2HV6,2IXN,2IXP


Conserved Protein Domain Family
PTPA

?
pfam03095: PTPA (This model is not part of the current CDD release)
Phosphotyrosyl phosphate activator (PTPA) protein
Phosphotyrosyl phosphatase activator (PTPA) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. The specific biological role of PTPA is unknown, Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1.
Statistics
?
PSSM-Id: 515380
Aligned: 244 rows
Threshold Bit Score: 257.394
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2HV6_A        26 PKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTF-E-YRvSEA-----------IEKLVALLNTLDRWI---- 88  human
XP_029341625  43 VCQRVREPRDMFDWERSEARADLLVFVRHMNDVAK-----R-YpAAaAARrrrrprpfddnVDRAMAVLRTVGEWAvkrc 116
ETN57795      17 PEKKIKSAMDMAKWEKSEAYYDLLGFISSMSVALQGTRASQ-N-LEvSPV-----------VEKLMNAIDRLEQLA---- 79 
Q17M03        15 PEKLIKTRADMELWERSEAYYDVFGFISSMCVALQGTKQSQ-P-LElSPI-----------IEKLIEALKRLEQLA---- 77  yellow fever mo...
XP_002027469  30 PKRQVLCLEDMDDWVRSQAYKDTIAYINNTSMAIQGKKL-S-SeFPvSEK-----------VRRLCDIFDGLEILL---- 92 
XP_001966659  27 PVKQVRSLEDLDRWVRSQAFYDTIAYISNTSMAIQGRRL-T-ReFPiSEQ-----------MRKLCQIFDGLEHLL---- 89 
EDW51530      27 PVKQVRSLEDLDRWVRSQAYYDIIAYISNTSKAIQGHRL-T-QaFPvTEQ-----------MRRLGEIFDGLEQLI---- 89 
XP_002073342  33 AVTRVRKLSDVEVWKRSVGYHKLIAYINNTSSVIQGIRQSDdY--PvSET-----------MSRLLTIFDKLENLL---- 95 
Q9VNG7        23 PVCRVQSSSDMEAWLASRAYFTLITYLNDVSAEIQGIRN-T-DlFPiSKN-----------IKRLTTIFEQLDSMI---- 85  fruit fly
XP_001955226  25 PHNRVETPADMEFWQQSKAYVILTTYLFDVSSHVQGVRT-T-DpFPvSRS-----------IKRLLGIFDALDVLI---- 87 
2HV6_A        89 -----DETPPVDQ-P---------SRFGN------------KAYRTWYAKLDEEAENLVATVVPTHLAA--AVPEVAVYL 139 human
XP_029341625 117 gpagqDDRPESAA-----------ERFCH-----------------FHSQLRADGRCLLNRTYGGRGRaeyRDVMLPAYL 168
ETN57795      80 -----VETPPIDQ-P---------ARFGN------------AAFKTWFQKMRSESTQLIADALPETAKE--AVKELQVYF 130
Q17M03        78 -----IETPPVDQ-P---------ARFGN------------IAFRSWFQKMQGETAKLIEQAIPEHLKD--AVPELNVYF 128 yellow fever mo...
XP_002027469  93 -----SENTP---------------KFESahswltaqqgnaNAYRNWMRLMHQFVFSVLDEAVQPECKh---INELGQYL 149
XP_001966659  90 -----VEHSP---------------KSEDydtsisisqvksRAYRVWMRHMFQHVFFKLDEAIKAKCKh---INELGQYL 146
EDW51530      90 -----VEHTP---------------KMEDsnlalpfgqvrsKAYRTWMRQMYQHVFSKLDEAINVNCKh---INELGQYL 146
XP_002073342  96 -----AANPPIYM-AgsikgsldkDRRGN------------PAYRNWSRHMLRDIFPILEQAVSNKNCi--hINELGQYL 155
Q9VNG7        86 -----VANSPAPLvLgan----mdSRT--------------KSYRRWAHGMLRDIYKIVEKAVPSSKCr--hVNELGVYL 140 fruit fly
XP_001955226  88 -----VANPPVVTgEpkt----smTESGN------------RAFRKWARCMLRDIYYMVEKAVPTKKCq--hVNELGQYL 144
2HV6_A       140 KESVGNSTRIDYGTGHEAAFAAFLCCLCKIGvlr-vdDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQ-----GVWGLD 213 human
XP_029341625 169 ERSFGDPVTMAYGPAHELSFCAFLVSLFKLHhlt-waDEPFVVTVIFDKYLDVVDYVIRSYQLYPSSSEyggnlGNWCLS 247
ETN57795     131 EESFGNSTRIDYGTGHELAFVMFLMCLFKIGaie-rkDEVAVGLKLFDKYIILVRKLQVTYRMEPAGSH-----GVWSLD 204
Q17M03       129 QESFGNATRIDYGTGHELSFIMFLMCLFKIGaie-rkDEVAVGLRLFVQYLNFVRKLQVTYRMEPAGSH-----GVWSLD 202 yellow fever mo...
XP_002027469 150 RRSFGCSSSLEFGPGNELMFLFFLCGLFRAGilf-adDTVAAALLLFHRYIRLVRRLILTYSLSLTKD------SRFSMD 222
XP_001966659 147 RRSFGNATSLDFGPGNELMFLFFLCGLFRSGill-akDTVAAALMLFGRYIHLVRRLVTTYALPIAKNP-----RSF-ID 219
EDW51530     147 RRSFGNANTLDFGPANELMFLFFLCGLFRAGill-akDTVAAALMLFNRYVNVVRRLISTYGLTIAKDP-----ACT-IE 219
XP_002073342 156 CESFGNSTRMSYGTGHELSFLFFLCALFEAEild-edDLAASALLLFDRYLKFVRRLQVLYNLYAAGRH-----GAYSLD 229
Q9VNG7       141 SGSFGSSAKIEYGTGHELSFLFFVCALFKAEildkeqDLAASALVLFDRYLHFVRRLQVTYSVNSSNWH-----GGYSLD 215 fruit fly
XP_001955226 145 SSSFGNSTKIEYGTTHELNFLFFVAGLFQARilnkeeDLAASGLILFVRYLKLVRRLQITYSMVPPANH-----GAYSLD 219
2HV6_A       214 DFQFLPFIWGSSQLIDH------------PYl-ePRHFVDEKAV-NENHKDYMFLECILFIT-EMKT-GPFAEHSNQLWN 277 human
XP_029341625 248 GYQFVGFLWGSAQLAGScgdgdgsapdgiPSlssPTAVISDAYAcRRHRDDYVFAKCMDAVYrRARKdVPLWYHSYQLWN 327
ETN57795     205 DFQFVPFIWGSAQLAVN------------SPi-ePAQFVEDKSI-DKYRKELMFVGCIDYIR-QVKT-GHFAEHSNQLWS 268
Q17M03       203 DFQFVPFIWGSAQLAVR------------SPi-ePAQFIEDNII-DVYRKEYMFVSCIDYIR-QVKT-GHFAEHSNQLWS 266 yellow fever mo...
XP_002027469 223 DYYVIPYIWGSAQLSLDa-----------PFs--PMESEMQLIM-EAHRQDYMLLEVIDHLR-KTRG-LQLNQVAFQLWC 286
XP_001966659 220 DYYVLPYLWGAAQLSSEe-----------LFs--PIQCEQPKLI-ENYRQDYMMMELIEHLQ-KTRG-GQLSHVAFQLWC 283
EDW51530     220 DYYFLPYLWGAAQLSLNs-----------PFs--PMQCEQGKIM-DSYRQDYMMLEIIDHLQ-KTRR-GPLSRVALQLWS 283
XP_002073342 230 DFQFVPFLWGCAQLSYN------------APf-vPNRMLDADVV-SEYKKDYMLMGCVGHIS-DTKD-GTFAMHSSQLWC 293
Q9VNG7       216 KFQFVPFVWGFAQLCHEa-----------PFs--PKKMLDEDTI-AKYRDAYMLINCVGHMA-TTNV-GTFARHSSQLWS 279 fruit fly
XP_001955226 220 KFQFIPFIWGAAQLCYDa-----------PFs--PRKMLDEDTV-AKYKNSYLLADCVGHIM-MTNI-GPFAGHSSQLWC 283
2HV6_A       278 ISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPI 317 human
XP_029341625 328 LTALPRWDRVNGCLITAYQRDVLGRFEVIRQLAFCELFKF 367
ETN57795     269 ISAVPQWSKISTGLLKMYQKEVLSKFPVIQHVFFGSILTL 308
Q17M03       267 ISAVPSWAKISTGLIKMYQKEVMSKFPVIQHVYFGSILTL 306 yellow fever mosquito
XP_002027469 287 ILSVPTWPEVYGAIERAYVSNVLSSFETVENAIFCELMSF 326
XP_001966659 284 ILSIPSWSQVYRGLERNYISHVLSSFETVENAIFCELMSF 323
EDW51530     284 ILSIPTWPQVYRGLNRNYVDHVLSSFGTVEQAIFCELMSF 323
XP_002073342 294 IASLSSWNELYGGLLDMYDKVVLRQFDLMQLARFGQLISF 333
Q9VNG7       280 LAALSSWTKIHRSLMFMYMEDILMDIDNLNALRFGELMSF 319 fruit fly
XP_001955226 284 LAALSQWPDIYRGLIFRYTEDIVVDFDLIQPMRFGALMPF 323
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap