5F5S,5F5T,5ZWO


Conserved Protein Domain Family
PRP38

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pfam03371: PRP38 
PRP38 family
Members of this family are related to the pre mRNA splicing factor PRP38 from yeast. Therefore all the members of this family could be involved in splicing. This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.
Statistics
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PSSM-Id: 397446
Aligned: 141 rows
Threshold Bit Score: 131.793
Threshold Setting Gi: 238933965
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5F5S_A        12 HSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTA----------ELVVDKAME-LRFVGG-VYGgNIkp-tpFLCLTLK 78 
XP_002179852  41 LPLWGAPDSFHFNPLLLRNTVRSLYFQKCCEKLLDw---------NAVVDEIYYeVKYLQPfALDksp---stAFCLLLR 108 Phaeodactylum t...
XP_001417208  18 nAAKTTGRTHGVEAVLRQNVVNSEYYR-KLCRSATgtvdgegmdfMSLVDEIYElVDHVEPwMSGnARga-stGFCILFR 95  Ostreococcus lu...
XP_003057645  20 gqalDNGKSYNMEKVLRTNILASDYFS-QLVKMNDf---------YELVDEIYNeVDHVEPwMSGnARgp-stAFCLLYR 88  Micromonas pusi...
EDP06100       1 mEIHGSNTTFNLENVLRQNILSSDYYKGTCSELSNc---------SDIVDEIYEsVDHVEPwMSGnARgp-stAFCLLHR 70  Chlamydomonas r...
EFN52225       1 meqYGNQTTFNLESVLLQNIKRSQYWEKRAKDIADw---------SELVDEIFEtVDNVEPwMSGnARgp-stAFNLLYR 70  Chlorella varia...
XP_001612015 171 LDM-TNSSTYNMNTLLLNNILNSDYYK-SLSTMTSh---------HSIIDELAQyADHVEPyCKTaTRvp-stLFCCLHK 238 Babesia bovis T2Bo
ESS30588     141 vEM-TDSTTYNVNALLRSNILSSEYFK-SLHELKTv---------PEVVDEITQyAQHAEPyCSGsSRap-stLFCCLYK 208 Toxoplasma gond...
Q8IM21       173 LEM-TNTTTYNVNTLLRNNILSSEYFK-SLIPIKTf---------KEVVDEIHSyADHVEPyCIGsNRap-stLFCCLYK 240 Plasmodium falc...
EFC45362      48 INVWGNSSTMNITPYLYKKVLASPYFK-SLYEYKTy---------HEVLDLIKN-IKYIHPfTDGdTNaepsiAFSLLFK 116 Naegleria gruberi
5F5S_A        79 MLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGe------------FELMHV 146
XP_002179852 109 LLTLRVTNHQMELTLKHTDSPYIRGIGFLYLRYAGPPEQIWSFIESSLQDEEelvie-------------aghrGKRSTI 175 Phaeodactylum t...
XP_001417208  96 FCEKELSDKEIWHLLRHGDSPYIRAIGFLYVRYVKNGRELLRWCEEFFDDAEkfsp---------------spgGKEVTM 160 Ostreococcus lu...
XP_003057645  89 LFTMEIEDNEVKHLINHGDSPYIRALGFLYVRYARDPKEFGRWFDEFLRDEEefsp---------------sphGKSVTM 153 Micromonas pusi...
EDP06100      71 LFTLKLSAKEVKGMLDHKDSPYIRAVGFLYLRYVGDPKTLWSWVAPYVKDQEkfsp--------------sgpnEKEVAM 136 Chlamydomonas r...
EFN52225      71 LCQLKPDVRQVRQMLDHVDSTFIRAIGLLYLRYVCDPRQLWDWFRNYVRDEEICKAGLLSLlftqefepsppglGRTVTI 150 Chlorella varia...
XP_001612015 239 LFTLRLTERQMEDLIDCTKSPYPRCCGFLYLRFVLPSDQLWAWFEPYLMDEEtfvm--------------svnpTRKTTI 304 Babesia bovis T2Bo
ESS30588     209 LFTMKLTTKQLEQLLDYSDSPYVRCTGFLYLRYVHPPEKLWKWYEQYFLDDEvfaa--------------ssdtKRTTTM 274 Toxoplasma gond...
Q8IM21       241 FFTMQLSEKQLKSLIENKDSCYIRACGFLYLRYVHSPANLWMWFEPYLLEEDefsi--------------scdkRRKVTI 306 Plasmodium falc...
EFC45362     117 LHTLKLSYKQLKGMLQKDMSTNTKAMALLYVRFAVQPDEMWDYFRDFVNDENntv----------------niyTKRISL 180 Naegleria gruberi
5F5S_A       147 DEFIDELLHSERVCDI--ILPRLQKRYVLE 174
XP_002179852 176 GQFVRSLFSSRDFYGT--SLPRLPIQTERD 203 Phaeodactylum tricornutum CCAP 1055/1
XP_001417208 161 GTYVRDLLLEQHYFET--IFPRIPEVARRE 188 Ostreococcus lucimarinus CCE9901
XP_003057645 154 GAFVRDLILDQYYFET--IFPRIPEVSRRa 181 Micromonas pusilla CCMP1545
EDP06100     137 GDYVRDLLLSQYYFET--IFPRIPKPVQDQ 164 Chlamydomonas reinhardtii
EFN52225     151 GAFARDILLDQFYFET--IFPRVPKPggad 178 Chlorella variabilis
XP_001612015 305 GKFCESLLVEDRYFNT--VLPRLPSRFKNM 332 Babesia bovis T2Bo
ESS30588     275 GEYVESLIMEDKYFNT--VLPRLPVKVKnl 302 Toxoplasma gondii VEG
Q8IM21       307 GEYVQSLLSDDKYFNT--VLPRLPIKIKNV 334 Plasmodium falciparum 3D7
EFC45362     181 GEFVRSLITNQKLFGSqcILPILPANLVrr 210 Naegleria gruberi
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