRAAFLSNFSKLFRIi 356 Trypanosoma brucei
Q4DQA4       295 pypndnvyltnGWYvdEPg----HSLTDPS---------------------------DYDLQVWLRGAALPNFRKLLRIi 343 Trypanosoma cruzi
CBJ31365     194 eykfwypddetTQFlyETy----PEVVSPIeg-----------------------vlNEHFIVWMRTAGLPRFRKLYGRi 246
XP_001562722 410 pypttneylrnGWYldEPg----HSLPDPS---------------------------DYDLQVWMRASFTSNFRKLYRIi 458
8OX4_B       281 ErksDLhptlPAGR-YSLNVTYNYPVHYFDGRKRMILSTISWMGGKNPFLGIAYIAVGSISFLLGVVLLVINHK-YRNS 357 human
XP_003722734 339 De--DL----VPGT-YLMRIQEHFNAASYGGTKSFSLATLSWLGGRNTFMAWMYFTIGAVSAVSGASFLCIHHWyGDRA 410
Q38DJ5       307 Rt--DL----RAGK-YVMKIRQNYNTKPYGGEKSFIFLQPSMLGGKLTSLSITYFAVGGLALIFTVLVLFASHVwGHHS 378 Trypanosoma brucei
Q4DU99       317 Nv--DL----PPGK-YVMVIGEHFDVSSFGGTKSFALATLSFLGGKNVWLEALYFSLGGFSVVFAVVLLLVHRFsGDRA 388 Trypanosoma cruzi
Q4CMM3       306 Tt--DL----VPGN-YLIDIVENFDVFSFSGEKYVSLVTRSWIGGKNYVLGILFLLMGCISFVLSLSFIIVQYLhSKRC 377 Trypanosoma cruzi
XP_001463565 455 Hv--PL----HPGT-YLVDISEFYDVVSFRGRKSVVLQHANWVGGRNIVLGVVFIIMGCASFVLGVTFTVECMLqLNGV 526
Q382L6       357 De--DL----REGN-YFLDIEEFFDVTTFHGTKGYLLRTSSMFGRSGTLFAATFLIVGSVAFVVGVAFAIQYCM-AKKG 427 Trypanosoma brucei
Q4DQA4       344 Dv--DL----EKGQ-YVMEIEEFFDVTTFRGSKGFLLRTTSWVGKDGHALGIAFLVVGALSFVLGASFAIEFFL-QRNR 414 Trypanosoma cruzi
CBJ31365     247 De--QI----EAPQvLTFNITANFFVGDFSGEKSLVVSNLSLMGARNPYLGIAYIALGSLSLAIGLAFLIKHLS-NPRK 318
XP_001562722 459 Dm--PL----YPGT-YLVDISEFYDVVSFRGRKSVVLQHTNWIGGPNIGLGVIFILMGCLSFILGVTFTVECLLqLNGV 530
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