Conserved Protein Domain Family
mRNA_G-N7_MeTrfase
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pfam03291: mRNA_G-N7_MeTrfase 
mRNA (guanine-N(7))-methyltransferase domain
This entry represents mRNA (guanine-N(7))-methyltransferase, which can either be found as a single domain protein, or as a domain within the mRNA-capping enzyme catalytic subunit. mRNA (guanine-N(7))-methyltransferase methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. It binds RNA containing 5'-terminal GpppC. Viral mRNA capping enzymes, meanwhile, are multidomain proteins that catalyze the first two reactions in the mRNA cap formation pathway. They are heterodimers consisting of a large (catalytic) and small subunit.
Links
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Statistics
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PSSM-Id: 486291
Aligned: 7 rows
Threshold Bit Score: 481.926
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9D0L8 125 QKLQKLEEGHSSAVAAHYNELQEVG--LAKRSQSRIFYLRNFNNWIKSILIGEILEKVRQrk--tRDITVLDLGCGKGGD 200 house mouse
O74880  52 YNRHENNGNAQDVVRSHYNARPDLG--YKKRQFSPIIQLKRFNNWIKSVLIQKFAPHASD-----YPILVLDMGCGKGGD 124 Schizosaccharomyces p...
P32783 109 EMTANRSINVDQIVREHYNERTIIAn-RAKRNLSPIIKLRNFNNAIKYMLIDKYTKPGDV---------VLELGCGKGGD 178 Saccharomyces cerevis...
Q5ADX5 137 RISNRENRDINSIVRAHYNQRTQQAkqQGSRVNSPIYKMRNFNNAIKYILLGNWAKHNPEe---lDLFSFLDLCCGKGGD 213 Candida albicans SC5314
Q9LHQ7  30 FLEDETTKNFARKVADHYSRRTNq--tLEEREASPIIHLKKLNNWIKSVLIQLYARPDDA---------VLDLACGKGGD 98  thale cress
Q9VJQ4  72 ETEAASGAANTHVVAHHYNELKEAG--RKDRQKSKIFFMRNFNNWIKSQLINEYMSQIKQnkrmgDALRVLDMCCGKGGD 149 fruit fly
Q28FT4  66 skrpRLEEGHGSLVVTHYNELPETG--LETRSQSRIFHLRNFNNWMKSALIGEFVEKVRQr---tRNIAVLDLGCGKGGD 140 tropical clawed frog

Q9D0L8 201 LLKWRKGRISRLVCADIADISMKQCQQRYedm---rcRRDNEHi---FSAEFITADCSKELLVEKFRD-------PEMYF 267 house mouse
O74880 125 LIKWDKAGIDGYIGIDIAEVSVNQAKKRY--------REMHAS----FDALFYAGDCFSSSINELLPP-------DQRKF 185 Schizosaccharomyces p...
P32783 179 LRKYGAAGISQFIGIDISNASIQEAHKRY--------RSMRNLd---YQVVLITGDCFGESLGVAVEPfp----dCRFPC 243 Saccharomyces cerevis...
Q5ADX5 214 LNKCQFIGIDQYIGIDIADLSVKEAFERYtkqkarfrHSNQNSnrytFEACFATGDCFTQFVPDILEPnfpgiieRAFPV 293 Candida albicans SC5314
Q9LHQ7  99 LIKWDKARIGYYVGIDIAEGSIEDCRTRYngdadhhqRRKKFS----FPSRLLCGDCFEVELDKILEE--------DAPF 166 thale cress
Q9VJQ4 150 LLKWEKAAISHLICTDIAEVSVEQCQRRYqdi---lqRSEKSKfankFTAEFFACDSTLVRLRERYKD-------PSLQL 219 fruit fly
Q28FT4 141 LLKWRKGGISKLVCTDIADVSVKQCEERYkdl---krKSRNERv---FEAEFLTADSTKELLSEKYND-------PEIKF 207 tropical clawed frog

Q9D0L8 268 DVCSCQFACHYSFESQVQADTMLRNACGRLNPGGYFIGTTPNSFEL----I-RRLEAS--ETESFGNEIYTVKFQ-KKGN 339 house mouse
O74880 186 DVVSLQFCMHYAFESEEKVRVLLGNVSKCLPRGGVMIGTIPNSDVI----V-KHIKMLkpGEKEWGNDIYKVRFPeSPPR 260 Schizosaccharomyces p...
P32783 244 DIVSTQFCLHYAFETEEKARRALLNVAKSLKIGGHFFGTIPDSEFIryklN-KFPKEVe--KPSWGNSIYKVTFEnNSYQ 320 Saccharomyces cerevis...
Q5ADX5 294 DIVSAQFSLHYSFESEEKVRTLLTNVTRSLRSGGTFIGTIPSSDFIkakiVdKHLQRDekGKAKFGNSLYSVTFEkDPPE 373 Candida albicans SC5314
Q9LHQ7 167 DICSCQFAMHYSWTTEARARRALANVSALLRPGGVFIGTMPDANVI----I-KKLREAe--GLEIGNSVYWIRFGeEYSQ 239 thale cress
Q9VJQ4 220 NLVSCQFAFHYCFESMAQADCMMRNAAECLKPGGFFIATMPDAYEI----I-RRLRAAgpDARRFGNDVYSIEFDcETDP 294 fruit fly
Q28FT4 208 DICSCQFVYHYSFETYEQADMMLRNACERLCPGGFFIGTTPDGFEL----V-KRLEAS--DTNSFGNDVYTVKFE-KKGK 279 tropical clawed frog

Q9D0L8 340 Y------PLFGCKYDFNLEGVV-DVPEFLVYFPLLTEMAKKYNMKLIYKKTFLEFYEEKIKNNENKMLLKRMQaleqypa 412 house mouse
O74880 261 Sf----rPPYGIQYYFYLEDAVtDVPEYVVPFEAFRAVAEGYNLELIWVKPFLDILNEEKNSETYGPLMDRMK------- 329 Schizosaccharomyces p...
P32783 321 KndyeftSPYGQMYTYWLEDAIdNVPEYVVPFETLRSLADEYGLELVSQMPFNKFFVQEIPKW-IERFSPKMRe------ 393 Saccharomyces cerevis...
Q5ADX5 374 Dgv--frPAFGNKYNYWLKDAVdNVPEYVVPFETLRSLCEEYDLVLKYKKSFTDIFNQEIPKY-FSKLNKNLId------ 444 Candida albicans SC5314
Q9LHQ7 240 Kkfk-ssSPFGIEYVFHLEDAV-DCPEWIVPFNVFKSLAEEYDLELVFVKNSHEFVHEYMKKPEFVELMRRLGa------ 311 thale cress
Q9VJQ4 295 L------PLFGAKYQFHLEGVV-DCPEFLVHFPTLVKLGRKYGLQLLKRSTFADYYKENLHH--GRHLLQRMSglesvqp 365 fruit fly
Q28FT4 280 Y------PLFGCKYDFSLEEVV-NVPEFLVYFPVLVEMAKKYQMKLIYKKTFREFFEEKVKNDEQKMLLKRMKalepypa 352 tropical clawed frog

Q9D0L8 413 hensklasekvgdythaaeylkkSQVRLPLGTLSKSEWEATS-IYLVFAFEKQ 464 house mouse
O74880 330 -----------------------VVDNEGHRGIGGQEKEAAG-FYLAFAFEKR 358 Schizosaccharomyces pombe 972h-
P32783 394 ----------------------gLQRSDGRYGVEGDEKEAASyFYTMFAFRKV 424 Saccharomyces cerevisiae S288C
Q5ADX5 445 ----------------------gMKRSDGKYGAEGDEKEAVA-FYIGFVFEKV 474 Candida albicans SC5314
Q9LHQ7 312 ----------------------lGDGSNDQSTLSADEWEAAY-LYLSFVLRKR 341 thale cress
Q9VJQ4 366 qrcen------deefahvsnfqgAQRSRSVGTLSKSEWEAAT-LYLVCAFKKC 411 fruit fly
Q28FT4 353 apnfklvsgrtedyehaqklvenGQVKLPLGTLSKSEWEATS-IYLLFAFEKQ 404 tropical clawed frog
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