6EOJ


Conserved Protein Domain Family
CPSF_A

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pfam03178: CPSF_A 
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CPSF A subunit region
This family includes a region that lies towards the C-terminus of the cleavage and polyadenylation specificity factor (CPSF) A (160 kDa) subunit. CPSF is involved in mRNA polyadenylation and binds the AAUAAA conserved sequence in pre-mRNA. CPSF has also been found to be necessary for splicing of single-intron pre-mRNAs. The function of the aligned region is unknown but may be involved in RNA/DNA binding.
Statistics
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PSSM-Id: 397339
Aligned: 63 rows
Threshold Bit Score: 185.874
Threshold Setting Gi: 75032529
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EOJ_A        990 QSGILLINP--KSwKViDKIDF--PK-NSVVNEMRSSMIqiNSKt---kRkREYIIAGVANATTEDTpPT----GAFHIY 1057 Saccharomyces...
EDO42742      801 IGSLLIIDQhtFE-VT-HAHQL--HD-NEQATSLMSCTLsdDp--------HTYYCVGTAYVFPEEPePKa---GRLLLF 864  starlet sea a...
XP_002633464  780 TSSFMILDQntFQ-VL-HAHEF--GP-FEAAVSCISGQFsdDa--------RQYYIVGTGLIYPDESdTKl---GRIIVF 843  Caenorhabditi...
O13807        733 LSFLRVYEKntLS-EI-AHHKF--NE-YEMVESIILMNd------------DKRVVVGTGFNFPDQDaPDs---GRLMVF 792  Schizosacchar...
Q7S9R0        792 HSSFKLVDEilFA-RVgKEFMLgtSSySELVEDVIRAELpdSYG-----NlVERFIVGTSFLEDPDRgAGtdkrGRILVF 865  Neurospora cr...
Q0UHP7        765 LSHFKLVDEiqFK-EL-DTYAL--NE-EELVECVMRCDLadGSG-----GtAERFVIGTAYLDDQNStVEr---GRILIL 831  Parastagonosp...
EDN03230      794 ASRFMLADEimFR-EL-DIYDL--NK-DELVESVIRAQFpdGIDregndLfKDLFVVGTSYLD-DFGeGSi--rGRILAF 865  Histoplasma c...
Q0CML9        782 KSQFVLADEilFR-RL-DAFDL--RS-EELVESVIRAEFpvGKDekgrdMfKDRFVVGTAYLDEDEDrDSi--rGRILMF 854  Aspergillus t...
Q5BFT4        781 KSQFVLADEilFR-RL-DAFDL--EG-EEIVECVIRAEApeSKDg----EaKDRFVVGSAYLGEDDG-DSt--lGYIRVF 848  Aspergillus n...
Q10426        711 NYHLELVDSydDN-SF-RVFSF--TE-NERCEKVLKIN-------------ESSLLVGTSIIEQDKLvPVn---GRLILL 769  Schizosacchar...
6EOJ_A       1058 DVIEVvpepgkpdtnyKLKEIFQEEVSGTVSTVCEVSGRFMISQSQKVLVRDIQEDNs----VIPVAFLdIPVFVTDSKS 1133 Saccharomyces...
EDO42742      865 HLSEg-----------KLVQVAEKEVKGAVYSLVEFNGKVLAGINSTVSIFEWTADKe----FRYECSYyDNILALYLKT 929  starlet sea a...
XP_002633464  844 EVDDVer--------tKLRRVHELVVRGSPLALRILNGKLVAAINSSVRLFEWTADKv----LRLECSNfNHIVALDLKV 911  Caenorhabditi...
O13807        793 EMTSd----------nNIEMQAEHKVQGSVNTLVLYKHLIVAGINASVCIFEYEHGT-----MHVRNSIrTPTYTIDISV 857  Schizosacchar...
Q7S9R0        866 GIDSn----------rDPYLVLKHELKGGCRALAVMGSKIVAALHKTVVISQYEETSsteahLVKLASYrCTTYPVDIAV 935  Neurospora cr...
Q0UHP7        832 EVTPe----------rVLKLVTEIAVKGGCRCLAMCEGKIVAALIKTIVVYDIEYRTqskpdLVKAATFrCSTAPIDITV 901  Parastagonosp...
EDN03230      866 EVTAn----------rQLAKVAEMPVKGACRALAIVQDKIVAALMKTVVVYTISKGQfadytLSKTASYrTSTAPIDIAV 935  Histoplasma c...
Q0CML9        855 EVDNg----------rKLTKVAELAVKGACRALAMLGDKVVAALVKTVVIYKVTGNNfgamkLEKLASYrTSTAPVDITV 924  Aspergillus t...
Q5BFT4        849 EVDNg----------rKLAKVAQERVKGACRALAVMGDKIVAALVKTVVVFQVVPRSgg-lqLQRLASYrTSTAPVDITV 917  Aspergillus n...
Q10426        770 EFEKEl---------qSLKVVSSMVLSAAVIDLGVYNDRYIVAFGQQVAIVKLTEER-----LMIDSRIsLGSIVLQLIV 835  Schizosacchar...
6EOJ_A       1134 FGNLLIIGDAMQGFQFIGFDA---------EPYrMISLGRSMSKFQTMSLEFLvNGgDmYFAATDADRNVHVLKYAPDEP 1204 Saccharomyces...
EDO42742      930 KGDFILVGDLMRSMTLLVYLPl--------EGS-FQEIAHDFSPKWMTAIEIL-DD-D-TFLGAENSYNLFTCTKD-SGA 996  starlet sea a...
XP_002633464  912 MNEEVAVADLMRSVSLLSYRMm--------EGN-FEEVAKDWNSEWMVTCEFI-TA-E-SILGGEAHLNMFTVEVDKSRP 979  Caenorhabditi...
O13807        858 NQDEIIAADLMKSITVLQFID----------DQ-LIEVARDYHPLWATSVEIL-SE-R-KYFVTEADGNAVILLRD-NVS 922  Schizosacchar...
Q7S9R0        936 HGNMIAVADMMKSATLVEYVPaktggekseAPK-LVECARHRHSAWATAVAHV-EG-E-SWLEADANGNLIVLQRN-AEG 1010 Neurospora cr...
Q0UHP7        902 NGTQIAIADLMKSMVVVEYQRge-----tgLPDkLVEVARHFQVTWATAVAEV-DE-N-TYLESDAEGNLLVLYRDPKGV 973  Parastagonosp...
EDN03230      936 TGNLIAVADLMKSVSIVEYQQgsn----glPDS-LTEVARHFQTLWSTAVAHV-AE-D-TWLESDAEGNLVMLHRN-VNG 1006 Histoplasma c...
Q0CML9        925 TDNVIAVSDLMKSSCLVEYIEged----glPDS-LKEVARHFQTVWATGIACI-AP-H-TYLESDAEGNLIILRRN-LSG 995  Aspergillus t...
Q5BFT4        918 TRNVIAIADLMKSVCVVEYHEgen----gaPDK-LVEVARHFQTVWATGVTSV-AP-D-TYLESDAEGNLIVLRRN-RSG 988  Aspergillus n...
Q10426        836 EGNEIAIADSIGRFTIMYF-----------DGQkFIVVARYLFGENIVKAALY-EG-T-VYIIATNSGLLKLLRYNKDAK 901  Schizosacchar...
6EOJ_A       1205 NSLSGQ-RLVHCSSFTLHSTNSCM---MLLPrn-eEFGSpqvpsfqNVGGQVDGSVFKIVP-LSEEKYRRLYVIQQQIID 1278 Saccharomyces...
EDO42742      997 TTDEERyHLQDAGQYHLGEFVNVFrhgSLVMehpgDASTpfq--gcVLFGTVNGRIG-IVAqIAQDLFNFLIQVQKKLNK 1073 starlet sea a...
XP_002633464  980 ITDDGRyVLEPTGYWYLGELPKVMvraSLVVqp-eDSTIeys--hpIMFGTNQGTIG-MLVqIDDKWKKFLVSIEKAISD 1055 Caenorhabditi...
O13807        923 PQLSDRkKLRWYKKFYLGELINKTrhcTFIEp---QDKSlvt--pqLLCATVDGSLM-IVGdAGMSNTPLLLQLQDNIRK 996  Schizosacchar...
Q7S9R0       1011 VTVEDQrQLRITSELNLGEQVNKIrpiK-VEt---SPNAiii--prAFLATAEGGIY-MFGtIARE-QDLLLRFQDKLAA 1082 Neurospora cr...
Q0UHP7        974 TDDDKR-RLNVSSEMLLGEMVNRIrriDVATap-dAVVVp-----rAFMGTVEGSIY-LFAlISQNYLDLLITLQSNLGN 1045 Parastagonosp...
EDN03230     1007 VTDDDRrRLEVTSEILLGEMVNRIrpvN-IQgs-qGAEAais--prAFLGTVEGSIY-LFGiINPTYQDLLMRLQSAMAG 1081 Histoplasma c...
Q0CML9        996 VEEDDKrRLEVTGEISLGEMVNRIrpvN-IQq---LASVtvt--prAFLGTVEGSIY-LYAiINPEHQDFLMRLQATMAG 1068 Aspergillus t...
Q5BFT4        989 VEEDDRrRLEVTGEICLNEMVNRIrpvN-IQq---LPSAtvv--prAFLATVEGSIY-LYAiINPDYQDFLMRLQATMAS 1061 Aspergillus n...
Q10426        902 NFND---RFICESVYHLHDKVSKFqnfPIt-----NTNSfle--pkMLFATEIGAIGSIVSlKDKELE--LEELTRKIRK 969  Schizosacchar...
6EOJ_A       1279 REL-QLGGLNPRME-----RLANdfyqm-----ghsmRPMLDFNVIRRFCG 1318 Saccharomyces cerevisiae S288C
EDO42742     1074 VIK-SVGKIDHSLYpfphcSNLshsrk------mepaHGFIDGDLIESFLD 1117 starlet sea anemone
XP_002633464 1056 SVK-NCMQIEHSTY-----RSFifqkr------ieppSGFIDGDLVESILD 1094 Caenorhabditis briggsae
O13807        997 VIP-SFGGLSHKEW-----KEYRgene-------tspSDLIDGSLIESILG 1034 Schizosaccharomyces pombe 972h-
Q7S9R0       1083 VIK-TVGELDFNSY-----RAFRnaergpeadgttgpVRFLDGELLERFLD 1127 Neurospora crassa
Q0UHP7       1046 LVV-SPGNMDFAKF-----RAFKnqvrt-----eeepNRFVDGELIERFLD 1085 Parastagonospora nodorum SN15
EDN03230     1082 MVV-TPGGMPFNKF-----RAFRntirq-----aeepYRFVDGELIERFLS 1121 Histoplasma capsulatum NAm1
Q0CML9       1069 KIE-SLGDMPFNEF-----RGFRsmvre-----akepYRFVDGELIERFLT 1108 Aspergillus terreus NIH2624
Q5BFT4       1062 RAD-SLGGIPFTDY-----RAFRtmtrq-----atepYRFVDGELIERFLT 1101 Aspergillus nidulans
Q10426        970 LKFsYLSSMDYESI-----EADLis-----------pVPFIDGDLVIDVKR 1004 Schizosaccharomyces pombe 972h-
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