Conserved Protein Domain Family
SART-1

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pfam03343: SART-1 (This model is not part of the current CDD release)
SART-1 family
SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognised by T cells.
Statistics
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PSSM-Id: 515524
Aligned: 97 rows
Threshold Bit Score: 188.316
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O01524       111 KDIKEKLEIAKAKRDVYSKVLkAKKLAD-SD-EE---DSAASFVNKMR-QKEDeakkAADRAAAFDqLDEELGvs----- 179 Caenorhabditis ...
XP_002506343  80 AALAAKIAAAKEKRTMEQRNRaTKQLGEaadaDD---DDMMAWVNKSR--KIEekrrKEERKKAEE-----LArkl---- 145
XP_004343271  73 KTLEERLAAHREARRIEDSLKaTKTLGA----ADkegDSASSWVTQSRkAQDAqrkaAEARLRAFDeLDEQAStsigs-- 146
XP_004992299  60 AELRDKLKERKEKRSVEAKLRsVKTLGEad-dDD---DSAAAWVKRSR-AKKQ----AQRQAKMLQdMDEQLTgsssasa 130
XP_032514990 152 DKLREKLAERRDKRDIDNKLq-TSLLAE-Gs-DD---EDASAWVRKTR-DMEKqkqeAAKRAALLDeMDEVFGvga---- 220
5_pfamImport   1 EKLREKIMESKKKREIAKKMSkVRTLG--EV-EE---DSAADWVVKSR-MAQQqreqDEKMMK----LGDEFGvsd---- 65 
XP_004913756 140 QELREKLAAAKEKRLLNQKLGkIKSLGDdEL-WL---DDTAAWIEKSR-KLQMekeiAEKRAKLLAeMDEEFGv------ 208
XP_004051587 165 EELREKLAAAKEKRLLNQKLGkIKTLGE-DDpWL---DDTAAWIERSR-QLQKekdlAEKRAKLLEeMDQEFGvst---- 235
Q6DG11       145 AEMREKLAALKEKRLLNQKLGkVKALGD-DEpWL---DDTAAWVERSR-KLAKekemAEKRAKLLEeMDEEFGvsn---- 215 zebrafish
XP_003449741 143 KEMREKLAALKEKRKLNQKLGkVKTLAE-DD-WL---DDTSSWVERSR-KLAKekemAEKRAKLLEeMDEEFGvsn---- 212
O01524       180 --------aIVd-KVKKPKKPKTkgPSDTAGMVIGHGREAFIEGDQ-ILVLQDKGV--LDD-----G--DEVLVNPNLLD 240 Caenorhabditis ...
XP_002506343 146 ------aeqDDeaEESEGDEIYG--GKDLAGMRVRHGLEDVAEGETmILTLKDSSI--LDDklqgiNeeDDELENVNVAQ 215
XP_004343271 147 ----skpkpAQkkAAATGAQSYD--SSNLAGLKVAHDVEDFEEGSt-VLVLQDTGVldDDN-----E---DVLENVNMAD 211
XP_004992299 131 saggssrkrKGskNPTIKQEEYT--STDLRGMTVRHDLDQFQEGAQtILTLEDRGVldDDE-----E---DVLVNVNIAE 200
XP_032514990 221 -------lvADdqHRDR-QEAYH--QEHLKGLRVAHTLDALPEEREtVLTLADKEV--LAD-----Dd-EDVLVNVNIVD 282
5_pfamImport  66 -------liKTelGSKSTAHDYT--ERDLAGLSVEHSLESFREGRNeILVIKDKEI--LGS-----De-EDVLHSLNVDD 128
XP_004913756 209 --------sNLveEEFGQKKHYS--SRDLQGLTVEHKINAFKEGQTvILTLKDKGVl-DED-----Da--DVLVNVNLVD 270
XP_004051587 236 -------lvEEefGQRR-QDLYS--ARDLQGLTVEHAIDSFREGETmILTLKDKGV--LQE-----Ee--DVLVNVNLVD 296
Q6DG11       216 -------lvEQefAQEK-RQAYS--SHDLKGLKVQHKVESFSEGQTvVLTLQDKGV--LEE-----Ee--DVLVNVGLID 276 zebrafish
XP_003449741 213 -------lvEEefAQIK-QDAYT--SRDLKGLKVQHKVESFSEGQTvILTLEDKGV--LEE-----Ee--DVLVNVGLVD 273
O01524       241 NERHVRNVElRKRkD--PNRNFde--dVDEFGNaKN-FG-VLAKYDE---TLeg---eqKKQFRLde-hgGVDLEEERRE 307 Caenorhabditis ...
XP_002506343 216 ERKRQKAKKaATKrSd---NPFgaddeDAG-------KK-ILSKYDEe-----------DEDEGLtldaaGAIDAAEEKR 273
XP_004343271 212 HERAKQNAIrRANsKrpGYNPLvgedgNDSGLGa---PTgLLSHYDEweeELkgd--rkLKKLTVldaqgSADTAEKKLE 286
XP_004992299 201 DEHAKRRVAeAQRsG--GYDPKrglddDDEDTLlGLkKKsVLDKYDDidsltgdkklkeTKTFRIgfedeK--------- 269
XP_032514990 283 DEKYKKNIEeRKKaRt-GYQAYde-eaDIQAALgYS-RP-VLAKYDD---EIepskgdkTRGFFIgdedaLMEQKLKDMM 355
5_pfamImport 129 VEKSKKNMEiKRRgV--GYKAYee-eeIDDMGFfKA-KV-VLGKYDE---EIeg---eqITKFKIga-sgKVDASWV-QQ 195
XP_004913756 271 KEKAEKNVElKKK-Kp-EYKPYeeeenVEDMAVfRP-KS-VLSKYDE---EIeg---ekKKSFQLes--gGVADGSWEKE 338
XP_004051587 297 KERAEKNVElRKKkP--DYLPYaedesVDDLAQqKP-RS-ILSKYDE---ELeg---erPHSFRLeq-ggTADGLRE-RE 364
Q6DG11       277 KEKAEKNVElKKKkP--DYKPYeeeesVDDMIVfKP-KS-VLSKYDE---EIeg---ekKKSFRLss-ggFVGGERE-RE 344 zebrafish
XP_003449741 274 KEKAEKNVElKKKkP--DYKPYeeeesVDDMVSfKS-RS-VLSKYDE---EIeg---ekKKSFRLnt-ggFADGERE-RE 341
O01524       308 M--EAFRRMKM-AGKrlESL-ETKkye----------laSEFYTQDEMtq--frKVKKgKKEk------NIRKRkv---l 362 Caenorhabditis ...
XP_002506343 274 k--ADIKRRLA------ASLgGVsvnavaetadvrkremSEFMSAAEVaeeaaaKFNKpKKKrr----kKLREKkfdise 341
XP_004343271 287 ------QEFFAkQRAkaVSLdSDtrt-----------svSDFYTPEEMi-----SFKKpSKDkk---hkKRRTRdrtqda 341
XP_004992299 270 SseEQRKEEVRqRLLqaESL-EFkhn-----------avSDFYTEEEMe-----KFKKkRKKrkakgrkKTRRVraddll 332
XP_032514990 356 R--AELIAGGP-DKv-lESL-QSTglr----------paSDYLQPDELq----aRFKKvKKKg------KIRKKak---q 407
5_pfamImport 196 K--EEMKQEIR-AKg--ESL-SLPplk----------laNEYLTEEDM------RFKKrKRKv-----kKSRKRev---f 245
XP_004913756 339 L--QNIRESLH-SQA--HTL-ELPqsk----------laSEYYTPEEMv-----SFKKtKRRv-----kKIRKRekv--v 390
XP_004051587 365 L--EEIRAKLR-LQa--QSL-STVgpr----------laSEYLTPEEMv-----TFKKtKRRv-----kKIRKKekevvv 418
Q6DG11       345 L--QAIRESLR-DQa--QSL-STSalt----------laTEYYTPQEMv-----GFKKtKRKv-----kKIRKKekv--p 396 zebrafish
XP_003449741 342 L--QAMKEMLR-NQa--QSL-EMPals----------iaSEYYTPQEMv-----GFKKtKRRv-----kKIRKKekt--s 393
O01524       363 kASDLvpVe-----kA-GEGRDfgrrrrdsdepedeglkkekqdgkdedgeisdkevpesssdngkwkkamrgngvdlqr 436 Caenorhabditis ...
XP_002506343 342 iENDHlaQaaqekqeAaAEPERa--------------------------------------------------------- 364
XP_004343271 342 dDDEDdsIatqqsasGvVRSKRkapsgedge-------------------------------------------deddvq 378
XP_004992299 333 gLDDEe-------------------------------------------------------------------------- 338
XP_032514990 408 ePIDV------------EEHEA---------------------------------------------------------- 417
5_pfamImport 246 kADDLlpLpg----sSeGLSNHgsrfvlcekeqyl-----------------------------------psysalrmlw 286
XP_004913756 391 rADDLlnIn-----hDtRETDFgsrsrgrgrrrve------------------------------------dsdeengie 429
XP_004051587 419 rADDLlpLg-----dQtQDGDFgsrlrgrgrrr---------------------------------------vseveeek 454
Q6DG11       397 rADELlvD-------DtRNSDFgsrsrgrgrkaadeeee---------------------------avpgdvvienisks 442 zebrafish
XP_003449741 394 tADDLhlD-------DtRSSDFgsrtrgrgrkqed------------------------------------dedqevkke 430
O01524       437 lqkLRSKHqiaeDDDSDNDlmfsggv--------------------------------dltgvviDDNAEe--eLSSILA 482 Caenorhabditis ...
XP_002506343 365 ---RGr-----fRNDAGEEerklmgfqnalnkak-----------------iktderilaemagdvEDEDt--eLAMALE 417
XP_004343271 379 pavTVRHLlnnsQAMDTSSsasgpdrgsrkrgrhdddehseatislpepgqfqalkpvtdasfdfVADDEgeveLARALE 458
XP_004992299 339 ---eQTQPeaegDTMETGAdvshavrdeedi------------------------lnqandaeleaaEREleaeLQASLT 391
XP_032514990 418 ---GS-------VPLDTDDteisqevta-----------------------------pvldedevEVDTEl----QAALH 454
5_pfamImport 287 nstKP-----------EDKsgtndgessqm------------------------nnkdernviedDDDAIn--dLQRALD 329
XP_004913756 430 eidEILQS----DDIRVESmvmsdqedn-----------------------------ddsaavieEDELEs--eLQKQLE 474
XP_004051587 455 epvPQpv---psDDTRVENmdisdeeegga-------------------------pppgspqvleEDEAEl--eLQKQLE 504
Q6DG11       443 rnvLQQs-----DDIRMADmdisdeedf----------------------------vppepsaleEDEAEq--eLQKQLE 487 zebrafish
XP_003449741 431 ekvVTHEIpllsDDIRMAEmdisddeef----------------------------tppepavieEDEAEq--eLQKQLE 480
O01524       483 KTRKv--K---Q------IDgkqmdndvgKKV--QDILTSHGVKme------iD-EEEDvkplkeGQIYIDSTTEYCRHV 542 Caenorhabditis ...
XP_002506343 418 RTKRlaerg----------------vgarSDVdvARVAAARRATdapdvgergAsG---------EGMVFNDVQEFVHGI 472
XP_004343271 459 RTRRl--KqqaEgflagpA---------------VPAVRPKSEDs----------tEDSaasagdSSLVFSATSEFVKNI 511
XP_004992299 392 RARRarkNaykK-----------------KDV--TELLDAAVKKs----------kENNngssagGGVVFSTMSEFVRGI 442
XP_032514990 455 RARRl--R---Qg----gDQhrt---pklEEI--LQQIKEEKTEes-------qeAg--------GSMVLDATAEFCRTL 505
5_pfamImport 330 KSRRa--K---Qk----kAdaaa--degaQKV--AQHLHNLTRVkl-----ekP-DEQFt-----NTLFLNATDEFCRQL 385
XP_004913756 475 KSRRlkqIq-qQk----dSS---------DKV--VALVKRVESQkgqde---edddDKK------GSIVFNATSEFCRTL 529
XP_004051587 505 KGRRl--RqlqQl----qQLrdsg--ekvVEI--VKKLESRQrg-------weE-DEDpe---rkGAIVFNATSEFCRTL 563
Q6DG11       488 KQRLl--R---Qk----qMLkdsg--ervIER--MKQLRARGd----------D-DNDpd---krNNIVFNATSEFCRTL 540 zebrafish
XP_003449741 481 KQRKl--K---Qm----qLLkdsg--akvAEQ--VKKL-VKDd----------N-EDDpd---krNNIVFNATSEFCRTL 532
O01524       543 GEITTLG-------LGGnrtvdvsevk-----------------------------------kvkeeemeqeGSEGFEkw 580 Caenorhabditis ...
XP_002506343 473 NVEDKRAtrs--eaAAAgdmppvpppppgsgdmppvpppppgsdvdgmppvpppppsgvgaeeeheddevnpLDG----- 545
XP_004343271 512 GARDLKPdpvqtqpAKPasfvpalvsqaqqpagvtapmdivsvgvpaanrtrrtklvgddeaeamdtqpikkEESKSDdk 591
XP_004992299 443 GANSKDDdqprkrnKQGssssatatatagatetsapp----------------vpaapasssssassaaaaaMETGEDka 506
XP_032514990 506 GDIPTYG-------LAGnreht---------------------------------------------aeimdFDREEAep 533
5_pfamImport 386 a------------qVPVkqevkq--------------------------------------------vedmdLDEDN--- 406
XP_004913756 530 GEIPTYG-------LAGnredq---------------------------------------------edlmdFEKDEAd- 556
XP_004051587 564 GEIPTYG-------LAGnreeq---------------------------------------------eelmdFERDEErs 591
Q6DG11       541 GDIPTYG-------LSGnredq---------------------------------------------edimdFEKDDEke 568 zebrafish
XP_003449741 533 GDIPTYG-------LSGnredq---------------------------------------------edimdFEQEEEkd 560
O01524       581 k------rakVDKelkekekrklrdqggwlaagepaPSNARIDSDDEDALEEAKkRKWSEdeeeDEDMEEDKDDYapaLG 654 Caenorhabditis ...
XP_002506343 546 -------------------------------------------------------------------------------V 546
XP_004343271 592 nd------------------------------------------------------------------------fqdfLT 599
XP_004992299 507 eeggdgdgtgRYF-----------------------QSSFTTDQATTDAEHAERkTEVDDt--pV-------------LG 548
XP_032514990 534 e--------pesGasgg----------------awsRV---------DV------RTd------RPADLEHEGASgagLE 568
5_pfamImport 407 ----------SDEddtqm--------------skwsSV---------NPGQ----ENIVKfkksLKKLTKFSVLEhapIE 449
XP_004913756 557 ---------sEN--------------------------ENGESDGEENIGWSMV-NLDEE-----KNQHDYSASSttiLD 595
XP_004051587 592 a------nggSESdgeen--------------igwsTV---------NL------DE-------EKQQQDFSASSttiLD 629
Q6DG11       569 g------ggqSDSdmddn--------------vgwsTV---------NL------DE-------EKNQADFSTASttiLD 606 zebrafish
XP_003449741 561 d------aggSDSdmden--------------vgwsTV---------NL------DE-------EQKQPDFATASatiLD 598
O01524       655 QEVDV-SKGVGRMLKLAGQKGYLQ------------------------------------NP---NAKShsgp----sld 690 Caenorhabditis ...
XP_002506343 547 QANPMgS-GLAATLALLKETGKLH-------------------------------------------------------- 569
XP_004343271 600 EEPSLvN-GVGAALAFMARRGMIEneskaqgvvvvetdrqrdkgkqrmdqeeerkieleiRRqreAERN----------- 667
XP_004992299 549 EEGNVgS-SVTAALNLALRKGYLAqkkkkqqqqqee-------------atasrlaeltsKNaqqEEHG----------- 603
XP_032514990 569 AEPAL-GAGVAGALRLALSKGYLE------------------------------------RDgalPAPRptrs----sla 607
5_pfamImport 450 AEPLA-ANGLMGALKLAERKGYL-------------------------------------QT----KREpffqikfpkrv 487
XP_004913756 596 EEPIV-NRGLGAALLLCKNKGLLEttvq-----------------------------kvaRVktpNKSL----------- 634
XP_004051587 630 EEPIV-NRGLAAALLLCQNKGLLE------------------------------------TT---VQKVarvka---pnk 666
Q6DG11       607 EEPIV-NSGLAAALLLCKNKGLLD------------------------------------TQ---MQKVarvka---pkp 643 zebrafish
XP_003449741 599 EEPIV-NSGLAAALLLCKNKGLLE------------------------------------TQ---MQKVarvka---pkg 635
O01524       691 hLKNKTtQRIDGQRFDPDDRNAKKADRLNSQH-RGPVM-PFAeKhDYKPDVNISYVDRKGREMDAKDAYRELSYKFHGRN 768 Caenorhabditis ...
XP_002506343 570 --------ENDMWDGRTNDKKPLALMRVREAAeITGAEfE-----GHKFDFKLDRYDEFGRKMTPKEAFRELCHRFHGIE 636
XP_004343271 668 -RDRRD-RRDVRDSRSDRDRNDRPPERDREADpFSMPA----------PEFTLDYVDENGRTMTTKEAFNHLSYKFHGIQ 735
XP_004992299 604 -PEDDDhGRDSRSSRDWRRDSRRDRDRG-----------DPFeKrGYQPSFRLSYTDNTGRELTPKEAFTYMSHQFHGKT 671
XP_032514990 608 aLAALHySIEDKTYGED-DKYGRR-E--RGGH-SGPLS-EFReKsDFRPDIKLEYVDDDGRPLCPKEAFRYLSHKFHGKG 681
5_pfamImport 488 yIFSKYySIEDKNAVDYLDKYAHE-KYSKERN-ASITV-DFTeKkDYKPQISIEYVDEKGRNLSAKEAFRKLSHRFHGKG 564
XP_004913756 635 -PSAVY-CIEDKMA--IDDKYSRR-EEYR-----GFTQ-DFKeKeGYRPDVKIEYVDETGRKLCPKEAFRQLSHRFHGKG 703
XP_004051587 667 sLPSAVyCIEDK-M-AIDDKYSRR-EEYR-----GFTQ-DFKeKdGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKG 737
Q6DG11       644 vLANDNyCIEDK-M-HIDDKYSRR-EEYR-----GFTQ-DFKeKdNYKPDVKIEYVDESGRKLCPKEAFRQLSHRFHGKG 714 zebrafish
XP_003449741 636 aLPNGDyCIEDK-M-GFDDKYSRR-EEYR-----GFTQ-DFKeKdGYKPDVKIEYVDESGRKLTPKEAFRQLSHRFHGKG 706
O01524       769 PGKKQLEKRANRKDKE 784 Caenorhabditis elegans
XP_002506343 637 PGRAKKEKRLRAYQEE 652
XP_004343271 736 PGKNKQEKRQRKLEEE 751
XP_004992299 672 SGRMKTEKKLRKRQQE 687
XP_032514990 682 PGKNKQEKRIKKAVQE 697
5_pfamImport 565 SGKMKQEKRMKKLTEQ 580
XP_004913756 704 SGKMKTERRMKKLDEE 719
XP_004051587 738 SGKMKTERRMKKLDEE 753
Q6DG11       715 SGKMKTERRMKKLEEE 730 zebrafish
XP_003449741 707 SGKMKTERRMKKLEEE 722
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