6SNH


Conserved Protein Domain Family
Alg6_Alg8

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pfam03155: Alg6_Alg8 (This model is not part of the current CDD release)
ALG6, ALG8 glycosyltransferase family
N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic.
Statistics
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PSSM-Id: 515418
Aligned: 194 rows
Threshold Bit Score: 283.601
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SNH_X        82 PPLYGDFEAQRHWMEITQHLPLSKW----YWYDLQYWGLDYPPLTAFHSYLLGLIG-SFfNPSWFALeKSRGFESPDngL 156 brewer's yeast
XP_002186451  51 SAYGGDFEAQRHWMELTLHLPVGEWyw----yDLSYWGLDYPPISAYVSWICGWLShRLvGPESVALeTSRGFENPT--H 124
EDS42995      35 RPMFGDFEAQRHWQEVTVNLPIADWyrntTDNDLLYWGLDYPPLTAYHSFLVGKWA-QLqDPKFVELhKSRGITNQG--H 111
XP_042934744  38 PPMYGDYEAQRHWMEITYHLPINQWyvngSDNDLNYWGLDYPPLTAYHSWLLGTLA-NKlNRSWIELhISRGMETET--H 114
Q09226        74 PPMYGDYEAQRHWMEITVNLPIEQWylngTHNDLLYWGLDYPPITAYHHYLLGVIS-NKiNKKWVELtTSRGYESIA--H 150 Caenorhabditis ...
XP_002629983  55 PPMYGDYEAQRHWMEITFNLPIEHWyvngSHNDLLYWGLDYPPLTAYHHNLLGVIT-YKiNKRWVELrDSRGFESVA--H 131
EFO86291      74 PPMFGDYEAQRHWMEITLNLPIEQWyvngTLNDLLYWGLDYPPLTAYHHNLLGLIA-YKiNKSWVELtDSRGFESVA--H 150
XP_018649914  37 PPMYGDYEAQRHWMEITVNLPFTEWymnsTHNDLNYWGLDYPPLTAYHSWLMGKLA-SKiDRDWVQLyTSRGFESKE--H 113
XP_001022240 181 APTYGDYEAQRHWMELTLHTPPSQWyvetLNNDLTYWRIDYPPLSAYVSYIFGYIShQF-DPKSVELyHSRGYEEPN--H 257
A0DD77        28 PPQYGDFEAQRHWMELTSHLNITQWyeksEFNDPKWWPLDYPPLSGYFAYALGKVAeKF-DPEIIAPySSRGIETFN--T 104 Paramecium tetr...
6SNH_X       157 KTYMRSTVIISDILFYFPaViyftKWLgR------YRNQSp---iGQSIAASAILFQPSLMLIDHGHFQYNSVMLGLTAY 227 brewer's yeast
XP_002186451 125 KAFMRSTVIVLDLLVYGTaVwf-wTMH-R-------QYDRnlpdsTRLWRFALAMSQPAILLIDHGHFQYNTTALGLSLW 195
EDS42995     112 KRFMRNTVLLADLLIYIPaVllacHAV-Rkti-hrESATG-----VDLLFMATAILYPGQLLVDNGHFQYNNISLGLAAA 184
XP_042934744 115 KIFMRFTVVATFWIVYVSsLllstGFF-R------NTLSQ-----RMLNYCAIAVLYPGLLVVDSGHFQYNHVSLGLFLF 182
Q09226       151 KLFMRLSAIIPFYIFYLPpLif-yFT------------RSk---kMSPILYALALLYPSLLVIDNGHFQYNSISLGLFLA 214 Caenorhabditis ...
XP_002629983 132 KIFMRVSAIVPFYIFYLPpLiy-aLM------------SSk---kTSPVLYPLSLLYPALLVIDNGHFQYNSVSLGLFLF 195
EFO86291     151 KMFMRISAIVPFYIFYLPpLif-fYL------------NSk---kTSPMSYALALLYPALLVIDNGHFQYNSISLGMFLA 214
XP_018649914 114 KLFMRYTVLVADLLFFIPsIllyfYYV-LpsimnkGNKSQq---iGGFYSACLTLTYPGLILIDHGHFQYNCISLGLYLS 189
XP_001022240 258 KIYMRMTVLISDILFFFTsLyyvtKIE-Fn-----KYSFT-----LRSLFYLLALLCPPFILIDHAHFQYNSFMHGLVLW 326
A0DD77       105 KLFMRLSVFISEIIFLYPpLiy-fI-------------LK-----QQSKQQLIALCCPLLVLVDHGHFQYNCIMLGLTLY 165 Paramecium tetr...
6SNH_X       228 AINNLLDEYYA------M-AAVCFVLSICFKQMALYYAPIFFAYLLSRS-L---Lf-----------PkfnIAR------ 279 brewer's yeast
XP_002186451 196 AFYFMT----LpdffycMiGSFMFCAALSFKQMTLYYAPAVFFYLLGRCfTtrg--------------rflVQR------ 251
EDS42995     185 AIAAILRNRNLl-------GAFFFVLALNYKQMELYHALPFFFYLLASC-FkstKgf---------sLgsgLWK------ 241
XP_042934744 183 SFACFVSSFLKl-------GSMFFVLSLSFKQMELYHALPVAIYLLSES-Fs-sDn-----------RlsmSQRyfcwae 242
Q09226       215 TYMFLTKNFTIi-------GSILFVAALNYKQMELYHALPVFVFILARS-InktQ------------LfnsFRR------ 268 Caenorhabditis ...
XP_002629983 196 AYIFLIQNWTLl-------GSMFFVAALNYKQMELYHALPVFVFILSRS-InqsQ------------PlgtILK------ 249
EFO86291     215 TYVFLTNNFTIl-------GSMFFVAALNYKQMELYHALPIFVFILARS-InkaQ------------PlnsVFK------ 268
XP_018649914 190 GINFLLLEWDMl-------GSILFCLAIGYKQMELYHALPIFFYLLGRCiYkk-------------sVyrgLTH------ 243
XP_001022240 327 SVYFCSQGSVVi-------GGILFTLALNFKQMGLYYSLGFFFYILGYLaVdsgFrsiktnkynfgaSlffILR------ 393
A0DD77       166 AIISLEKGKLVl-------GSIFYVMALHFKVMSLYYSLPFFIYILSKTyk-------------------ePKK------ 213 Paramecium tetr...
6SNH_X       280 -LTVIAFATLATFAIIFAPLyflg----gglkNIHQCIHRIFPFARGIFEDKVANFWCVTNVF-VKYKE-------RFTI 346 brewer's yeast
XP_002186451 252 -FYLLGMTVVATTFALWWPFvafgpegtshieRAAHVFRRIIPLQRGLFEGKVSNLWCVLSLKpIRIRK-------LIPS 323
EDS42995     242 -LIKLGALVVATFAVLWSPWlgs-------vdSALQVLHRVFPVARGVFEDKVSNVWCIVNVF-VKLRN--------FDN 304
XP_042934744 243 qLLILFITVIVTILFVCFPFlit-------rsDLMQILYRIFPFYRGIFEDKVANFWCSINVF-YKLKD-------NFET 307
Q09226       269 -ILTIGLFVVGTFLIIWLPFll--------tgTAKDVIIRVFPFNRGLYEDKVASFWCAFSFI-LKRLP---------LQ 329 Caenorhabditis ...
XP_002629983 250 -LAKIGVMVLSTFLIIWLPFil--------teTAKDVLIRVFPFNRGLYEDKVASFWCAFSFV-LKRLP--------IVQ 311
EFO86291     269 -IAKIGAVVISTFILIWLPFil--------tgTAKDVLLRVFPFNRGLYEDKVASFWCAFSFI-LKRLP---------FQ 329
XP_018649914 244 -LAKLSFVVFLTIFLIFAPFvltt-----dlsLLFQVVRRLFPFDRGIYEDKVSNFWCATSPL-VKWRSplfmsslTLSS 316
XP_001022240 394 -IALVGFGVIATFVLMILPWitd-------kyLLTSLVSAIFPVHRGLYQLKVANFWCFSNIF-IKWTQ-------IFDQ 457
A0DD77       214 -VAVVGITVILTTLIIWLPWlsd-------lkLIQEAIATIFPIHRGLYQLHVATFWCISHIV-IKWNL-------VFNN 277 Paramecium tetr...
6SNH_X       347 QQLQLYSLIATVIGFLPAMIMTLL--------H--PKKH--LLPYVLIACSMSFFLFSFQVHEKTILIPLLPITLLYS-S 413 brewer's yeast
XP_002186451 324 QLQPLAALLLTLIFAAPACYRLFRlgqkqqqdN--EQHQgkLILYGATSSALAFFLASFQVHEKSLLLALGPASLLFF-D 400
EDS42995     305 AHMAIVCLTCTLFAVLPSCVHLLF--------HstS-KR--NFLLALANSALGFFLFSFQVHEKSILLAALPITLLFP-L 372
XP_042934744 308 VFLLRISTIMVLITNIPWSVCLFC--------H--PTMT--NFKYCLLASSLSFFLFSFQVHEKSILLVALPAILLWN-E 374
Q09226       330 SVQIYISTALVLAGSAPSLLVLFL--------R--PTEK--QFRISLTATGLSFFLFSFHVHEKTILLAAVPALLLIS-E 396 Caenorhabditis ...
XP_002629983 312 NVQIYLSTALVMICSLPSLVSLFL--------Q--PSER--NFRLSLTTTALSFFLFSFHVHEKTILLATIPALLLLP-E 378
EFO86291     330 SVQIYLSTALVLLCSLPSLISLFR--------Q--PSER--NFRLSLVTTSLSFFLFSFHVHEKTILLATIPSLLLIS-D 396
XP_018649914 317 TKLVWVSAQLVLITCLPSCLVLLK--------K--SKKQ--KFLVSLALCALNFYLFSFQVHEKSILLVSIPALCLLP-F 383
XP_001022240 458 KVIILMSIAFTLVACLPSIYVVFL--------R--PKYK--YLKLALFNISMSFFFFSYHVHEKTILIPLVLYVLCIR-Y 524
A0DD77       278 QLLFRLAAILTLLFSIPSLIRLFK--------Q--PN----LFRHTLFIVSQTFFLFSFHVHEKTILLPII-LLLISQkD 342 Paramecium tetr...
6SNH_X       414 tDWnVLSLVSWINNVALFTLWPLLKKDGLHLQYAVSFLLSNWLIG--------NFSFitpRFLPKSltPgps-------- 477 brewer's yeast
XP_002186451 401 -DA---TFVQWFSVIAAWTLWPLLVVDRLQVAYTCIMIIFIMLQRl-------------lHSLQQGstAstsgfle---- 459
EDS42995     373 -YP---AQCFWFLQIATFSMVPLLAKDGLVGPYLGLTVLTLAFLKislgfltnFTLK---PSFCTLdaFgveslfkgkra 445
XP_042934744 375 -NP---VLVSWLLIISNTSLYPLCIKDGNAI-HLALFIFYYIITYs--------------SFSKLSmfMq---------- 425
Q09226       397 -YT---SLVIWFLNITNISIFSLCVKDNFALS-LSFFFAYFVVSYayta------------------------------- 440 Caenorhabditis ...
XP_002629983 379 -YP---SLVILFLNISNISIFSLCIKDNFPFA-LVFFFAYFVVSYsvsvynreAKP------------------------ 429
EFO86291     397 -YP---SSVLWLLNISNISIFSLCVKDNFPLS-VFLFIGYFLVSYstfpssspLKRL----------------------- 448
XP_018649914 384 -YP---ISSFLFSLCSTLSMWPLLKKDGLQLASLCLTCIHTILGCfiilksnnGDKH---VAERKKlqNsatsn------ 450
XP_001022240 525 -MN-IYYL--DFVTISCLTLYPLLREDKQTLCWFVLTIVHHFFVRk-------------tLKYLEIqgVikknltdqctl 587
A0DD77       343 -YG---YLVYDYTIIATITHHPLMIEDKLFIEYCVLLVLFFIFTRnnqppqfqDSWI---LRFYSKirNvii-------- 407 Paramecium tetr...
6SNH_X       478 -----------------issINSDYRrrsllpy------nvvwksFIIGTYIaMGFYHFLDQFVaPpSKYPDLWVLLNCA 534 brewer's yeast
XP_002186451 460 --------------------------------------hlpllrwVPHFSGLvMLLLHFTELGVtIpPHLPDVFSVLWSI 501
EDS42995     446 ----------------------------------ipsrwdislvhLYYASLVaQAMLLLAFQYVpPpPQLPFLWPLLISA 491
XP_042934744 426 --------------------------------------------lVVHGSCLaSLALCLASLLFaPpARFPHIFSLLIAV 461
Q09226       441 -----------------------------------------prkiSHILTILiGFAICILELYGpSnQRFPHIYQLANAF 479 Caenorhabditis ...
XP_002629983 430 ---------------------------------------------LHILSISiGFLICILEMYGpAnQRFPHIYQLANAF 464
EFO86291     449 ---------------------------------------------LQIFSVStGFLICVLELYGpSnQRFPHIYQLANAF 483
XP_018649914 451 ----------------------------------------nvtisIILLILIgYSSLIIGDLLItPpVAYPDLFPLLSSI 490
XP_001022240 588 isdskvtdqttqkkileqekDIPLIVklisltdlfyksifrkaiyIL------SIIAIIAEKYVkPpTNYPYLFSLIYAV 661
A0DD77       408 -------------------------------------------qfQVQIPVLlYVILFFCQQLIqPpQRFPFLYELSMQV 444 Paramecium tetr...
6SNH_X       535 VGFICFSIFWLW 546 brewer's yeast
XP_002186451 502 AGCAFCSLAWLA 513
EDS42995     492 FSCGHFVLFFVY 503
XP_042934744 462 YCFLHFITFFLY 473
Q09226       480 FSCVHFIYFLLY 491 Caenorhabditis elegans
XP_002629983 465 FSCLNFLYLLVS 476
EFO86291     484 FSCVHLLYFLVS 495
XP_018649914 491 YSFTLFSLFMLY 502
XP_001022240 662 LGFGLFAYVFIQ 673
A0DD77       445 LGFSMYTFMYII 456 Paramecium tetraurelia
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