7PP2,2B1E,2PFT


Conserved Protein Domain Family
Exo70_C

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pfam03081: Exo70_C (This model is not part of the current CDD release)
Exo70 exocyst complex subunit C-terminal
The Exo70 protein is a subunit of the exocyst complex, first identified in yeast, it is evolutionarily conserved. It mediates the tethering of post-Golgi secretory vesicles to the plasma membrane and promotes the assembly of the SNARE complex for membrane fusion. It also plays a role in cell polarisation, primary ciliogenesis, cytokinesis, pathogen invasion, tumourigenesis and metastasis. It is a member of the the Complex Associated with Tethering Containing Helical Rods (CATCHRs) family which also includes Conserved Oligomeric Golgi complex (COG) and Golgi-Associated Retrograde Protein complex (GARP) and DSL1 complexes, all evolutionarily related and share structural features consisting of alpha-helical bundles at the C-terminus and coiled-coil region at the N-terminus. Exo70 interacts with phospholipids and Rho3 GTPase. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicle from the mother cell to the bud). This is the C-terminal domain of Exo70, which consists of alpha-helical bundles involved in binding the small GTPase Rho3 and it is important for localization to the plasma membrane as it directly interacts with phosphatidylinositol 4,5-biphosphate The interaction with phospholipids is essential for the membrane association of the exocyst complex.
Statistics
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PSSM-Id: 515374
Aligned: 233 rows
Threshold Bit Score: 137.417
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7PP2_A       218 KKWVQAVKTVVRVLLAGERRLCDQVLsvs---deLREECFIESTKGCI---M--QI-LS-FGD--AVAv-C----PR--S 278 Asian cultivate...
XP_001384975 218 SNGITSFTTTFMNVIENELRLLKELNl-------PRSEVVGPIVERSVgeiYnhGI-INrFSHf-FNSssA--------I 280
Q5AH25       230 TNGITKYTDVLSGEIEQELIILNECQ--------LSTHLIGPIVEESIsryN--GI-INkYNQvyFKTpqE--------I 290 Candida albican...
EMG45898     209 SNGITKYTDVFLTEIHDELELLNVCE--------LSPKLLDAITQEPMfkyN--EI-ITrYNQf-FDApsV--------I 268
XP_002550757 215 SNGITQYTDIMINEVGQEVNLLRSCN--------LPVTFIGTIIEEQIfkyN--EI-IMkYNQv-FSSpsL--------I 274
XP_036664317 213 TKGYNQFTDATDNVLKEEVLVLKQCS--------LPPELIAQISEYAIreyN--QV-MQsLAT--RLStsLg------aS 273
CCE82415     212 SNGINRYTNELIRELKAQNSRLQDIGneigmtngTRKQLLRDIAIKGVedsY--SGvLAeFQR--FFSgsE--------I 279
XP_001485876 208 TNGINRYNNELIELIKLEIALAAEINqni---aiDHHKIVSSIVARVVndsY--TSvVDtLNE--FVSsqG--------V 272
XP_001523290 213 QFKYNKFTEVVDQALHNEYSVLKQCS--------LSTSFINPISEYAIteyN--QT-IIsLSQ--QLQsqQqvtaQEntR 279
EEQ38197     216 SSGIEKYTEKLLLYAKSVSTVCEELRv-------SGSPILSNTLCGYLdnrL--TPiLIrYNT--SLDqsG--------P 276 Clavispora lusi...
7PP2_A       279 PEKLSRILDMYEALAEVIPEMKDLCLGssgdgvISDVQANLDRLGDAIRGTLFEFGKVLQLESSR--RAM-TAGEIHPMT 355 Asian cultivate...
XP_001384975 281 IQNDILLLEFIDNLLQFQEFLRKNGVS------NKEFDNSIALFITKSSVLFKEYIKLIELR--FqnTEKiTEINIPQII 352
Q5AH25       291 VDNVILILEVLNNLIDFKVKLKQIGLNrt--leQSNFINTFEQYLETNSVIFKEFIQAIDNR--FqnLGKfNEINTQEVI 366 Candida albican...
EMG45898     269 TENIVLILEILDNLQRFKFELNKFNIN------NHEFNKSLSIYVYQNSVIFKEFIKSVVNR--YnnVSKiTENNSQEIV 340
XP_002550757 275 IDNIVLILEILDNLNKFKYNLHKNGIS------NEEFNKTMGLFVQQNSVIFEEFILSVSKR--FnnLPKfTENSTQEVI 346
XP_036664317 274 NDNYLILLEIIDNLLRVDYQLKHRYVVk-----STSFSKIFDQFIAIGSSIFPNCIRSIESQ--FqhIIQfNDSTTFGAT 346
CCE82415     280 VSNDTLMLEVIENVSHFEKFLEVSGLSge---yFAKFNENYHRLIEGGQVLFRELIEQAESR-VKaaEHRlTDLTVTEIV 355
XP_001485876 273 LDNDIMLLEVIENLDHFSKFMVASNLSpa---tMDRFNDAYGRLTQSSRNIFGELMKWVDAR--VtsVEKyNDKTIAEIT 347
XP_001523290 280 NKSIFVTLEVLDNLLLLESSLKSLQVK------SVGFDRSLRSFLELGSEIFPKFYREVDAKCSS--LPQyTESNTSQMT 351
EEQ38197     277 LTYDIATLELLDSLVHMDAALTKYKCSfa---aCASVTKEYGKLRNKASSLLIEWVKYVDAR--VsqVERfNEFSIPEVI 351 Clavispora lusi...
7PP2_A       356 RYVMNYLRLLVVYSDTLD---ALLDDNADDQI-------------D----LARAEDQDQEHLESMT-PLGKRLLKLISYL 414 Asian cultivate...
XP_001384975 353 VDLFSRIRRISEFPHALLsliSTYKLGDWLIVkpp-------vkfIt--vYTSVIPNTANDESAEY-HLSSFFSDIIDSI 422
Q5AH25       367 VELMSKLRRLSEFKLALLqliKNYSIGQWLVSqppmrfvnvfssvIpnsqPQANSDGEEDEVIQEY-LLSSFYSDVIDAI 445 Candida albican...
EMG45898     341 VDIMSKLRKISEFRNSLLeliKNFALGDWVNDqqf--------isTf---SSVILDSNNGKPDSEY-LLSSFYSDVIDAI 408
XP_002550757 347 VEIMSKLRKLSEFKAGLLqliKNHQLGDWVKSaqf--------akVf---SSVIINTNVDTSTPDF-LLSSFYSDVIDDI 414
XP_036664317 347 SNSMIQAKKMAEFKQPLLqliQTRKPGDWISEsppl------qyiAv--fNSIIINTTFDDKSPEF-LLSSYFADIIDCV 417
CCE82415     356 VEQISKMRKLCEYGDSLKvlmSGMKLGSWLNTrppa-----rfigVyt-sVIPNINDEIDESSPDY-LISCFVSDYIDCL 428
XP_001485876 348 VEIILRVRRVLEYPLSLLdliQGINLGSWLTGlkf--------vlVy---TSVVSNNGVIDDSPET-LLSSYFSDIIDCV 415
XP_001523290 352 VEIASVMRRMSEFRQPLLesiSMLSQSDWKSEqynta---tytkpHsk-nSTTSTINDTNSTTPES-LLSLYFTDIIERI 426
EEQ38197     352 VDVISKIRRICEF-NSLQlliEGKKLGSWLDIkppl------rfiSv--yTSVIPGAEASAEDLNKfLASSYISDLIDEL 422 Clavispora lusi...
7PP2_A       415 EANLEEK----SKLy----------------------------EDSALECIFSMNNLLYIVQKVRDS-ELGKILGDHWVK 461 Asian cultivate...
XP_001384975 423 TINIEIG----LKNne-------------------------anYKKSTQGFHLIKNVVMIETILNRSeTLHKSLGNLGME 473
Q5AH25       446 MINIEIG----LKKntsggdslpsssstsastnatsgtsslslNKKSTQGFILIKNLFMLESIVNRSqYLYQSLGSLGEE 521 Candida albican...
EMG45898     409 MVNLEIA----LKNasd------------------------psYKKSTQGFILIKNLFMLDSIIKRSkELFNSLGKLGER 460
XP_002550757 415 MVSIELG----LKMdq--------------------------tMKKSTQGFILVKNLFMLESIVNRSqDLFNSLGPLGME 464
XP_036664317 418 MINIEIG----LKKphg-----------------------ehaMKKSTQGFILLRNLFIAEQIINRSqDLFHMLGSNGQE 470
CCE82415     429 MINLEVG----LKQdv--------------------------nTKKSTQGYYLVKNLVMIETIINRTqSFYRILGNVGLE 478
XP_001485876 416 MINIEIG----LRSd---------------------------dSKKSTQGYLLIKNLVLIETIINRShQLFDTLSTIGMD 464
XP_001523290 427 MLDLQDGlangSKHptpalstsyp---------sstgennnqkMKRPAQAFILLKNLFYIENFVNRS-ELYNVLGSKGQD 496
EEQ38197     423 MVNIEIN----LKEqtg-----------------------dnsLRKSSQGFLLIKNLVMIETIINRSeSFYQQLGQIGLE 475 Clavispora lusi...
7PP2_A       462 RRNGKIRQYSKSYlRISWMKVLSFLKDDghgsgsGSSS----------------------------G---------SGSG 504 Asian cultivate...
XP_001384975 474 RLNKLKNRFLKLF-LDDWNYASYIIIRD------MTTIatshaha---------------aggqgpStg-----gsSGHL 526
Q5AH25       522 RILRLKNRFLKLF-LDDWSHASYIIIRD------MTTIatqsaqhqq----------sqqqssntiGtgg----gtVTNL 580 Candida albican...
EMG45898     461 RIEKLRTRFLKLF-LEDWNHASFIIIRG------MTDIatqmaqs--------------qnnttagTgg-----gpVSNL 514
XP_002550757 465 RIGKLKNRFLKLF-LEDWNHASFIIIRD------MTNIvsqsaiag-------------sssgttsGtgg----gpVSNL 520
XP_036664317 471 RINKLKNRFLKLF-LEDWSYASYIIIER------MTLIatqagsgs-------------vnpntsiGtgg----gqATNL 526
CCE82415     479 RLTKLKKRFLKLF-LDDWNYASYIIIRD------MTTIttsnavsghs---------negggitsgLglg---hssHGNM 539
XP_001485876 465 RLARLKNRFLKLF-LDDWNYASYIIIRD------MTNItttnai----------------ahgamlPrs------sSLGL 515
XP_001523290 497 KIKQLRERFTKIF-LEDWSFASFSIIQG------MSDVaklsgqvtftnieaptagastnnyasanTsmastsmsnTNNL 569
EEQ38197     476 RLQRLKNRFLKLF-LDDWNYASYIIIRD------MTQIttt-----------------------naMn--------GGQH 517 Clavispora lusi...
7PP2_A       505 HSSSRMsIKEKFKNFNLAFEEIYRNQTTWKVPDPQLREELKISISENVIPAYRAFLGRYGsqvDGGRNSGKYIKYTPEDL 584 Asian cultivate...
XP_001384975 527 SNKEKEqIKDLFKNFNDSFEDAIRNYEKYNITDVNLRNYLSNEIKKLIINAYFKLYDKYGn-sDFTKNKSKYVKYDKQQF 605
Q5AH25       581 SNKEKDqVKDLFKNFNESFEEALFNYQKYNFGDAILKKYLSNEIKKLILNTYFKLYDKYGn-sDFTKNKSKYVKYDKLNF 659 Candida albican...
EMG45898     515 SSKEREsVKELFKNFNESFEEALLNYTRYNFGDMGLKNFLGGEVKKLIANTYFKLYDKYGt-sDFTKNKSKYVKYDKIQF 593
XP_002550757 521 SNKEREqVKELFKNFNESFEQALATYSRYNFGDVGLKRYLGNEVKKLVMNAYFKLYDKYGt-sDFTKNKSKYVKYDKIEF 599
XP_036664317 527 SNKEREqVKELFKKFNDSFEEALTNYRALDFGDSNLKSFLGNEVKKMILNAYFKLYDKYGn-sDFTKNRSKYVRWDKLQF 605
CCE82415     540 SSKEKEqVKELFRNFNESFEEALRNYDKHNITDANLRNYLATEIKKLIINAYFKLYDKYGe-sDFTKNRAKYVKYDKRSF 618
XP_001485876 516 SSKEKEqVKELFRKFNESFEEALQNYEKFNISDPNLRNYLSNEIKKLTVNAYFKLYEKYGt-sDFTKNRSKYIKWDKHQF 594
XP_001523290 570 SSKEKEqIKELFKKFNQAFEDALSLYQTFHFGEPTFQKQMANEVKKMVLNAYFKLYDKYGn-aDFTRNRSKYVKWNRQEF 648
EEQ38197     518 STKEREqTKELFKNFNESFEEALKQYEKFNIQEKDLKVYLSGEIKKLIINAYNKLYDKYGn-gEFTKNRAKYIKYDKSQF 596 Clavispora lusi...
7PP2_A       585 ESQLSD 590 Asian cultivated rice
XP_001384975 606 ERILNE 611
Q5AH25       660 EKLLNE 665 Candida albicans SC5314
EMG45898     594 QKLLDE 599
XP_002550757 600 EKLLNE 605
XP_036664317 606 ERLLNE 611
CCE82415     619 ERILNE 624
XP_001485876 595 EQVLNE 600
XP_001523290 649 EKLLND 654
EEQ38197     597 ERLLNE 602 Clavispora lusitaniae ATCC 42720
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