Conserved Protein Domain Family
Herpes_UL49_1
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pfam03117: Herpes_UL49_1 
UL49 family
Members of this family, found in several herpesviruses, include EBV BFRF2 and other UL49 proteins (e.g. HCMVA UL49, HSV6 U33). There are eight conserved cysteine residues in this alignment, all lying towards the C-terminus. Their function is unknown.
Links
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Statistics
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PSSM-Id: 281157
Aligned: 6 rows
Threshold Bit Score: 283.244
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6SW82 249 QLRGLIAALRRHAGKVPCGNPLYVLARQAVQTFCDTCPRYLVPLralglhdetrgggstaaaaavghagagqqahHVEPT 328 Human herpesvirus 5 s...
O36416 214 HGEALASALKSCCEDVPCGSPFDSMVKNLALRCALSHQFSVIPV-------------------------------SDQSP 262 Alcelaphine herpesvir...
P14347 269 HASALLASLQKKASDTPCGNPIQWMWYRLLVNSCLRSAHCLLPIpavseggrkt------------gggvgeelvGAGGP 336 Epstein-Barr virus (s...
P52441 195 HVLSFPSMLRKYALKSPAGNFMFTMAKALVENFCFSADRYLIPVehnnlvp-----------------mvpskpeRGDFP 257 Human herpesvirus 6 (...
F5HG20 200 ADTGLREALERVAPTVPCGNPFDAMLGSLCFLSLIKSRHVVLPAc------------------------------EQEGP 249 Human herpesvirus 8 s...
Q66668 233 HDLSFLKALRDGGRTVPCGNPFNAMVGALAFQSMAASRYVVLPNt------------------------------TDIKS 282 Equid herpesvirus typ...

Q6SW82 329 KIVLFALSAALRGGLIGSVIDLPLWCLCRLKCERHLDARs-------lVAVVCRQCGHCLNLGK-----EKLHcQQNFPL 396 Human herpesvirus 5 s...
O36416 263 NIVTQIREKILSISVLACVVRVPILSATVWSLVETKRPT---------FFVYCGECKHCLNFGK-----GKFL-KVNFNP 327 Alcelaphine herpesvir...
P14347 337 CLSRDVFVAIVSRNVLSCLLNVPAAGPRAYKCFRSHASRpvsgpdyppLAVFCMDCGYCLNFGKqtgvgGRLN---SFRP 413 Epstein-Barr virus (s...
P52441 258 KILTFALATSLKDGLATSVISLPVMCYCKTKCSRFILEEs-------yICVICAKCGHCLNSGK-----EKLCsPQGFSL 325 Human herpesvirus 6 (...
F5HG20 250 GLVRNLGRRLLAYNVLSPCVSIPVICSRVARAALAKRARc-------aRAVVCMECGHCLNFGR-----GKFH-TVNFPP 316 Human herpesvirus 8 s...
Q66668 283 FTAHDLYSKIIGYNILCPFLSVPV--HRGYRGGDGAGAR---------LAVVCAECGYCLNLGK-----GKFS-KVSFNP 345 Equid herpesvirus typ...

Q6SW82 397 NSMFYYRDRQEKSVIFNTHAELVHCSLCGSQRVVRQRVYELVSETLFGqrcvrvgwKAVLGLNAACAVYDHRLAFDVILP 476 Human herpesvirus 5 s...
O36416 328 THAFYCRDQKEKQCNVCATTGRIYCSFCGSADIHTASLTQMLDGVPII--------RAVMANNAAFMLDTAQRSVDFILP 399 Alcelaphine herpesvir...
P14347 414 TLQFYPRDQKEKHVLTCHASGRVYCSNCGSAAVGCQRLAEPPSARS-Gwrp---riRAVLPHNAAYELDRGSRLLDAIIP 489 Epstein-Barr virus (s...
P52441 326 SSMFYFRDKQEKNLIYSMHTDVMYCSLCGSQQLVFERIYEMSEHCVLGmkvktvswKAVIGTNSACTILNDNVKFDVIVP 405 Human herpesvirus 6 (...
F5HG20 317 TNVFFSRDRKEKQFTICATTGRIYCSYCGSEHMRVYPLCDITGRGTLArv----viRAVLANNAALAIRDLDQTVSFVVP 392 Human herpesvirus 8 s...
Q66668 346 THIFYCRDQKEKYLTTCASTGRIYCSFCGSCRIRTYPL-----KFTVGnrq---yiRAVGASNCSIVVSDSATELDLVLP 417 Equid herpesvirus typ...

Q6SW82 477 CAAR--TCdSTVVVRGVTVPRLLRLTSHG-HGLLCARCQ 512 Human herpesvirus 5 strain Merlin
O36416 400 CLGThaKC-EGSVLRRLSLLQLLYLTLNA-SELMCARCQ 436 Alcelaphine herpesvirus 1 strain C500
P14347 490 CLGPdrTCmRPVVLRGVTVRQLLYLTLRTeARAVCSICQ 528 Epstein-Barr virus (strain B95-8)
P52441 406 CSCR--SCySTVHLYNVTVKKLLRLVSHG-SDFQCQRCQ 441 Human herpesvirus 6 (strain Uganda-1102)
F5HG20 393 CLGTp-DC-EAALLKHRDVRGLLQLTSQL-LEFCCGKCS 428 Human herpesvirus 8 strain GK18
Q66668 418 CLGD--DC-TQVLLRRVAVCDLFYLTELG-PGLYCSRCL 452 Equid herpesvirus type 2 strain 86/87
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