4MQY,3U1Y,1XXE


Conserved Protein Domain Family
LpxC

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pfam03331: LpxC 
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UDP-3-O-acyl N-acetylglycosamine deacetylase
The enzymes in this family catalyze the second step in the biosynthetic pathway for lipid A.
Statistics
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PSSM-Id: 397424
Aligned: 311 rows
Threshold Bit Score: 266.562
Threshold Setting Gi: 663073025
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4MQY_A           4 QRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRtdln---------ppvD--F-PADA--KSV-RDTMLCTCLVn 68  Escherichia coli
XP_002500440     1 QQTVRRSFTLIGVGLHSGEWETVRVCPARAGEGRYFVRvri----------------paAAALaqDNLrLSMRLAVd--- 61  Micromonas co...
EEH56289         1 QQTVRRAFTILGIGMHSGEVEAVRVCPAHANEGRYFVRrelpaqtpsdfpavagEkrV-RASL--DNVeEGLRLSMKLSl 77  Micromonas pu...
WP_011933854    11 awTLAGPVHRSGIGLHSGQPVSVTLKPSLE-PGVWVQWas------------ddAa-PvRLAP--SQV-RDSQLCTTLDl 73  Synechococcus...
Q7V5X3          11 awTLGGAVSRQGIGLHGGEVAEVRLQPSAQ-VGFHVSWld------------nsDs-PvTLGP--HQV-RDSQLCTTLEl 73  Prochlorococc...
Q7VAP0          11 awTLGGAVRRRGVCLHSGQESEVTLLPYDD-IGFHLSWvn------------rsEk-PvRLNS--NQV-VHSELCTTLDl 73  Prochlorococc...
WP_011936234    10 aYTLAAAVERRGVGLHSGKDCLVRLKPGSK-PGFWVGFlg------------qpDqePvMLAP--HQV-RDTRLCTALEi 73  Synechococcus...
jgi:Cyagr_3116  11 awTLRSSVERSGVGLHSGAVSRVRLGPSER-PGYWLGWld------------apElpMqRLGP--TQV-SDTRLCTCLQv 74  Cyanobium gra...
F4IAT8          39 QQTLAGSVEVKGKSLHSGKFSTVKLNPEIAGAGRFFEFrs----------------rFiPASI--EFA-QESPLCTTLLk 99  thale cress
XP_002315856    25 QQTLKRCVEASGTTLHSGKSSTVRLLPELAGKGRYFYFns----------------kSiPASI--DYA-QESSLCTTLSn 85  black cottonwood
4MQY_A          69 e--hDVRISTVEHLNAALAGLGIDNIVIEVN-AP---------EIPIMDGSAAPFVYLLLDAGID-----------ELNC 125 Escherichia coli
XP_002500440    62 ---dDNGVITCEHLLSALEAIGVDNARIELEgSG---------EVPIVDGSAYQFAYECARVGLVpaha----dgsTAEV 125 Micromonas co...
EEH56289        78 egddDHSVITTEHLLSALEAMGVDDARIEVEgNG---------EIPILDGSAYDYVYQIGRVGLVaaadpaggdgqT--- 145 Micromonas pu...
WP_011933854    74 g---srRLATVEHLLAALAGCGLTHALLEVD-GE---------EIPLLDGSALGWVEAIAEADLL-----------EVPG 129 Synechococcus...
Q7V5X3          74 g---drHLGTVEHLLAALAGCGLTHVEIQVG-GE---------EIPLLDGSALGWVEAIAEVGLT-----------PAAT 129 Prochlorococc...
Q7VAP0          74 a---feRLATVEHLLAALVGCGLTHVHIVVS-GN---------EVPLLDGSAMGWVEAISEVGMI-----------PLKD 129 Prochlorococc...
WP_011936234    74 g---grPLATVEHLLAALAGVGLTQAEIWLE-GH---------EIPLLDGSALPWVEVIAEAGLE-----------DLGP 129 Synechococcus...
jgi:Cyagr_3116  75 g---erRLATVEHLLAALAGTGVSQAELWVE-GE---------EIPLLDGSGLPWVEAIAEAGLS-----------DRGE 130 Cyanobium gra...
F4IAT8         100 ---dELKIRTVEHLLSALEAKGVDNCRIQIE-SEssdd--revEVPIFDGSAKEWVDAIQGVGIN-----------AAQN 162 thale cress
XP_002315856    86 ---dGVKIRTVEHLLSALEAMSVDNCRIEIT-NLdsddsdldsEVPILDGSAREWVERIEKDGLV-----------AAKD 150 black cottonwood
4MQY_A         126 AKK---FVR---IKE-------T---VRV----EDGDKWAEFKPYNgFSLDFTIDFnh--paIDSsnQRYAMN-FSAD-- 180 Escherichia coli
XP_002500440   126 PRM---AWR-------------PsemITV----RDGDAFVQFIPDavTKLTYGVDFtykstaIGK--QWESWTpTEDG-- 181 Micromonas co...
EEH56289       146 PRK---SFK-------------P---SEVvmltGDNEAFIMFTPGEcTKLTYGIDFtyksraIGK--QWESWTpTEDG-- 202 Micromonas pu...
WP_011933854   130 W------------HPqrpelehP---LAL----HRGSSVITATPAEqfSVVGVIDFpq--paIGR--QQFTLE-LTPQ-- 183 Synechococcus...
Q7V5X3         130 P------------RAdplvlehA---LVC----HRGSSVITATPAErfNVVGVIDFpq--aaIGH--QMLAIE-LTPE-- 183 Prochlorococc...
Q7VAP0         130 S------------SSlwpvlknA---LVI----HKGTSVITATPSDrvTLIGIIDFpy--paIGK--QMFSLD-LTPQ-- 183 Prochlorococc...
WP_011936234   130 R-------------AplpalaaP---ISC----QRGNSFVQALPSEqlLLSAAIEFpq--paIGR--QLFSLV-LSPE-- 182 Synechococcus...
jgi:Cyagr_3116 131 R-----------LEPplp--plP---LTL----GQGLGFVAALPSErlRLAAAIEFpq--aaIGR--QLYALD-LTPE-- 183 Cyanobium gra...
F4IAT8         163 HDGesvEKMvahVNK-------P---VYV----CKNDTFVAAFPAleTRITCGIDFpqv-paIGC--QWFS---WRPIhe 222 thale cress
XP_002315856   151 ECGndcEKLapyLNE-------P---IHV----SKNDSFVAAFPSpkVRVSYGIDFpq--vaIGS--QWFS---LAPLed 209 black cottonwood
4MQY_A         181 -AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDY-RVLNeDGLRFEDEFVRHKMLDAIGDLFMCGH-----N 253 Escherichia coli
XP_002500440   182 -DYVDLIARARTFGTMQDYMAYFRAGYIRGGLEQCALIANGD-KFWN-PPMILPNENARHKILDLVGDLSLMAEpgmagV 258 Micromonas co...
EEH56289       203 -EYSDFLARARTFGTMKDVMAYFRAGVLRGGLENSALLANAD-QWWN-PPMMLPNECARHKMLDLIGDLSLMAEpgmagV 279 Micromonas pu...
WP_011933854   184 -RFVEEIAPARTFGFRDQVEHLRAAGLIQGGALDNALVCDGE-HWLN-PPLRFPDEPVRHKLLDLIGDLALVG------F 254 Synechococcus...
Q7V5X3         184 -GFTEQIAPARTFGFREQVDQLLAAGLIQGGALDNALVCDGD-HWLN-PPLRFADEPVRHKLLDLIGDLALVG------F 254 Prochlorococc...
Q7VAP0         184 -SFLQDIAPARTFGFKDQIDHLREKGMIKGGGLDNSLVCDGK-SWIN-PPLRFKDEPVRHKLLDLIGDLALVG------L 254 Prochlorococc...
WP_011936234   183 -SFVREIAPARTFGFKDQVEQLREAGLIQGGALDNALVCDGD-QWVN-PPLRFADEPVRHKLLDLIGDLALAG------L 253 Synechococcus...
jgi:Cyagr_3116 184 -RFVAEIAPARTFGFREQVEQLLAAGLIRGGALDNALVCDGD-DWLN-PPLRFADEPVRHKLLDLLGDLALVG------L 254 Cyanobium gra...
F4IAT8         223 sSFAKDIASSRTFCVYEEVERMREAGLIKGGSLDNAIVCSAEhGWMN-PPLRFDDEACRHKILDLIGDLSLVSRggnggL 301 thale cress
XP_002315856   210 sLYAREIAPSRTFCIYEEVEYMRNAGLIKGGSLDNAIVCSASkGWLN-PPLRFSDEPCRHKILDLVGDLSLFARfgnqgL 288 black cottonwood
4MQY_A         254 IIGAFTAYKSGHALNNKLLQAVLA 277 Escherichia coli
XP_002500440   259 PIGHVLAYKGSHRLHAKFLAALAa 282 Micromonas commoda
EEH56289       280 PIGHIVAYKANHNMHAEFAKKL-- 301 Micromonas pusilla CCMP1545
WP_011933854   255 PRAQVLVYRGSHGLHADLAAALAD 278 Synechococcus sp. WH 7803
Q7V5X3         255 PQAQVLVYRGSHGLHNDLANALLA 278 Prochlorococcus marinus str. MIT 9313
Q7VAP0         255 PKAQVLVYKGSHALHVELAKSISR 278 Prochlorococcus marinus
WP_011936234   254 PLAQVMAFRASHNLHTQLAAALAA 277 Synechococcus sp. RCC307
jgi:Cyagr_3116 255 PRAHVFAYRGSHGLHTAMAAALAA 278 Cyanobium gracile PCC 6307
F4IAT8         302 PVAHIVAYKAGHALHTDLARHLTm 325 thale cress
XP_002315856   289 PVAHIVVYKGGHALHTNFGRHLND 312 black cottonwood
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