Conserved Protein Domain Family
HSR
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pfam03172: HSR (This model is not part of the current CDD release)
HSR domain
The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.
Links
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Statistics
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PSSM-Id: 515429
Aligned: 44 rows
Threshold Bit Score: 111.115
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ELK17128      120 EIVFSHFRRHKVEIANAIKKPFPFLEVLRDRGHISNKMYDDSQESArNLVPVQRVVYNVLSTLETTFDLSL---LEALFS 196 
XP_015216560   10 ADLRSQLRMLRTEIAMAIDDPFPLLYGLADHDIITEQLFKDTLDKK-KHEGIHKAVYSLLSRLLEKETLTIqnfWSNLFK 88  
24_pfamImport   3 TNLRSLLRELRTDIAMAVDDPFPLVYGLADKNIITEQLLKETLEKE-AREGIHKAMYSLLSWVLEQSRSTVqafLNNLSK 81  
10_pfamImport   3 ETLRQHFIFQKLEISYAICKPFPFLEGLRDKSFISDKMYMESMEACrNMVPVSKVVYNILTKMEEPFNLSF---LEMLFS 79  
11_pfamImport   3 EALLQHFTCRKLEIAYAIHKPFPFFEGLRDKAFITERMYTESLEACrNLVPVSRVVYNVLTRLEQTFSLQL---LEALFS 79  
13_pfamImport   3 EALFQHFICQKLEIAYAIHKPFPFFEGLRDKFCITEKMYKESLEACqNLVPVSRVVHNVLTQLERRFHLSF---LMTLFS 79  
NP_001365376   10 EALFQHFMHQKLGIAYAIHKPFPFFEGLLDNSIITKRMYMESLEACrNLIPVSRVVHNILTQLERTFNLSL---LVTLFS 86   human
XP_029687002   27 TNLRSLLRQLRTDIAMAVDDSFPLVFGLADKNIITDQLQKDTLEKE-SREGIHKAMYSLLSWVLEQRRSIIrafWSNLSK 105  torafugu
NP_001258486    6 GMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLK-EKEGCPQAFHALLSWLLTRDSGAIldfWRILFK 84   house mouse
XP_028925360    7 KQLLIKFREKKLAISDAVNKLFPFIYSLRDQALISNRMLQHYKNES---VPMKERIYNVLEKLEKNFNKKV---LKVLFS 80   platypus

ELK17128      197 EVNMQEYPDLIQIRKSFENA 216 
XP_015216560   89 DYNLERYPKLQSVFTSFPKD 108 
24_pfamImport  82 DYNLDSYPRLQTLLTNLDCP 101 
10_pfamImport  80 QINLREYPNLVAIHRSFRNV 99  
11_pfamImport  80 QINLREYPRLAAVLRSFRGA 99  
13_pfamImport  80 PINLREYPDLMTIYRSFKRG 99  
NP_001365376   87 QINLREYPNLVTIYRSFKRV 106  human
XP_029687002  106 DYNLDSYPKLHKLIANLPcr 125  torafugu
NP_001258486   85 DYNLERYSRLHSILDGFPKD 104  house mouse
XP_028925360   81 RNNVKEYPDLKRIRRTFEDV 100  platypus
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