Conserved Protein Domain Family
V-ATPase_H_N
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pfam03224: V-ATPase_H_N (This model is not part of the current CDD release)
V-ATPase subunit H
The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer. This domain corresponds to the N terminal domain of the H subunit of V-ATPase. The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolyzis to proton translocation.
Links
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Statistics
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PSSM-Id: 515461
Aligned: 31 rows
Threshold Bit Score: 156.293
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011391828  35 KWIQELTQRIRAR----PIPWEGYHRADLLSAEELKMIKSVDAIVVGQnRSKldpLL-DEHGPDYVSLYLRLLSKL---S 106
A8XDF8        12 THFQKEADKVRQM----KTNWGLFTRSRMIAQSDYDFVVTYEQAETEQdRST---VL-SVFKEKAVYAFVHLMSQI---S 80  Caenorhabditis ...
Q38CG7         5 PEVADALFHVR--------------KTGFVDETMTQVLEQLFDCPQHG-R-----VLeTYMRGRHEDICMVLIKTLattH 64  Trypanosoma brucei
Q4QC61         6 AAAADTISLVR--------------QLQLLDDNTIRLLEQLFTNRLNG-E-----LVtSLVDGREESLAVALFRLCagtH 65  Leishmania major
Q4E1T6         6 PEATDAICQMR--------------EMRVADESTVRLMEHLFSCPPTS-D-----LLhSLLDGKHQAVAVALFKTTqgiH 65  Trypanosoma cruzi
Q22W07        20 REIQERTNDIV----------NLQNQGSLVRPENQALFKKFVEADINQ-QRD---MItKSEGIGYVNMLFDITNQCn--H 83  Tetrahymena the...
Q4UD25         4 EILNKLMLKNKINydlvNPEYDEWLITGALDTESVELIKHFTSLNSLE-RVE---MV-KKDNLILK----ILLNATyatG 74  Theileria annulata
Q8MML6        15 AESSFRTKVVLAR----EIPWNGFASSNSITSEQYNLISKYDKHTDAE-KKE---KF-AANSASYVNFFVNFINST---S 82  Dictyostelium d...
Q9LX65         2 DQAELSIEQVLKR----DIPWETYMNTKLVSAKGLQLLRRYDKKPESA-RAQ---LL-DEDGPAYVHLFVSILRDI---F 69  thale cress
Q84ZC0         2 DHAELTTEQVLKR----DIPWESYMANKLISGTCLQLLRRYDHKPESQ-RGP---LL-DEDGPSYVRVFLNILRNI---S 69  Japanese rice

XP_011391828 107 RTDTLQQILVLIDD-MLSDRDdrlelFLSlngqeeqdgigfPWKPFVK-LLDVP-DDFVQMKSAQFLTLLLVFSATHSGQ 183
A8XDF8        81 KDDYVRYTLTIIDD-MLREDVsrtkiFEEvavl----lkrsPFSFFLG-LLHRQ-DQYIVHTTFSVLTKMAVFGNIKVTG 153 Caenorhabditis ...
Q38CG7        65 NKSTLGVLLRLFADlARSSTVmgktlGLCssvlv---dqedPVQMFLYlATTHSrDRMISDPALYLAATTLRYADPKLNE 141 Trypanosoma brucei
Q4QC61        66 AENILGYSLRFLADlVYADREigvqlGRGdlvke---fgghPASLLLQiASSHSeSLGIANPAIYLAATALRYGEYEGNE 142 Leishmania major
Q4E1T6        66 SSKILGFVLRFFADlVLYCGAlgeqlGAPsaeel---fgdnPAKSFLYlVMIHReEYGITDPALFLAATSLRYGPIEKNE 142 Trypanosoma cruzi
Q22W07        84 NSAIMMYVLPTIDGiILDDRRniqkfLQSfqdqpdnknwltVLNQIL--QLPSF-DKIVYEAAARVRSQILAELDKKSFL 160 Tetrahymena the...
Q4UD25        75 PGLLRLYSLQHIHD-ICRIDNhiyniLLEiln------hrdVYSIYYDiITHEK-DKKIIQIILYLLTGFIAYNKNNIFN 146 Theileria annulata
Q8MML6        83 NIEIIQYLLTLINE-IIEIDPraagaFSKitkdd---dksyPYSVFFR-LLNRE-DAYTNLHASIALAQIMCAGKPTQND 156 Dictyostelium d...
Q9LX65        70 KEETVEYVLALIYE-MLSANPtrarlFHDesla-----nedTYEPFLR-LLWKG-NWFIQEKSCKILAWIISARPKAGNA 141 thale cress
Q84ZC0        70 KEDTVEYVLALIDE-MLAVNPkraalFYDnsls-----gedIYDPFLR-LLLKG-NWFVQEKSCKILTQIISARPKMQNG 141 Japanese rice

XP_011391828 184 PSpp-------------sSVLPRLLTF--LSSslrGASSnpSSNgsgraqtganaspasrrmspdfaegngpEIALVLLQ 248
A8XDF8       154 ------------------DELDYFMGS--LKE---AITRg-IANdy-------------------------iATAVRCMQ 184 Caenorhabditis ...
Q38CG7       142 ------------------ESLERFFAI--VNE---SLSV--NPLqve-----------------------avSFTVHNCA 173 Trypanosoma brucei
Q4QC61       143 ------------------TAFKDFFAL--ARH---TFAP--ETLqvt-----------------------diAFTVQACV 174 Leishmania major
Q4E1T6       143 ------------------EALRRFFAH--VTD---VLSA--ETLqvs-----------------------avAFAVQGCS 174 Trypanosoma cruzi
Q22W07       161 NEq--------------kQFLQWLIRSkdVSHssnHLDD---------------------------------FCLTTCFA 193 Tetrahymena the...
Q4UD25       147 NEei-------------dNIINLILKL--------TIND---------------------------------YSKLYSLS 172 Theileria annulata
Q8MML6       157 v----------------eSFFNWILKL--LRK---------NNSse-------------------------vEVGLIALQ 184 Dictyostelium d...
Q9LX65       142 VIgng-----------idDVLKGLVEW--LCAqlkQPSH--PTRg--------------------------vPIAISCLS 180 thale cress
Q84ZC0       142 IVpngeasnskskltstqDVLRGLVDW--LCSqlrNPTH--PNCs--------------------------vPTAMHCLA 191 Japanese rice

XP_011391828 249 ALLRTQKYREQAWEydVAKMGQVPSsSTgkakavsdddddesaqqqqsedvdrgflselahilrlgnapaggssfnssan 328
A8XDF8       185 TLFRIDPYRVSFVN--ISGYESLSHaLY---------------------------------------------------- 210 Caenorhabditis ...
Q38CG7       174 IMAHAKALRHYFFD--NKLVQYFPR-LLtdt------------------------------------------------- 201 Trypanosoma brucei
Q4QC61       175 QLARRKDFRPLLFE--ANLVSCIPH-LLtdi------------------------------------------------- 202 Leishmania major
Q4E1T6       175 IVARTKALRRWFFE--EQIVQFLPR-LLfdi------------------------------------------------- 202 Trypanosoma cruzi
Q22W07       194 FLLKHEHLVKVFLD--NNGAQFLHE-NM---------------------------------------------------- 218 Tetrahymena the...
Q4UD25       173 NILQLSKYHVLIE---NESVLTLIKnNL---------------------------------------------------- 197 Theileria annulata
Q8MML6       185 SLLLKDDFRIFFNN--IDGSALLLN-ILqa-------------------------------------------------- 211 Dictyostelium d...
Q9LX65       181 SLLKEPVVRSSFVQ--ADGVKLLVP-LIsp-------------------------------------------------- 207 thale cress
Q84ZC0       192 TLLREQYVRALFVQ--ADGVKLLIP-LIsp-------------------------------------------------- 218 Japanese rice

XP_011391828 329 spagsgsatpsrqttasgastlvagastgaNSTRAGTQLIYQVVLCFWLLSFNKDIAAEl-NVKLGLIPLLVDVARNAVK 407
A8XDF8       211 ------------------------------STRKCGFQIQYQIIFCMWLLTFNGHAAEValCGN--LIQTISTILGTSHK 258 Caenorhabditis ...
Q38CG7       202 ----------------------------igDDAASLVQLTYEVLVVTWLLSYEVDGVVSlqEHK--MLPHIHRVIQRMQK 251 Trypanosoma brucei
Q4QC61       203 ----------------------------vsSDSAGIIQVIYETLLLSWLLSFEYEGLVLlvRER--MIPQLHRVLQRVQK 252 Leishmania major
Q4E1T6       203 ----------------------------vaNDSASIVQLIYETLLVSWLLSYEYRGVVElqKHK--MIPHVHRVLHRMLK 252 Trypanosoma cruzi
Q22W07       219 ------------------------------KKNPSDLQKMYYTLLILWLISFSEKSVPFftDPKLRLIGQSIEVIQKISR 268 Tetrahymena the...
Q4UD25       198 -------------------------------DKEILPNSQYKAIFCLWLVSRTNKYIEYfyQQK--VIHLLCNILSTTKI 244 Theileria annulata
Q8MML6       212 -----------------------------lSTSSVNIQLLYETIYAIWLLTYNKDIAAAysGTG--LVANLVQLVKTVAK 260 Dictyostelium d...
Q9LX65       208 ------------------------------asTQQSIQLLYETCLCIWLLSYYEPAIEYlaTSR--TMQRLTEVVKHSTK 255 thale cress
Q84ZC0       219 ------------------------------asTQQSIQLLYETCLCIWLLSFYDAAVDYlsTTR--VMPRLVEVVKGSTK 266 Japanese rice

XP_011391828 408 EKVTRVTVATFRNLLAQAPGI-----------------------------------------NAPVLLGSKALALTETLL 446
A8XDF8       259 EKVIRIVLATLRNLIASNEDEymk------------------------------------kqAARQMVQNQILVKLDHLE 302 Caenorhabditis ...
Q38CG7       252 EKCIRVALMVLWNFVQAERQYmdavtnpsdatwvsd-----------eifklarvnggkgpsFIAEMVGVGMLKTLTQLA 320 Trypanosoma brucei
Q4QC61       253 EKCVRVSLMTLLNMVEAERKYmnkllnpsseewvdsriyqlgrlhqsetpgqqistfkkgpsLVAEMVSVGMIKTLSQVS 332 Leishmania major
Q4E1T6       253 EKCVRVALMVLWNMVEAERQYitlisnpsttdwvns-----------diyelgranagkgpnFIAEMVGVGMLKTLAQLS 321 Trypanosoma cruzi
Q22W07       269 EKLVRVAFACYKNLSQYNN-------------------------------------------CIEVIVDNDLLKVCETLL 305 Tetrahymena the...
Q4UD25       245 EKIIRISLLLFKNLLNNIN-------------------------------------------CLQVIVEYNIINSLTLLL 281 Theileria annulata
Q8MML6       261 EKIVRLSLSTLRNLLNNGK-------------------------------------------SNEEMIDNGFVRMLNILN 297 Dictyostelium d...
Q9LX65       256 EKVVRVVILTFRNLLPKGT-------------------------------------------FGAQMVDLGLPHIIHSLK 292 thale cress
Q84ZC0       267 EKVVRVVIMSIRNLLAKGA-------------------------------------------FAAQMIDLGLPHIVQNLK 303 Japanese rice

XP_011391828 447 SRKWSDEEIQEDLEYVKSEL 466
A8XDF8       303 NRKFQDVDLIDDMAFLQKEL 322 Caenorhabditis briggsae
Q38CG7       321 RRKFGDEDISELIQDLLNVL 340 Trypanosoma brucei
Q4QC61       333 RRKFGDEDINVMVDQLNAAL 352 Leishmania major
Q4E1T6       322 RRKFGDEDISVVINELKNVL 341 Trypanosoma cruzi
Q22W07       306 KGNIKEKEVLDDIQFMGEIL 325 Tetrahymena thermophila SB210
Q4UD25       282 YDKWNDTELYDNLQKLLVQL 301 Theileria annulata
Q8MML6       298 IKKWGDDDIPADIEVLINGL 317 Dictyostelium discoideum
Q9LX65       293 TQAWSDEDLLDALNQLEEGL 312 thale cress
Q84ZC0       304 AQAWTDEDLLDALNQLEIGL 323 Japanese rice
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