8DFV,2KOU,8HF0


Conserved Protein Domain Family
Dicer_dimer
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pfam03368: Dicer_dimer (This model is not part of the current CDD release)
Dicer dimerization domain
This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer. It is a divergent double stranded RNA-binding domain. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity. This domain has weak dsRNA-binding activity. It mediates heterodimerization of Dicer proteins with their respective protein partners.
Links
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Statistics
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PSSM-Id: 515540
Aligned: 192 rows
Threshold Bit Score: 50.1846
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8DFV_A         825 AIALVNKYCARL--PSDTftkL--TALWRCTRNeRagvTLFQYTLRLPINSPLKHdIVGLPMPTQTLARRLAALQACVEL 900  fruit fly
33_pfamImport    1 SLDVLARFTASLrqSNDE---Il-VPDYVVINQ-G---QNFVAEVQLPSKSPILS-KTGFPHRNKQSARCSAAFEMCKEL 71  
XP_031885297   660 SLEVLSNFTSSLrqSNDE---Vl-APEYVVVNE-G---QKFLAEVQLPPRSPIQT-MAGNPHSTKQDARCSAAFEMCKEL 730 
XP_006674454   580 SMVVLARFVSTLgqGTEK---Sp-APEYVVSGV-G---TNFTCWVILPDSAPFKS-TSGSMERSKIKARCAAAYEACTRL 650 
XP_013944263   548 SLACLAKYTSSLsrDGLQ------KIEYVVKSD-K---KQFIASVVLPDGSPIKT-IQGISQRTKQLARCSAAFEACRIL 616 
XP_006969254   530 SLDVLAKFASSFpnEAED---GimPLEYIVNTV-G---KKFIARVVLPEGSPIKT-ITGEAQQSKQLARCSAAFEACVRL 601 
XP_013954908   477 SLEVLAKYASSFpnNAID---GllPLEYIVTSI-G---KKFVARVILPDASPIKM-FPGEVQKSKQLARCSAAFEACVHL 548 
XP_003046961   564 SMDVLSKYAASItpGVSS------KVEFTVTKL-G---PKFIADVILPDASPLKA-MSGFPQRSKLLAKYSAAFEACVKL 632 
XP_011328775   606 SLEILARFVASLgtAE-S---ShsKAEYHVYKV-G---TYFTAAVNLPSSSPIVS-QTGYPQRSKLLAKCSAAFEVCKKL 676 
EWY87316       612 SLEILARFVSHLstDSYA------KVEYQVQKV-G---DRYLADVVMPLQSPVNF-VKGTQQRSKLLAKCSAAFEACKIL 680  Fusarium oxy...

8DFV_A         901 HRIGELDDQLQPIGKE 916  fruit fly
33_pfamImport   72 IKKKYIDHYLNPVFVK 87  
XP_031885297   731 IKKKYIDDRLRPVFVK 746 
XP_006674454   651 IDLGSINKNLQPTFRK 666 
XP_013944263   617 IEKGYIDKHLRPAFAK 632 
XP_006969254   602 IQKKYITGNLQPAFAK 617 
XP_013954908   549 IGKKYINGNLQPAFTK 564 
XP_003046961   633 IKDKHIDGHLQPTLSK 648 
XP_011328775   677 INGKHIDDHLQPTFKK 692 
EWY87316       681 IRDKHVDGNLQPTFKK 696  Fusarium oxysporum NRRL 32931
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