5Y6O


Conserved Protein Domain Family
Daxx
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pfam03344: Daxx (This model is not part of the current CDD release)
Daxx N-terminal Rassf1C-interacting domain
The Daxx protein (also known as the Fas-binding protein) is thought to play a role in apoptosis. Daxx forms a complex with Axin. Remodelling of the family to a short domain based on the PDB:2kzs structure gives a more representative family. DAXX is a scaffold protein shown to play diverse roles in transcription and cell cycle regulation. This N-terminal domain folds into a left-handed four-helix bundle (H1, H2, H4, H5) that binds to the N-terminal residues of the tumour-suppressor Rassf1C.
Links
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Statistics
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PSSM-Id: 515525
Aligned: 10 rows
Threshold Bit Score: 155.694
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5Y6O_I         1 SSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYVYINE 80  human
Q3UKR0        56 SSNSGSRKCYKLDNEKLFEEFLELCKTETSDHPEVVPFLHKLQQRAQSVFLASAEFCNILSRVLARSRKRPAKIYVYINE 135 house mouse
XP_003510877  50 SRNSGGRKCYKLENERLFEEFLELCKVQTSDHPEVVPFLHKQQQRAQSLFLASAEFCNIMSRVLSRARNRPAKLYVYINE 129
Q5TJE1        50 SSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRAQSRPAKLYVYINE 129 dog
XP_007253142  47 STAKKEGHVLKVENEKLFGEFLEHCMAHTKEHPEVVTFLQTKYSKASPDFLMSVEFRNALGRCLTRAQASTTKTFVYINE 126
1_pfamImport   3 ASAKKDKHVLQAENQRLFTEFVEHCSSLTQSCPEVLTFLQTKHAKASPEYLSSVEFRNTLGRCLTRTQANRSKAFVYINE 82 
5_pfamImport   3 VSARREPHVLQAENERLFGEFVDHCLADTTDCPEVLDYLKTRHAKASPEYLCSVEFRNTLGHCLSRAQAHRSKTFVYINE 82 
XP_006000990  52 SEKDAEKVILKAQNEKLFAEFVEFCSKLSDGHPEVISFLKGRHEKARPEYLASTEFRNVIGRCLTRVQNKKGKVFVYINE 131 coelacanth
XP_056673992  51 SSSGGSKKCYQLENEKLFEEFVDLCKKQTGEHPEVVPFLCNKRQRARPTFLASAELRNVLSRVLSRAQARPTKLYVYINE 130 gray short-tail...
XP_004846863  51 SSSSGGKKCYKLENEKLFEEFLELCKMQTSDHPEVVPFLCKLQQRAHSVFLASAEFCNILSRVLSRARSRPSKLYVYINE 130

5Y6O_I        81 LCTVLKAHSAKKKLN 95  human
Q3UKR0       136 LCTVLKAHSIKKKLN 150 house mouse
XP_003510877 130 LCTVLKAHSNKKKLN 144
Q5TJE1       130 LCTVLKAHSAKKKLN 144 dog
XP_007253142 127 LCTLLKQHSAKRRAL 141
1_pfamImport  83 LCTALRQHAVKRRQT 97 
5_pfamImport  83 LCTVLTQHAAKKRQV 97 
XP_006000990 132 VCTALKANSQKKKVP 146 coelacanth
XP_056673992 131 LCTLLKAHSTKRKVP 145 gray short-tailed opossum
XP_004846863 131 LCTVLKAHSAKKKLN 145
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