2OEV


Conserved Protein Domain Family
BRO1

?
pfam03097: BRO1 
BRO1-like domain
This domain is found in a number proteins including Rhophilin and BRO1. It is known to have a role in endosomal targeting. ESCRT-III subunit Snf7 binds to a conserved hydrophobic patch in the BRO1 domain that is required for protein complex formation and for the protein-sorting function of BRO1.
Statistics
?
PSSM-Id: 397286
Aligned: 201 rows
Threshold Bit Score: 195.112
Threshold Setting Gi: 326434926
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2OEV_A        11 FISVQLKKTSE--VD--LAKPLVkFIQQTYpsGGEeQAqYCRA--AEELSKLRRAaVgRP-LDKH--EGA---LETLLR- 77 
Q4DP85        11 FVTLPFRRGKDevPD--WELCLK-FISVNH--SSNnTSaVEAT--LKRMNTLHKTiV-QTfRTDTkaPPTetfIEHTLKp 82  Trypanosoma cruzi
Q386T1        11 lplLPFRRGKKdsVD--WTLCIR-YISSNF--TSNyTSnVESA--LRQMNSFHHTiV-QTcHEDAtqAPTesfIEEKLTp 82  Trypanosoma brucei
Q9U7F6         9 FPVIPMRKSDPadVTyaFTYALQnCVLEKk---------AILA--LQSLSQLRQQiI-SVePCQQl-------RDVSWK- 68  Entamoeba histo...
XP_002173790   8 FISIPSKNSNV--VD--WKTPLKkFFEENY--GRD----QDLDeiVRNFDSLRRDaI----NVDEt-PAG---REVIYT- 68  Schizosaccharom...
XP_013022656   8 FLFLKKKETER--ID--WVEPFTtFVSRIY--GNS--IdIDDE--IKNFNSLRDNmL----GADDt-NSG---KNVIYS- 68  Schizosaccharom...
O13783         8 FFYLNKKETKH--SD--WVEPFTtFVSRIY--GNS--VdVEDQ--IKAFNTLRENaA----DVDDt-VAG---KDILYS- 68  Schizosaccharom...
XP_002554042   5 LLPLKVKDTES--IN--WSKALAaYLKRSY--GSStWSqFFNTklAEDLDHLRNN------ANGT--LAPealLEQNFL- 69  Lachancea therm...
Q6CM12         5 LLPLKIKDTES--IS--WTKGLItYLKRSY--GSSqWSvFYDGdkTAEIDSCRTT------ANSD--LAPeslLDQNYK- 69  Kluyveromyces l...
Q74ZJ6         5 LIGLKLKDTEP--LD--WSKALAsYLKRNY--GQHqWSqFYDDkkSAELDQLRIS------ANSD--LGLealLEQNLR- 69  Eremothecium go...
2OEV_A        78 YYDQICSIEPKFPFsENQ--IC-LTFTWKDAFd---KGSlfggsVKLALASLGYEKSCVLFNCAALASQIAAE-QNL-DN 149
Q4DP85        83 YCQLVAMAQAHLPL-HGAqvHKnMTFVWRDSF----DDN-----QKNESMNGNLELISCIYNLAASWAYVGAH-QAQtGT 151 Trypanosoma cruzi
Q386T1        83 YCKLVAMVQSHLPL-HGGlvHGdLRFIWYDSF-----DG-----TKYESKNANLELLSCVYNLAASWAYIGAQ-QTRdGL 150 Trypanosoma brucei
Q9U7F6        69 YYQYLNQLSGRVt-------IN-LQFTWYDTYlqedSKP-----KKFIYSTLDFEKANVMYNMGCCCMALGSSfSKT-TD 134 Entamoeba histo...
XP_002173790  69 YYKQLNYLSFRFPIgTNE--ID-VHFEWSDTLd---PKN-----RLVKEMSVAFEKANVLYNVAAVCSKTGAE-SCVhEG 136 Schizosaccharom...
XP_013022656  69 YYGQLDYLSFRFPTgGNG--ID-IAFEWKDSLs---KGD-----SWYKQSSLAFERACVLFNLAGLLSRLAAT-HTTrYT 136 Schizosaccharom...
O13783        69 YYGQLDYLSFRFPTgGNG--IN-ISFEWSDILd---PDA-----DFVKQSSLAFEKASVLFNLVSLLSRMAAN-HASaYT 136 Schizosaccharom...
XP_002554042  70 YYAFLEQLHLRLGNnSTQ--LK-LEFTWYDASytsqSAS-----QKYTQRTVAFEKSSVLYNLGALMTQVAKD-K---LE 137 Lachancea therm...
Q6CM12        70 YAAILEQIYLRLGAhSGS--LQ-MDFTWYEAEyhsrLSE-----KKFKQHTVVFEKSSVMYNIGVLLSQIAKK-K---MS 137 Kluyveromyces l...
Q74ZJ6        70 YYGFLEQLYLRLGSqSVQ--LK-LDYTWYDAEhg-mNGG-----QKYKQHTLVFEKSSTLFNIGVLLAQLAGE-Q---LR 136 Eremothecium go...
2OEV_A       150 DEGLKIAAKHYQFASGAFLHIKETVLSAlsreP----TVDISPDTVGTLSLIMLAQAQEVFFLKAt----rD---KMKDA 218
Q4DP85       152 VGDVKSAFKSFQNAAGYYEMVENLLKRL----PpehiKGDLTSEALNLLRRMCLVMAHHSAYLKA------EndmKGNHS 221 Trypanosoma cruzi
Q386T1       151 VDKLKVASKAFQNATGYYEMAEGLLSRL----PpelaTGDLTHESLSLLKRICAAMTHHCAYLKA------EidmKDNHS 220 Trypanosoma brucei
Q9U7F6       135 ANSLKSAVQSFQQAAGAFQKAAdcaql------caagSGDLHPRRLQTLTTLALGCAHLIMHINAva-------qGKSES 201 Entamoeba histo...
XP_002173790 137 VDGLKEAANDMQCASGVLANIREYFLRL----S----QKDLDSSYLLAMSNIMLAQAHECVLERLridgngE---PANLS 205 Schizosaccharom...
XP_013022656 137 VQDYKQAANYLQCASGIFKMIRESFLHA----P----GNDFDSQFLLGIHHLLLAQAQECVLGHMs----mS---KMSSS 201 Schizosaccharom...
O13783       137 VDDYKAAANCLQCASGIAKLLRESFIHA----P----GRDLDSNFLLGIYNLFLGQAQECVLGHMsfsasdS---NMNYS 205 Schizosaccharom...
XP_002554042 138 S-DIKVSITYMSKAFGIFQYLSENFLNS----P----SVDLQAENTSLLADICHAEAQELFLLKVing-pdV---TKHAS 204 Lachancea therm...
Q6CM12       138 D-NYKSAIPYLSKAMACFDYMSNNFLNS----P----SIDCAAENTSFLSTLLHAEAQEMFLMTLing-pdA---SKRAS 204 Kluyveromyces l...
Q74ZJ6       137 A-SYKEAIPQLARAVACFEYMSETFLNS----P----SVDLQAENTGFLAALLHAEAQELFLLNVing-gdA---ARRAS 203 Eremothecium go...
2OEV_A       219 IIAKLANQAADYFGDAFKQCQ-----------YKDTl-PKEVFPVlaakHCIMQANAEYHQSiLAK-QQYYFGEEIARLQ 285
Q4DP85       222 MLAKIAREGGRQYEEVASSIKssawytgskrnSSVVliEQLFSTM----GTVFYARSHLHLA-TSMaDTECIGTAIAHFE 296 Trypanosoma cruzi
Q386T1       221 VLSKIAREGGKVYQIVATSLKesawytnsrrgSKAVllEQELRTL----CCVFNARAHLHVA-EVHsNANDQGIAVAHFN 295 Trypanosoma brucei
Q9U7F6       202 LQTKLAAAAANQLIPSVDAFKtfy------kiTVGFnfLSNFIIIkdyaIYCVQTLAA-----KGAeEKMEYGEQVKRLK 270 Entamoeba histo...
XP_002173790 206 LASKIASATASLYASATqd-----------lkAVQFslPKDIIELvsakNNAMEASASYYAGqAEM-SMDAAGVAVARFQ 273 Schizosaccharom...
XP_013022656 202 LAAKIANSAASLYESSVra-----------feSMEPstNTFFVSLasakNQTLEGIACYLMAqSCK-QESKYGLAIGFYN 269 Schizosaccharom...
O13783       206 LAAKIASSAATLYDSCVha-----------feSMEPacNPNFIRLasakKAALEGFSSYFMArAQL-EKSKQGLAIGYLQ 273 Schizosaccharom...
XP_002554042 205 LIAKLSLMASSLYQKVLDTLNgnpd----tntSEVSygEPKWKSIisckCSVYKSISAYNNAlALE-QAGRFGDAIGFLQ 279 Lachancea therm...
Q6CM12       205 LISKLAHTALNLYEKCQEFYEdsst----atfGTTPygEDKWKDIitlkVHLYRAISTYNHLrVLE-EAKKIGEAIAYGK 279 Kluyveromyces l...
Q74ZJ6       204 LLCRLSYTCARFYRKCVEFYKadga---deaaAAVPygEAKWRDVvnmkMHLYEGVAAYNSAlVLE-QAGKIGHAVGLLE 279 Eremothecium go...
2OEV_A       286 HAAELIKTvasry------------deyvnV-----------KDF-SDKINRALAAAKKDNDFIYHDRVPDLkdldpIG- 340
Q4DP85       297 KAKSYLTDi---------------------PklstnelrnwiNGI-IANVNKEHEKAIAANESVYFMRVPKE-----VEa 349 Trypanosoma cruzi
Q386T1       296 EAQKHLQQi---------------------EklhsvelrswiSSI-ISNVNKGNERALSMNNTVYFCRVPNE-----VEp 348 Trypanosoma brucei
Q9U7F6       271 WAMKAMYQa--------------------cNiayssankdalKKI-YTEAKAAYTQAEKNNNNIYMNNLPRRrdlppIT- 328 Entamoeba histo...
XP_002173790 274 QSKRLVEAafkqfssihpdprfvslpvledFnq-------wfKQY-IDKMEGKLRELIKQNDFVFQERVPPEeelepLP- 344 Schizosaccharom...
XP_013022656 270 KAKSKLQAgqksfswlkpdpdfihkqstteYtn-------ylSTFiKDNLKNSLSSTEKDNDFVFHEPVVREaelpqIQ- 341 Schizosaccharom...
O13783       274 QAKSILSSaqklfngiklstdfihkpslsdYpq-------tiSTFiKSSLSHLLKTAEKDNDFVFHDLVVKEvelpkIS- 345 Schizosaccharom...
XP_002554042 280 SANDFIISamaqkly--------------------vkdsidlESI-KSLIADKQKTLVKDNDFIYHDSVPPStslesIK- 337 Lachancea therm...
Q6CM12       280 LAVHEIKEagfykvy--------------------vkdeidlTGL-KAVIEEKLKSLIKDNDFIYNDLIPADvsiesIK- 337 Kluyveromyces l...
Q74ZJ6       280 KAAASMATanthrkalqg--------------taylrdevdlDGI-SSVVNEKLKTTAKDNDYIYHDHVPSDisldsTK- 343 Eremothecium go...
2OEV_A       341 KATLVKStpvNV----PIS-Q-----KFTDLFEKMVPVSVQQSLAAYNQRKADLV 385
Q4DP85       350 PSGLPRP---LGkateHPGfTtfqskRGEDPFFGIVPAHIASIASKWREKERNLV 401 Trypanosoma cruzi
Q386T1       349 PAGLPRP---LGkateHQSfFafestRENDPLFGIVPAHIASTAAGWRDRQRSLV 400 Trypanosoma brucei
Q9U7F6       329 EVLAAKPie---------------leTIENLFDNILPANLSKALNEYNSKAQVIL 368 Entamoeba histolytica
XP_002173790 345 SKHVLSPihvTQ----MYArNrkdvaSAKDMFRNFTPTALASTSSLCSETAANLV 395 Schizosaccharomyces japonicus yFS275
XP_013022656 342 SLQALPYltlDRl---YSGkEsaksvVGEDLFKAFVPSAITTAISLYSEETAKLY 393 Schizosaccharomyces cryophilus OY26
O13783       346 PLQALPPlplEKlygsQDGfEtakkiVGDDLFKAFVPSAVTTASSLYSEETAKVF 400 Schizosaccharomyces pombe 972h-
XP_002554042 338 SMDAVKMqtlPQq---LDTyMekvtePADALFKGIIPLEVYEKESIYSEQKAALL 389 Lachancea thermotolerans CBS 6340
Q6CM12       338 TMDAVKPvtwEEq---LKVyLeqvvdLCNGAFKGIVPMEVYENESIYSEEKASLL 389 Kluyveromyces lactis NRRL Y-1140
Q74ZJ6       344 LMDAIKVpefDAv---VGPyLeaateTCNDLFRGIVPMAVYERESMYTEEKTQLL 395 Eremothecium gossypii ATCC 10895
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap