4AVR


Conserved Protein Domain Family
DPBB_1

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pfam03330: DPBB_1 
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Lytic transglycolase
Rare lipoprotein A (RlpA) contains a conserved region that has the double-psi beta-barrel (DPBB) fold. The function of RlpA is not well understood, but it has been shown to act as a prc mutant suppressor in Escherichia coli. The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions. Another example of this domain is found in the N-terminus of pollen allergen. Recent studies show that the full-length RlpA protein from Pseudomonas Aeruginosa is an outer membrane protein that is a lytic transglycolase with specificity for peptidoglycan lacking stem peptides. Residue D157 in UniProtKB:Q9X6V6 is critical for lytic activity.
Statistics
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PSSM-Id: 397423
Aligned: 88 rows
Threshold Bit Score: 42.1888
Threshold Setting Gi: 75141292
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4AVR_A   2 DTGEASYYgSRHaglrTASGERYNPNAMTAAHRTlpfgarVRVtnldnrRSVVVRINDRGPF----RRGRIIDVSRKAAE 77  Pseudomonas aeruginos...
Q8H7T4  79 SCGNDPIF-KDG----KGCGSCFEVKC--SKPEA------CSD------KPVIIHITDMNTEp---IAAYHFDLSGHAFG 136 Japanese rice
Q7XCG7  81 SCGNVPIF-KDG----RGCGSCYEVKC--EQPAA------CSK------QPVTVFITDMNYEp---ISAYHFDFSGKAFG 138 Japanese rice
Q94LR4  93 SCGNQPLF-KDG----KGCGSCYKIRC--TKDQS------CSG------RSETVIITDMNYYp---VAPFHFDLSGTAFG 150 Japanese rice
Q9ZR84  78 ACGNEPIF-AGG----EGCGMCYEIKCEYSNNPS------CSG------QPRRIVITDMNYYp---VARYHLDLSGTAFG 137 bread wheat
O24230  69 SCGNEPLF-QDG----KGCGACYQIRC--TNNPS------CSG------QPRTVIITDMNYYp---VARYHFDLSGTAFG 126 Japanese rice
Q7XT39  82 AAGGPSLF-KNG----KGCGSCYQIKC--TGNRA------CSG------RPVTVVITDSCPGgvclNEAAHFDMSGTAFG 142 Japanese rice
Q39802  85 SAGSPLIY-DSG----KGCGSCYEVKC--TGNSA------CSG------NPVKVVITDECAGcg-sDAQYHFDLSGNAFG 144 soybean
Q9M203  71 SAGGPSLF-KDG----KGCGACYRLKC---DHPL------CTK------KPIKVMISDECPGc--tKESVHFDLSGKAFG 128 thale cress
Q9SHY6  84 SAGGPSLF-KSG----KGCGACYQVKC--TSKSA------CSK------NPVTVVITDECPGc--vKESVHFDLSGTAFG 142 thale cress
4AVR_A  78 GLGMI-------RSGVAPVRI 91  Pseudomonas aeruginosa PAO1
Q8H7T4 137 AMAKEgkdeelrKAGIIDMQF 157 Japanese rice
Q7XCG7 139 AMACPgketelrKAGIIDMQF 159 Japanese rice
Q94LR4 151 RLAKPglndklrHSGIIDIEF 171 Japanese rice
Q9ZR84 138 SMAKYglndrlrHAGIIDMQF 158 bread wheat
O24230 127 AMARPglndqlrHAGIIDIQF 147 Japanese rice
Q7XT39 143 AMANRgmgdrlrSAGVLKIQY 163 Japanese rice
Q39802 145 AMAISgqdenlrNAGKINIQH 165 soybean
Q9M203 129 ALAKRgkgdqlrNLGELKVSY 149 thale cress
Q9SHY6 143 AMAISgqdsqlrNVGELQILY 163 thale cress
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