5FIR


Conserved Protein Domain Family
XRN_N

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pfam03159: XRN_N 
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XRN 5'-3' exonuclease N-terminus
This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalyzing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus.
Statistics
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PSSM-Id: 397325
Aligned: 136 rows
Threshold Bit Score: 124.183
Threshold Setting Gi: 328871882
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5FIR_C                           2 GVPAFFRWLTKKYpatvvnaNEdrqrdqdgNRVpvdctqpnPNFQ-EFDNLYLDXNGIIHPCThpe-------------- 66   Caenorhabditis elegans...
XP_001610853                     1 ----mFYWLLDNFgsfksgl-------------------ekvierrPVDHLYMDMNAVIHVAThgni------------- 44   Babesia bovis T2Bo...
Q4UI27                          79 GVPRLYGWMMENFsrvriplD-----------D--------SEISkGVDYFYVDMNAVIHSAThgni------------- 126  Theileria annulata...
EFC46364                         2 GVPFLFSFLLSECpemikeiIPs-------SSAss-----sSNTTmTIDHLYLDMNGIIHTFKdtnlqtkllerlvssss 69   Naegleria gruberi...
Q555U6                           2 TVPGLSGFINSKF-------QG--------TCIke-----rGNGKiKVDHLFVDVNNLLYRKYky--------------- 46   Dictyostelium discoideum AX4...
EGC39673                         2 GVEGLQVFIKKRYnlykp-----------------------lpnnfHTDHIYIDVNNYLHKTItkk-------------- 44   Dictyostelium purpureum...
XP_004029912                     2 GVPGYFGWICRRYpfcirkiY-----------Q--------SGKKkYVDCLYIDVNSFCYQYIkddln------------ 50   Ichthyophthirius multifiliis...
WGS:AAGF:cds.TTHERM_00663830A    2 GVPGYFSWIHRKYpyqvrkvR-----------R--------NGRKkHIDCLYIDVNGICYQYArdehq------------ 50   Tetrahymena thermophila SB210...
A0CLH9                           2 GVPNFYSWLSKRYpmckypfT-----------K---------HHGhQIDFLYLDMNQVIYKCAtnqti------------ 49   Paramecium tetraurelia...
A0CZ91                           2 GVPNFYSWLMRRFplcl------------yehT----------RAqRVDYFYLDMNQIIYKCAtdptvl----------- 48   Paramecium tetraurelia...
5FIR_C                          67 -----------drpAPKNEDEXFALIFEYIDRIYSIVRPRRLLYXAIDGVAPRAKXNQQRSRRFRASKEXAEK------- 128  Caenorhabditis elegans...
XP_001610853                    45 -----------spvVQMANEQRLRRITSAIEMMFDIVRPRKMLYMAVDGVCPTAKINQQRGRRFLTSKNVDPLadicsav 113  Babesia bovis T2Bo...
Q4UI27                         127 -----------fpiLMMEDQQRMRRIVAALLNTFNLVKPKKMMYIGVDGVCPSAKINQQRTRRFRLYKSSNSDneyykve 195  Theileria annulata...
EFC46364                        70 ssssssssnneeveIPMTMEKFIFSILLYLEEVIYRFRPSKTLMFALDGSAPCAKINQQRERRWVSFNNHSGLpkrhhhh 149  Naegleria gruberi...
Q555U6                          47 -------------sKTKPDRTLFDIVNLQIYSLFDKVDVEKSIFFAVDGPGPISKFSEQKDRRFKNDALPNFLhklntkk 113  Dictyostelium discoideum AX4...
EGC39673                        45 ------------pnIQNVEINALKRLKHFLNEIIYSTKIRHTIFFSVDGPGPRSKMTTQRERRLKNLNLHKLLyyinknr 112  Dictyostelium purpureum...
XP_004029912                    51 ----------qyllNPQSLDQIYQNILTHIESIIQLIEPQSQVYLMMDGTCPRAKMNQQRQRRFHAQKNLNQT------- 113  Ichthyophthirius multifiliis...
WGS:AAGF:cds.TTHERM_00663830A   51 ---------ynyllKPKSLETIFKQVIDHIDSIIELVEPQLQVYLMLDGPCPRAKMNQQRQRRFHAEMHHLTL------- 114  Tetrahymena thermophila SB210...
A0CLH9                          50 ---------lkdymIEKSIESLWTSILNYIDTIINLVDPQLVIYLTFDGVAPRAKANQQRQRRFASSKGDAKIkqllkql 120  Paramecium tetraurelia...
A0CZ91                          49 ---------fkdqlRERDFDDIWVSILNYLDMIINLVNPQQLLFLAFDGVAPRAKMNQQRQRRFQSQKRYKYLsahlqqi 119  Paramecium tetraurelia...
5FIR_C                         129 --EA-----S-IEEQRNRLXAEGIAVPpkkKEEAHFDSNCITPGTPFXARLADALRYYIHD---RVTnda---------- 187  Caenorhabditis elegans...
XP_001610853                   114 saEDgytyiAkRLPFDEYDNVS-------------FNPNYISPGTDFMKIVDSEISNWLAL---KTEegf---------- 167  Babesia bovis T2Bo...
Q4UI27                         196 dgKMkykvnKlKIGAYDNVS---------------FNPSYISPGTQFMSMMDSEIRNWIALqnyEGTw------------ 248  Theileria annulata...
EFC46364                       150 hqHGnhhgeQhDLHHGEENRKKKED-------ESLFDSISITSGTSFMKELSEHLQFFIKR---KLQddp---------- 209  Naegleria gruberi...
Q555U6                         114 lnLQegdenKsDLQLVEDSWFDQSSI----VEDKCYTSDSFTSGTDTMGYVKAILYSITKNfkwKGYf------------ 177  Dictyostelium discoideum AX4...
EGC39673                       113 deETgendiNlLKHDYDYLEGLEL--------NVGFSTLNFTPGTSFMGLLKSFFIYYTKN---KLSf------------ 169  Dictyostelium purpureum...
XP_004029912                   114 --KE------------------DFKNQgiqIKEQTVPSNSVSPGTPFMFELNKRIREHFEK---KIQeeqplne------ 164  Ichthyophthirius multifiliis...
WGS:AAGF:cds.TTHERM_00663830A  115 --KD------------------ELKKHgfdVKEETVPNNSIAPGTPFMYELNEQLRRYIET---RIalsnkamtdgeadh 171  Tetrahymena thermophila SB210...
A0CLH9                         121 dlEQqn---------------------------htFKNNQITAGTEFMYELNEQVKFFINR---KFKede---------- 160  Paramecium tetraurelia...
A0CZ91                         120 glFQkn---------------------------etYKNNQFSPGTEFMTQLNQQIKFYIER---KYSedp---------- 159  Paramecium tetraurelia...
5FIR_C                         188 -----swAN-IEIILSDANVPGEGEHKIXDYVRKQRgnPAHDPNTV---HCLCGADADLIXLGIATHEANFNI 251  Cae...
XP_001610853                   168 -----fgK--CMVTYNGVTVPGEGEHKIFQCIRKMN---KVCKRSRkdvHLVYGLDADLMMLSMAVKMPNIKV 230  Bab...
Q4UI27                         249 --------NdCYIVYNGTDVPGEGEHKIYDTIRKML---ELDPDVRnstHLVYGLDADLVMLSLITKLPKMYI 310  The...
EFC46364                       210 -----nwRNiENIIFSDSSVFGEGEHKIMSHIRKVQ----QIPNRKsekFMIYGMDSDLILLSLVTHEEDIYV 273  Nae...
Q555U6                         178 -------EDlENVYISPHDRYGEGEWKIFEMINSDN----IKPREP---ILIYSSDSDVILFSILAKNKSINI 236  Dic...
EGC39673                       170 ------aK---NVFISAADRMGEGEWKIFQHINNSN----YNLNDI---ITIASNDSDMILFCLLSKYNNIQI 226  Dic...
XP_004029912                   165 -ktdftyKR-LHIIISDSNCQGEGEHKILEVIRKHK-----NFKLT---HCIVSPDADLILLSLSAIGRKILI 227  Ich...
WGS:AAGF:cds.TTHERM_00663830A  172 kehqvsyKK-LQFILSDSNAPGEGEHKILEVIRKHT-----NLQLT---HCIVGADADLLLLSLATIGKRILI 235  Tet...
A0CLH9                         161 -----kyAN-LQVIFSGSDVPGEGEHKILEFMRGIKnqQNFNPDWT---HCIYSADADLIMLGLGIHLKYVSI 224  Par...
A0CZ91                         160 -----kfKN-LKIIFSGCDVPGEGEHKLLSFIRNLQ----CDPNSV---HMIYGADADLIMLGLLTQLKNVLI 219  Par...
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