3W2X,5CFE,7MEV,8KA3,8IGI,6LPM,1AKO,2VOA,2DNJ,1ZWX,4AWN,4F1R


Conserved Protein Domain Family
Exo_endo_phos

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pfam03372: Exo_endo_phos (This model is not part of the current CDD release)
Endonuclease/Exonuclease/phosphatase family
This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.
Statistics
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PSSM-Id: 515543
Aligned: 319 rows
Threshold Bit Score: 33.7462
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3W2X_A        10 ISWNVNGl-rA------VHRKGFLKWFMEE-------KP---------D----ILCLQEIKAAPEQLPRKLRHVEG---- 58  Methanothermoba...
Q2UNN7        69 YTWNIDFmvpFaaarmrPALAHLYQLTRLL-------PLhv------aP----VIFLQECTPSDLETIAATP-------- 123 Aspergillus oryzae
Q0CY83        48 TTWNIDFqvpCknertaAALRYLSQRPPAP-------YP---------E----VIFLQEMVASDLELIKATP-------- 99  Aspergillus ter...
Q2UFE1        75 TTWNIDFqqpCkaertqAGLNYLSTVLLKP-------SDdknndvtpiN----IIFLQEMVPNDLTIIQQTK-------- 135 Aspergillus oryzae
XP_001909648 123 WSWNIDFkldVpvarmrAALNHVRSLVASQ------------------DgtpcIVMFNEMVASDLDVIADDE-------- 176
Q08227        11 TTFNCGKe--Fpv---eNSKAIVKQLLFPYddgisqlELqd------lY----VLGFQE-------VVPIWQ--GSfpav 66  Saccharomyces c...
O76745        32 VSWNSGHe--Ra-------PTNLEELLGLNs-----gETpd------vI----AVAVQG---------------FGfqtd 72  bed bug
Q9XWG3       123 MSWNIDG---LdgrsllTRMKAVAHIVKNV-------NP---------D----ILFLQEVVDRDLAPIDKLQ--SL---- 173 Caenorhabditis ...
O95551       117 ITWNIDG---LdlnnlsERARGVCSYLALY-------SP---------D----VIFLQEVIPPYYSYLKKRS--S----- 166 human
ETI56156       6 LTFNIFFdev----arsMRMKAIGRLVEHF-------RP---------A----VIGFQEVTRDALAMLKAQQWAKF---- 57 
3W2X_A        59 -----------YRSF-----------------------------FTP-----------------AERKGYSGVAMYTKVP 81  Methanothermoba...
Q2UNN7           --------------------------------------------------------------------------------     Aspergillus oryzae
Q0CY83           --------------------------------------------------------------------------------     Aspergillus ter...
Q2UFE1           --------------------------------------------------------------------------------     Aspergillus oryzae
XP_001909648     --------------------------------------------------------------------------------    
Q08227        67 nrdlidritttAVNClnekvsatqgdeqysclgvnslgaitiivLYNnnalkvkddilkrngkcGWFGTHLKGGTLISFQ 146 Saccharomyces c...
O76745        73 kpq--qgpacvKNFQslltskgytklkn----titetmgltvycLEKhldqntl---knetiivTVDDQKKSGGIVTSFT 143 bed bug
Q9XWG3       174 -----------YKIY------------------------------YS------------------NKGCQYYTAILVSKM 194 Caenorhabditis ...
O95551       167 -----------NYEI------------------------------IT------------------GHEEGYFTAIMLKKS 187 human
ETI56156      58 -----------YDCS-----------------------------VDTa----------------PPFQEAYFVALFSALP 81 
3W2X_A        82 P--------SSLREGFGVERFDTEGRIQIADFDDFLLYNIYFP------------------------------------- 116 Methanothermoba...
Q2UNN7       124 -----------WVQANFHLTDIDTTNWATTQYGTTVLVGKHLPitsvfrvhyshtrmdrda----------lfvdvstel 182 Aspergillus oryzae
Q0CY83       100 -----------WVQDNFYITDFSTQHWLGSYGTTTLVDKRLPVervfrvpyaasrmqrdalfvd---ialnpnaplrlcn 165 Aspergillus ter...
Q2UFE1       136 -----------WIQDHFFITDLNHTQWRGSYGTTTLIDRRCHVqrvfrvpystsrmqrdglfvdldcqeggetggtlrlc 204 Aspergillus oryzae
XP_001909648 177 -----------WVRENYNVTDLTGENWDFHDFPPGFGYGTCILvpkvlpikavfrvyypnss-------mqrdalfvdia 238
Q08227       147 MtrngeenwERF-------------------------------------------------------------------- 158 Saccharomyces c...
O76745       144 Iy------nKRF-------------------------------------------------------------------- 149 bed bug
Q9XWG3       195 F--------DVEKHDVIHFQNSGMYRTLQILEGSIGGLKVFLLnt----------------------------------- 231 Caenorhabditis ...
O95551       188 R--------VKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLm------------------------------------ 223 human
ETI56156      82 V--------KSLETHPFSNTGMGRELVIMQVEPIPGKTLFVGTshleslpqfagp----------------------rvs 131
3W2X_A       117 --------NGKMSEERLKYKLEFYDAFLEDVNRERDSGRNVII------------------------------------- 151 Methanothermoba...
Q2UNN7       183 eekrirlcNTHLESMALDPPYRPPQMQLVAQYMHHDGVHAALV------------------------------------- 225 Aspergillus oryzae
Q0CY83       166 thleslvsVPPRRPVQLRRAADFMHGTADGGEVSLPTPHGAIL------------------------------------- 208 Aspergillus ter...
Q2UFE1       205 nthlesllSNPPIRPMQLHLASQFMHGSGPGETDLPTPHAAIL------------------------------------- 247 Aspergillus oryzae
XP_001909648 239 iprdkvlrVCSTHLESLVARPPKRPAQLATAARFLHQAHVGIL------------------------------------- 281
Q08227       159 ----------------------------------------SYIcahlnanegvnnrnqriddykrimsevcdsevaksdh 198 Saccharomyces c...
O76745       150 ----------------------------------------SFTtsrmsdedvtstntkyay----dtrldyskkddpsdf 185 bed bug
Q9XWG3       232 -------hLESTREHRPQRCAQFGFCMDKVREIIAQNPGALVF------------------------------------- 267 Caenorhabditis ...
O95551       224 -------tSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIF------------------------------------- 259 human
ETI56156     132 qlkesltlLRDRVNNAESDDMVAIGDKRRADGNPKNVCLGAIF------------------------------------- 174
3W2X_A       152 ---CG-DFNTAHREIDLARPKENSNVsgflpverawidkfien------------------------------------- 190 Methanothermoba...
Q2UNN7       226 ---AG-DFNAIQPFDRTLHVDNNLKDaflelgga---------------------------------------------- 255 Aspergillus oryzae
Q0CY83       209 ---AG-DLNAFAPEDAVAPRDCNLHDaflvlggr---------------------------------------------- 238 Aspergillus ter...
Q2UFE1       248 ---AG-DLNAFAPEDLTAPNECALRDaflvlggk---------------------------------------------- 277 Aspergillus oryzae
XP_001909648 282 ---AG-DLNAIERFDWTLHKENRLKDayletggk---------------------------------------------- 311
Q08227       199 fffLG-DLNF---------------------------------------------------------------------- 207 Saccharomyces c...
O76745       186 lfwIG-DLNV---------------------------------------------------------------------- 194 bed bug
Q9XWG3       268 ---FGgDLNLRDEEVSRVPDGVKDAWeaagsdn----------------------------------------------- 297 Caenorhabditis ...
O95551       260 ---AG-DTNLRDREVTRCGGLPNNIVdvweflgk---------------------------------------------- 289 human
ETI56156     175 ---MG-DTNLMKTDMKLLDRRLAAFAdvdvelaktgrskcrtceevidkgavrvgkmakstvtggkvleirlwfhdtcfl 250
3W2X_A       191 --------------------------------------------gyvdtfrmfnsdpgqyTWWSYRTRARERNVGWRL-- 224 Methanothermoba...
Q2UNN7       256 ----------------------------------------------------edteegytWGQQATTKQRAQFGCSRM-- 281 Aspergillus oryzae
Q0CY83       239 ----------------------------------------------------dgteesftWGQQIPDWMREKFGCSRM-- 264 Aspergillus ter...
Q2UFE1       278 ----------------------------------------------------dgteesftWGQQIPNWLREKFGCSRM-- 303 Aspergillus oryzae
XP_001909648 312 ----------------------------------------------------qgdeagatWGLMGRSNDRQRYGTSRM-- 337
Q08227       208 ----------------------------------------------------------------------------RVts 211 Saccharomyces c...
O76745       195 ----------------------------------------------------------------------------RVet 198 bed bug
Q9XWG3       298 ------------------------------------------------------ktkftwDTFKNDNKQGFHGAKMRF-- 321 Caenorhabditis ...
O95551       290 ----------------------------------------------------pkhcqytwDTQMNSNLGITAACKLRF-- 315 human
ETI56156     251 nassttddektlvkrmerelrgeskrgdeetvdlatmglpggwkdlwlsvpgnteengytFDGTRNTLVTSRSFRSRL-- 328
3W2X_A       225 ---------------------------------------------------------------------DYFFVNE-EFK 234 Methanothermoba...
Q2UNN7       282 ---------------------------------------------------------------------DKVYFRG---- 288 Aspergillus oryzae
Q0CY83       265 ---------------------------------------------------------------------DKVLFCG---- 271 Aspergillus ter...
Q2UFE1       304 ---------------------------------------------------------------------DKVLFCG---- 310 Aspergillus oryzae
XP_001909648 338 ---------------------------------------------------------------------DKVLFCG---- 344
Q08227       212 tydpttnysstttlrrllenheelnllrkgedeplckgfqelkitfpptykfklfeketyntkripswcDRILYKSyAVP 291 Saccharomyces c...
O76745       199 nathakslvdqnnidglmafdqlkkakeqkl-----fdgwtepqvtfkptykfkpntdeydlsatpswtDRALYK----- 268 bed bug
Q9XWG3       322 ---------------------------------------------------------------------DRLYWSG---- 328 Caenorhabditis ...
O95551       316 ---------------------------------------------------------------------DRIFFRA---- 322 human
ETI56156     329 ---------------------------------------------------------------------DRMYFYS---- 335
3W2X_A       235 -GKVKRSWILSDvm-----------------------------------gSDH 251 Methanothermobacter thermautotrophicus str...
Q2UNN7       289 -----------Svkllkfekfgegilaeg----deerrqivelgfekpwvTDH 326 Aspergillus oryzae
Q0CY83       272 -----------GlrvtalqrigagekiwveypkgdsneesdgekgeemwvTDH 313 Aspergillus terreus NIH2624
Q2UFE1       311 -----------Gleverlerigagemvwiey-pdvsdeetedekgeevwiTDH 351 Aspergillus oryzae
XP_001909648 345 -----------Kaglldygtfgldvevede---adrqklkrswglakawvTDH 383
Q08227       292 tFAQEGTYHSVPrsna-------------------------------llfSDH 313 Saccharomyces cerevisiae S288C
O76745       269 -SGTGKTIQPLSynslt-----------------------------nykqTEH 291 bed bug
Q9XWG3       329 -----------Pldkvkftlegr-----------------qrirsclcfpSDH 353 Caenorhabditis elegans
O95551       323 -----------Aaeeghiiprsldl-------------lglekldcgrfpSDH 351 human
ETI56156     336 -----------Asndeagkcefdqiv-----------ivgqqkiadglwpSDH 366
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