1U7F,5C4V,5C4V,3GMJ,7CD1,4R9P


Conserved Protein Domain Family
MH2

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pfam03166: MH2 (This model is not part of the current CDD release)
MH2 domain
This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2.
Statistics
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PSSM-Id: 515424
Aligned: 73 rows
Threshold Bit Score: 93.5199
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1U7F_B          8 EYWCSIAYFEMDVQVGETFKVPS-ScPIVTVDGYVDPSGGdRFCLGQLSN-V-HRTE-AIERARLHIGKGVQLECKGEGD 83  human
XP_008195997  130 PVWATIYYYEKGSRIGDAFPCQGlSaWVHCLQGGPQRND--RFNLFEKEN-A-GREW-TVKNTRQQIGRGITLHYV-KGQ 203
XP_045095713   49 EIWGKIVIMERCKRVAKAYLRKT----TVIIDGSEDEFDGkTLGFNHFDN-PtRDDHtK--EIRAKIADGVILKMDYQGN 121
16_pfamImport   1 DIWAKVIFMERNRRVAKAYVRAQ----VITFNGSERGFDGhLVGLKGFAN-SkRDERtA--KVLEDLGEGIKMKIDESGD 73 
17_pfamImport   1 EIWAKVICMEKNRRVAKAYARLP----FLIVDGSDIGFDGiRVGLKGFEN-IdRPEKtK--EILETFGEGVKIKMDGKGN 73 
XP_015782979   53 EIWGKIICMERNRRIAKAYARVP----VLTVSGSDDGFDGfKIGLNGFDRaPsRDPLvK--RVRDHIGEGVRIKMDEFGN 126
XP_002066231   51 EIWAKIIVFEKNRRVAKAYARSS----VITINGSKHGFDGvRIGLNGFEN-PmRDSEtK--VIKKSIGDGFKIKMDDIGN 123
Q7QJC4         16 EIWAKVIVFERNRRVAKAYARAP----VLTINGSDDGFDGmRIGLCGFDN-PmRDHKtE--EVKRHVGQGVKIKMDDAGN 88  Anopheles gamb...
15_pfamImport   1 EIWAKVIVFERNRRVAKAYARAP----CLTINGANDGFDGmRIGLCGFDN-PmRDTQtD--EVKKRIDQGAKIKMDDYGN 73 
4R9P_A         57 EIWAKVIVFERNRRVAKAYARA----PVLTINGSDDGFDGmRIGLCGFDN-P-MRDQ-KTDEMKRVIGQGVKIKMDDAGN 129 fruit fly
1U7F_B         84 VWVRCLSDHAVFVQSY-YLDREAGRAPgDAVHKIYP-S-------A-----YIKVFDLRQCHRQMQQqaataqaaaaaqa 149 human
XP_008195997  204 IYVQLWSDSDLYVNSR-FYNRLKNYPG-GTICKLSPfR-------Cr----HMKLFRDDEFHEMLSA------------- 257
XP_045095713  122 IKGMARGAAPIVCQGwkepr---nncisDRVVRLHGkLnhgvtedEk----AYKVFDMRKFKHALERelhdgtpd----- 189
16_pfamImport  74 ILIKRLTRSNVKVSGstpdy----nclgSELIESNGrl-----emDr----AMTLFQMKKLISTIGSeirstypn----- 135
17_pfamImport  74 ILIKRVGKAAVYVKSfvgssdglgscigKDIIESKGkl-----eyKk----VSTLFDIRSFQAGISAelkatypq----- 139
XP_015782979  127 IIIKRLSHCDVFIRGydrea----nsisKGILDLDGel-----tlEk----SVKLFDMKKFQSGLNKelrsaypd----- 188
XP_002066231  124 IFIKRYGKSNIFVNStsqgne--etvigADIMQMPQmSlt---saGi----TAKLFDMKKFQTNINRefarnype----- 189
Q7QJC4         89 ILIRRYSKSNVYVKStanqpn-eetaigADILKLPGqai----esEk----IVKLFDMKKFQSNVNRelrraypd----- 154 Anopheles gamb...
15_pfamImport  74 IFIKRYANSNVFVKStalnpq-densigTDILKLQNqal----ekGe----TYKLFDMRKFHHNMNAefrrsypd----- 139
4R9P_A        130 ILIRRYAKSNVYVKSTaSSPNEETSIG-AEILKLPN-Q-------AlesekIVKLFDMKKFQSNVNRelrr--------- 191 fruit fly
1U7F_B        150 aavagnipgpgsvggiapaislSAAagiG-VDDLRRLCILRMSFVKGWGPDYP-RQSIKETPCWIEIHLH 217 human
XP_008195997  258 ----------------------EVAkgwEaVYSLAKVCTVRISFVEGWGNEV---GGITEKPCWLEVRFL 302
XP_045095713  190 ---------------arslllkT---------------CMRIALVKV-----GdGADMNRTPCWFAIVNL 224
16_pfamImport 136 ---------------qrrlenqC---------------ITCISVDIE-------SDNLLETPCWMMVINI 168
17_pfamImport 140 ---------------tqklesqC---------------ITAIAFGKE-----SgTLDLLETPSWIMIINI 174
XP_015782979  189 ---------------rrrlenqC---------------INVIAFVKD-------ATDVLDLPVWIMVVNI 221
XP_002066231  190 ---------------rgrlerqC---------------LSAVSLVKS-------NNNLINTPVWILVVNV 222
Q7QJC4        155 ---------------rrrletqC---------------LSAIAFVKS-------ENDILDCPMWVLIINV 187 Anopheles gambiae str. PEST
15_pfamImport 140 ---------------rqrletqC---------------LSALVFVKQ-------ENDILDCPVWILVINV 172
4R9P_A        192 -------------------------aypD-RRRLETQCLSAVAFVK------S-ENDILECPIWVLIVNV 228 fruit fly
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