Conserved Protein Domain Family
Mlp
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pfam03304: Mlp 
Mlp lipoprotein family
The Mlp (for Multicopy Lipoprotein) family of lipoproteins is found in Borrelia species. This family were previously known as 2.9 lipoprotein genes. These surface expressed genes may represent new candidate vaccinogens for Lyme disease. Members of this family generally are downstream of four ORFs called A,B,C and D that are involved in hemolytic activity.
Links
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Statistics
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PSSM-Id: 308750
Aligned: 13 rows
Threshold Bit Score: 109.15
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q44801        30 AQQTKSRKKRDLSQEELpQQEKITLTPDEEKMFTSLKalftytidklyddmqecsNGNKNkceskcnnFFNWLStniq-k 108 Lyme disease sp...
P70813        34 TQEVKSRGKRDLDTKES-QQEKITLTDEESKLFNSLVtafkytiekvtngiqgcpKDNKSkc----tnFFDWLLidiq-k 107 Borreliella afz...
Q9RZZ0        30 AQQTKSRKKRDLSQEELpQQEKITLTSDEEKMFTSLInvfkytieklnneiqgcmNGNKSkc----ndFFDWLSediq-k 104 Borreliella bur...
Q9S0B7        30 AQQTKSRGKRDLTQKEAtPE-KPKSK--EELLREKLS------------------EDQKT--------HLDWLK------ 74  Borreliella bur...
Q9S0E8        25 NSQTKSRQKRDLTQKEAtQE-KPKSK--EELLREKLN------------------DNQKT--------HLDWLK------ 69  Borreliella bur...
Q44811        25 TKQIKSRQKRDLSQQEPpQQ-KPKSK--EELLKEKLN------------------DDQKK--------HLDWLK------ 69  Lyme disease sp...
Q9S069        30 AQQTKSRRKRDLTQKEVtQE-KPKSK--EELLREKLN------------------DDQKT--------QLDWLK------ 74  Borreliella bur...
Q9S0H7        30 AQQTKRRGKRDLTQKETtQE-KPKSK--EELLREKLS------------------DDQKT--------HLDWLK------ 74  Borreliella bur...
Q9S083        25 TKQTKSRQKRDLTQKEAtQE-KPKSKSKEDLLREKLS------------------DDQKT--------QLDWLK------ 71  Borreliella bur...
WP_012621432  25 TQQTKSRGKRDLTQKEEvQQEKPKSK--EELLRKKLS------------------DDQKT--------HLDWLK------ 70  Lyme disease sp...
WP_015056323  31 VQQAESRKKRDLSQEELpQQEKITLTSDEEKMFNSLInvfkytidklnneiqgcmNGNKSqc----ndFFDWLSstdtqk 106 Lyme disease sp...
WP_012672739  30 AQQTKSRKKRDLSQEELpQQEKITLTSDEEKMFTSLVtafkytveklseningcnNGDNGkc----nnFFDWLSstdtqk 105 Lyme disease sp...
WP_012663366  30 AQQTKSRKKRDLSQEELpQQEKITLTPDEEKMFTSLKalftytieklyndmqecsNGNKNkceikcnnFFNWLStdiq-k 108 Lyme disease sp...

Q44801       109 qkELANAFTKVYDFLESKrqsKASGESFDTYIKGAIDCKNNN-----------------NNKYGDGSgNLIEQYFRGVAG 171 Lyme disease sp...
P70813       108 qkELAGAFKKVYEFLEGKrqsKEKDRDFDTYIKDGINCKVTKdnaqnqngnqnqndcdkDNKYGNGT-NEIEQYFRGVAN 186 Borreliella afz...
Q9RZZ0       105 qkELAGAFTKVYNFLKS----KAQNETFDTYIKGAIDCKKNTpqd-----------cnkNNKYGDGD-NLIEQYFRGVAN 168 Borreliella bur...
Q9S0B7        75 --EALGNDGEFDKFLGYD---ESKIKSALNHIKSELDKCTGd----------------nSEQQKSTFkQTVQGFFSGGNI 133 Borreliella bur...
Q9S0E8        70 --EALGNDGEFNKFLGYD---ESKIKSALDHIKSELDSCTGd----------------kV-ENKNTFkQVVQEALKGG-I 126 Borreliella bur...
Q44811        70 --TALTGTGEFDKFLEND---ESKIKTALDHIKSELDKCTGd----------------nANEQKTTFkQTVQGALSGG-I 127 Lyme disease sp...
Q9S069        75 --TALTDAGEFDKFLENN---EDKIKSALDHIKSELDKCNGKe---------------nGDVQKNTFkQVVQGALKGG-I 133 Borreliella bur...
Q9S0H7        75 --PALTGAGEFDKFLEND---DDKIKSALDHIKTQLDSCNGd----------------qAEQQKTTFkTVVTEFFKNGDI 133 Borreliella bur...
Q9S083        72 --TALTGVGKFDKFLEND---EGKIKSALEHIKTELDKCNGn------------------DEGKNTFkTTVQGFFSGGNI 128 Borreliella bur...
WP_012621432  71 --EALKSDREFDKFLEYD---ESKIKSALDHIKSELDKCNGKd---------------nANDQKNTFkQVVKGALGGG-I 129 Lyme disease sp...
WP_015056323 107 qkELAQAFTTAYNFLDSKrklKEKDKDFDTYIKGAIDCKKANnq-------------kdCNKYGNGS-NDIEQYFRGVAG 172 Lyme disease sp...
WP_012672739 106 qkELAQAFAKVYNFLESKrqsKASDEDFDTYIKGAIDCKKNNpnk------------cnDNKHGNGNsNDIEQYFRGVAG 173 Lyme disease sp...
WP_012663366 109 qkELAQAFAKVYNFLESKrrlKEKDKDFDTYIKGAIDCKANTpqd------------ckNNKYGKGT-NEIEQYFRGVTG 175 Lyme disease sp...

Q44801       172 DIFNe-nSNEEIYKCL 186 Lyme disease spirochete
P70813       187 DMSNk-nDNDEIYQYL 201 Borreliella afzelii
Q9RZZ0       169 DMSNr-nSNEEIYQYL 183 Borreliella burgdorferi B31
Q9S0B7       134 DNF----ANNAVSNCN 145 Borreliella burgdorferi B31
Q9S0E8       127 DGF----ENTASSTCK 138 Borreliella burgdorferi B31
Q44811       128 DGFG---SNNAVTTCG 140 Lyme disease spirochete
Q9S069       134 DGFG---ASNATTTCN 146 Borreliella burgdorferi B31
Q9S0H7       134 DNF----ATGAVSNCN 145 Borreliella burgdorferi B31
Q9S083       129 DNF----ADQATATCN 140 Borreliella burgdorferi B31
WP_012621432 130 DTF----TAQATTTCN 141 Lyme disease spirochete
WP_015056323 173 DIFNe-nSNEEIYKCL 187 Lyme disease spirochete
WP_012672739 174 SIFIdknDKDEIYKCL 189 Lyme disease spirochete
WP_012663366 176 DIFNk-nSNEEIYKCL 190 Lyme disease spirochete
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