Conserved Protein Domain Family
EXS

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pfam03124: EXS 
EXS family
We have named this region the EXS family after (ERD1, XPR1, and SYG1). This family includes C-terminus portions from the SYG1 G-protein associated signal transduction protein from Saccharomyces cerevisiae, and sequences that are thought to be murine leukaemia virus (MLV) receptors (XPR1). N-terminus portions from these proteins are aligned in the SPX pfam03105 family. The previously noted similarity between SYG1 and MLV receptors over their whole sequences is thus borne out in pfam03105 and this family. While the N-termini aligned in pfam03105 are thought to be involved in signal transduction, the role of the C-terminus sequences aligned in this family is not known. This region of similarity contains several predicted transmembrane helices. This family also includes the ERD1 (ERD: ER retention defective) yeast proteins. ERD1 proteins are involved in the localization of endogenous endoplasmic reticulum (ER) proteins. erd1 null mutants secrete such proteins even though they possess the C-terminal HDEL ER lumen localization label sequence. In addition, null mutants also exhibit defects in the Golgi-dependent processing of several glycoproteins, which led to the suggestion that the sorting of luminal ER proteins actually occurs in the Golgi, with subsequent return of these proteins to the ER via `salvage' vesicles.
Statistics
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PSSM-Id: 397303
Aligned: 309 rows
Threshold Bit Score: 146.573
Threshold Setting Gi: 124476487
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCF53782      30 FPPPYRVLLLASIGLLLFAVNVKVLQHKGIDLFGLFRA-------DEvekkrnigaaagsggggfhrsttgastqygsyh 102 Ustilago hordei
A0CVS2       241 TYLLFITMGIPLFYLWFFSTLLQIFKKRYINYWVIFKI-------DY--------------------------------- 280 Paramecium tetr...
A0CNT1       303 QFPIYRGALLFILYYWSLTIVIYLWSKSKINYKLYFCFnhhfstiNE--------------------------------- 349 Paramecium tetr...
A0CKP8       303 SFPIYRGALLFILYYWSLTIVIHLWNLSKINYKLYFSFnhhfstiNE--------------------------------- 349 Paramecium tetr...
A0D6T3       265 IFPSIRGGGLLLIYYWLLTLDQYIWIKYQINYKLYLGF-------NH--------------------------------- 304 Paramecium tetr...
A0E055       295 MFPCFRGLALFIIYYWYLALDLWGWTHFRINYKIYLGF-------NH--------------------------------- 334 Paramecium tetr...
A0DUP5       299 AFPCFRGMALFIIYYWFITLDLAGWNYFNINYKVYLGF-------NH--------------------------------- 338 Paramecium tetr...
A0DA13       277 VFPCFRGVALFIFYFWMISLDVAGWNYFNVNYKLYLGF-------NH--------------------------------- 316 Paramecium tetr...
XP_001706083 323 CRHLNRFHLSIVIYSLSLAMVFAIYEVKRINYVLILEL------------------------------------------ 360 Giardia lamblia...
XP_001009178  34 TFPIYRALAVFVLYVGILGINELIFNEYKINYQKLLNI-------DF--------------------------------- 73  Tetrahymena the...
CCF53782     103 nhnsssgtstsndgpgilpttapsrptggeaGvgGGMTTKPLFAFG--LFQLAWSL--LNWA-----SYR------YYVD 167 Ustilago hordei
A0CVS2       281 ----------------------------------IRDSISKFYYLAa-VITIIFLLivNYGLiselqFYAlsnhliYYHI 325 Paramecium tetr...
A0CNT1       350 -------------------------------QlkRVMSLTSIF-LLv-SLFYLCDVs-KLGI-----IFSn-----LKG- 384 Paramecium tetr...
A0CKP8       350 -------------------------------QlkRVMTLTSIF-LLv-SLFYLCDVs-KLGV-----IFSn-----LKG- 384 Paramecium tetr...
A0D6T3       305 ----------------------------------HFSTLTEVIKRVs-FLSTIYLL--LFLI-----TCIqv---eEIAF 339 Paramecium tetr...
A0E055       335 ----------------------------------HFSTVEEVFKRVs-YFSAMFLLs-FVFY-----SLQae---nIDPF 370 Paramecium tetr...
A0DUP5       339 ----------------------------------HFSTVQELLQRVs-ILTAIFLVt-FLWY-----CIAve---dSLGD 374 Paramecium tetr...
A0DA13       317 ----------------------------------HYSTLSEILKRVt-IFKEDIGK-----------LAQe-----LQVF 345 Paramecium tetr...
XP_001706083 361 -------------------------------PsaNMVAGANTIAIRalWFSTIHCI--AIVMgt-asAYTsl---sSHGQ 403 Giardia lamblia...
XP_001009178  74 ----------------------------------SIKPKRVIRKVLv-FLFIFFVF--FIWYqleidILDes---dQISK 113 Tetrahymena the...
CCF53782     168 -----S-LSgdhkgrhaqAF--------QG-FCVSGAVLALLWP-GN-LF---FK----SMRR---AFGRAILVILSPSL 220 Ustilago hordei
A0CVS2       326 fn--fFeFDp--------IY--------ALfILWIFLILFMINP-FK-IF---GY----QARK---YFWILQIKTLSGLY 375 Paramecium tetr...
A0CNT1       385 -------EE---------YF--------PL-IIWTSVFATVAFP-SK--FminG-----QGRL---WLYRNLWQCLN--L 426 Paramecium tetr...
A0CKP8       385 -------EE---------YF--------PL-VIWASLLATVAFP-SK-IF---INg---KGRI---WLYRNLWQSIN--P 426 Paramecium tetr...
A0D6T3       340 kdykqI-VK---------IL--------PL-LYWVIFFGYLLIPtIK-KF---NG----QGRR---WMYRMLKGALFTHF 389 Paramecium tetr...
A0E055       371 -----S-YRdsy----tkYI--------PL-VLWCILLLYIFFP-FTtIL---NG----PGRV---WLYKILAGAVYGHF 420 Paramecium tetr...
A0DUP5       375 -----L-SRavql-fdirYL--------PI-ICWIVSILYVFYPtTK-YF---NP----QGRK---WMYKMFYGAIWGHF 427 Paramecium tetr...
A0DA13       346 -----D-VR---------LY--------PL-LIWVCLLIYVLYP-FKkIF---NP----EGKK---YMYQMLYGMFWGFL 390 Paramecium tetr...
XP_001706083 404 -----P-AFseplpypfgKYlaalaqltPYeLWLCIPFAFYFYWlVT-AI---FFskrhKLRH---YCLMVFLRCLNPRV 470 Giardia lamblia...
XP_001009178 114 -----V-FD---------AI--------EK-EYLGIVLWILCIA----YF---LF----VGRQtclWAAHTFLQSLLSPF 158 Tetrahymena the...
CCF53782     221 K--QQItFGDVILADILTSFAKVFGDVWLTA--CFLvpRke--------hHTWWN-G------K---GS-----VAVP-L 272 Ustilago hordei
A0CVS2       376 Y--S---KEILWNVEQMVSCSQFFRLFSYTI--HYY--F-----------CYFKH-Q------T---QFkefnyLSQG-V 424 Paramecium tetr...
A0CNT1       427 K--LIE-QRHYFIFSQFTSLIIPFTDLTYTV--CEY--Skgin---nqeeTDFNQ-Y------D---ECffisrYFTLaL 486 Paramecium tetr...
A0CKP8       427 K--LID-QRHFFIISQFTSLIIPFTDLTYTI--CEY--SkgiknqeendnDQYD-------------ECffisrYFTLaL 486 Paramecium tetr...
A0D6T3       390 L--SYD-ARYTFVLDQFVSLFSPIRDLEYTI--CYY--S-----------NDLFNdNee---iIhykECesgqriVGD-I 447 Paramecium tetr...
A0E055       421 I--KYE-SRFTFCLDQFISMAIPLRDLDYTI--CYY--K-----------TIWQTgEih---dN---ECfs-snRLTGaL 475 Paramecium tetr...
A0DUP5       428 I--KYE-SRYTFFTDQFTSMITSMRDFDYTI--CYYhhFi---------fLGHEH-N------G---ECnf-qrRFTA-A 481 Paramecium tetr...
A0DA13       391 F--NYE-SRYTFMADQFASFTTPIRDLDYTI--CYY----------------YYIiFkgyeheG---QCep-rtRFTSaL 445 Paramecium tetr...
XP_001706083 471 R--RIN-FPQFFFMDQCVSLSVMIIDLCYVLsgGYI------------------PdY------It--AC----------F 511 Giardia lamblia...
XP_001009178 159 RpsTVP-FQLGFATDQIVSLVGPLKDAEYTL--CYY--S-----------SDYQSvDq----lN---QCkk--tpVLL-Y 212 Tetrahymena the...
CCF53782     273 LIS-LPYAIRFRQCISEYCIsppiqgrnggeK--SKR----PLWNAVKYASAFPVIWLSAWYE-ADKDPgghqgEWVTrY 344 Ustilago hordei
A0CVS2       425 LIV--PFIYGFYYSLRVYVQ-----------D--Kk-----SYLNLIKFASMLTLISLSQINIfVTFLP----------N 474 Paramecium tetr...
A0CNT1       487 VLI--PYLILMIQIIFLTQK-----------QmnGNL----FIIEFIRNIFSIVLIIFATLSY-QESDL----------F 538 Paramecium tetr...
A0CKP8       487 VLF--PYFILTIQILFLTQK-----------Q--QNIk--lYSIEFIRNILSIALIIFATLSY-QEPNF----------F 538 Paramecium tetr...
A0D6T3       448 CLV-VVFSLKCLHCLTLAKK-----------N--GKFyntlEMWNFLKNLLAVSVGIVGCLNK-FDKTD----------A 502 Paramecium tetr...
A0E055       476 IAI-IPFSMKTIHYITRARD-----------K--GKFwhtdEMWNFFKTLLATWVAVLSFLAN-KHYIY----------R 530 Paramecium tetr...
A0DUP5       482 QASiIPYFLKCIQYLTRARD-----------K--GKFlftdEMYNFIKTFIAMSVGILAYLTRl----------DIGW-K 537 Paramecium tetr...
A0DA13       446 PAT-VPYLIKCAHYLVRARV-----------K--GRLfgtdEWYNFLKTANAAQVGVWSFLAR-RNPDV------TEF-R 503 Paramecium tetr...
XP_001706083 512 LTT-F-NIIRAMQCGRRYKE-----------S--GNAy--pNIHNMLKYLVSIPGCFMEVSAL-VKISG--------I-K 564 Giardia lamblia...
XP_001009178 213 IAF-FPLLLRMGQCLRNCYQ-----------K--RDYkg-pDMLNMIKYFLSVLVVYYSHVAA-GNQKY----------L 266 Tetrahymena the...
CCF53782     345 VWWLLAVFVNSMFSFWWDVTNDWGLS-----LLQwqnmgsvgqvaqnavhlhrrgmsymplplseeaevlpmasfrpdek 419 Ustilago hordei
A0CVS2       475 YLLQSLIILCGLSVSYVDVKYDWGLLn---kLSS---------------------------------------------- 505 Paramecium tetr...
A0CNT1       539 YYWLGMAIFIAFFNIISSIKK-WSYLd---vKERr--------------------------------------------- 569 Paramecium tetr...
A0CKP8       539 YYWLGMAVAIGFLNIIFAIKK-WNYL-----DIK---------------------------------------------- 566 Paramecium tetr...
A0D6T3       503 ILWIILAGTFTILQQYWEIKNDWLFLq----P-D---------------------------------------------- 531 Paramecium tetr...
A0E055       531 IIWIPFAAFCSLFQYWWDLKKDWLFFe---kGSN---------------------------------------------- 561 Paramecium tetr...
A0DUP5       538 HYWIAVACFCSCFEYYWDLKKDFMFFe---kGTK---------------------------------------------- 568 Paramecium tetr...
A0DA13       504 VIWIFVAIISTFWQYYWDLAKDFLFFe----K-D---------------------------------------------- 532 Paramecium tetr...
XP_001706083 565 YTLYSIRWVEIIYKLYWDTVEDWALFsggsgALLfk-------------------------------------------- 600 Giardia lamblia...
XP_001009178 267 DIWIFFAVISTVYSYAWDIKKDWNLG-------D---------------------------------------------- 293 Tetrahymena the...
CCF53782     420 psfsnssagtgdgvggytslavppttNpsggpsrtttrtghrrnlsamerILRpsPSLL-FPA----S-FYQIAIILDLL 493 Ustilago hordei
A0CVS2       506 --------------------------Nc----------------------LLR--QILG-YNKn-----FYYFSIFYNIV 529 Paramecium tetr...
A0CNT1       570 ---------------------------------------------------KK--KQLLsYKQk---L------LIIYLP 587 Paramecium tetr...
A0CKP8       567 ---------------------------------------------------IK--RK---KRS------ISYKQKLVLLY 584 Paramecium tetr...
A0D6T3       532 --------------------------Skf--------------------kFLR--SDLA-FINp---H-FYYFLIILNMF 558 Paramecium tetr...
A0E055       562 --------------------------Vr----------------------FLR--NDLG-YNHp---C-IYYFIGISNFF 586 Paramecium tetr...
A0DUP5       569 --------------------------Yk----------------------FLR--SDLG-YNNp---Y-IYYTLGVLNFF 593 Paramecium tetr...
A0DA13       533 --------------------------Sky--------------------kFLR--NDLG-YNSp---T-IYYIFAGVNLV 559 Paramecium tetr...
XP_001706083 601 -------------------------qIhsds------------------kayR--KGIL-QRSslfsIpTLYFCFFLNIA 634 Giardia lamblia...
XP_001009178 294 --------------------------Trh--------------------gFLR--EKII-YKKp---H-LYYSAMALNFG 320 Tetrahymena the...
CCF53782     494 LRFF--WSLKLSSH-LHHI---IE-WQGGVFSMELLEMIRRWVWVFFRVEWEVV 540 Ustilago hordei
A0CVS2       530 GRIC--LFQQLCFI--------IQ-SKNLLLILCIIESIRLFLWNLIAIEKEHV 572 Paramecium tetraurelia
A0CNT1       588 FGVI--QPLSISTS-IFGCfdkKEqHSLLILYIGIVELIRRMIVNYYIVDAEHF 638 Paramecium tetraurelia
A0CKP8       585 IPFGiiQPVSISSS-IFGCldkNEqHSLLILYIGIAELIRRMIINYYTVDAEHF 637 Paramecium tetraurelia
A0D6T3       559 VISA--WTFTISPQmYLYLk--IPnQQLFIMIVGIMELTRRFIHNLIKVEKEHI 608 Paramecium tetraurelia
A0E055       587 LRLT--WILTVSPN-MYLYlniTN-KELFIFVIGFLEMTRRLINNFIKIEKEYI 636 Paramecium tetraurelia
A0DUP5       594 LRIA--WVLTISPD-MYRIigiKN--EIFILGFGFLEMSRRLINNFLKMEKEHI 642 Paramecium tetraurelia
A0DA13       560 LRCT--WVLSLSPDiCKLFg--IK-NELFVLLVGFLEMSRRFLNNFLKVEKEHI 608 Paramecium tetraurelia
XP_001706083 635 IRIY--LPISLVIP-HPSL---RD-F-WIASIAGLLEVFRRNIWNILRLDNQQA 680 Giardia lamblia ATCC 50803
XP_001009178 321 LRCM--WVFTISGGvVNHFdikRE---SFKFLIYLLEVIRRCIWNLLRMENEQI 369 Tetrahymena thermophila SB210
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