8PG0,8KGI,7EEB


Conserved Protein Domain Family
OATP

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pfam03137: OATP (This model is not part of the current CDD release)
Organic Anion Transporter Polypeptide (OATP) family
This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Statistics
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PSSM-Id: 515406
Aligned: 187 rows
Threshold Bit Score: 381.564
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8PG0_A          29 MFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGS 108  human
XP_011052736    51 LFVGLICWIGVVQAASYAYFHVTGSTIARRFQIDPYIMDWILVTAELTPIVLGLVIAYWGDKIHRASWIGALTLLQSVAH 130 
EDS26845        25 SFIMVYGFLGTTQAMAYIYFVITLTTLEKRFKIPSSTTGIILSGNEISQILLSLILSYAGGHRNRPRWIAWGVVFCALSC 104 
EFX77080        37 SYLLTYSFLGLFQAMFFSYSIATLTTLEKQFKLKSQTTGILLSGNEVSQILLSLVLTYFGGHGHRPRLAALGVVFSGVAS 116 
EFX81434         1 MFLAVFCLACVLQGMFYTYFVSVLTTIEKLFQIQSKTTGIIMSATEMGQIGGALLLTYYGGQGHRPKWIGWGMVLFGASA 80  
EFN72542        99 AFLVTFCLTWVLQGMYYTYFVSVITTIEKLFQIQSKTTGIIMSATEIGQIGSSLLLTYYGGQGHRPKWIAWGMILFAVSS 178 
46_pfamImport    1 AFLVTFCITWVLQGMYYTYFVSVITTIEKLFQLQSKTTGFIMSATEIGQIGSSLLLTYYGGQGHRPKWIACGMVLFAVSS 80  
Q9VVH9         175 VFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAA 254  fruit fly
EEC20306         6 AFLAVFCLTSVLQGMYYTYFVSVLTTIEKLYQIPSKTTGIIMSATEIGQIGGALLLTYYGGQGHRPKWIACGMLIFAVAS 85  
ETN67154        25 SFIMVYGFLGTVQAMAYIYFVITLTTLEKRFKIPSSTTGIILSGNEISQILLSLILSYVGGHRNRPRWIAWGVVFCALSC 104 
8PG0_A         109 ILTSLPHFFMgyyryskethinpsenstsslstclinq----------------------------tlsfngtspeivek 160  human
XP_011052736   131 FVLIIPHLTHrvrvieetqnvthmslyaddspe--------------------------------------lctpvlsri 172 
EDS26845       105 FILASPHFIYgagenalqltkefindqeaeasvlrshnlt-----------------------aivkstnrlcldtfspk 161 
EFX77080       117 IIVVVPHFVYgqfatatnvtrsfdvcststds---------------------------------------vmptmnped 157 
EFX81434        81 ALCSLPHFLFwrtkpntgsssslssmlapdlyggglg------------------------------llatmdpsssseq 130 
EFN72542       179 FTCSLPHFIFgeqlilqnemllsgvgpggngrglnntdpipanlckfpernntldgwnistpasqtdsseyckgdflreq 258 
46_pfamImport   81 FACSMPHFIFgqqmmaenssvlappnvcllsessqmpln-------------------------ssihdeqckeeylveq 135 
Q9VVH9         255 FSCALPHFIFgeqlmhssvilqqtqvsppnnsfsshwlnasseqvnp---------nlcilggnqthsgsecneerqleq 325  fruit fly
EEC20306        86 ILCAMPHFLFidtslsvtslaraknaqnatvasq-----------------------------------waklchssdmp 130 
ETN67154       105 FILALPHFIYgpgedalrltkeylrdkaedeanlrlhqnvt----------------------mlvkssnrlcmaestek 162 
8PG0_A         161 dcvkesgshmwiyVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIgyv 240  human
XP_011052736   173 ileeepcyitmviIILVLIVSGMSNITYYALGISYLDDNTKRKHVTGFIGIIIAVKITGIVLGYLLGWGCLRID------ 246 
EDS26845       162 echdvisvvplvlIFMSQFVLGIGNTLYYSLGQTYLDDNTKKTNTPLMLAYASSLRTFGPVVGFALGYFALKIYIDP--- 238 
EFX77080       158 scdetapigpmiyIFMSQFVSGIGTTLFSILGITYLDDNVKRKQTPMLIGLMSSLRLIGPVFGYGLAAICMRLYVNL--- 234 
EFX81434       131 qaisrtttvvlafFFLSLLGIGMGRTAVETLGIPYMDDNVAGRESPTYFAINIGVKILGPVFGFVLGSLCTSIYVDP--- 207 
EFN72542       259 riqskittvvlaiFFVSLLGVGMGQTAVYTLGIPYIDDNVASRESPLYFAITIGVRILGPALGFILGSLCTMVYADL--- 335 
46_pfamImport  136 riqskittivlaiFFISLLGVGMGQTAVYTLGIPYIDDNVASRESPLYFAITIGVRILGPALGFILGSLCTRLYVDL--- 212 
Q9VVH9         326 ashskitvivlciFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNF--- 402  fruit fly
EEC20306       131 lsqsrithvvlsvFFISLLLIGIGATAVYTLGIPYIDDNVANRESPLYFGITIGVRIFGPVFGFLLGSYCTSVYVNF--- 207 
ETN67154       163 ecldtisivplvlIFMSQFVLGIGNTLYYSLGQTYLDDNTKKTNTPLMLAYASSLRTFGPVVGFALGYLALKIYIDP--- 239 
8PG0_A         241 dlstiRiTP-----KDSR-WVGAWWLGFLVSGLFSIISSIPFFFLPKNpnKPQKERKISLSLHVLKT------------- 301  human
XP_011052736   247 -------AEdfsvvNSYRdQIGAWWLGFPILSILLVIPGLLLSWFPRR--LPSEVVEQAAASLLDRA------------- 304 
EDS26845       239 -----SkTPvi-dsTDPR-WLGAWWLGWIILGVAMLFFAALIGLFPKE--LPKKQDVEKRPRSNMPVvlmnd---aeafg 306 
EFX77080       235 -----SeTTtl-kpRDPS-WIGAWWLGFMIIGIIQISTAWLLACYPRR--LPKKSTTAVGF------------------- 286 
EFX81434       208 -----LvEPdv-tpKDPR-WIGAWWLGMIFVASTILLASLSMFAFPRR--LPRKGRQAAHRPKQINGkm---------lp 269 
EFN72542       336 -----TrTPqi-tpTDPR-WVGAWWLGLVLISAMLMFVSIGMFAFPTR--LP-KSRT----------------------- 382 
46_pfamImport  213 -----SlDPqi-tpTDPR-WVGAWWLGLVMISSLLMLASLAMFSFPKR--LS-TCRPIA--------------------- 261 
Q9VVH9         403 -----S-NPgf-daTDPR-WIGAWWLGPVAIGSLMLLASIAMFSFPKQ--LRGKQKPPGQT------------------- 453  fruit fly
EEC20306       208 -----PfETsnlspGDPH-WIGAWWLGVFIVGAALIVTALPMMAFPRN--LPQRRSLAQLRALRP--------------- 264 
ETN67154       240 -----TkTPii-dsSDPR-WLGAWWLGWILLGIAMLFFAMLTGLFPKE--IPKKQAAAATTTKRPNSnmpvilmndaeaf 310 
8PG0_A         302 NDDRNQTAnlTNQGKN----------------VTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQ 365  human
XP_011052736   305 AIRNRAPH--RTTSQK------------------VGNPDFWPSLCRLFTNRILICNILATAFSAMALLNFMTLENIFLES 364 
EDS26845       307 KEKNPLSA--RGVKEQnnhvvpngedagaslvEFPQLKDFPKALMRLLRNKLLMCNIISGIFYILGSSGYITFLSKYIEV 384 
EFX77080       287 ------MT--IAAQKStqqp---------nkpKERTFKEFPAALRRLLTNKILILNNCAGVFFVFALSGYITFLPKYMET 349 
EFX81434       270 AQAKTEQT--VASAMRn---------------KNPSLKDFPKAIRRLLKNDILLFRTASSVLHILPVAGLYTFLPKYLES 332 
EFN72542       383 -----------PPRRAd--------------aKKPSLRDFPSAVKRLLKNDILMFRTASSVLHILPIAGLYTFLPKYLES 437 
46_pfamImport  262 ----------PLKKHTret-----------arKNPSLRDFPKAVKRLLKNDILMFRTASSVLHILPIAGLYTFLPKYLES 320 
Q9VVH9         454 ------AT--PAAPVEp--------------eEKPKLKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLET 511  fruit fly
EEC20306       265 -GSDQHRN--GMVCLKhqqalq-----qklyiAPSSLSDFPSAIRRLLKNEILLYRTASSVLHILPIAGLYTFLPKYLES 336 
ETN67154       311 GKEKEELR--QAARHQrtvsenap-efaesivEFPKLKDFPTALMRLLKNKLLMFNILSGIFYILGSSGYITFLSKYIEV 387 
8PG0_A         366 QYGQSASHANFLLG---------II-TIPTVATGM--FLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPlICESK 433  human
XP_011052736   365 RFLIPRPTGMLR-GfddplpsrlVTnIGRPILIGLviIISGLVLAKAKPRARFIIGYSFIIVFLIIAIIIGLIFaTCDKS 443 
EDS26845       385 QFHKTTANATVITG---------PI-TLFGMVAGF--LISGVVISKKKPSPKILLFWNVIVGIGYMMGQFSYLFlTCPDG 452 
EFX77080       350 QFQQSSSMSGLVNG---------LT-GILFMCTGL--LMAGYLISKFKFHAWKLQVWDVIVGIIWIIILVVFAFlGCDSK 417 
EFX81434       333 QFRMAAHTANMISG---------IG-GIGVMGIGI--FFSGVFIRLKKPSPKFVAAWIALTALLYAIGMALLMLlGCPMS 400 
EFN72542       438 QFRLPAHHANMISG---------VG-GILVMGLGI--IISGVFILRAKPNARFVAAWIAFTAVVYAIGMGVLMFiGCPMD 505 
46_pfamImport  321 QFRLTAHAANMVSG---------VG-GILVMGLGI--ILSGVFILRVKPNARFVAAWIAFTAVVYAIGMGILMFvGCSMD 388 
Q9VVH9         512 QFRLATYDANMIAA---------FC-GILVMGIGI--VISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFiGCSMN 579  fruit fly
EEC20306       337 QFRLTETKANMITG---------FA-GILVMGVGI--FASGTFMRKYKPNARFVAKWIAFCALAYSIGMVILMWvGCPLG 404 
ETN67154       388 QFHKSPANATVITG---------PI-TLFGMVAGF--LISGIVISKKKPSPRKLLFWNVIVGFGYMAGQFSYLFlTCPDG 455 
8PG0_A         434 SVAGltlTYDGNNsvashvdvPLSYCNSE--CNCDESQWEPVCGNN---------------------------------- 477  human
XP_011052736   444 SVVNlekss----------dtllRYCNKD--CRCSKDADFRPICDSs--------------------------------- 478 
EDS26845       453 TMPL---VEGRLN--------LSTVCNSR--CHCEGIPYSPVCQEDtgitffsachagcdqwnakgkyydqctcqnenys 519 
EFX77080       418 PIHGlenAENGSNaml---giPTTSCNEE--CNCQANRFAPACSEDgqvnf----------------------------- 463 
EFX81434       401 DFSGl--EQ---Tdsg---mtVKLPCNRT--CECDTSVFAPICTSTg--------------------------------- 437 
EFN72542       506 DFAGl--VS---Hsdg--lssFEPICEAS--CDCDRNKFSPICGADgrtyfsach------------------------- 551 
46_pfamImport  389 DFAGl---Q---Reyg--tnkFNYACDTG--CTCDYNKFSPICGHDgr-------------------------------- 426 
Q9VVH9         580 DFAGy--KP---Sdgns-palIEPTCSAAlnCTCDKENFAPICADG---------------------------------- 619  fruit fly
EEC20306       405 EYVGl--NS---Ehkg--ldfLPPACNSS--CDCKSGLFSPV-------------------------------------- 437 
ETN67154       456 TMPL---VQGRLN--------LTTECNSH--CHCDGIPYTPVCQEEtgitffsachagcdnwhtadkyydrcscqnenys 522 
8PG0_A         478 --------------------------------------GITYLSPCLAGCKSSSGIKKHTVFYNCSCVEVTg-------- 511  human
XP_011052736   479 -------------------------------------gEFTYYNPCYAGCSTIIYVDDVKIYSGCNCVEEM--------- 512 
EDS26845       520 ----pitklpwemytstpmrstepftkpwtteasssssSSSTFTTSSIPSTTITSTNRPPLEKATNVPPPKtstgsaldd 595 
EFX77080       464 ---------------------------------fsachAGCTSMNSTGDRTVIFINQTSHFNLATDNDFSIsnst----- 505 
EFX81434       438 -------------------------------------eTYFSACHAGCANLTQFGSQIGNTTYSNCECLDA--------- 471 
EFN72542       552 ------------------------------agcsnytvADGKVASVSAKPSRNNTPQDMFYNCQCIEHNVTi-------- 593 
46_pfamImport  427 -------------------------------------tYFSACHAGCQNVTVVDGTIVQYSECLCVGDPDSr-------- 461 
Q9VVH9         620 --------------------------------------KMYISACHAGCSSSSLRPSDNRTLYSDCACIPD--------- 652  fruit fly
EEC20306       438 ------------------------------------------CHNSVTYLS-PCLAGCSQPTFNSCHCTGT--------- 465 
ETN67154       523 pitklpwerppngsgsatylpsthpyqttvststvlvqYTTTDAPSSTRSETTESTTTLSTSTAAVTVTDTiqlladane 602 
8PG0_A         512 -------------------------------------------------------------------------------L 512  human
XP_011052736   513 -------------------------------------------------------------------------------T 513 
EDS26845       596 vyiyddeddeatantendspdvtvq---------------------kelnagtsekpierrrrevggeqesttstpsgsT 654 
EFX77080       506 ----------------------------------------------------------------------------ldsG 509 
EFX81434       472 -------------------------------------------------------------------------------G 472 
EFN72542       594 ------------------------------------------------------------------------------pE 595 
46_pfamImport  462 ------------------------------------------------------------------------------hP 463 
Q9VVH9         653 -------------------------------------------------------------------------------A 653  fruit fly
EEC20306       466 -------------------------------------------------------------------------------N 466 
ETN67154       603 tkvnytlshdsppdlmapdatgelpmeitesttavpvdgedsvvmeaaeeaassypeaerrrkratstgdgedsstttnP 682 
8PG0_A         513 ---QNRNYSAHLGECP-RDntCtRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAP 588  human
XP_011052736   514 ---EWGNDQAKDGPCDsSK--CqVGWMVFEFGSLLAYTLIASTFVGDILVNIRSVYKQDKAISIGFWMMWVAVFVYIPGK 588 
EDS26845       655 tteSPFTARLIPGACL-KG--CaLGFYLFSIISSIINCFGASGRIGNLLVNYRCVAKEDKSFTQGLILMMISLFALIPGP 731 
EFX77080       510 a--WY-NGKAVGGYCP-SN--CfQMFLIYISVMGIIKFLSSFGRVSNILITFRCVPQEDKSFAIGLGYLLTSLFAFIPAP 583 
EFX81434       473 ----VT---ATSGYCH-LE--CnNY-IWYIGIFSLFVLIHSTSEVGSMLLTLRCVHAKDKAMALGLIQFAIGLFANVPCP 541 
EFN72542       596 a--FST---ATIGYCE-LE--CsNF-WVYMILFSVFVFIHSTSEVGSMLLILRCVDPRDKAMALGLIQFAIGLFGNVPCP 666 
46_pfamImport  464 e--PGV---ANVGYCD-LE--CgNF-VWYILLFSLFVFIHSTSEVGSMLLILRCVDPTDKAMALGLIQFAIGLFGNVPCP 534 
Q9VVH9         654 ----PE---AVNGYCD-NN--CkNF-IYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCP 722  fruit fly
EEC20306       467 ----DT---ISNGFCS-LE--CnNL-VWYIIVFSFFVLIHSTSEVGSMLLTLRCVESHDKALALGLIQFAIGLFGNVPCP 535 
ETN67154       683 pdtTLYSVKLVPGACI-QG--CaLGFYLFSIISSIINCLGASGRIGNLLVNYRCVSKQDKSFTQGLILMMISLFALIPGP 759 
8PG0_A         589 IYFGALIDKTCMKWsTNSCGAQ-GACRIYNSVFF 621  human
XP_011052736   589 IVYEFVSNQMCQYW-----GSQkTICHLHNSEKL 617 
EDS26845       732 ILYGRIIDSTCLVW-TEECGKR-GNCQLYDQRLF 763 
EFX77080       584 IVYGAVIDQACILWrTDSCGVR-GNCWIYDQEKM 616 
EFX81434       542 IIYGAVVDSACFVW-EKTCGEQ-GACWLYDAKTF 573 
EFN72542       667 IVYGAVVDSACLVW-EYACGER-GACWLYDSNVF 698 
46_pfamImport  535 IVYGAVVDSACLIW-ETTCGKQ-GACKLYDENFF 566 
Q9VVH9         723 IIYGAVVDSACLIW-KSVCGKH-GACSLYDADTF 754  fruit fly
EEC20306       536 IIYGAVVDSACLFW-EDNCGEP-GACRVYDPSKF 567 
ETN67154       760 IIYGRIIDSTCLVW-TEECGKR-GNCQLHDQKLF 791 
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