8AG3


Conserved Protein Domain Family
Pox_C4_C10
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pfam03336: Pox_C4_C10 (This model is not part of the current CDD release)
Poxvirus C4/C10 protein
This family represents proteins found in Poxvirus, including Protein C10 and Protein C4. Vaccinia virus protein C4 plays a role in the inhibition of host NF-kappa-B activation. It blocks the subunit p65/RELA translocation into the host nucleus.
Links
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Statistics
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PSSM-Id: 515522
Aligned: 6 rows
Threshold Bit Score: 353.696
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8AG3_C   9 LQTIKLFNN-EFDCIRNDIRELFK---HVT-------------------------DSDSIQLPmEDNSDIIENIRKI--- 56  Vaccinia virus Wester...
P14361  11 QLAVHRFTEtRFTSFKKELLVNLGisdLNDiknicedskiffpekrtellsikdrKSKQIVFEnSLNDDLLKKLHAL--- 87  Fowlpox virus strain ...
Q6TV05   8 VLRLKIFAD-EFKNIKEEIKFMLNsw----------------------------dDSDVLRRRnSIPCEVVAVGKNKrti 58  Yaba monkey tumor virus
P17370   1 MDTIKIFNHgEFDTIRNELVNLLKvvkWNT-------------------------INSNVTVSsTDTIDISDCIREI--- 52  Vaccinia virus WR
P03296   9 lQTIKLFNN-EFDCIRNDIRELFKhv----------------------------tDSDSIQLPmEDNSDIIENIRKI--- 56  Vaccinia virus WR
Q9J5I1  10 IPKMHIFSDdYFSDFKKLLIEEIE---TNYmdydfsesrildehtgyeildlehcKSKQIVYE-SLCKDLTTKLENL--- 82  Fowlpox virus

8AG3_C  57 -LYRRLKN-VE------CVDIDSTITFMKYDPNDDNKRTCS-NWVPLTNNYMEYCLVIYLETPICGGKIKLY-HPTGN-- 124 Vaccinia virus Wester...
P14361  88 -IYDELSTvVD------SVTVENTVTLIMYEKGDYFARHRD-FSTVFSKNIICVHLLLYLEQPETGGETVIYiDNNTS-- 157 Fowlpox virus strain ...
Q6TV05  59 pVFDAVKRvLSfslgdyDVCVGDHLTVVKCFKGAGFDNRFNiLTGDDGRRGVEYSLVVHLSIPEDGGETDICv--SGNtv 136 Yaba monkey tumor virus
P17370  53 -LYKQFKN-VR------NIEVSSDISFIKYNRF---------NDTTLTDDNVGYYLVIYLNRTK---SVKTLiYPTPEtv 112 Vaccinia virus WR
P03296  57 -LYRRLKN-VE------CVDIDSTITFMKYDPNDDNKRTCS-NWVPLTNNYMEYCLVIYLETPICGGKIKLY-HPTGN-- 124 Vaccinia virus WR
Q9J5I1  83 -IVSQLKYiVS------EVRVENKVTFVVYGVGDYLKKTNNkPCKKKSKNTLCMYILLLLQKATEGGKTKFYlKGINS-- 153 Fowlpox virus

8AG3_C 125 IKSDKDIMFAKTLDFKSKKVLTGRKTIAVLDISVS-----YNRSMTTIHY-NDdVDIDIHTDKNGKELCYCYIT-IDDHY 197 Vaccinia virus Wester...
P14361 158 VKLKTDHLFDKTIEHESITVESGRKCVALFDVLLEkklsaSTNVIGSIEY-LG-KKINLYDRENDLQLCYCDMV-IERMT 234 Fowlpox virus strain ...
Q6TV05 137 ISTTEDFLLEDGCSQLSNVVSEGEKIVAAIKVFLKr---kDKDVIFTLAR-SL-RDVKFYDKEGDRDLCYSLVD-VNSPF 210 Yaba monkey tumor virus
P17370 113 ITSSEDIMFSKSLNFRFENVKRDYKLV-MCSISLT-----YKPSICRIQYdNN-KYLDISDSQECNNLCYCVIT-MDPHH 184 Vaccinia virus WR
P03296 125 IKSDKDIMFAKTLDFKSKKVLTGRKTIAVLDISVS-----YNRSMTTIHYnDD-VDIDIHTDKNGKELCYCYIT-IDDHY 197 Vaccinia virus WR
Q9J5I1 154 LDISSDVLFDKSVYHETTIVESGVTYVALLDVTMKlk--tEKGIVDTIEY-LD-VSINLYDRENNNTLCYCEVIyIAPPC 229 Fowlpox virus

8AG3_C 198 LVDVETIGVIVNRSGKCLLVNNHLGIGIVKDkRISDSFGDVCMDTIFdfsEar---eLFSLTNDDNRNIAWdTDKL-DDD 273 Vaccinia virus Wester...
P14361 235 EDKEYSLGMISDRSGRCIKSHHNGSIVRYRK-EEYGSFDALCIYNMN---E------VDEIWTGDKKHIIW-STID-KKT 302 Fowlpox virus strain ...
Q6TV05 211 -AEVERFGVISDRSGKCLLVNRHQKLVKKAI--VEKTFADMCAEIAF---Eg-----FYDLVNVDGKDVAW-KELG-AVE 277 Yaba monkey tumor virus
P17370 185 LIDLETICVLVDKSGKCLLVNEFYIRFRKNH--IYNSFADLCMDHIF---ElpntkeLFTLRNDDGRNIAW-DNDKlESG 258 Vaccinia virus WR
P03296 198 LVDVETIGVIVNRSGKCLLVNNHLGIGIVKDkRISDSFGDVCMDTIF---DfseareLFSLTNDDNRNIAW-DTDKlDDD 273 Vaccinia virus WR
Q9J5I1 230 NKKLVRAGILINRKGKCLLTHINNKIHSIEHpIVFSSFQDVSVSKFN---Rey---tVAYLEKNTINDIAW-SSID-SNE 301 Fowlpox virus

8AG3_C 274 TDIWTPVTEDDYKFLSRLVLYAKSqSDTVFDyyVLTGDTEPptVFIFKVTRFYFNMPK 331 Vaccinia virus Western Reserve
P14361 303 GTSFIPIDPVLYEKLKAISSKEHK-EYKDLR--GFCNSRTE--YICCSVSKYYFDLPT 355 Fowlpox virus strain NVSL
Q6TV05 278 EDIWVPSSEDDYSFLKELVDHVSCnLKTKVGyyVLSTCDDEtlYVSFNVIRCYFSM-R 334 Yaba monkey tumor virus
P17370 259 NNTWIPKTDDEYKFLSKLMNIAKF-NNTKFDyyVLVGDTDPctVFTFKVTKYYINLNY 315 Vaccinia virus WR
P03296 274 TDIWTPVTEDDYKFLSRLVLYAKSqSDTVFDyyVLTGDTEPptVFIFKVTRFYFNMPK 331 Vaccinia virus WR
Q9J5I1 302 NDNYLPNDKELFDKLMKISSKEHA-KCYEIEyiDESNEDAEpyYAYCMVSKYYFKLPD 358 Fowlpox virus
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