4J5T


Conserved Protein Domain Family
Glyco_hydro_63

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pfam03200: Glyco_hydro_63 
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Glycosyl hydrolase family 63 C-terminal domain
This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.
Statistics
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PSSM-Id: 397353
Aligned: 16 rows
Threshold Bit Score: 650.571
Threshold Setting Gi: 74855976
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4J5T_A       288 STREQVTELITWSLNEINARFDKQFSFGEGpdsiESVEVKRRFALETLSNLLGGIGYFYGNQLIDr-eTEFDEsQFTEIK 366 Saccharomyces c...
XP_001631876 283 LEGEVFTDTLNKYKEAFDAKFEEKFPLKAK----GFDHSQKGFAQAAFSNMLGGIGYFYGSSRVV---SRYLK-EPVDYW 354 starlet sea ane...
Q95R68       352 PTGRAYQDSLQAKIAQFEQRFEDRFQLKQK----GHSPEEVRFARNALSNLLGGIGYFYGSSRVQ---SVYTK-NPVPYW 423 fruit fly
Q1MX35       363 LTGAAYEQELVRHVNEFNKKFNNKFSLSKK----DYNDDYIKFAKATLSNMLGGIGYFYGQSLVT---SVEAEgEKLPYW 435 Enchytraeus jap...
NP_001073659 347 LVGSVLTDELEKRKVAFDEKFEATFGLQAK----GFTSSHIKFAKAALSNMLGGMGYFFGPSVVQ---SVYNE-HPVLYP 418 zebrafish
Q497D5       347 LSGVSLGTELDRHKTNMENRFQSIFRLEEK----GFTPDQVAFAQAALSNMLGGMGYFYGSSVVK---SPHNA-EPVLYP 418 tropical clawed...
Q19426       310 MKPEEFTNILRIRSYNFNKKYENVFQLAGK----NYTKTQLKMAKVSLSNMLGSVGYWYGHNRVLf-nGIV-----QPYG 379 Caenorhabditis ...
O14255       297 ISEEMISQAIDKNLQEFEEKFQATFPLKAPy---DTEKAHQIFAHTAFSNLFGNVGFFTGDSIVSknpIELDDeDYEFMQ 373 Schizosaccharom...
Q6BS17       331 ITFDNINTKAKKAIKAFDKKFSQSFDLKAPf---NKDKTHEKFAKEMLSGLLGGLSYFYGDHLVDr-nTVFDEdSFESYQ 406 Debaryomyces ha...
XP_001386789 329 ITSKNINSKIKQVLTLINEKFNQHFSLNKPf---DNSSKFRKFGKEILSGLLGGISYFHGDHLVDr-eTAFDEdSFESHQ 404 Scheffersomyces...
4J5T_A       367 llna----------keegPFELFTSVPSRGFFPRGFYWDEGFHLLQIMEYDFDLAFEILASWFEMIEDDsGWIAREIILG 436 Saccharomyces c...
XP_001631876 355 ------------------EAPLYTAVPSRPFFPRGFLWDEGFHQLLISHWDTSISTDIIGHWLDLMNAE-GWIPREQILG 415 starlet sea ane...
Q95R68       424 ------------------KAPLYTAVPSRSFFPRGFLWDEGFHGLLISAWDIDIELDIICHWFDLLNVE-GWIPREQILG 484 fruit fly
Q1MX35       436 ------------------AAPLYTGVPSRSFFPRGFLWDEGFHNLLIGTWDRRLTLDIVGHWFDLVNVE-GWIPREQILG 496 Enchytraeus jap...
NP_001073659 419 ------------------EGPLFTAVPSRSFFPRGFLWDEGFHQLLLSKWDTQLTQEVFAHWLDLINIE-GWIPREQILD 479 zebrafish
Q497D5       419 ------------------AAPLYTAVPSRSFFPRGFLWDEGFHLLLIGRWNPSLAWQSLGHWLDLMNAD-GWIPREQILG 479 tropical clawed...
Q19426       380 ------------------PHVLFSAVPSRPFFPRGFLWDEGFHQMLIRKMDSKMTLEAIASWMNAMDTS-GWIPREMIVG 440 Caenorhabditis ...
O14255       374 gfesaagklaegtafhdiERSLFTIVPSRPHFPRGFYWDEGFHLLPVGLWDNDFSLEILKSWFSLVNED-GWVGREQILG 452 Schizosaccharom...
Q6BS17       407 lqgs-----------fegPHELFTLVPSRPFFPRGFYWDEGFHLLPLLKFDSDLALEVVQSWFNLIDDD-GWIAREQILG 474 Debaryomyces ha...
XP_001386789 405 ltgy-----------pegPHELFTLVPSRPFFPRGFLWDEGFHLLPLLKYDSDLVMEIMKSWFSLIDDD-GWIAREQILG 472 Scheffersomyces...
4J5T_A       437 NEARSKVPQEFQVQNPNIANPPTLLLAFSEMLSRAIenigdfnsdsyh----qvmfnsrtakfMTnnleanpgllTEYAK 512 Saccharomyces c...
XP_001631876 416 DEARTKVPAEFITQHNENANPPTLILPIKAMIDKGV---------------------------LD----------RDYLS 458 starlet sea ane...
Q95R68       485 VEALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHR---------------------------AElsq----ngrLATLE 533 fruit fly
Q1MX35       497 AEARARVPEEFILQHSKNANPPTFFLPLKKIVDDVR---------------------------ANpmd----kegLEFLR 545 Enchytraeus jap...
NP_001073659 480 DEARSKVPSEFIVQHNENANPPTLFLALQELLEQLD---------------------------AElvss---qtmLPFLR 529 zebrafish
Q497D5       480 SEARSKVPDEFVIQKSENANPPTLFLALRQLLANTE---------------------------GD-----------EALR 521 tropical clawed...
Q19426       441 SEAEAKVPAEFIPQKNDVANPPTLFYVMDKLVNDektv----------------------------------gryAGILK 486 Caenorhabditis ...
O14255       453 EEARSKVPDEFQTQYPDIANPPTLILALKGYIERLQeqqgklnnrfsg---egedyslddleyLRsvsisnpeksVQFLR 529 Schizosaccharom...
Q6BS17       475 PELRSKVPEQFQVQSPEIVNPPTLMLIFSELLESIQnsntygdinepqqvsdygdgktfdkkdLGliiiknpevmTDYAK 554 Debaryomyces ha...
XP_001386789 473 PESRSRVPEQFQVQSPEIVNPPTLMLAFTYLLESAKsagnygnvnepl---fysdeaiithkdLGsvilnnpellTNYTK 549 Scheffersomyces...
4J5T_A       513 KIYPKLLKHYNWFRKSQTGLIDEYeeiledegiwdkihknevYRWVGRTFT-------HCLPSGMDDYPRAQPPDVAELN 585 Saccharomyces c...
XP_001631876 459 KIYPRLKTWFSWFNNTQTGSLPST------------------YRWHGRDGKsdrelnpKTLTSGLDDYPRASHPSEIERH 520 starlet sea ane...
Q95R68       534 RLYPRVQAWFNWFNTTQRGEVLGT------------------YLWRGRNATttrelnpKSLSSGLDDYPRASHPTDKERH 595 fruit fly
Q1MX35       546 KLFPRLKYWYSYYENTQSGKLNST------------------YRWRGRNATniyelnpKTLTSGLDDYPRASHPTDDERH 607 Enchytraeus jap...
NP_001073659 530 KLYPRLQVWFEWFNTTQVGPVPNS------------------YRWRGRDKDtnlflnpKTLTSGLDDYPRASHPSADERH 591 zebrafish
Q497D5       522 RAWPRLQTWYDWYNSTQAGLLPHT------------------YRWRGRDQDplrflnpKTLTSGLDDYPRASHPSEEERH 583 tropical clawed...
Q19426       487 LLYPRLEKWFHWIRITQSGPTRTT------------------YRWRGRNETiktelnpKTLSSGLDDFPRASHPSDLEYH 548 Caenorhabditis ...
O14255       530 DLFPLLLRHYEWFRETQKGDFETWerecf--------sqvegYRWRGRTYQ-------HCLASGLDDYPRAQPPSTAELH 594 Schizosaccharom...
Q6BS17       555 RIYPKLKTHFEWFRRTQQGYIEEFdrgt----------nkegYRWRGRTLT-------HCLASGLDDYPRVIPADIAELN 617 Debaryomyces ha...
XP_001386789 550 EIYPRLKTHYEWFRRTQKGYVEEFgrga----------nleaYRWRGRTIT-------HCLASGIDDYPRPNPADVAELN 612 Scheffersomyces...
4J5T_A       586 VDALAWVGVMTRSMKQIAHVLKLTQDEqrYAQIEQEVVEN--LDLLHWSENDNCYCDISIDP------------------ 645 Saccharomyces c...
XP_001631876 521 VDLRCWMAFAAGLMADIAEAVGQNSDP--YKQTSAYLSDVklLDKYHWSVRQQMYSDFGNHTkfvklvhrstqp------ 592 starlet sea ane...
Q95R68       596 LDLRCWIALAAGVMAELSTLLGKDDAK--YYETASYLTDNvrLNRLHLAPYSEQYADWGLHTdqvklkrppsmapqqqqr 673 fruit fly
Q1MX35       608 VDLRCWMALSSGVMADLAKIFNVSSHS--YATTHATLMDNerLNELHWSERTRRYADFGLHTdavrlerpevrlapg--- 682 Enchytraeus jap...
NP_001073659 592 VDLYCWMTLASGVMANVARILGEPHQL--YENTHRSLSNNdlLNELHWSENLHAFSDYGNHTqavslqqekvfvppg--- 666 zebrafish
Q497D5       584 VDLRCWMALASQVMADIAERLEEDGGR--YRHDHNILTDNalLDHHHWSERLGAYADYGNHTqntalewvrpraapg--- 658 tropical clawed...
Q19426       549 LDLRCWLALASRVLNRLAKSYGTDADYqrTAKAMEELNNFdsLVKDHWSEEAQGFFDYGKHSfdvalspvptpg------ 622 Caenorhabditis ...
O14255       595 VDLLSWMTSFTRSLHFVAEFLGETEEAekLAGYENAMLRN--LEDNHWDEEVQAYCDSSVDE------------------ 654 Schizosaccharom...
Q6BS17       618 VDLLSWVGVMTKSMKSIAGFLNYENDFqkYQKIENDIVEN--LDNLHWSDSEKTYCDLSV-------------------- 675 Debaryomyces ha...
XP_001386789 613 VDLLSWIGVMSRSMKLIAQLLKHDEDAeiFAQHEDNVVDN--LSKLHWSDEEKAYCDVTV-------------------- 670 Scheffersomyces...
4J5T_A       646 ---------------EDDEIREFV-CHEGYVSVLPFALKLIPK-NSPKLEKVVALMSDPEKIFSDYGLLSLSRQDDYFGK 708 Saccharomyces c...
XP_001631876 593 ---ggptrmvrivtsRTGPTSRFV-NSFGYVSLFPFLLQILKP-DSPRLETILKGLRDPDKLWTDYGLRSLSRTDPLYMK 667 starlet sea ane...
Q95R68       674 hhhqyyqlpemqrvtGELPTYQFVdSAFGYVSLFPLLLEQLDH-DSPYLTKLLNDLRDPEQLWTNYGLRSLSKRSPLYMQ 752 fruit fly
Q1MX35       683 -qrppsnppqkirvvRGEPSPQLIdNSYGYVNLFPLLLRILDP-DSPHLEQTIQDMR--ALLWTRFGLRSLEKKAPMYGK 758 Enchytraeus jap...
NP_001073659 667 qprhqfpvarlvrsvRRAPKLQYV-NALGYVSLFPFLLHILTP-DSPKIEHILQAIKDPERLWTPYGLRSLSRADPLYMK 744 zebrafish
Q497D5       659 qdprsvpppqlirvvRKPPRLQYV-GALGYVSLFPFLLQVLDP-SAPHLGRLLDLIRDADKLWTPYGIRSLSKGSPLYLQ 736 tropical clawed...
Q19426       623 ----sprqfeyqrvtSRAPSYTLVsDAFGYNNLFPMMLKLIPS-KSPILKSMLDKIRDPKILWTNYGLRSISRSSPYYMA 697 Caenorhabditis ...
O14255       655 ---------------YDDPIN--V-CHKGYVTLLPMMLGLLPA-DSGRLTSLLKLIRDENELWSPYGIRSLSMNDVYFGT 715 Schizosaccharom...
Q6BS17       676 ---------------DDNDENKHI-CHKGYISLFPFLTKLTPAdDVDKIEQIVDLISDPEELWSDYGIRSLSKSNEFYGT 739 Debaryomyces ha...
XP_001386789 671 ---------------DEDDENIKV-CHKGYLSLFPFLTKLIHIeELDKLEAMVDLISDPEELWSDYGIRSLSKSNQFYRT 734 Scheffersomyces...
4J5T_A       709 -----DENYWRGPIWMNINYLCLDAMRYYYpevilDVAGE------ASNAKKLYQSLKINLSNNIYKVWEEQGYCYENYS 777 Saccharomyces c...
XP_001631876 668 yntehDGPYWRGSIWININFLSVRALHFYG-----NTPGPy-----RSFAKEIYGELRRNLIGNIYRQYVTSGFVWEQYD 737 starlet sea ane...
Q95R68       753 rntehDPPYWRGPIWININYLAAKALHHYG-----KIDGPn-----AALARQIYAELRDNLVGNILRQYKRSGYLWEQYD 822 fruit fly
Q1MX35       759 hntehDPAYWRGAIWINMNYLAVSALKHYS-----TEAGPy-----KDLAAAAYKELRQNLVRNIYDQYVTTGYVWEQYD 828 Enchytraeus jap...
NP_001073659 745 rntehDAPYWRGPIWININYLAVRALHHYG-----SIEGPy-----KEKAATLYQELRTNLMNNVYKQYLETGYIWEQYN 814 zebrafish
Q497D5       737 rntehDAPYWRGPIWINMNYLTVRALYLYS-----QMEGPh-----RDRLVSLYRELRQNLLANLYRQYKNTGFLWEQYN 806 tropical clawed...
Q19426       698 rntehDPPYWRGYIWINVNYMVLSSLRHYA-----DQPGPy-----RENAENIFSELRANLVKNLATQFQKTGFLWENYD 767 Caenorhabditis ...
O14255       716 -----GENYWRGPIWINMNYLILSSLYQNYi----NTPGPn-----QNLARSIYEELRTNVVNNVFENWRQTGIFWEQYD 781 Schizosaccharom...
Q6BS17       740 -----EENYWRSPIWIHMNSLILESLQHYS-----KTSSPymskglKQKISETYKNLRTNVVNNIIKQWKRTGFVWEQYD 809 Debaryomyces ha...
XP_001386789 735 -----EENYWRSPIWLNINYLILEGLQHYYdvahiRMNSDi-----SNKFKRVYKDLRLNLVNNVVEQWENTGYVWEQYD 804 Scheffersomyces...
4J5T_A       778 PIDGHGTGAEHFTGWTALVVNILGR 802 Saccharomyces cerevisiae S288C
XP_001631876 738 DGTGRGKGTHPFTGWSSLVVLMMAE 762 starlet sea anemone
Q95R68       823 DTSGEGKGCNPFTGWTATVVLLMAE 847 fruit fly
Q1MX35       829 DESGRGKGSHPFTGWSALVVSIMAE 853 Enchytraeus japonensis
NP_001073659 815 DSTGRGQGSHPFTGWSALTVLIMAE 839 zebrafish
Q497D5       807 DQTGQGQGCFPFTGWSSLLVLIMAE 831 tropical clawed frog
Q19426       768 DRTGEGRGCHPFTGWSSLILLIMSD 792 Caenorhabditis elegans
O14255       782 PTTGKGQRTKDFTGWTSLVVNIMSE 806 Schizosaccharomyces pombe 972h-
Q6BS17       810 DQTGKAKGAKNFLGWTSTVLIIMNM 834 Debaryomyces hansenii
XP_001386789 805 DETGNAKGAKNFLGWTSTILLIMNM 829 Scheffersomyces stipitis CBS 6054
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