1HJG,6FXM


Conserved Protein Domain Family
2OG-FeII_Oxy

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pfam03171: 2OG-FeII_Oxy 
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2OG-Fe(II) oxygenase superfamily
This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. This family includes the C-terminal of prolyl 4-hydroxylase alpha subunit. The holoenzyme has the activity EC:1.14.11.2 catalyzing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2. The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.
Statistics
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PSSM-Id: 397334
Aligned: 135 rows
Threshold Bit Score: 32.0386
Threshold Setting Gi: 193806639
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HJG_A 155 CEPLLRFRY-----F--PQV----------PEHR--SaeeqPLRMAPHYDLSM--VTL-IQQTPc----ANGFvSL--Q- 205 Streptomyces clavulig...
P0A3X2  79 IFPPLFNRYeggeaF--GYH----------VDNAlrP-------VPGTAERVRtdLSAtLFFSE-----PDSY------- 127 Bordetella pertussis ...
Q9HVQ7  79 VFPPLFNCYtgggsF--DFH----------IDNAvrD-------VHGGRERVRtdLSStLFFSD-----------P--Ed 126 Pseudomonas aeruginos...
Q9R1J8 564 IEESQAERKdsshpVhvDNCilnaeslvciKEPP----------AYTFRDYSA--ILY-LNGDF-----DGGN-FY---- 620 Norway rat
P74376 239 YVEAQLTAHnhgnyY--KVH----------NDNG--Sp---DSA---TRELTY--VYY-FNREPka-fsGGEL-AI--Y- 290 Synechocystis sp. PCC...
P22039 190 EIELQLTAHndgcyY--RIH----------NDAG--S----EKT--ASRQITY--VYY-FYQEPka--fSGGElRL--Y- 241 Synechocystis sp. PCC...
Q09973 138 QVDCNGSCYartdsLl--------------PHND----------LIETRRFAF--VYY-ITSADwdsevNGGDlQL--F- 187 Caenorhabditis elegans
Q17985 168 TEQISALSYikgghY--ALH----------TDFL----------TFANAEDSN--RHFgEMGNR-----LATFiMV--F- 215 Caenorhabditis elegans
Q8VZJ7 165 GESFNILRYelgqkY--DSH----------YDVF--N----PTEYGPQSSQRI--ASFlLYLSDv---eEGGE-TMfpFe 220 thale cress
Q3ED68 241 SHHGYIVEY-----G---------------KDRD--V----DLGFHVDDSEVS--LNV-CLGKQf----SGGE-LY--F- 283 thale cress
1HJG_A 206 -AEv-gGA---FTDLPY--RP-DAVLV----FCGAIATLVTGG----QVKAPRHHVAa-PRR-----DQiagssQTSSVF 263 Streptomyces clavulig...
P0A3X2 128 -DG---GElvvDDTYGP-----RTVKL----PAGHM--VLYPG-------TSLHKVTp-VTR-----GA-----RISAFF 174 Bordetella pertussis ...
Q9HVQ7 127 yDG---GElviQDTYG----------LqqvkLPAGDLVLYPGT--------SLHKVNp-VTR-----GA-----RYASFF 174 Pseudomonas aeruginos...
Q9R1J8 621 -----------FTELDAktVT-AEVQP----QCGRAVGFSSGT-------ENPHGVKa-VTR-----GQ-----RCAIAL 666 Norway rat
P74376 291 -DSk-iENn--FYVAAE--SF-KTVQP----VNNSIVFF---L------SRYMHEVLp-VNCpsqafADs----RFTING 345 Synechocystis sp. PCC...
P22039 242 -DTe-lKNn--TITTHP--KF--QTIT----PINNSIIFFNSR--------CRHEVMsvVCP-----SRefahsRFTVNG 296 Synechocystis sp. PCC...
Q09973 188 -NH---DKk--LQPTSV-----AAQFS----PLRNSFMLFEVS------EKSWHRVAemLSE-----EP-----RLSING 236 Caenorhabditis elegans
Q17985 216 -KKaekGG---GTLFPQ--LG-NVFRA----NPGDAFLWFNCNgnleREAKSLHGGCp-IRA-----GE-----KIIATI 273 Caenorhabditis elegans
Q8VZJ7 221 nGSn-mGIg--YDYKQC--IG-LKVKP----RKGDGL----------LFYSVFPNGTidQTSlhgscpvtkgekwvatkw 280 thale cress
Q3ED68 284 -RGv-rCDk--HVNSDS--TEkEVYDY----SHVPGHAILHRG----RHR---HGAR--ATT-----SGh----RANLIL 335 thale cress
1HJG_A 264 FLRP 267 Streptomyces clavuligerus
P0A3X2 175 WLQS 178 Bordetella pertussis Tohama I
Q9HVQ7 175 WTQS 178 Pseudomonas aeruginosa PAO1
Q9R1J8 667 WFTL 670 Norway rat
P74376 346 WVRK 349 Synechocystis sp. PCC 6803
P22039 297 WIRK 300 Synechocystis sp. PCC 6803 substr. Kazusa
Q09973 237 WFHS 240 Caenorhabditis elegans
Q17985 274 WIRI 277 Caenorhabditis elegans
Q8VZJ7 281 irdq 284 thale cress
Q3ED68 336 WCRS 339 thale cress
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