5J6P,6H0F


Conserved Protein Domain Family
Yippee-Mis18

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pfam03226: Yippee-Mis18 
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Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus. This entry also includes the CULT domain proteins such as Cereblon.
Statistics
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PSSM-Id: 397368
Aligned: 46 rows
Threshold Bit Score: 60.0197
Threshold Setting Gi: 1621110753
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5J6P_C         5 SVFQCKKCF-QIVGDSNAWVI------SHREy---------------------------LSFTLSDAVENSVRVEDTFKR 50  Schizosaccharom...
EDO02993     113 STIRCLTCS-THLSYASQVVSkgftgrHGRAylvapppsvpvpvippfpptahdrsknlANIRVGRPVNRELLTGHHVVA 191 Sclerotinia scl...
6H0F_B       303 TSLCCKQCQeTEITTKNEIFSlslcgpMAAYvnph--------------------gyvhETLTVYKACNLNLI--GRPST 360 human
EDN07093      98 SYLRCARCS-ADLCLTSQIISkgftgrHGRAylvaanpstdgts---iaptplmqrsslPNTVTQQPITRQLVTGTHTVS 173 Histoplasma cap...
EAW13784      45 SCLHCSRCA-ADLCLTSQIISkgftgrHGRAylvsgelvarav----sltessspnvslPNTVLRRPVARQLVTGLHSIS 119 Aspergillus cla...
XP_001400614  47 SCIRCSCCA-ADICLTSQIISkgftgrYGRAylvsgepsla---------rkasptdtlLNTVIQQPVPRRLVTGAHTVG 116 Aspergillus nig...
Q2UMI8        81 SYIQCSRCA-TDLCLTSQIISkgftgrHGRAylvsaepiaca------isttcsptetlPNTIMQKPVSRQLVTGAHTVG 153 Aspergillus oryzae
EHY52476      13 KIFGCKNCK-THLADFDDIISrnfrgqHGKAflf----------------------asvVNIKQAEAMERNMTTGRHVVR 69  Exophiala derma...
O44440        14 SLYGCVVCN-TYLTCSKELTSkaftgsTGPAtlf----------------------kraWNVVYGRCEHRKMTTGWHTVR 70  Caenorhabditis ...
EFC38446     190 LVFSCKHCR-TIFIDSNALFF------NGEE----------------------------HGIITFLKV-HKVEVRENVQI 233 Naegleria gruberi
5J6P_C        51 Sddglc----vyseLSCTRCNEVIGKVYNSTPIY-LDDIRDMYTFSMDKLQAYQLGN 102 Schizosaccharomyces pombe 972h-
EDO02993     192 D-------------VNCMICNTLLGWKYVDARELgQKYKIGKFILETKRCGIFNTYE 235 Sclerotinia sclerotiorum 1980 UF-70
6H0F_B       361 Ehswfpg--yawtvAQCKICASHIGWKFTATKKD-MSPQK-FWGLTRSALLPTIPDT 413 human
EDN07093     174 D-------------ITCRFCGSLLGWKYVAAEEElQKYKVGKFILETKRITVFSSWE 217 Histoplasma capsulatum NAm1
EAW13784     120 D-------------ICCAFCDSVLGWKYVSAEEEsQRYKVGKFILETRQITKSSTWE 163 Aspergillus clavatus NRRL 1
XP_001400614 117 D-------------INCSVCGNVLGWKYIAAEEEsQRYKIGKFILETERVMISSFWE 160 Aspergillus niger CBS 513.88
Q2UMI8       154 D-------------ISCAFCGNILGWKYVAAEEEaQRYKVGKFILETKRTMTSSLWE 197 Aspergillus oryzae
EHY52476      70 D-------------IKCKQCDETVGWKYDKAYEAsEKYKEGKYILESELLCTVT--- 110 Exophiala dermatitidis NIH/UT8656
O44440        71 D-------------VFCVTCNQKLGWMYEMAVSEsQTYKETQVIIENANFEKIAGAI 114 Caenorhabditis elegans
EFC38446     234 ApndrfdagsnyypLFCKQCQTLVGRKYLMSDKSpIVDIIGYYTLDIDALSLYEMWT 290 Naegleria gruberi
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