Conserved Protein Domain Family
V-ATPase_H_N

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pfam03224: V-ATPase_H_N 
V-ATPase subunit H
The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer. This domain corresponds to the N terminal domain of the H subunit of V-ATPase. The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation.
Statistics
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PSSM-Id: 397367
Aligned: 32 rows
Threshold Bit Score: 159.75
Threshold Setting Gi: 74951946
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O14265        22 SQVDEIINNVRCVAIPWQGYQRSGSLEENELQEIENLTGKPLSAy-VKTA-EEDTTAYSNLFL------KLLSMK---DT 90  Schizosaccharom...
A8XDF8        12 THFQKEADKVRQMKTNWGLFTRSRMIAQSDYDFVVTYEQAETEQdrSTVL-SVFKEKAVYAFV------HLMSQI---SK 81  Caenorhabditis ...
XP_004929804  31 sVLQIRASEIRQTRINWQSYLQSQMITQRDHDFIVNLDQR---Gq-KDLP-DKNPDACAEVFL------NLLTHI---SK 96  domestic silkworm
Q22W07        20 REIQERTNDIV------NLQNQGSLVRPENQALFKKFVEADINQq-RDMItKSEGIGYVNMLF------DITNQCn--HN 84  Tetrahymena the...
EAX92283      10 VRLEQRDAIFR------DGNPASLSLESENAEDCKAFVS---------LF-QASPENQLTEFVknknhaEIFTKLlstRS 73  Trichomonas vag...
Q8MML6        15 AESSFRTKVVLAREIPWNGFASSNSITSEQYNLISKYDKHTDAEk-KEKF-AANSASYVNFFV------NFINST---SN 83  Dictyostelium d...
Q9LX65         2 DQAELSIEQVLKRDIPWETYMNTKLVSAKGLQLLRRYDKKPESAr-AQLL-DEDGPAYVHLFV------SILRDI---FK 70  thale cress
Q84ZC0         2 DHAELTTEQVLKRDIPWESYMANKLISGTCLQLLRRYDHKPESQr-GPLL-DEDGPSYVRVFL------NILRNI---SK 70  Japanese rice
XP_002014753  19 SVLQQQAADIRTKTINWASYMQSQMISEEDYRAISALDK----Sr-AAFL-AQNSSQVVKTLL------NLVSHL---SK 83  Drosophila pers...
CAG12279      14 niIAAKAAEVRANQVNWQSYLQSQMISVEDCEFIKKFEVANSEEk-QIIL-TNEGHQCAKTFL------NLMAHI---SK 82  spotted green p...
O14265        91 PDVVNFALVKLADtLLNSNK-------FLS------------AFGPAFYdfleKD-ESYINYLdddSKLLFARVFALCSS 150 Schizosaccharom...
A8XDF8        82 DDYVRYTLTIIDD-MLREDVsrt--kiFEEvavl----lkrsPFSFFLGll-hRQ-DQYIVHT---TFSVLTKMAVFGNI 149 Caenorhabditis ...
XP_004929804  97 DHTIQYILVLIDD-ILSEDKsrv--kiFREtkf------sgnVWQPFLNll-nRQ-DEFVQHM---TARIIAKLACWHPQ 162 domestic silkworm
Q22W07        85 SAIMMYVLPTIDGiILDDRRniq--kfLQSfqdqpdnknwltVLNQILql--pSF-DKIVYEA---AARVRSQILAELDK 156 Tetrahymena the...
EAX92283      74 DPAPLNLLCAFIDrLLDLDFnatigalMANsqkl-----segCAKILIGhtadHLnQAFLVRT---ILLLLGTIISERDT 145 Trichomonas vag...
Q8MML6        84 IEIIQYLLTLINE-IIEIDPraa--gaFSKitkdd---dksyPYSVFFRll-nRE-DAYTNLH---ASIALAQIMCAGKP 152 Dictyostelium d...
Q9LX65        71 EETVEYVLALIYE-MLSANPtra--rlFHDesla-----nedTYEPFLRll-wKG-NWFIQEK---SCKILAWIISARPK 137 thale cress
Q84ZC0        71 EDTVEYVLALIDE-MLAVNPkra--alFYDnsls-----gedIYDPFLRll-lKG-NWFVQEK---SCKILTQIISARPK 137 Japanese rice
XP_002014753  84 DSTIQYILVLLDD-LLQEDRsrv--dlFHDtagk----lkqcIWGPFLNll-nRQ-DGFIVNM---ASRILAKFACWGHE 151 Drosophila pers...
CAG12279      83 EQTVQYILTLIDD-TLQENHqrv--niFFDyakk----tkntAWSYFLPml-nRQ-DLFTVHM---AARIIAKLAAWGRD 150 spotted green p...
O14265       151 SSPCsv---------------aKAF----TLFLEY--LGKlmqSLNP--------------------------------- 176 Schizosaccharom...
A8XDF8       150 KVTG------------------DEL----DYFMGS--LKE---AITRg-------------------------------- 170 Caenorhabditis ...
XP_004929804 163 LMDK------------------SDL----HFYLSW--LKD---QLKT--------------------------------- 182 domestic silkworm
Q22W07       157 KSFLne--------------qkQFL----QWLIRSkdVSHssnHLDD--------------------------------- 185 Tetrahymena the...
EAX92283     146 KATT------------------EAFqtftRTALSL--LSA---KLNEa-------------------------------- 170 Trichomonas vag...
Q8MML6       153 TQNDv----------------eSFF----NWILKL--LRK---------------------------------------- 170 Dictyostelium d...
Q9LX65       138 AGNAvign-----------gidDVL----KGLVEW--LCAqlkQPSH--------------------------------- 167 thale cress
Q84ZC0       138 MQNGivpngeasnskskltstqDVL----RGLVDW--LCSqlrNPTH--------------------------------- 178 Japanese rice
XP_002014753 152 TMPK------------------SDL----NFYLQF--LKD---QLASnstsylqemallakrtqtilvhthglhgnskdh 204 Drosophila pers...
CAG12279     151 LMEG------------------SDL----NYYFNW--IKS---QLSSqnlhgtgpet----------------------- 180 spotted green p...
O14265       177 -----------------------------------------------LTR---LFAVQCLNGVLTLKAHRYALWAENTCS 206 Schizosaccharom...
A8XDF8       171 -----------------------------------------------IANdyiATAVRCMQTLFRIDPYRVSFVNISGYE 203 Caenorhabditis ...
XP_004929804 183 -----------------------------------------------NNNdyiQSVARCLQMMLRIDEYRFAFLSVDGIS 215 domestic silkworm
Q22W07       186 -----------------------------------------------------FCLTTCFAFLLKHEHLVKVFLDNNGAQ 212 Tetrahymena the...
EAX92283     171 -----------------------------------------------------SIALECVKRALRSEQFRSTFISEKGTK 197 Trichomonas vag...
Q8MML6       171 -----------------------------------------------NNSsevEVGLIALQSLLLKDDFRIFFNNIDGSA 203 Dictyostelium d...
Q9LX65       168 -----------------------------------------------PTRg-vPIAISCLSSLLKEPVVRSSFVQADGVK 199 thale cress
Q84ZC0       179 -----------------------------------------------PNCs-vPTAMHCLATLLREQYVRALFVQADGVK 210 Japanese rice
XP_002014753 205 hgnqyspslaqlqhqheqelvvsanesyrqvpnsseqahqqeskcaiPNNeyiQSVARCLQMMLRVDEYRFAFVGVDGIS 284 Drosophila pers...
CAG12279     181 --------------------------------------clgagispsESSqyvQCVAGCLQLMLKVNEYRFAWVEADGVN 222 spotted green p...
O14265       207 FRLAeLLr---NSIGDTQLQYYSLFCFWQLTFESHIAQD-INKRfdLIKLLVQIIRSDT--KTKVYRLVLAILVNLIDKA 280 Schizosaccharom...
A8XDF8       204 SLSHaLYs---TRKCGFQIQYQIIFCMWLLTFNGHAAEVaLCGN--LIQTISTILGTSH--KEKVIRIVLATLRNLIASN 276 Caenorhabditis ...
XP_004929804 216 TLLS-IL----ASRVNFQVQYQLVFCLWVLTFNPLLAEKmNKFN--VIPILADILSDSV--KEKVTRIVLAVFRNLIEKP 286 domestic silkworm
Q22W07       213 FLHE-NMk---KNPSDLQKMYYTLLILWLISFSEKSVPFfTDPKlrLIGQSIEVIQKIS--REKLVRVAFACYKNLSQYN 286 Tetrahymena the...
EAX92283     198 LLLD-LLtq-aQKASNTDSLYHILFCIWGISFSAEGAGQlSEGD--FIPILTKLLSTVQpeREELVRLLTFIIQQLNPSI 273 Trichomonas vag...
Q8MML6       204 LLLN-ILqalsTSSVNIQLLYETIYAIWLLTYNKDIAAAySGTG--LVANLVQLVKTVA--KEKIVRLSLSTLRNLLNNG 278 Dictyostelium d...
Q9LX65       200 LLVP-LIsp-asTQQSIQLLYETCLCIWLLSYYEPAIEYlATSR--TMQRLTEVVKHST--KEKVVRVVILTFRNLLPKG 273 thale cress
Q84ZC0       211 LLIP-LIsp-asTQQSIQLLYETCLCIWLLSFYDAAVDYlSTTR--VMPRLVEVVKGST--KEKVVRVVIMSIRNLLAKG 284 Japanese rice
XP_002014753 285 TLIR-IL----STRVNFQVQYQLIFCLWVLTFNPLLAAKmNKFS--VIPILADILSDCA--KEKVTRIILAVFRNLIEKP 355 Drosophila pers...
CAG12279     223 CITA-VL----SNKCGFQLQYQMIFCVWLLAFSPQLCEQlRRYN--VVPALSDILQESV--KEKVTRIILAAFRNLLEKA 293 spotted green p...
O14265       281 PKD-----TISTMLLEHVDKAVQLLQKRKWADEDITNYLDFITSTL 321 Schizosaccharomyces pombe 972h-
A8XDF8       277 EDEymkkqAARQMVQNQILVKLDHLENRKFQDVDLIDDMAFLQKEL 322 Caenorhabditis briggsae
XP_004929804 287 EDQqvakeHCIAMVQCKVLKQLSILEQKRSDDEDIMNDVEYLNERL 332 domestic silkworm
Q22W07       287 N-------CIEVIVDNDLLKVCETLLKGNIKEKEVLDDIQFMGEIL 325 Tetrahymena thermophila SB210
EAX92283     274 V-------FIENAYDYDILRLVRNLQTKHYVDPELTTEIAKVADDM 312 Trichomonas vaginalis G3
Q8MML6       279 K-------SNEEMIDNGFVRMLNILNIKKWGDDDIPADIEVLINGL 317 Dictyostelium discoideum
Q9LX65       274 T-------FGAQMVDLGLPHIIHSLKTQAWSDEDLLDALNQLEEGL 312 thale cress
Q84ZC0       285 A-------FAAQMIDLGLPHIVQNLKAQAWTDEDLLDALNQLEIGL 323 Japanese rice
XP_002014753 356 EDSsvakdHCIAMVQCKVLKQLSILEQRRFDDEDITADVEYLSEKL 401 Drosophila persimilis
CAG12279     294 AERetrqeYALAMIQCKVLKQLENLEQQKYDDEDITEDIKFLLERL 339 spotted green pufferfish
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