5F5S,5F5T,5ZWO


Conserved Protein Domain Family
PRP38

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pfam03371: PRP38 (This model is not part of the current CDD release)
PRP38 family
Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.
Statistics
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PSSM-Id: 515542
Aligned: 129 rows
Threshold Bit Score: 131.414
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5F5S_A        12 HSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTA----------ELVVDKAME-LRFVGG-VYGgNIkp-tpFLCLTLK 78  human
XP_002179852  41 LPLWGAPDSFHFNPLLLRNTVRSLYFQKCCEKLLDw---------NAVVDEIYYeVKYLQPfALDksp---stAFCLLLR 108
XP_001417208  18 nAAKTTGRTHGVEAVLRQNVVNSEYYR-KLCRSATgtvdgegmdfMSLVDEIYElVDHVEPwMSGnARga-stGFCILFR 95 
XP_003057645  20 gqalDNGKSYNMEKVLRTNILASDYFS-QLVKMNDf---------YELVDEIYNeVDHVEPwMSGnARgp-stAFCLLYR 88 
XP_001703418   1 mEIHGSNTTFNLENVLRQNILSSDYYKGTCSELSNc---------SDIVDEIYEsVDHVEPwMSGnARgp-stAFCLLHR 70 
XP_005844327   1 meqYGNQTTFNLESVLLQNIKRSQYWEKRAKDIADw---------SELVDEIFEtVDNVEPwMSGnARgp-stAFNLLYR 70 
XP_051623515 159 LDM-TNSSTYNMNTLLLNNILNSDYYK-SLSTMTSh---------HSIIDELAQyADHVEPyCKTaTRvp-stLFCCLHK 226
XP_002678106  48 INVWGNSSTMNITPYLYKKVLASPYFK-SLYEYKTy---------HEVLDLIKN-IKYIHPfTDGdTNaepsiAFSLLFK 116
XP_002369181 141 vEM-TDSTTYNVNALLRSNILSSEYFK-SLHELKTv---------PEVVDEITQyAQHAEPyCSGsSRap-stLFCCLYK 208 Toxoplasma gond...
XP_654426      7 LPTQGNTRTMNIDSILFTNITHSDYMFKTLGSIHSi---------SDLIDIIINdVHYISPyIQKsSSsp-stAFCVLLR 76  Entamoeba histo...
5F5S_A        79 MLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGe------------FELMHV 146 human
XP_002179852 109 LLTLRVTNHQMELTLKHTDSPYIRGIGFLYLRYAGPPEQIWSFIESSLQDEEelvie-------------aghrGKRSTI 175
XP_001417208  96 FCEKELSDKEIWHLLRHGDSPYIRAIGFLYVRYVKNGRELLRWCEEFFDDAEkfsp---------------spgGKEVTM 160
XP_003057645  89 LFTMEIEDNEVKHLINHGDSPYIRALGFLYVRYARDPKEFGRWFDEFLRDEEefsp---------------sphGKSVTM 153
XP_001703418  71 LFTLKLSAKEVKGMLDHKDSPYIRAVGFLYLRYVGDPKTLWSWVAPYVKDQEkfsp--------------sgpnEKEVAM 136
XP_005844327  71 LCQLKPDVRQVRQMLDHVDSTFIRAIGLLYLRYVCDPRQLWDWFRNYVRDEEICKAGLLSLlftqefepsppglGRTVTI 150
XP_051623515 227 LFTLRLTERQMEDLIDCTKSPYPRCCGFLYLRFVLPSDQLWAWFEPYLMDEEtfvm--------------svnpTRKTTI 292
XP_002678106 117 LHTLKLSYKQLKGMLQKDMSTNTKAMALLYVRFAVQPDEMWDYFRDFVNDENntv----------------niyTKRISL 180
XP_002369181 209 LFTMKLTTKQLEQLLDYSDSPYVRCTGFLYLRYVHPPEKLWKWYEQYFLDDEvfaa--------------ssdtKRTTTM 274 Toxoplasma gond...
XP_654426     77 LFQLNPTPDDIRMMSTHSNK-YVRCIAALIIRYSIQFNLLLSYLKPFVDDRAvvni--------------slhgEKTKQI 141 Entamoeba histo...
5F5S_A       147 DEFIDELLHSERVCDI--ILPRLQKRYVLE 174 human
XP_002179852 176 GQFVRSLFSSRDFYGT--SLPRLPIQTERD 203
XP_001417208 161 GTYVRDLLLEQHYFET--IFPRIPEVARRE 188
XP_003057645 154 GAFVRDLILDQYYFET--IFPRIPEVSRRa 181
XP_001703418 137 GDYVRDLLLSQYYFET--IFPRIPKPVQDQ 164
XP_005844327 151 GAFARDILLDQFYFET--IFPRVPKPggad 178
XP_051623515 293 GKFCESLLVEDRYFNT--VLPRLPSRFKNM 320
XP_002678106 181 GEFVRSLITNQKLFGSqcILPILPANLVrr 210
XP_002369181 275 GEYVESLIMEDKYFNT--VLPRLPVKVKnl 302 Toxoplasma gondii ME49
XP_654426    142 KCLVKDLILEPKFEGC--ILPRIPQVyykp 169 Entamoeba histolytica HM-1:IMSS
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