8Q6V,3PIE,5FIR


Conserved Protein Domain Family
XRN_N

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pfam03159: XRN_N (This model is not part of the current CDD release)
XRN 5'-3' exonuclease N-terminus
This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus.
Statistics
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PSSM-Id: 515419
Aligned: 128 rows
Threshold Bit Score: 127.273
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8Q6V_B          1 MGVPSFFRWLSRKYpkiispvLE-EQP---QIvdgvilpldysasnpNg-ELDNLYLDMNGIVHPCShpe---------- 65   brewer's yeast
XP_004029912    1 MGVPGYFGWICRRYpfcirkiY----Q---SG---------------KkkYVDCLYIDVNSFCYQYIkddln-------- 50  
XP_001020149    1 MGVPGYFSWIHRKYpyqvrkvR----R---NG---------------RkkHIDCLYIDVNGICYQYArdehq-------- 50  
XP_004036545    1 MGVPGFYSWLSRRYplivnqlN----S---KL---------------DvpYIDCFYLDMNGLIYKCTkeedtv------- 51  
XP_001027386    1 MGVPGFYSWLARRYplilhqiK----K----G---------------EvpNIDCFYLDMNGIIYKCSkdegtv------- 50  
A0CLH9          1 MGVPNFYSWLSKRYpmckypfT----K----H---------------HghQIDFLYLDMNQVIYKCAtnqti-------- 49   Paramecium te...
A0CZ91          1 MGVPNFYSWLMRRFplcl-----yehT--------------------RaqRVDYFYLDMNQIIYKCAtdptvl------- 48   Paramecium te...
XP_002679108    1 MGVPFLFSFLLSECpemikeiIPsSSAsssSN---------------TtmTIDHLYLDMNGIIHTFKdtnlqtkllerlv 65  
Q555U6          1 MTVPGLSGFINSKF-------QG-TCIkerGN---------------GkiKVDHLFVDVNNLLYRKYky----------- 46   Dictyostelium...
XP_003283782    1 MGVEGLQVFIKKRYnlykp--------------------------lpnnfHTDHIYIDVNNYLHKTItkk---------- 44  
8Q6V_B         66 ---------------nkpPPETEDEMLLAVFEYTNRVLNMARPRKVLVMAVDGVAPRAKMNQQRARRFRSARDAQIE--- 127  brewer's yeast
XP_004029912   51 --------------qyllNPQSLDQIYQNILTHIESIIQLIEPQSQVYLMMDGTCPRAKMNQQRQRRFHAQKNLNQT--- 113 
XP_001020149   51 -------------ynyllKPKSLETIFKQVIDHIDSIIELVEPQLQVYLMLDGPCPRAKMNQQRQRRFHAEMHHLTL--- 114 
XP_004036545   52 -------------fkdllLQKNMQEIFTLIFNYIDEMVNLVQPKKVLYLFLDGPAPRAKQNQQRTRRFLSAKSHKDLnns 118 
XP_001027386   51 -------------fkdllLQRNIQEIFSMIFNYIDEMVNLVEPKKVLYLFLDGPCPRAKQNQQRTRRFQSAQSWKDLnds 117 
A0CLH9         50 -------------lkdymIEKSIESLWTSILNYIDTIINLVDPQLVIYLTFDGVAPRAKANQQRQRRFASSKGDAKIkql 116  Paramecium te...
A0CZ91         49 -------------fkdqlRERDFDDIWVSILNYLDMIINLVNPQQLLFLAFDGVAPRAKMNQQRQRRFQSQKRYKYLsah 115  Paramecium te...
XP_002679108   66 ssssssssssssnneeveIPMTMEKFIFSILLYLEEVIYRFRPSKTLMFALDGSAPCAKINQQRERRWVSFNNHSGLpkr 145 
Q555U6         47 -----------------sKTKPDRTLFDIVNLQIYSLFDKVDVEKSIFFAVDGPGPISKFSEQKDRRFKNDALPNFLhkl 109  Dictyostelium...
XP_003283782   45 ----------------pnIQNVEINALKRLKHFLNEIIYSTKIRHTIFFSVDGPGPRSKMTTQRERRLKNLNLHKLLyyi 108 
8Q6V_B        128 ------NE-----A-REEIMRQREE-VGEII---DDavrnKKTWDSNAITPGTPFMDKLAAALRYWTAF---KLAtdp-- 186  brewer's yeast
XP_004029912  114 ------KE------------------DFKNQgiqIK----EQTVPSNSVSPGTPFMFELNKRIREHFEK---KIQeeqpl 162 
XP_001020149  115 ------KD------------------ELKKHgfdVK----EETVPNNSIAPGTPFMYELNEQLRRYIET---RIalsnka 163 
XP_004036545  119 lkncgiLAen-------------------------------qtMQNNAISTGTTFMHELNQQIQFYIKN---KFKqdp-- 162 
XP_001027386  118 lrncgfLSeg-------------------------------etMKNNSISTGTEFMHDLNKQLHFYICK---KFEqdp-- 161 
A0CLH9        117 lkqldlEQqn-------------------------------htFKNNQITAGTEFMYELNEQVKFFINR---KFKede-- 160  Paramecium te...
A0CZ91        116 lqqiglFQkn-------------------------------etYKNNQFSPGTEFMTQLNQQIKFYIER---KYSedp-- 159  Paramecium te...
XP_002679108  146 hhhhhqHGnhhgeQhDLHHGEENRKkKED-----------ESLFDSISITSGTSFMKELSEHLQFFIKR---KLQddp-- 209 
Q555U6        110 ntkklnLQegdenKsDLQLVEDSWFdQSSI----VE----DKCYTSDSFTSGTDTMGYVKAILYSITKNfkwKGYf---- 177  Dictyostelium...
XP_003283782  109 nknrdeETgendiNlLKHDYDYLEGlEL------------NVGFSTLNFTPGTSFMGLLKSFFIYYTKN---KLSf---- 169 
8Q6V_B        187 -------------gwKN-LQVIISDATVPGEGEHKIMNFIRSQRadPEYNPNTT---HCIYGLDADLIFLGLATHEPHFK 249  brewer's yeast
XP_004029912  163 ne-------ktdftyKR-LHIIISDSNCQGEGEHKILEVIRKHK-----NFKLT---HCIVSPDADLILLSLSAIGRKIL 226 
XP_001020149  164 mtdgeadhkehqvsyKK-LQFILSDSNAPGEGEHKILEVIRKHT-----NLQLT---HCIVGADADLLLLSLATIGKRIL 234 
XP_004036545  163 -------------qwKN-LEVFFSGSNVPGEGEHKIINFMHQYCssDNYDPSTT---HCIYGVDADLIMLGLSTHIKYVS 225 
XP_001027386  162 -------------rwSN-LEVFFSGSNVPGEGEHKIINFMHQYCssQDYDPTTT---HCIYGADADLIMLGLSTHIKYVS 224 
A0CLH9        161 -------------kyAN-LQVIFSGSDVPGEGEHKILEFMRGIKnqQNFNPDWT---HCIYSADADLIMLGLGIHLKYVS 223  Paramecium te...
A0CZ91        160 -------------kfKN-LKIIFSGCDVPGEGEHKLLSFIRNLQ----CDPNSV---HMIYGADADLIMLGLLTQLKNVL 218  Paramecium te...
XP_002679108  210 -------------nwRNiENIIFSDSSVFGEGEHKIMSHIRKVQ----QIPNRKsekFMIYGMDSDLILLSLVTHEEDIY 272 
Q555U6        178 ---------------EDlENVYISPHDRYGEGEWKIFEMINSDN----IKPREP---ILIYSSDSDVILFSILAKNKSIN 235  Dictyostelium...
XP_003283782  170 --------------aK---NVFISAADRMGEGEWKIFQHINNSN----YNLNDI---ITIASNDSDMILFCLLSKYNNIQ 225 
8Q6V_B        250 I 250  brewer's yeast
XP_004029912  227 I 227 
XP_001020149  235 I 235 
XP_004036545  226 I 226 
XP_001027386  225 I 225 
A0CLH9        224 I 224  Paramecium tetraurelia
A0CZ91        219 I 219  Paramecium tetraurelia
XP_002679108  273 V 273 
Q555U6        236 I 236  Dictyostelium discoideum AX4
XP_003283782  226 I 226 
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