Conserved Protein Domain Family
Nucleoporin_C

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pfam03177: Nucleoporin_C 
Non-repetitive/WGA-negative nucleoporin C-terminal
This is the C-termainl half of a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two nucleoporin classes are known: one is characterized by the FG repeat pfam03093; the other is represented by this family, and lacks any repeats. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore.
Statistics
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PSSM-Id: 397338
Aligned: 61 rows
Threshold Bit Score: 244.144
Threshold Setting Gi: 927377995
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003715046  630 PAILEGNLRGRTSYLERLMSYLNSLSVDIDREVRWGLLWNAEKMSaatvlwkqheqfllergerpgsdtrsiISEIVEFI 709  Pyricularia o...
XP_002562605  654 AISLEQNLRLRAKALDDLASLLSRQGNPVSRPARWELLWAAEKIAaqramwkvqea-----ckikngeegpfLSHVIASM 728  Penicillium r...
Q4WNI2        412 SVTLEQNLKLRAKALDDLASLLLQHKKPLHRQTWYELLWGAEKLAaqralwksedk-----arramgqgntfLAHVIGSM 486  Aspergillus f...
EAW10045      616 SVTLDQNLRLRSKALEDLAALLLRHHKNLRRQTRYELLWSAEKLAaqkalwkvedv-----srrakgqghtfLAHVIRSM 690  Aspergillus c...
Q2UG20        525 AISLEQNLRSRAKALDDLACLLMQQNKLLGEQIWWELLWGAEKLAaqramwkieeg-----srklkgkgstfLTHVINSM 599  Aspergillus o...
Q0CHJ8        474 AISIQQNLRSRAKALDDLASLLMQQNKAFDRQTWWELLWGAEKIAaqraiwkieed------arkskgnktfLTHVIESM 547  Aspergillus t...
EHA20317      604 gISVDQNLKLRAKALDDLALLLTQQNETIRREVWWQLLWSAEKLAaqramwklede-----arkcasknstlLAHIIGLM 678  Aspergillus n...
Q5B587        582 AISIDQNLKLRSKALDDLSRILLDQNKIIDRRIWWELLWGAEKLAaqraiwrleas-----arkrnssgatfLAHVLGLM 656  Aspergillus n...
EGP82845      577 PTSMEQHLVSKARALQALAGHIRTSYPAIPRQTMWRLLFDAEHVAagqelwtafeehv--adsfdgkrkatiLDEVCTWF 654  Zymoseptoria ...
EME44689      654 PTSMEQHLAAKAQALKSLVAHVRQNYAALSRATMWRLLWNAERVAaaqqlwvafeehv-ammsekgkrkatlLDEICEWF 732  Dothistroma s...
XP_003715046  710 hesekkvpnqnkgeldnvrhwft---hdigrlevfvawayevikykyqqKVAN-DADITRLMYEAmqvvlealGEAFAYR 785  Pyricularia o...
XP_002562605  729 hdkfktpinpqqgetdpvrqwfl----rdsyrmehiipwiknaiklgrsNTSNpARALSEKILAAselflavtETAFRYR 804  Penicillium r...
Q4WNI2        487 nekfktksedyedkdnvrdwfl-----fdtfrmehiipwifkalklqkgISTKqGRRVLEEIVQAselslavlETAFRFR 561  Aspergillus f...
EAW10045      691 nekfktktksqtgdadevrdwfl----ydtfrmehivpwifkaikpqrsHSANnCRIMTEEIVEAselslavlETAFHYR 766  Aspergillus c...
Q2UG20        600 sdkfktrvekqdgevdpvrnwfl----hdtfqmehvvpwifnaikpkkgHSSRqGRKMSEQILEAselslavlETAFRFR 675  Aspergillus o...
Q0CHJ8        548 sekfrtkarsdgddpvrnwfly------dtfrmehivpwifnavkpqkgFSSRqGRKISEQILEAselslavlETAFRFR 621  Aspergillus t...
EHA20317      679 sekfktkieeqtgecdpvrhwfl----ydtfqmehivpwvfhaikpqkgSSSKpGRRMSEQLLEAsdlslavlETAFRYR 754  Aspergillus n...
Q5B587        657 nekfktklddtddpirqwflf-------dsyrmehivpwifhaikpqkgNTSKqMRRMSEQILEAgelslavlETAFRYR 729  Aspergillus n...
EGP82845      655 tqdhfaqrsdlanedpvrrffig----glhrlepllnhvklcvaglkqdD--KpPKHILRIVIQAndlwirslGTAFTFR 728  Zymoseptoria ...
EME44689      733 dnesdpeepftkrkelkdeeavrkffigglhrleslfrytklfleelrtNTEWtPERVLRVVIQTndvflrglRAAFTFR 812  Dothistroma s...
XP_003715046  786 AKKLEFYGLsndrlergv--lqdgyealsEPWTcdfnittNTKRMMDLAHKWLTSYYPPSvTISAGSPDPRLIQTIRDRL 863  Pyricularia o...
XP_002562605  805 DEHVALYGLrgdfledgv--lsdgyedlpEFWTsrgvgysEAGHLLDLELDSCRSWKTPA--SAADAPDTHVLNQVAKNS 880  Penicillium r...
Q4WNI2        562 DEHARQYGLedehiedgv--lssgydglsEFWTsrdivflETGHLLDLELDTCRAWTQQA-TTSLDLREQKLVRQIAENS 638  Aspergillus f...
EAW10045      767 DGHARQYGLvidciedgv--stadygglpEFWTsegiiyiETGHLLDLELETCRAWIQQT-TPSLELPEHQALRRIAENS 843  Aspergillus c...
Q2UG20        676 DEHASRYGIrdgyledgv--lvtgfkglpEFWTsqnfsyvETGHLLDLELDSCRAWIQQA-TSVTEAPESLTVKRIAGNS 752  Aspergillus o...
Q0CHJ8        622 DEHASRYGLgdgyiedgv--lvtgynglpEFWTsqsisyvETGHLLDLELDSCRAWIQQR-NSNMEMPEDKIVKKISKNS 698  Aspergillus t...
EHA20317      755 DENSSRYGIgdgylengi--ltgdytglsEFWTsqrycyiEFGHLLDLELDSCRAWIQKT-TIGVELPETQTVRRIARNS 831  Aspergillus n...
Q5B587        730 DEHASQFGIgdgyleegv--lttnyeglpEFWTsqsisysEIGHLLDLELDSCRAIQQTS--TSSDGGDQQISAKIARNS 805  Aspergillus n...
EGP82845      729 GRNASDYGIlpdlledgvlvetteyvdlpEFWTsvarlteNTVAIARLSRFIANRYYETG---DQEAVVEQMAGELAQFN 805  Zymoseptoria ...
EME44689      813 SENAAEYGIlpeliddgvlidsveytdvpEFWTstdnlvgYTTQVATSSREFASEAYEKY--DQIPATIDQLVREIAVAN 890  Dothistroma s...
XP_003715046  864 PSLTDKYLLTVLERSRWALTRNNQKLVHHGEICRKTYSNdrydklvllKDFGLFREAIRVAEAHNSIEALALLMVEEVKs 943  Pyricularia o...
XP_002562605  881 YRHLRVIGQMHLERTRWLSAQGDPKLMDESVSIEQAHVEdrkwqlfklAGIDHLADAVELAESFRDMGALVELIIELQDq 960  Penicillium r...
Q4WNI2        639 ARQLRVLSLMHYERVRWLSSQDNPKSVDEGIELEQTYTKqrrwqlfklAGIGQLEDAISLAEKFRDMSALVELIIELQDq 718  Aspergillus f...
EAW10045      844 ARQLRVLSLVHCERVRWLSVQDDPKLVDESIAIEQAHIQqrrwqlfklAGIGQLEHAITLAENFRDMSALVELIIELQDq 923  Aspergillus c...
Q2UG20        753 ARQLCVLGQMHYERVRWLSAQEDPKLVDEGIATEQAHVKqrkwrlfklAGIGRLDDAITLAEKFRDMSALVELIIELQDq 832  Aspergillus o...
Q0CHJ8        699 SRLLRVLGQMHSERVRWLSAQQESKLVDESIATDQSHVKqrkwqlfklAGIGQLEDAITLAEQFRDMDALVELIIELQDq 778  Aspergillus t...
EHA20317      832 SRQLQILGLMHCERVRWLSAQENQKLIDESIATKQAHIKqrkwqlfklAGIGHLDDAIMLAEQFRDMGALVELIIELQDq 911  Aspergillus n...
Q5B587        806 ARHLRIMGQMYSERIRWLSAQEDQKLIDEASATKQSHIKqrrwqlfklAGIGQLNEAIELAESFQDMSALVELIIELQDq 885  Aspergillus n...
EGP82845      806 PSILQLYCQLSEESINWRASRPSQKERDYAESLREHYDSvrysqlrslADVGQAEAGMRLAEKYNDMNTLTDLVIAEDQy 885  Zymoseptoria ...
EME44689      891 PTLVELMCLQFKECINWKASRPSPKDHVAAEQLRSKFESarheqfrslATVGHAEDGMRLAEKYRDMHTLTDIVVAEDQy 970  Dothistroma s...
XP_003715046  944 lrqralDRDQTPSRVTELRerarikQHEIAESFDRFGDQFAFAVYDILLREEGVKAVLDFpg-nRKGYATKFLRTKPELS 1022 Pyricularia o...
XP_002562605  961 katqhpQPPS-DVSTNQTDida---dqlIAKYFDKFGDIWADAYFSRQIAMGYPGTLFTMr--kYQSAVTRFLRSNPAYS 1034 Penicillium r...
Q4WNI2        719 tl------adsEHAENVTNyeseqlGRRISTYFEKFGEPWADAFFTRQISMGQSEILFTMr--rFQPFINRFLHKNPTYA 790  Aspergillus f...
EAW10045      924 tl-------dsEDAAESTNreseqlSKRISTYFERFGESWADAFFSRQISMGQSGTLFTMr--kFQPFITRFLHKYPTYA 994  Aspergillus c...
Q2UG20        833 tkgeilPSSR-NDASDTIScesdhlNKKISLYFEKFGESWANAFFSRQISMRQSGILFAMk--kFQPFITQFLRKDAAYS 909  Aspergillus o...
Q0CHJ8        779 rkvednSDSL-DGNGDVLSrdshelGEKISLYFEKFGEPWADAFFSRQISMGQSGVLFSMr--kFQPFITRFLRKHPVYS 855  Aspergillus t...
EHA20317      912 tkslvtHQDSPNKNAGADEnaserlSQKISFYFEKFGESWADSFFSRQISMGQSGILFAMk--kFQPFVTRFLRKHPAYL 989  Aspergillus n...
Q5B587        886 n---------kVVFTNVDTpdgielDRKISLYFEKFGDAWADAFFGRQISMGQPGILFSAk--kFQSFVTRFLHKHQPYA 954  Aspergillus n...
EGP82845      886 lietaeKTPI-TTDRQFILnarteiQAKILTYFERYGEAWATPFFDKMFSDGATGAKLDQaqktWKSAVTKYLRADSRRA 964  Zymoseptoria ...
EME44689      971 nedqiqGAP--EETVQVIYknredlNDKVKKFFDRYGTAWADAFFDKLFSSSSVGKKLEQaqlrWQRSLAEYLQSHPSRA 1048 Dothistroma s...
XP_003715046 1023 KISWINDVeQEKDINHAAETLIELGLNREQQVWNKKIELSLGKLALLAEgatvnkqgparnqlvvvrgergdraaadltQ 1102 Pyricularia o...
XP_002562605 1035 RLSWINDViGEDDYDTAATSLEDLAIGSEKDLWSHRVEISLAKLGKLATkermdspvv------------astlqedvkR 1102 Penicillium r...
Q4WNI2        791 RLCWINDAiGEDNYEAAARSLETLALERESDLWCHRVELSLSKLATLAAweessaaak-------------pifgneikR 857  Aspergillus f...
EAW10045      995 RLCWINDAiGENNYEVAGRSLESLAVEHESDIWSHRVELSLSKLTKLAAlegddgank-------------silnkeirR 1061 Aspergillus c...
Q2UG20        910 RLGWINDViGENDYNAAAQSLEKLAIEGESDLWSHRVELSLAKLAKLATleetnipsh-------------sgfhndirH 976  Aspergillus o...
Q0CHJ8        856 RLGWINDVlGEDKYNAAAESLQTLAVEHETDLWSHRVELSIAKLAKLATweentapad-------------slihtdirR 922  Aspergillus t...
EHA20317      990 RLGWINDViGENDYEGAARSLEKLATKHESDIWSHRVELSLAKLANLAVweesrmpds-------------lvvrrnvrR 1056 Aspergillus n...
Q5B587        955 RLSWINDViGEADYECAAKTLEHLALEQEQDVWGHRVKLALAKLSHLARwekdapsdt-------------ralqndikR 1021 Aspergillus n...
EGP82845      965 KLCWINDVmEASDFEHAGKALADTATEQENKLWAKKVELSMSRLALMAAeedaattrla-----------nggpvqsinP 1033 Zymoseptoria ...
EME44689     1049 KICWINDVtQEGDFAHASSALAQAAEAQESRLWAKKVELSMSKLALLAAqeagepiskl-----------sngtsslphD 1117 Dothistroma s...
XP_003715046 1103 INRELTIIGIQDKLYNLILpsvsmavdeaaalelameysaqniPKKHkaLARVFEDAMGRLLRHEALDPLTLIDLLTlvs 1182 Pyricularia o...
XP_002562605 1103 LDDYVEVDGIQDILYSHIQpilqgaidrkaelelvldqcgehiFEDRpsLHEILSDALFTLIERQVVGADGLIDILTlmg 1182 Penicillium r...
Q4WNI2        858 LEDLAELDAVQEVVYAYMMpalqgaidqkae-telaidqfgrfVNDTpsLHEVLSALLTKVISRQILRVDQLVDLLTlid 936  Aspergillus f...
EAW10045     1062 LEDLAEIDAVQEVIYSYVMpalqgaidqkae-ielamdqfgklVVDMpsLREVLCHALTKVINRHILTFDEMVNVLTlmd 1140 Aspergillus c...
Q2UG20        977 LEDLSEIDAVQELIYAYISpalqgaidqraevdlaidhfgkniAGDRpsLHELLSETLTKVVTRQIIDIHQLVDILTlid 1056 Aspergillus o...
Q0CHJ8        923 LEDLTEIDAVQEVIYAYITpflqgaidqkaeldlavdhfgksiSSDRpsLLELLSETLGMVIARQVIGAERLVDLLTlmn 1002 Aspergillus t...
EHA20317     1057 LEDLAEVDAVQEVIFAYVSpalhsaidqkaeidiaieqfrnpaAADRpsLHEIFSEALAKIVTRQVLDSDELVDLLThiy 1136 Aspergillus n...
Q5B587       1022 LEGLAEMGAVQEVIYSYVSpvlrdaidqkaeidlaidhfakstAQKLpsLHELLKEALTGVVTRKMLSLDQLVDVLTlid 1101 Aspergillus n...
EGP82845     1034 ATKDLQIVEAQEKLYDHIHgtiigsldreae-tincmlkfgthISDMiaLRQLLENGLNMIIDHTVLSIEQLIDVLTlid 1112 Zymoseptoria ...
EME44689     1118 PRDELAIVDVQERLYQHFYpeivasldrvae-veicmqkfashVKDWpaLRQLLENGIHATLNHTALSIEQLIDVLTlmn 1196 Dothistroma s...
XP_003715046 1183 irhdpttpgfnIYDDLYFSALRVSHL---SLRGEEQqntnrl---iwrrcfIRDDWSKINNTQ--SKGDDMMSMMLGSTA 1254 Pyricularia o...
XP_002562605 1183 paqladdtegeLVRSEFHLALQVLDYg--RYGQRDPsyltalrrliwrrclIKDDWVARGKAA--EGPNGNASNLVADTT 1258 Penicillium r...
Q4WNI2        937 ggqvseetqneFIGKEFYLALRVIRLn--SSTQEGPlyciplqklvwrrcmIRDDWQLEKNA---DNTDHEPGDHMHCVS 1011 Aspergillus f...
EAW10045     1141 gcqvpddilseFSSKEFYLALRVIRL---ASSQGDPlyqvpfqklvwrrcmIRDDWQIMREAE--GGVRDELEDPIYNTA 1215 Aspergillus c...
Q2UG20       1057 sdkaseygqseLSGKEFYLALRVIRLg--IYAQQDSlnyitmqklvwrrcmIKDNWVATGRAA--ESMDNGSEPFIYDTA 1132 Aspergillus o...
Q0CHJ8       1003 psqtmeydhsdLLGKEFYLALRVVRLa--SFSQQDSryhaamqrliwrrcmIRDDWVETGKAA--ERLGADSEASAYETS 1078 Aspergillus t...
EHA20317     1137 lsqaseqgqdeIVGKQFYLALRIIRL---SYDQRDPqyhaalqklvwrrcmIDNNWERMEEAA--EGLGMDTESFLYATT 1211 Aspergillus n...
Q5B587       1102 psqdpdigqndFSGDEFHLALRVIRLg--HNAQGDPnyslalqklvwrrciIRDKWDATGGTA--EQMGSETESPLTATA 1177 Aspergillus n...
EGP82845     1113 ihpdssddddsIGGGEFVLALSALDAaapSLPSDRFetllql---iwkrcyIYDDWTQFRLSG--KQSDADRTGILRSTI 1187 Zymoseptoria ...
EME44689     1197 ivp--sevegnMQGTEFMLAFIALDAaapSMPPARLetllql---vwkrcyIYDDWAKLKLSGktKQSDQERGKELRGTA 1271 Dothistroma s...
XP_003715046 1255 TYLTLYACHS 1264 Pyricularia oryzae 70-15
XP_002562605 1259 LYRSLTACLE 1268 Penicillium rubens Wisconsin 54-1255
Q4WNI2       1012 LLRTLTLCLR 1021 Aspergillus fumigatus
EAW10045     1216 LFRTLSLCTK 1225 Aspergillus clavatus NRRL 1
Q2UG20       1133 LFRTMGLCLR 1142 Aspergillus oryzae
Q0CHJ8       1079 LFRTLSLCLG 1088 Aspergillus terreus NIH2624
EHA20317     1212 LSRTLCWCLR 1221 Aspergillus niger ATCC 1015
Q5B587       1178 LSRTLALCLN 1187 Aspergillus nidulans
EGP82845     1188 LWSTLRQALD 1197 Zymoseptoria tritici IPO323
EME44689     1272 IWQTLYHLLD 1281 Dothistroma septosporum NZE10
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