Conserved Protein Domain Family
GILT

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pfam03227: GILT 
Gamma interferon inducible lysosomal thiol reductase (GILT)
This family includes the two characterized human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences. It also contains several other eukaryotic putative proteins with similarity to GILT. The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction.
Statistics
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PSSM-Id: 397369
Aligned: 158 rows
Threshold Bit Score: 58.4951
Threshold Setting Gi: 74959585
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDW42318      26 PISIYYESLCPDSAKFITEQVYPAVKgelrD---VVDLTFVPFG-KSQFVTQGse-vTFTCHHGPNECYGNKVHACAIEH 100 Drosophila sech...
XP_007329479  36 PVQLGVMSKCPDALLC-ESTFNEVLG----KvgdKMDLSLVYVA--KFDESEPdf-gGIICKHGAEECAGNVQQLCIAKY 107 Agaricus bispor...
EPT03814      44 pVVLGVMSRCPDAVLC-EAVFDQVLK----KvgnKIDLSLTFVA--HANISEPd--fGVTCKHGPTECAGNVHELCAMKY 114 Fomitopsis pini...
EDR12404      40 PVQLGVMSRCPDALLC-ESRFNQVLD----QvsdKVDLSLVYVA--KLDSSQPd--fGVWCMHGPDECAGNVQQLCVAKY 110 Laccaria bicolo...
XP_007416000  48 PVTLIVMSQCPEAKKC-QKAIDEALI----KlgdKMDVEVGYVA--KLNSSSRf---GVTCFHGDTECEGNIQQLCYkar 117 Melampsora lari...
A0BYJ1        22 dVKIYIESRCPDTAAMMRGISNATID----SldqLANVEFIPSG-KLNSNSYEantyITNCQHSEEECYGNMILACGLQL 96  Paramecium tetr...
A0CWN1        17 QIDIFIESQCPDTVRLFK-RMKTLLDy--eQineYVQFNFIPFG-KGNEKLVLnkgyEFNCQHGNKECYGNLIDSCVLEQ 92  Paramecium tetr...
Q7Q1K2         1 VVVYYETLCPDSKNFVLHQLQPAFDRap-eL---MDIEFVPFGK-ASWTTKSDgsleFDCQHGPIECEGNTIHACVVEAV 75  Anopheles gambi...
EEY53139     143 QLEMYWRAFCPGCMSFITKPLLSLIRn--kEfqeIIDFRPVPAAgTSFDAKG-----NFVCTAGMVECLGHKWLSCAVEE 215 Phytophthora in...
EDO41893       5 KLAVYYNSKNPEFRRFMVAQLYPTSN----KipnILDISMVPFG-DGKEIKAKsg-fQYYCTNGAEECLENLIQACAVAT 78  starlet sea ane...
EDW42318     101 IqansyqveytRESLTMDFINCLMK----AGKnfpdnvypGq---rCASE 143 Drosophila sechellia
XP_007329479 108 Asp----------dqWWNFVQCQNFe--gTAQig-----kPsvalkCAEA 140 Agaricus bisporus var. burnettii JB137-S8
EPT03814     115 Asp----------saFWEFVQCQNYq--gLEKig-----qPetalkCAST 147 Fomitopsis pinicola FP-58527 SS1
EDR12404     111 App----------enWWEFVQCQNYq--gRENig-----dSdvalkCAKT 143 Laccaria bicolor S238N-H82
XP_007416000 118 f------pffkD---WWSFIQCQTSnplgSKHig-----tKsllekCIKK 153 Melampsora larici-populina 98AG31
A0BYJ1        97 Qk---------DQVSSTKFVRCFFKeaykQNFqeq--------idkCLEN 129 Paramecium tetraurelia
A0CWN1        93 L----------DQIEQLRYLTCIHQekqnNEElin--lslKk----CVQN 126 Paramecium tetraurelia
Q7Q1K2        76 Re---------pRTRLAMVACMIQN----NIMp------rDifyrcAKEH 106 Anopheles gambiae str. PEST
EEY53139     216 Fh---------QIGDLVERIACMESkdnkGMTwsf--iinR-----Cfeg 249 Phytophthora infestans T30-4
EDO41893      79 En---------NPEILTSFVGCLSYydgsvd----------kiakyCSNQ 109 starlet sea anemone
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