Conserved Protein Domain Family
CobD_Cbib
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pfam03186: CobD_Cbib (This model is not part of the current CDD release)
CobD/Cbib protein
This family includes CobD proteins from a number of bacteria, in Salmonella this protein is called Cbib. Salmonella CobD is a different protein. This protein is involved in cobalamin biosynthesis and is probably an enzyme responsible for the conversion of adenosylcobyric acid to adenosylcobinamide or adenosylcobinamide phosphate.
Links
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Statistics
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PSSM-Id: 515438
Aligned: 398 rows
Threshold Bit Score: 151.467
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011933664   1 MIAAAGFDWLIGDPHWSPHPVVWMGRAIHWLRQrlePwaGdrpRALRL-------SGGLITAALVLTSAGAGWLIERlwl 73  Synechococcus s...
WP_012258432  15 LL-ALVLDFALGDPPNQLHPVSLMGHWLKWGER---LapAtpla--------rlaWG---GGWLYGGWWLVGRVASRlpr 79  Chloroflexus au...
WP_012695311   7 LL-ALALD-ALGEPPPRWHPVVWMGNYLSWARR---Gw-R---ARtsag---qlrEG---AVSWGLGAGMAGMAGLLaar 71  Deinococcus des...
Q53WA0         4 LL-ALLLDALFGEPPSRLHPVVWMGRYLAWAWR---Rvrg-------------fpSG---AFYWALGALLFALPAFLld- 62  Thermus thermop...
WP_012204652  48 PV-ALLIDRLWGEPPVWIHPVVAMGRLLAAVGR---RlaP---REEHVrdwprfaLG---AVAWCLLALLFFTIYAFiq- 116 Delftia
WP_013457030   4 LL-AALLDAVFREPPARLHPVVGIGRLLAGLEcfwr---------------agagAG---ALAWLAGAAAVLALSSLaw- 63  Oceanithermus p...
WP_013252799   8 LAGALLYDLLWGDPPNRFHPVAWMGSLISRLWQ---HrpK----QGKWll---fsYGALMTICGALLFSLPll------- 70  Sediminispiroch...
WP_014433656  19 LL-AIGIDWLWGDPGNRWHPVAWMGTAIAGLRR---Ca-P---QRgrga---alfYG---LCLAGGGAAASAWMVRLls- 83  Caldilinea
WP_015017626   9 LAAGVGVDWLFGDPPNKYHPVAWLGRLVGYCVP---RlkG---GAEKA-------KG----------AAFAVLLVIAva- 64  Candidatus Nitr...
WP_012215966   9 VGFALVIDLVFGDPKNRYHPTAWIGGLIAKLTP---LgqN---QNQKL-------ERFGGIFVVTIPAGIVVTLLLTld- 74  Nitrosopumilus ...

WP_011933664  74 qsSG-----------------LWqwaagvilIVALASALAARSLHDSVMAVVKALpakgdEEPTLARERLS-WI--VGRE 133 Synechococcus s...
WP_012258432  80 ------------------hllVQ--------GACVSLLLAYRGLDRAVAGVEQALr---tGNLAEARHLLGwHL--VSRP 128 Chloroflexus au...
WP_012695311  72 g-----------------pwwVQ--------GAALKPLLARKALFDAVAEVRAALv---rDDLREARRLLAwHL--VSRD 121 Deinococcus des...
Q53WA0        63 llLRplaw----------gwvVL--------GLLLKPLFSLRMLLLEVFGVEKALe----EGLEAGRRRLS-RI--VSRR 117 Thermus thermop...
WP_012204652 117 wlLPpmpww--------lgalVL--------GVLLKPLLSWRMLRDEVLAVEAALq----QSLPAGRERLT-WL--VSRD 173 Delftia
WP_013457030  64 wgVSaleap--------gralLA--------GLLLWPAFSLQMLTGEVAAVEAALs----RDLDEARARLA-RL--VSRD 120 Oceanithermus p...
WP_013252799  71 -lLNripil--------prlvLS--------IVFLKMSFSLTTLLRTGDKIARALe---aGDLASAR-KLT-AFhlVSRN 128 Sediminispiroch...
WP_014433656  84 daLSrmpmp--------vavlLE--------AVLLKMTFSLRGLLTAGGSVKAALe---qGELDAARRLLAwHL--VSRD 142 Caldilinea
WP_015017626  65 laVHflvfasmylagivalaiAS--------AIILKITIAVRGMERHAKAIMSCLe---tGDLAGARQNLS-MI--VRRK 130 Candidatus Nitr...
WP_012215966  75 fgISllstdwi---tlivsvvIG--------ALLLKTTIAIKGLERYAMAVVESLe---mNNLDSARENLS-MI--VKRN 137 Nitrosopumilus ...

WP_011933664 134 TKQLSGNEILRAAAETASENAVDGVFAPLFWMlvgva--lwsaGwlqspgplALAwgFKASSTLDSMLGYR--------R 203 Synechococcus s...
WP_012258432 129 TADLSAAEVAGAAIESLAENLSDSIIAPLLAFlvg-----glpA--------LAI--YRLTNTADAMWGYR--------T 185 Chloroflexus au...
WP_012695311 122 TSQLSASEVAGAAIESLAENLSDSVVAPLLAFrvg-----glpL--------AST--YRLCNTADAMWGYR--------T 178 Deinococcus des...
Q53WA0       118 TEDLSAEEVREAALESLAENLSDSLLAPLLYYalf-----glgG--------AAL--YRYANTADAMWGYPehg------ 176 Thermus thermop...
WP_012204652 174 TARLDAGQVRESAIETLAENLSDSVLAPLFWFava-----glpG--------AAL--YRLANTADAMWGYPgwrgqgddR 238 Delftia
WP_013457030 121 TRGLDAAGVRMAALETLAENLSDSLVAPLFYFvlf-----glpG--------AWL--YRYANTADAVWGYRtp-----rY 180 Oceanithermus p...
WP_013252799 129 TSELEESELCGAVVESLAENLTDSFTSPLLYYlla-----glpG--------AFA--FRYINTSDAMIGYR--------T 185 Sediminispiroch...
WP_014433656 143 VSQLDASQVAAATIESLAENLSDGVLAPLLYYalmpraewglpA--------AYA--YRFLNTADAMLGYR--------D 204 Caldilinea
WP_015017626 131 TNDLDEQHILSATIECVSESTVDGITGPIFYYslf-----gpvG--------AFA--YRAINTLDSMVGYK--------D 187 Candidatus Nitr...
WP_012215966 138 TSNLDKNHVISGVLESVSENTVDGITGPLFYYaif-----glpG--------AFV--YRIINTADSMIGYK--------T 194 Nitrosopumilus ...

WP_011933664 204 GRLRWLGTAGARLDDALTWLPCRLVMVTLPLIsrswwfwpSL-------------------VRAAERDGAADPSPNAGRS 264 Synechococcus s...
WP_012258432 186 ERYEYLGKIAARCDDAFNLVPARLTALLLALA--------THlingr----------gwhaWQTALRDARHTASPNAGWP 247 Chloroflexus au...
WP_012695311 179 PELEWTGKTAARADDLLNLAPARLTALCTLVA--------SGgr----------------gLGVWVRDRGRTSSPNAGHP 234 Deinococcus des...
Q53WA0       177 ----arGAFAARADDLLNLLPARLTGLLLCPP--------GL-------------------WGRLLQEARKTPSPNAGFP 225 Thermus thermop...
WP_012204652 239 RHWQWAGKWTARADDLLNWIPARLTALLL-----------ALsglaa---------grrpgWGALRHDARITPSPNGGWP 298 Delftia
WP_013457030 181 RRWGW---LAARADDLLNWIPARLTGLLLAPR--------GL--------------------AALRREAGRTPSPNAGWP 229 Oceanithermus p...
WP_013252799 186 GDFEFGGKWAARCDDLLNFIPARVTALLIILA--------GSiipirsapgegngagrkrsLASLFAWQNATESPNAGWT 257 Sediminispiroch...
WP_014433656 205 AEREWLGKASARLDDLANLIPARVTALLIIAC--------ARaadgs----------srhaWRIWRQDARQTASPNAGHP 266 Caldilinea
WP_015017626 188 DYFKDIGWMSARLDTAANYMPARITALLMIVS--------AKmlgad----------wknsLSVLQRDHAKTFSSNAGYP 249 Candidatus Nitr...
WP_012215966 195 DIFKNLGWFAATCDTVLNYIPSRLTGLVMIIS--------AAilqnn----------wkesYKIMIRDGKKTESPNAGYP 256 Nitrosopumilus ...

WP_011933664 265 EAIYAHCAGVELGGWNRY--GntwIEKPLlgaggAQaDPRGVRTILSLS 311 Synechococcus sp. CS-197
WP_012258432 248 MAAMAGALDTVLTKRDHYalG---DGS-C-----IP-DAAMIGQARRIV 286 Chloroflexus aurantiacus
WP_012695311 235 MSAFAGVLDVQLDKRGVYvlN---PGG-R-----EP-TAGDVRHALGLA 273 Deinococcus deserti
Q53WA0       226 MAALALRLGVRLRKRGAYalN---PLA-P-----SP-KASHTRKALWLV 264 Thermus thermophilus HB8
WP_012204652 299 MGAMARLLGVRLGKPGVYvlN---PAG-R-----VP-QAAELQQAVAHA 337 Delftia
WP_013457030 230 MGALALALGVRLEKRGAYvlH---PSG-R-----AP-EPADLRRALVRV 268 Oceanithermus profundus
WP_013252799 258 MGAAAAILGLRLEKRGHYviN---STG-R-----LP-KPADIRRCIRLV 296 Sediminispirochaeta smaragdinae
WP_014433656 267 MAAMAGALGVALEKVDHYvlG---AGS-P-----NP-DSGDIGRALRLV 305 Caldilinea
WP_015017626 250 MATMAGALRVRLEKIGHYalG---DDQEP-----A--SLEKCKTAISIM 288 Candidatus Nitrososphaera gargensis
WP_012215966 257 MAALAGALGTKFEKVNHYelG---SG-EL-----TL-TKEHVHSAISIM 295 Nitrosopumilus maritimus
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