4JIO


Conserved Protein Domain Family
BRO1

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pfam03097: BRO1 (This model is not part of the current CDD release)
BRO1-like domain
This domain is found in a number proteins including Rhophilin and BRO1. It is known to have a role in endosomal targeting. ESCRT-III subunit Snf7 binds to a conserved hydrophobic patch in the BRO1 domain that is required for protein complex formation and for the protein-sorting function of BRO1.
Statistics
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PSSM-Id: 515382
Aligned: 188 rows
Threshold Bit Score: 58.8197
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JIO_A           1 IDPFTEIYEK-E--SI--YSEEKAQLLRKEXESVeTAd----LEYTsfVEFTNLPK--LI-----NDLA--AAYttgGNN 62   Naumovozyma ...
16_pfamImport    1 MLKVNMKDNQeYsgWF--YLPFFLNHIRECY-SDdPEk----YRDC--IAKFLELH--LAaykviPAPD--FDG---CNT 64  
XP_004992303    14 AFKTPLKIGh---hVD--LSAPIKKVIETVY-EEpADr----YTQE--LRDLNLLR--ANvlrpsYDATs-VEH------ 72  
XP_001748392    53 FLAASVKTAQpCaiED-----TLIKFISQT-LEQpGEd----YRVE--LQQLRNLR--ATlhtghVDQQy-LAN------ 111 
XP_002908775     1 MLGIGFKLSD-TsaAS--IRSSLGEFLRREYASDgDAqqtetHQAA--LDQFGQLK--KD-----VDLVr-TPSaisRHV 67  
XP_002676920     9 IKSILTKKTD-Q--LD--LVRPLTKFISIQYGEHiLKd----YETP--ISALQQRR--NE-----MRNLq-EKSegsRDL 69  
XP_002175018     3 IISINGKNSl---pYD---FQKFCKYLENEHc----------LNEDklTQDINELAlaRDqls------kkRYSdnyLVL 60  
Q4DP85          11 FVTLPFRRGK-DevPD--WELCLK-FISVNHSSNnTSa----VEAT--LKRMNTLH--KTivqtfRTDTkaPPTetfIEH 78   Trypanosoma ...
XP_652232       10 FPPLKLKDT-----TNvpIYQALTRVISSQFGTVyPS-----IQPS--LKLIENLR--DKlv-------nsNNPeiiIKS 68   Entamoeba hi...
XP_652992        9 FPVIPMRKSD-PadVTyaFTYALQNCVLEKk-----------AILA--LQSLSQLR--QQiisvePCQQl-------RDV 65   Entamoeba hi...
4JIO_A          63 NDA-DPQLEXXRDQIK--SW-------AYAV--QQ-NEFNDIERIinviSsKRKEILDILATLPAEEKENILKLKASL-V 128  Naumovozyma ...
16_pfamImport   65 LKK-YFGQLHYMQSRF--PFylqtcvgKQPLnsFF-ITLTWS--L----S-MRTLIKKDACHSLS------GACHSIL-G 126 
XP_004992303    73 -LNnYFSQLQPLKARF--YH--------DPSseVR-IIYTWTDTFs-----DTTQSSHEIAFETACVAYNIGAALAHS-A 134 
XP_001748392   112 -ARlYAAQLHFAKSRF------------YAGstTPqLDFSWLDTFt-----KSFVSSHALAHEYGSVLFNIAGAAGRLaS 173 
XP_002908775    68 LLR-YYAQLEKMAQRF--PCdge--saGRTA--LQ-LQFTWNDSF----CpRKKSTQTGVSFEKAAVMFNVGALESQL-G 134 
XP_002676920    70 CIR-YAVDMMQVASHF--PI-------DTGVqrIQ-VQFSWYDSL----S-RARTTQGNSNFEIANVLFNSAVLSHQL-G 132 
XP_002175018    61 LDK-YEAMLRVLEQKYsnAV--------------P-YPFAWSTSI----SpSRVEQFSSLYFEHGSLLFQRAAVCTQL-A 119 
Q4DP85          79 TLKpYCQLVAMAQAHL--PL--------HGAqvHKnMTFVWRDSF----DdNQKNESMNGNLELISCIYNLAASWAYV-G 143  Trypanosoma ...
XP_652232       69 GTD-YYNYLNLLVHRI------------DLNsnPLqITFKWSDTFk---KdNSSSSSSLIYFELANVLYNVAVSHILL-C 131  Entamoeba hi...
XP_652992       66 SWK-YYQYLNQLSGRVt----------------IN-LQFTWYDTYlqedSkPKKFIYSTLDFEKANVMYNMGCCCMAL-G 126  Entamoeba hi...
4JIO_A         129 ---EA-S---QSD-EKLFRLIKPYVAEIKLLCND-------SSLWRKF----DEFQSAGAFQPSLLDID----------- 178  Naumovozyma ...
16_pfamImport  127 ---QM-Dn-rVSEeGTKTSCVHFQCSAGMFQYLS-------NNLDTTL----SYDSSQLMLKLMINTMLvrksvflsgrw 190 
XP_004992303   135 amlLDgAaasaVDgSLKEASTRFNQAAGAFMIVKsmg------------aqaEGDVAPDSAAVLIHIMR----------- 191 
XP_001748392   174 lefAGaD---SSDdTLKTCLQMQQLSVAAIMAVQqqel----------gdtpSHDMHAAALDVLLHVYT----------- 229 
XP_002908775   135 ---VQ-Td-rNTAeGLKTACRHFMRAAGAFQEVK-------DKLVERTlgarTPDMSAEGLGLLTYLML----------- 191 
XP_002676920   133 ---TS-Qn-rNSEeGCLEAAKHFQSAAGMFTYIQ-------KKVCPNIveklNQDLTNEALEALVLICL----------- 189 
XP_002175018   120 qecMQ-N---DVVdSVK-ACQYLQASAGTFKFIY-------QKYVFPD----SEDLRLELLKGYEHVCL----------- 172 
Q4DP85         144 ---AH-QaqtGTVgDVKSAFKSFQNAAGYYEMVE-------NLLKRLPpehiKGDLTSEALNLLRRMCL----------- 201  Trypanosoma ...
XP_652232      132 islFKiQ--------IQPAINHLKSAAYIFNEILkvisgneKQITLLD-------IHPDVLKTLNQFCI----------- 185  Entamoeba hi...
XP_652992      127 ---SSfSk-tTDAnSLKSAVQSFQQAAGAFQKAAdcaql---------caagSGDLHPRRLQTLTTLAL----------- 182  Entamoeba hi...
4JIO_A         179 -----------DSKTELILSKL-KAitqF---AEDLRLLKEERARTXGELKDYVNNNd-------DITSLLLAnkDKSDA 236  Naumovozyma ...
16_pfamImport  191 cfnkldniihrAKDRNVYWEKS-MQ---D---NRKDSIVAKISQQVVDYYKVALTSLnsa---eaKDIMG--DslNKSWL 258 
XP_004992303   192 -----------AHAHECYLIKAiHT-------NKSKGTIARVAAQVAELYDEALKALa------sVHVDQKSAhpWRHWA 247 
XP_001748392   230 -----------AQSYQCSLYKAlHS-------NMKATTIARIAIRVANEFDAAHKAL--------YSIETNKDhpWHLWQ 283 
XP_002908775   192 -----------AQAQACFYEKA-IK---D---QMKDAIKAKLVHQALDYYVSALEFC--------RSSALAGAi-DRSWS 244 
XP_002676920   190 -----------ANAQQCICEKAhKK-------NMKGAILSKLYMGASHSYKLAAEVI--------DASNTTKNlfDKTWK 243 
XP_002175018   173 -----------AYAQACVLFKAiEK---K---SVRVSILAKIASQVAVYFTQAESYMrqa------------esvPNYIF 223 
Q4DP85         202 -----------VMAHHSAYLKA------EndmKGNHSMLAKIAREGGRQYEEVASSIkssawytgSKRNSSVVliEQLFS 264  Trypanosoma ...
XP_652232      186 -----------LSIQYLFYQKSkQE-------NKTQTTQLKLGAGVYRLSLLVHESLkiskeffsRPIYAVICmfLRIVV 247  Entamoeba hi...
XP_652992      183 -----------GCAHLIMHINAvAQ-------GKSESLQTKLAAAAANQLIPSVDAFk------tFYKITVGFnfLSNFI 238  Entamoeba hi...
4JIO_A         237 ELQSLFESELAKFEPLTTRI-----EAT-IFKQGSTINGVKI----ELDNIFGLtGIQDktpEEQKA-----------EL 295  Naumovozyma ...
16_pfamImport  259 KLVSFKTAFYAAVARYYAGC-----SSW-DQERYGEGVGYLV----SALQYYEQaVKA-----AKSLkgdvknqvekaLK 323 
XP_004992303   248 LMLRLKAMLHRAGAQFHMS------GACrQTEKAGEEVARLR----AAKDLCEElqsvaskak------svvkvdataCT 311 
XP_001748392   284 LCVQLKSMHARGLAQFYQG------QAAnKASEWGEEVGRLR----AARDVLQAaietakav--------knavdvaaIQ 345 
XP_002908775   245 VHLQFQVHCMRAATQYWQGTaskaaALD-RGEGYGEEITRLA----AADAECTEaCKVA---TQNKLptsl----lqsAQ 312 
XP_002676920   244 SYLRFCQHYFEALASYLIAL-----DLH-EEMCIGKEITRII----HAQNCLVDc-----------SeqrvtgnlklvMD 302 
XP_002175018   224 VLLKTNYFYYKAIAHQHFAK-----VAL-ESSKFGVQVGHLNclidACRNVLKQssipst------------ntiktnAQ 285 
Q4DP85         265 TM----GTVFYARSHLHLA------TSMaDTECIGTAIAHFE----KAKSYLTDipklst------------nelrnwIN 318  Trypanosoma ...
XP_652232      248 SEVQLQISSHNAKEE----L------------KYGEQIARTM----IVINDLESishlkel----------pkeykgsCD 297  Entamoeba hi...
XP_652992      239 IIKDYAIYCVQTLAA----------KGAeEKMEYGEQVKRLK----WAMKAMYQacniays-----------sankdaLK 293  Entamoeba hi...
4JIO_A         296 ERKLFFDKLEEATTKFTIFSSDIQKGLNFYNS-LLK-XSK-DLQNSVE---QNp---S 344  Naumovozyma castellii
16_pfamImport  324 YSSDIFNGRYNGAKKDNEFIYHERVVDAALLP-DIK-GAS-LVKALPFepsnqmvtgp 378 
XP_004992303   312 TLLNQINERLPKAERENQSIYMEVVPVEGKLQ-DIT-PAE-LVTTSPYevpspyrdvl 366 
XP_001748392   346 HTLNLVTERLTKAETDNNTIFHETVPSDAALS-EIV-AAD-LFAFKPFepdpsavdil 400 
XP_002908775   313 ALQRVVREHLDAARKDNASVYLENVPKFSELP-AVG-KAA-MVKPLAFtsdELq--qE 365 
XP_002676920   303 ELDQVLNNLLKTAQHENSKIYHDRVPELKDLE-LVE-AKT-MSKIQEV---Neisdll 354 
XP_002175018   286 DLLTIVEPELTIAMRDNDLIHLEAVPTSKELA-SLE-KID-MVRSIVPqnledepkvn 340 
Q4DP85         319 GIIANVNKEHEKAIAANESVYFMRVPKE------VEaPSG-LPRP------LGkateH 363  Trypanosoma cruzi
XP_652232      298 NIIKSLKADLAQYEKDNNEIYFQNIPEPNELEyP---EATiLAKPNPIsqiennpfke 352  Entamoeba histolytica HM-1:IMSS
XP_652992      294 KIYTEAKAAYTQAEKNNNNIYMNNLPRRRDLP-PIT-EVL-AAKPIELetienlfdni 348  Entamoeba histolytica HM-1:IMSS
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