Conserved Protein Domain Family
Mlo

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pfam03094: Mlo 
Mlo family
A family of plant integral membrane proteins, first discovered in barley. Mutants lacking wild-type Mlo proteins show broad spectrum resistance to the powdery mildew fungus, and dysregulated cell death control, with spontaneous cell death in response to developmental or abiotic stimuli. Thus wild-type Mlo proteins are thought to be inhibitors of cell death whose deficiency lowers the threshold required to trigger the cascade of events that result in plant cell death. Mlo proteins are localised in the plasma membrane and possess seven transmembrane regions; thus the Mlo family is the only major higher plant family to possess 7 transmembrane domains. It has been suggested that Mlo proteins function as G-protein coupled receptors in plants; however the molecular and biological functions of Mlo proteins remain to be fully determined.
Statistics
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PSSM-Id: 486165
Aligned: 31 rows
Threshold Bit Score: 608.894
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006850616   7 SRSLEETPTWAVAVVCFVMVLVSILIEHAIHLVGKWLTKRHKRALYEALEKIKAELMLLGFISLLLTIGQDT-ISRICIS 85 
EEF29044       9 GTTLEYTPTWVVALVCSVIVVISLAVERLLHYLGKLLKRKQQKPLFEALQKIKEELMLLGFISLLLTVFQGR-INSICIP 87 
7_pfamImport   1 GTSLEYTPTWVVALVCSVIVSISFAVERGLHRAGKHFDKNNQKQLSGALQKVKEELMLLGFISLLLSVSQSR-IAKICIS 79 
O80580         5 GTTLEYTPTWVVALVCSVIVSISFAVERLIHRAGKHFKNNDQKQLFGALQKIKEELMLVGFISLLLSVGQSK-IAKICIS 83  thale cress
XP_002892614   8 GRSLAETPTYSVASVVTVLVFVCFLVERAIYRFGKWLKKTRRKALFTSLEKMKEELMLLGLISLLLSQSARW-ISEICVN 86 
XP_002306989   8 DKTLQNTPTWAVAAVCAVFVIISVLIDHSIHSLGKWFQKRQKKAMSEALEKIKAELMLLGFISLLLTVGTRA-ILKICIP 86 
1_pfamImport   1 ERSLQETPTWALALVCAVFVVISVLIEHVIHSLGKLFQKRRNKAMSEALEKIKAELMLLGFISLLLTVGTKY-IAKICIP 79 
XP_044983060   9 ARELPETPSWAVAVVFAAMVLVSVLMEHGLHKLGHWFQHRHKKALWEALEKMKAELMLVGFISLLLIVTQDPiIAKICIS 88 
XP_002465934   7 GRDLPSTPTWAVAVVCAVIVLVSVAMEHGLHKLGHWFHTRQKKAMREALEKIKAELMLMGFISLLLAVGQTP-ISKICIP 85 
XP_006579025   9 ERSLKETPTWAVAAVCSVFIIISVLIEHGIHSLGKWFQKRHKKAMNEALEKIKSELMLLGFISLLITFGTKY-IAKICIP 87  soybean
XP_006850616  86 KSM-GDSLLPCRKNDQSingGEHVSESGDDdegssNRRLLWLDDFDQphpSLRRVLAGS---KYDKCSpQGKVPLISYDG 161
EEF29044      88 EEM-SKKWLPCKEESETattTT---------------AHFQTFFSFIsggAPQRHLLAEssdSSSSCP-EGKVPILSTTA 150
7_pfamImport  80 KEL-SEKLLPCKKPKEDk-sLNDN-------------SHFQLSFT-------GRHLLAGdsgAGDYCSqKGKAPLMSISA 137
O80580        84 KEL-SEKFLPCTKPAGAeksLKDS-------------SHFQFSFT-------GRHLLAGdapAGDYCSlKGKVPIMSLSA 142 thale cress
XP_002892614  87 SSLfNSKFYICSEEDYGihkK----------------VLLEHTSSTNqssLPHHGMHE----ASHQCG-HGREPFVSYEG 145
XP_002306989  87 EKY-EKIMLPCKNAYGLd-kYEDKSGGKGGeggynKRKLLSFAGNVA----IHRVLAAAggdGGDYCS-KGKVSLISQTG 159
1_pfamImport  80 AKY-GDDMLPCKSGYEEs--YSDKGGDDR------RRKLLSFAGDVI----WRRGLAAAa-gGDDYCAkKGKIPLISQTG 145
XP_044983060  89 EDA-ADVMWPCKRGTE-------------------GRKPSKYV---------------------DYCP-EGKVALMSTGS 126
XP_002465934  86 TKA-GNIMLPCKAQKDDdseSGGDA----------RRRLLWYSPYSGeeyGHHRRFLAGaaaTDDYCDkQGKVSLISTNG 154
XP_006579025  88 VSA-GDIMLPCKKVEVS------DSDDDSNd----RRKLLSFDDNVV---EWRRVLAAAs--GGDYCSqKGKVPLISQSG 151 soybean
XP_006850616 162 THQLHIFIFVLAVFHVLYCISTMALGRLKMKRWKKWEQETKTIEYQWSH-DPERFRFARETSFGRRHL-NFWTKSPILIW 239
EEF29044     151 LHHLHIFIFVLACVHVAFCALTILFGSAKIRQWKHWEDSVTKGEYDQEE---ARLTHVQDHDFIKKRFkGIGKNSYLLGW 227
7_pfamImport 138 LHELHIFIFVLAIAHIIFCLLTILFGTMKIMQWRKWEDKVLEKDYNADEvIQKKYTAVREHDFIRGRFlGVGKADACFGW 217
O80580       143 LHELHIFIFVLAVAHIIFCLLTIVFGTMKIKQWKKWEDKVLEKDFDTDQ-SIKKFTHVQEHEFIRSRFlGVGKADASLGW 221 thale cress
XP_002892614 146 LEQLLRFLFVLGITHVLYSGIAIGLAMSKIYSWRKWEAQAIIMAESDIH-AKKTKVMKRQSTFVFHHAsHPWSNNRFLIW 224
XP_002306989 160 VHQLHIFLFVLAIFHVLYSVITMALGQAKMKKWKAWELETSSLEYQFSN-DSARFRLVHQTSFVKRHS-GI-ATAPGIKW 236
1_pfamImport 146 VHQLHIFIFVLAVFHVLYSVLTIALAQAKMKKWKTWESETSSLEYQFTN-DPSRFRLAHQTSFVKRHS-GI-STAPGIRW 222
XP_044983060 127 LHQLHVFIFVLAVFHVTYSVITIALSRLKMRTWKKWETETTSLEYQFAN-DPARFRFTHQTSFVKRHL-GL-SSTPGIRW 203
XP_002465934 155 VHQLHIFIFVLAVFHISYSVATMALGRLKMRKWKKWELETNSVEYQFAN-DPSRFRFTHQTSFVKRHL-GL-SSTPGVRW 231
XP_006579025 152 VHQLHIFIFVLAVFHIFYSVMTMVLARAKMKKWKAWEAETSSLEYQFTN-DPARFRLAHQTSFVRRHS-GW-SRMPGIRW 228 soybean
XP_006850616 240 IVCFFRQFVRSVPKVDYLTLRHGFIMAHLAPQSStkFDFHKYIKRSLEEDFKVVVGISPIIWFFAVVFLLFNTHGWYSYL 319
EEF29044     228 VHSFFKQFYGSVTKSDYITLRLGFIMTHCRGNPK--FNFHKYMMRALEADFKKVVGISWYLWLFVVIFLLLNVAGWHAYF 305
7_pfamImport 218 VHSFMKQFLASVNESDYITMRLGFVTTHCKTNPK--FNFHKYLIRALNSDFKKVVGISWYLWVFVVLFLLLNIAAWHVYF 295
O80580       222 VQSFMKQFLASVNESDYITMRLGFVTTHCKTNPK--FNFHKYLMRALNSDFKKVVGISWYLWVFVVLFLLLNIVAWHVYF 299 thale cress
XP_002892614 225 MLCFLRQFRGSIRKSDYFALRLGFLTKHNLPFT---YNFHMYMVRTMEDEFHGIVGISWPLWVYAIVCICINVHGLNMYF 301
XP_002306989 237 VVALFRLFTGSVTKVDYMAIRHGFINAHFAPNSK--FDFHKYIKRCMEDEFKVVVGVSMPLWIFAILFLLLNVYKWYTFT 314
1_pfamImport 223 IVAFFRQFFGSVTKVDYLTMRNGFINAHFAPNSK--FDFHKYIKRCMEDDFKVVVGISIPLWVFAIAFLLLNVYKWYTLT 300
XP_044983060 204 VVAFFRQFFRSVTKVDYLTLRAGFINAHLSQNSK--FDFHKYIKRSMEDDFKVVVGISLPLWGVAILTLFLDINGVGTLI 281
XP_002465934 232 IVGFFRQFFASVTKVDYLTMRQGFINYHLSPNAK--FNFQQYIKRSLEDDFKVVVGISLPLWFVAIFILLLDIEGLGTLI 309
XP_006579025 229 IVAFFRQFFGSVTKVDYMTMRHGFINAHFAPDSK--FDFQKYIKRSMEDDFKVVVGISIPLWVFAIVFMLVNVYKWYTLT 306 soybean
XP_006850616 320 WLPFIPLIIILLVGTKLQVVITKMGLKIQDRGDVVKGVPVVQPTDKLFWFNQPRLILYLIHFVLFQNAFQLAFFTWTWYE 399
EEF29044     306 WIAFIPFVLLVAVGAKLEHVITQLAHEVAEKHIAVEGDLVVQPSDDHFWFHRPRIVLILIHIILFQNSFELAFFFWIWVQ 385
7_pfamImport 296 WLAFLPLILLLAVGMKLEHIITDLAHEVAEKHIAVEGDLVVRPSDDLFWFKSPRLVLFLIHFILFQNSFELAFIFFIFAQ 375
O80580       300 WLAFIPLILLLAVGTKLEHIITDLAHEVAEKHIAVEGDLVVRPSDDLFWFQSPRLVLFLIHFILFQNSFEIAYFFFILFQ 379 thale cress
XP_002892614 302 WISFIPAILVMLVGTKLEHVVSKLALEVKEQQTGTSNGAQVKPRDGLFWFGKPEILLRLIQFIIFQNAFEMATFIWFLWG 381
XP_002306989 315 WLAVVPLVILLLVGAKLELVIMEMAQEAQDRSHVVRGAPLVEPNNKYFWFNRPHWILLLIHYTLFQNAFEMAFFLWTWYE 394
1_pfamImport 301 WLTIVPLIILLMVGTKLELVIIEMAEQIQERSTVVRGAPVVEPNNKYFWFNRPQWILLLIHYTLFQNAFQMAFFLWTWYE 380
XP_044983060 282 WISFIPLVILLCVGTKLEMIIMEMALEIQDRASVIKGAPVVEPSNKFFWFHRPDWVLFFIHLTLFQNAFQMAHFVWTVAT 361
XP_002465934 310 WISFVPLVILLLVGTKLEVVIMEMANEIQDKATVIKGAPAVEPSDRFFWFNRPRWVLFLIHLTLFQNAFQMAHFVWTLLT 389
XP_006579025 307 WLSLAPLVILLLVGTKLELIIMEMAQQIQDRATIVRGVPIVEPNNKYFWFNRPQWIIFLIHFTLFENAFQIAFFLWTWYE 386 soybean
XP_006850616 400 FGLRSCFHKHLEDVIIRISMGVLIQFLCSYVTLPLYALVTQMGSNMKTTVFDDRVAAALRKWHHTAKKHIK-EGRKSASV 478
EEF29044     386 YGFDSCIMEEVGYLIPRLIIGVFIQFVCSYSTLPLYAIVTQMGSSFKKAIFDEHIQTGLVGWAKQVKKKMVlRKAANGS- 464
7_pfamImport 376 YGFDSCIMGQVKFIIPRLVIGVLVQLLCSYSTLPLYALVAQMGSSFKGAIFTDQAQQQIAGWAKSAK-----MAKKKGS- 449
O80580       380 FGWDSCIMDHVKFVIPRLVIGVIIQLLCSYSTLPLYALVTQMGSSFKGAIFNEQTQEHLVGWAKMAK-----RGVKKGA- 453 thale cress
XP_002892614 382 IKERSCFMKNHVMISSRLISGVLVQFWCSYGTVPLNVIVTQMGSRHKKAVIAESVRDSLHSWCKRVKERSK-HTRSVCSL 460
XP_002306989 395 FGIKSCFHENLALILTRVFLGLILQFVCSYITFPLYSLVTQMGSHMKKGIFEEQTAKALRKWQMAAKLRNK-SRKTAGDQ 473
1_pfamImport 381 FGLKSCFHENLAAILARVFLGVALQFVCSYITFPLYCLVTQMGSHMKKAIFEEQTTKALRKWQKAAKERKK-SRKAGGGg 459
XP_044983060 362 PGLKKCYHTQIGLSIMKVVVGLALQFLCSYMTFPLYALVTQMGSNMKRSIFDEQTSKALTNWRNTAKEKKK-VRDTDMLM 440
XP_002465934 390 PDLKKCYHEQMGLTIMKVVVGVALQVLCSYITFPLYALVTQMGSHMKKTIFEEQTAKAVMKWRKTAKDNVK-QREAKGYL 468
XP_006579025 387 FKITSCFHENLPLILTRVVLGIALQVVCSYITFPLYSLVTQMGSHMKKTIFEEQTAKALKKWQKAAKDKRK-LRKAGIDI 465 soybean
XP_006850616 479 --------TP--FSSRPGTPLhpsaggEGLSPVHLL--RHYK 508
EEF29044     465 --------TQ--VSKKED----------SPGSVQLS--HAGS 484
7_pfamImport 450 --------TH--AGSSHGG-SpnpiatPSPKSIQLQ--SLLV 478
O80580       454 --------TQ--VGTSHDATSpr-------pSIQLN--SLLG 476 thale cress
XP_002892614 461 dtatiderDEmtVGTLSRSSSmtslnqITINSIDqaesifga 502
XP_002306989 474 ag-----gSSlgFMSSEMTPS------QGASPVHLL--HKYR 502
1_pfamImport 460 g------sSPgfMSVESTTPS------QGASPIHLLhgHKYR 489
XP_044983060 441 aqmi-gdaTP--SRGSSPMPS------RGSSPVHLL--HKGM 471
XP_002465934 469 dglmsadtTP--SHSRATSPS------RGNSPVHLL--HKYK 500
XP_006579025 466 ---------PsgTMSGETTPS------QGTSPLHLL--HKYK 490 soybean
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