Conserved Protein Domain Family
SART-1

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pfam03343: SART-1 
SART-1 family
SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumor antigen in a range of cancers recognized by T cells.
Statistics
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PSSM-Id: 397428
Aligned: 113 rows
Threshold Bit Score: 140.534
Threshold Setting Gi: 387511685
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O01524        52 SMSIEETNKLRASLGLAPLEtNDnk---eRDANDGT---NEKIYNEDG---FEFRHRKAENISDKKKEKDIKEKLEIAKA 122 Caenorhabditis ...
EGF80696      13 SLSVEETNKLRTLLGLKPLE---------------------TGPSSKNaqaEDNFQRHKDDAIKKKERMDLAEKINREKE 71  Batrachochytriu...
EIE84649       4 SISIEETNALREKLGLPPLAaq----------------dSDDEVVDPEkeaYDNYQKMKQEQEKAKRAEEIKKNIEKSQN 67  Rhizopus delema...
XP_002506343  30 SMSLEETNRVREKLGLKPLRt------------------GESDRTKARreaEETERAAREADAKDAETAALAAKIAAAKE 91  Micromonas commoda
XP_001421608 160 SMSIEATNAMRLKLGLAPLR-------------------------EGAskkTHDADALRRDEAKAAETAALAEKIAARKR 214 Ostreococcus lu...
XP_004343271   6 VLSIEETNAQRAALGLKPLK-LKaannadDASASDQpaaPALSEDERRdiaAFKFLEEQAQIQKEKDAKTLEERLAAHRE 84  Capsaspora owcz...
XP_004992299   8 SLNVEESNALRAKLGLAPLRgd----------------dEPREAKPGQssmETDVLLAPVVPGEKQREAELRDKLKERKE 71  Salpingoeca ros...
1_pfamImport   1 SLSIDETNKIRAKLGLKPLDiGNsqsedgVKLNSD----------------ENFVHAPAEDLAEKKKQEKLREKIMESKK 64 
CDS40635      96 SLSIEETNKLRAKLGLSPLDlGNvsk-adSDECKPRns------------dAEFVHVPAKDLTKAKQVEKLQEKITTAKE 162 Echinococcus mu...
XP_002120093 114 SLSIEATNALRAKLGLKPLNvGGsgsgngDNAGGE----------------DEFVHAPAEHLGEKKKQEIMKEKILASKR 177 vase tunicate
O01524       123 KRDVYSKVLkAKKLAD--SDeE---DSAASFVNKMR---------QKEDeakkAADRaaAFDqLDEElgvsa-------- 180 Caenorhabditis ...
EGF80696      72 LAHRNKKLA-GKGLGEasDEeDa-vGDAAAWVLKTKaksvsnkvsKREQ----RLANkrAQElTEMD------------- 132 Batrachochytriu...
EIE84649      68 RKRNLSKLQ-GKGLGEasDDeD---DSALNWVKKSR---------TRER----DLAArrAREiee--------------- 115 Rhizopus delema...
XP_002506343  92 KRTMEQRNRaTKQLGEaadadD---DDMMAWVNKSR----------KIEekrrKEERkkAEElarklae----------- 147 Micromonas commoda
XP_001421608 215 QREIEKLNAaTTKLGDad-deE---EDAGAWLAKSK---------TKMAtkaqELERakAAKvaamfaerdedae----a 277 Ostreococcus lu...
XP_004343271  85 ARRIEDSLKaTKTLGAa----DkegDSASSWVTQSRk--------AQDAqrkaAEARlrAFDeLDEQastsigssk---- 148 Capsaspora owcz...
XP_004992299  72 KRSVEAKLRsVKTLGEad-ddD---DSAAAWVKRSR---------AKKQ----AQRQakMLQdMDEQltgsssasasagg 134 Salpingoeca ros...
1_pfamImport  65 KREIAKKMSkVRTLG---EVeE---DSAADWVVKSR---------MAQQqreqDEKMm----kLGDEfgvsdli------ 119
CDS40635     163 KRELLSKLReVK-SLG--SGeE---TSVSSWVEKMR---------SKEKakleAEKReqMLTeMDAVfgvsavv------ 221 Echinococcus mu...
XP_002120093 178 KREIAKKMSkVRTLGE--ENeE---ESAANWVLKSR---------STQQqreqEEKMm----kLGEEfgvsdli------ 233 vase tunicate
O01524       181 ------ivdkvKKPKKPKTkgPSD----TAGMVIGHGREAFIEGDQ-ILVLQDKGV--LDD-----Gd--EVLVNPNLLD 240 Caenorhabditis ...
EGF80696     133 --------------QQAYS--SATfivdLAGLRVGHAIDDLAETGEtTLILKDSTI--MEN-----EedgDELVSVSLAE 189 Batrachochytriu...
EIE84649     116 --------mdnTFQSGQYD--ASH----LSGLKVGHSLSEFDEVGEtILTLKDRSIldEQD-----Ed-aDELTNVNIED 175 Rhizopus delema...
XP_002506343 148 ----qddeaeeSEGDEIYG--GKD----LAGMRVRHGLEDVAEGETmILTLKDSSI--LDDklqgiNeedDELENVNVAQ 215 Micromonas commoda
XP_001421608 278 saseeedegakKSKSAAYT--SKD----LRGLKVRHTADEINEGQEvVLTLKDTSV--LDD-----Ed--DELENVLIAE 342 Ostreococcus lu...
XP_004343271 149 --pkpaqkkaaATGAQSYD--SSN----LAGLKVAHDVEDFEEGSt-VLVLQDTGVldDDN-----E---DVLENVNMAD 211 Capsaspora owcz...
XP_004992299 135 ssrkrkgsknpTIKQEEYT--STD----LRGMTVRHDLDQFQEGAQtILTLEDRGVldDDE-----E---DVLVNVNIAE 200 Salpingoeca ros...
1_pfamImport 120 -----ktelgsKSTAHDYT--ERD----LAGLSVEHSLESFREGRNeILVIKDKEI--LGS-----De-eDVLHSLNVDD 180
CDS40635     222 -----eerirpKALKPEYS--SAS----LEGLKVEHSVDRFSEGKPiILTLKDSDV--LAE-----Da-sDVLTNVNLED 282 Echinococcus mu...
XP_002120093 234 -----eselgsKKNVPAYT--EKD----LTGLSVEHSVESFREGKDaVLVIKDKDI--LAS-----Dd-eDVLHSINIDD 294 vase tunicate
O01524       241 NERHVRNVELRKRkD--PNRNfded--vdeFGNaKN-FG-VLAKYDE---TL-EGEq--KKQFRLd-EhgGVDLEEERRE 307 Caenorhabditis ...
EGF80696     190 HERTKKNLDNKKK-Rp-GYNPyd-----ddSELgGK-KD-ILHQYND---EDv------KTSFTL-----GSKGIVDIEK 246 Batrachochytriu...
EIE84649     176 KERVKKNLEAKKK-Kp-GYNPyd-----ddQFNgSK-QS-ILPQYEE---EEg------IEGFVI-----GASGTVSSKD 232 Rhizopus delema...
XP_002506343 216 ERKRQKAKKAATKrSd---NPfgadd-------edagKK-ILSKYDEe-----------DEDEGLtlDaaGAIDAAEEKR 273 Micromonas commoda
XP_001421608 343 RKSRKKARKESTKkSd---DPfgegk-------dveaKKtVLGKYDAh-----------DEDAAMelDgeGGLDAAEEKR 401 Ostreococcus lu...
XP_004343271 212 HERAKQNAIRRANsKrpGYNPlvgedgndsGLGa---PTgLLSHYDEweeELkGDRk--LKKLTVldAqgSADTAEKKLE 286 Capsaspora owcz...
XP_004992299 201 DEHAKRRVAEAQRsG--GYDPkrglddddeDTLlGLkKKsVLDKYDDidsltgDKKlkeTKTFRIgfEdeKss------- 271 Salpingoeca ros...
1_pfamImport 181 VEKSKKNMEIKRRgV--GYKAyeee-eiddMGFfKA-KV-VLGKYDE---EI-EGEq--ITKFKIg-AsgKVDASWV-QQ 247
CDS40635     283 EERAEKNRENQRKlA--GLGGilqdedddvVMGlRE-KG-ILEKYDV---EI-SGPk--KAEFILe-AngTYATDHE-RA 350 Echinococcus mu...
XP_002120093 295 VEKSKKNLEVKRRgV--GYKAyeee-eiddMGFfKA-KV-VLGKYDE---EI-EGEk--SSKFKIg-RsgQVDTSWE-QQ 361 vase tunicate
O01524       308 m------EAFRRMKM-AGKrlESL-ETK----------KYELASEFYTQDEMtq--frKVKKGKKe------kNIRKRkv 361 Caenorhabditis ...
EGF80696     247 let--akIEVSEKMRlQT---VSL-DYE----------KTRQIADYYTKDELv-----SFKKPKSksks-kraSSRKQld 304 Batrachochytriu...
EIE84649     233 kdqaenqKTVSEKLK-EQT--LSY---T----------KMQEIKDYYTQEEIe----aTFKKPKSkkkk-mrrKTK---- 287 Rhizopus delema...
XP_002506343 274 k------ADIKRRLA------ASLgGVsvnavaetadvRKREMSEFMSAAEVaeeaaaKFNKPKKkr----rkKLREKkf 337 Micromonas commoda
XP_001421608 402 k------AEIKARLA------AELsGLkgkae--taevVKGEQADFHTQEEMq----aKFVKREKkkk--mrkKLRKKhi 461 Ostreococcus lu...
XP_004343271 287 ----------QEFFAkQRAkaVSLdSD-----------TRTSVSDFYTPEEMi-----SFKKPSKdkk---hkKRRTRdr 337 Capsaspora owcz...
XP_004992299 272 ------eEQRKEEVRqRLLqaESL-EF-----------KHNAVSDFYTEEEMe-----KFKKKRKkrkakgrkKTRRVra 328 Salpingoeca ros...
1_pfamImport 248 k------EEMKQEIR-AKg--ESL-SLP----------PLKLANEYLTEEDM------RFKKRKRkv-----kKSRKRev 296
CDS40635     351 l------RRLQEELQ-TTr--QSL-EDQ----------ELRPAADFYTEDEMa-----QFKKKKRr-------KV-QRri 397 Echinococcus mu...
XP_002120093 362 k------EQMKQEIR-AKg--ESL-TLP----------PLKIASEYLTEEEM------KFKKRKRkv-----kKVRKRdv 410 vase tunicate
O01524       362 ---lkASDLvpv------ekaGEGRdfgrrrrdsdepedeglkkekqdgkdedgeisdkevpesssdngkwkkamrgngv 432 Caenorhabditis ...
EGF80696     305 ksdelYENLs---------------------------------------------------------------------- 314 Batrachochytriu...
EIE84649     288 -----EENE----------------------------------------------------------------------- 291 Rhizopus delema...
XP_002506343 338 diseiENDHlaqaaqekqeaaAEPErarg--------------------------------------------------- 366 Micromonas commoda
XP_001421608 462 daaelEQDAla---------pESSDlgsrrs------------------------------------------------- 483 Ostreococcus lu...
XP_004343271 338 tqdadDDEDdsiatqqsasgvVRSKrkapsgedgededdv---------------------------------------- 377 Capsaspora owcz...
XP_004992299 329 ddllgLDDEeeqtqp----------------------------------------------------------------- 343 Salpingoeca ros...
1_pfamImport 297 ---fkADDLlplp----gsseGLSNhgsrfvlcekeqylp---------------------------------------- 329
CDS40635     398 ---lrADDLipdpgs---astvsTDhgsrgrremqetagpalkeegevvdvkkveed---------ikppalapltglnp 462 Echinococcus mu...
XP_002120093 411 ---lkPEDIlplp----gssqSV-Nhgsr--------------------------------------------------- 431 vase tunicate
O01524       433 dlqrlqklrskhqiaedDDSDNDLmf---sgGvdL-----------TGvv------------------idDNAEe--eLS 478 Caenorhabditis ...
EGF80696     315 ----------------aNMDVDQPatgvfanSn------------iTAdvdn--------------infvDDDD----LQ 348 Batrachochytriu...
EIE84649     292 -------------------DFSAAaasanttSesRpar-------vrNheed--------------anfvDDDD----LQ 327 Rhizopus delema...
XP_002506343 367 --------------rfrNDAGEEErklmgfqNalNkakiktderilAEmag-----------------dvEDEDt--eLA 413 Micromonas commoda
XP_001421608 484 -----------rgessaEAKATTNekdakfaNalQkarevtdkkilAElage--------------aeeeEDDE----LA 534 Ostreococcus lu...
XP_004343271 378 ---qpavtvrhllnnsqAMDTSSSasgpdrgSrkRgrhdddehseaTIslpepgqfqalkpvtdasfdfvADDEgeveLA 454 Capsaspora owcz...
XP_004992299 344 ------------eaegdTMETGADvshavrdEedIlnqandaeleaA------------------------EREleaeLQ 387 Salpingoeca ros...
1_pfamImport 330 ------sysalrmlwnstkpEDKSgt---ndGesSqmn-----nkdERnvi----------------eddDDAIn--dLQ 377
CDS40635     463 aiaallsvqtipeeeeqIDAGDEDv--------------------aNQwsae--------------plepDNLQl--eLE 506 Echinococcus mu...
XP_002120093 432 ----------------ktkeVDGKgg---ndGrsSvnn------ndDDdvi----------------ddeEDAIn--dLQ 468 vase tunicate
O01524       479 SILAKTRK---VK---Q------IDgkqmdndvgKKV--QDILTSHgv---kmEId----EEedvkplkeGQIYIDSTTE 537 Caenorhabditis ...
EGF80696     349 LALAGARRr-aATki------nlSG---------ESI--ATQVTTGafdlqksNDqn------------sSGLVMSDTSE 398 Batrachochytriu...
EIE84649     328 EALSRARRv-aNKq-kNklikkmTP---------EEI--AKQIKEEeanqmktEEdd-----------esGGLVLSETSE 383 Rhizopus delema...
XP_002506343 414 MALERTKRlaerg-----------------vgarSDVdvARVAAARratdapdVGergasG---------EGMVFNDVQE 467 Micromonas commoda
XP_001421608 535 RALARSRKmanISnkaAr----sAP---------ADV--VAQVAARrqadeakA-------RenaanvadESLVFTDMSE 592 Ostreococcus lu...
XP_004343271 455 RALERTRR---LKqqaEgflagpA---------------VPAVRPKsed----------stEdsaasagdSSLVFSATSE 506 Capsaspora owcz...
XP_004992299 388 ASLTRARRa-rKNaykK-----------------KDV--TELLDAAvkk----------skEnnngssagGGVVFSTMSE 437 Salpingoeca ros...
1_pfamImport 378 RALDKSRR---AK---Qk----kAdaaa--degaQKV--AQHLHNLtrv--klEKp----DEqf-----tNTLFLNATDE 432
CDS40635     507 KTLSRVRN---TNlakcv------------pqpeERL--QMVMKEVesetfvpKA-----Qngns-ggdgGGLVFDATAE 563 Echinococcus mu...
XP_002120093 469 RALEKSRR---AK---Qk----kSnsvv--dsgaLRV--AKHLETLgqv--klEKp----DEqf-----tNTLFLNATDE 523 vase tunicate
O01524       538 YCRHVGEITTLg-------lGGNRTvdvs----------------------------------evkK-VKeeemeqeGSE 575 Caenorhabditis ...
EGF80696     399 FVQTLGNVSMLat------rEAERAaskalvmesvva-----------------sqiqadhkapaeSnEDpddgkmdLDG 455 Batrachochytriu...
EIE84649     384 FVGSLGINIPSfinnepkpqQVKKEpetptikeepvy------------------eeikqeetyikQePEnmdvitvQEE 445 Rhizopus delema...
XP_002506343 468 FVHGINVEDKRatrs--eaaAAGDMppvpppppgsgdmppvpppppgsdvdgmppvpppppsgvgaEeEHeddevnpLDG 545 Micromonas commoda
XP_001421608 593 FVQGINTQDGAldevydedaDTEEMpdvppppppggedepmd--------dempdvpppppqeevdAhVNmp-------- 656 Ostreococcus lu...
XP_004343271 507 FVKNIGARDLKpdpvqtqpaKPASFvpalvsqaqqpagvtapmdivsvgvpaanrtrrtklvgddeAeAMdtqpikkEES 586 Capsaspora owcz...
XP_004992299 438 FVRGIGANSKDddqprkrnkQGSSSsatatatagatet----------------sappvpaapassSsSAssaaaaaMET 501 Salpingoeca ros...
1_pfamImport 433 FCRQLaq------------vPVKQE-------------------------------------------VKqve-dmdLDE 456
CDS40635     564 FFKQISGglqnd----vtakMVKREaeaele------------------------------eaeveVqRRqp-------- 601 Echinococcus mu...
XP_002120093 524 FCRQLga-----------hmPVKQE-------------------------------------------IKqeeddmdVDE 549 vase tunicate
O01524       576 GFEkwk------rakVDkelkekekrklrd---qggwlaagepapsNARIDSdDEDALEEAKkrKWSEdeeedEDMEEDK 646 Caenorhabditis ...
EGF80696     456 ENEd------------------------------------------GEIDEIsKTEQEPEASkqKAVI------------ 481 Batrachochytriu...
EIE84649     446 ETDepm--------------------------------------------pdiKEEPTYEDVkeEPII------------ 469 Rhizopus delema...
XP_002506343     --------------------------------------------------------------------------------     Micromonas commoda
XP_001421608     --------------------------------------------------------------------------------     Ostreococcus lu...
XP_004343271 587 KSDdkndf------------------------------------------------------------------------ 594 Capsaspora owcz...
XP_004992299 502 GEDkaeeggdgdgtgRYfq--------------------------sSFTTDQaTTDAEHAERktEVDDtp---------- 545 Salpingoeca ros...
1_pfamImport 457 DN-------------SDeddtqm--------------------------skwssvNPGQe----NIVKfkkslKKLTKFS 493
CDS40635     602 vREkdsrserapekkERhrdssgrytsstkhsssshrhyeekasmsKSSGSStRSKEg------KEREdisaiSFTPTAS 675 Echinococcus mu...
XP_002120093 550 NP-------------ESedesnt--------------------------skwssvHPNNGHKieHVVP--------TQEV 582 vase tunicate
O01524       647 DDYApalGQEVDV-SKGVGRMLKLAGQKgylqnpnakshsgps------------------------------ldhlknk 695 Caenorhabditis ...
EGF80696     482 -------VDEPLVsS-GIAATMALLNQKgliqplteearareaklqehqkwlt----------qrklldrlkdskrlsgs 543 Batrachochytriu...
EIE84649     470 --------EEPLVsG-GLAATLALLNQKgmiakpteeqikrdkiaaeqirwqneqr---kkehrraleeqkekerrrdhg 537 Rhizopus delema...
XP_002506343 546 -------VQANPMgS-GLAATLALLKETgklh------------------------------------------------ 569 Micromonas commoda
XP_001421608 657 ------vLAEKHVvQKGLASTLALLKDKaqlddaq--------------------------------------------- 685 Ostreococcus lu...
XP_004343271 595 ---qdflTEEPSLvN-GVGAALAFMARRgmieneskaqgvvvvetdrqrdkgkqrmdqeeerkieleirrqreaernrdr 670 Capsaspora owcz...
XP_004992299 546 -----vlGEEGNVgS-SVTAALNLALRKgylaqkkkkqqqqqeeatasrlae------------ltsknaqqeehgpedd 607 Salpingoeca ros...
1_pfamImport 494 VLEHapiEAEPLA-ANGLMGALKLAERKgylqtkrepffqikfp----------------------------krvyifsk 544
CDS40635     676 AGGgv-fEEEPAL-NQGVFSALLLAQKKgyveeekekerpmgq------------------------------lvnlmak 723 Echinococcus mu...
XP_002120093 583 EGEHapiEAEPLA-ATGLMGALKLAERKgylgeekkkgnvvvt-----------------------------tnlniqak 632 vase tunicate
O01524       696 ttqridgQRFDPDDRNAKKADRLNSQH-----RGPVM-PFAEKhDYKPDVNISYVDRKGREMDAKDAYRELSYKFHGRNP 769 Caenorhabditis ...
EGF80696     544 srdrgysRSAQEMEDDRDRERAERDAEr----ARLREvERRFE-NYSPDVNIKYHDDHGRELSTKEAWNQLAYKFYGIMP 618 Batrachochytriu...
EIE84649     538 rgrdhdrDRMRELEREREREREREEAQ------RMKEfELAMQ-NYKPEVNLEYTDNKGRVLKTAEAFRFMSHQFHGKTS 610 Rhizopus delema...
XP_002506343 570 ---endmWDGRTNDKKPLALMRVREAAe----ITGAEfE-----GHKFDFKLDRYDEFGRKMTPKEAFRELCHRFHGIEP 637 Micromonas commoda
XP_001421608 686 -ntrwsgRANDMKDRFDRQHVLEAHAIe----EKAVD-------GYKFGFKLDKLDEFGRKLTPKEAFRELCHRFHGIEP 753 Ostreococcus lu...
XP_004343271 671 rdrrdvrDSRSDRDRNDRPPERDREADp----FSMPA----------PEFTLDYVDENGRTMTTKEAFNHLSYKFHGIQP 736 Capsaspora owcz...
XP_004992299 608 dhgrdsrSSRDWRRDSRRDRDRG---------------DPFEKrGYQPSFRLSYTDNTGRELTPKEAFTYMSHQFHGKTS 672 Salpingoeca ros...
1_pfamImport 545 yysiedkNAVDYLDKYAHE-KYSKERN-----ASITV-DFTEKkDYKPQISIEYVDEKGRNLSAKEAFRKLSHRFHGKGS 617
CDS40635     724 hyvkedvRYDDIDAKFAKR-ERYN---------GPLC-DFREKsSYKPDVKLYYVDEMGRNLTPKEAFRQLSHKFHGKGS 792 Echinococcus mu...
XP_002120093 633 hysiedkNAVDYLDKYAHE-KYSKerntsrydrGITT-EFSEKkDYKPKVNIEYVDEKGRNLSAKEAFRKLSHRFHGKGS 710 vase tunicate
O01524       770 GKKQLEKRANRKDKE 784 Caenorhabditis elegans
EGF80696     619 GKLKTEKRLKKLQEE 633 Batrachochytrium dendrobatidis JAM81
EIE84649     611 GKTKTEKRMRKIEEE 625 Rhizopus delemar RA 99-880
XP_002506343 638 GRAKKEKRLRAYQEE 652 Micromonas commoda
XP_001421608 754 GKMKREKRLRQFQEE 768 Ostreococcus lucimarinus CCE9901
XP_004343271 737 GKNKQEKRQRKLEEE 751 Capsaspora owczarzaki ATCC 30864
XP_004992299 673 GRMKTEKKLRKRQQE 687 Salpingoeca rosetta
1_pfamImport 618 GKMKQEKRMKKLTEQ 632
CDS40635     793 GKKKTERRTKKIIEE 807 Echinococcus multilocularis
XP_002120093 711 GKMKQEKRMKKMTEQ 725 vase tunicate
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