Conserved Protein Domain Family
Neprosin

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pfam03080: Neprosin (This model is not part of the current CDD release)
Neprosin
Pitcher plants are insectivorous and secrete a digestive fluid into the pitcher. This fluid contains a mixture of enzymes including peptidases. One of these is neprosin, characterized from the pitcher plant Nepenthes ventrata. This peptidase is of unknown catalytic type and is unaffected by standard peptidase inhibitors. Unusually, activity is directed towards prolyl bonds, but unlike most peptidase that cleave after proline, there is no restriction on sequence length or position of the proline residue. The peptidase is secreted and is presumed to possess an N-terminal activation peptide. The neprosin domain corresponds to the mature peptidase. It is not known if other proteins with this domain are peptidases.
Statistics
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PSSM-Id: 515373
Aligned: 146 rows
Threshold Bit Score: 85.3845
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERN06117     100 PNEFSLSQIWV-L-SGp-Ye-------eLNSVEAGWMAYPDVNGDNHTRIFTYWTGdGYKhtG----CYNHLCPGFIQTS 165
XP_007811872 153 DGDFSLLQVAV---VHerAdqpngaakqDQTVEAGWTNYPVL-HKGGPILFAFYTTnGYRgqAdyvgGYNFKVKGWFQQD 228
XP_006674769 157 QQEFSLVQTAI---VRyeAktve-fgtiPQSLEAGWMYYPP--RGPKPMFFVFFNTnGYHgvGdymcGWNTEQKGWVQVD 230
XP_008599201 158 QSDFSLIQTAM---VRwyAktte-lgtvTQSLEAGWMYYPP--RGPKPMFFVFFNTnGYQgsSdymcGWNTEVKGWVQVD 231
XP_001884090 237 VGDFSLSQQWY-VgGSgaN---------LQTVEGGWVVYPGKFKTKNAVLFIFYTAdNYKtkK----CWNLDCAAFVQTN 302
XP_001882591 224 VGDFSLSQQWY-VgGSgaS---------LQTAEGGWVVYPQHF-STQAVLFIFWTPdDYt-tG----CYNLECKAFVQIS 287
XP_001886457 226 VGDFSISQQWY-VgGSgaS---------TQTVEGGWIVYPQKF-SAQAVLFIFYTPdDYs-tG----CYNLECKGFVQIN 289
WP_012590133 230 SQIFSLSQHWY-V-GGngAg--------LQTAETGWQVYPKFYNTPKPVFFIYWTAdGYTntG----CYNLTCAAFVQTN 295 Methylocella si...
CCA89892     156 DQIFSLCQHWY-S-AGagAa--------HQTVEVGWQVYPAKYGHSQPVLFIYWTAdNYGpsG----AYNLDKAGFVQTN 221
Q7NKY2       180 KKDASLTQLATlSsDGgnV------------VEIGWQVDEEVYLDKQIYLYAARYv-----kGaflpAINTS-SGYKPIS 241 Gloeobacter vio...
ERN06117     166 RD-IALGAKIVpISSYGg---nQYHIIILIYKDPKTANWWMIYK-----DEpVGYWPSSLFTs-------lARS-ANSIE 228
XP_007811872 229 RE-IYPGMPISaFSVEGgk-qeEIEIRYKLF----NNCWWLYTMg----RY-IGCYPTSLFAregvnpkntLATsATNIL 297
XP_006674769 231 DS-IYPGMSFEhMSVIGge-qhDFDVHFHLS----GGRWWLKAFg----KD-IGYYSADLFSkksk-kedtLASyGDRID 298
XP_008599201 232 DS-IFPGMSFEhMSVIGge-qhDFDVKFHLD----DGKWWLKAFg----KD-IGYYPAELFSkksn-aedtLAAyGDVIN 299
XP_001884090 303 KN-WFLGRGFThYSAFGgg-qwGFEMQWKLV----GGNWWLYLKgp-gaYEaVGYYPTKIFGsg------qLSKsAEVVE 369
XP_001882591 288 NK-WNLGGTFDqYSVTGdg-qrGFDLQYKLF----QGNWWLFLRgssanYDaVGYYPGSIYNkg------qLTKnAELVE 355
XP_001886457 290 NN-WQLGGTFGqYSVTGgv-qkGVDLQWYFY----QGNWWLYLRga-gaYDaVGYYPGSIYNgg------qLTKsAQLIE 356
WP_012590133 296 NS-WAVGGALKpWSTSPk---kQVVLELSYF--LFQGRWWLYVNgt-aaANaIGYYPATLYKgg------aMSVgAQEID 362 Methylocella si...
CCA89892     222 SD-WTIGGTLSpVGSGGg---qQYEIEIAFY--LNGGNWWLYLGgl-saQHaVGYYPASLFNgg------aMASnATKAL 288
Q7NKY2       242 GApVT----IAq--ELTgggnaSFAIAHKAASGSLPARWALSYNg----TE-FGYFPDTVWSg--------SFTqGAIVG 302 Gloeobacter vio...
ERN06117     229 WGGEVTDLqtdGKHTTTQMGSGHWPSEGWKK---AAFISNLQi-----------Vdg---snYLRRPEGLKTIAE-K-EE 289
XP_007811872 298 LYGEVYNTg--ERLTTTDMGTGRHASEGWKY---AASMRVMKw-----------Vdtn-gqeHDWS-GFVH--AD-D-PA 355
XP_006674769 299 FYGEVYNSg--PALTTTDMGSGNFPEAGDGK---VGYVKNMVy-----------Ldg-----dgKQQMYSGYTQEsD-AS 356
XP_008599201 300 FFGEVYNSg--SELTNTDMGSGNFPEAGDGK---VAYVKNMVy-----------Ldg----dgNEQMFTDGYIQEsD-RT 358
XP_001884090 370 YGGEVTRDs--ADHRWPQMGSSIFPSYGFGQ---SAFQRTIYytardepg------------gvgvwtnLQKLVIgS-NK 431
XP_001882591 356 YGGEVTRFt--TADVWPQMGSGMFPSKGYSQ---AAFQNTIYynprdesd------------gvgvwsfLTKVVVgS-HS 417
XP_001886457 357 YGGEVLRFt--TAVAWPQMGSGMFPDKGFEQ---AAYQNAIFysppdvngsaspTvw----------sdLTKAVIgS-RS 420
WP_012590133 363 YGGEVVg----TK-SWPPMGSGKFASLGFGK---AAYQSDIYyfpp-----agaNvpanltvSQDWPWAY---TG-S-FS 424 Methylocella si...
CCA89892     289 FGGETVCGa--AG-PWPEMGSGAFSGAIYPH---AAWQRAVFvmpk-----sggAqwasltgQSPSPGCYDQFIG-S-YT 355
Q7NKY2       303 AQGEVISPr--GKGTCTDMGNGVL---GNSTsatPAKFTNLA-----------------------------YLKTgSgTA 348 Gloeobacter vio...
ERN06117     290 CYS-VQIGGQGGk------nWGDF----MYYGGP 312
XP_007811872 356 RYSiMPRFQSGWq------gWHSH----MFLGGP 379
XP_006674769 357 RYRiKTFFNSGTs-------WDSY----VYLGGP 379
XP_008599201 359 RYRiKPFWNSGTt-------WKSY----IYLGGP 381
XP_001884090 432 CWDiNITQAAQGg------sWGTY----FFFGGP 455
XP_001882591 418 CWDiNITESAQGg------gWGTF----FFFGGP 441
XP_001886457 421 CWDiNITESAQGg------dWGTF----FFFGGP 444
WP_012590133 425 YLNs---------------pNFST----LFFGGP 439 Methylocella silvestris
CCA89892     356 a------------------pWNIT----LFYGGP 367
Q7NKY2       349 AYPpDIFEPPSVssqytfggQSSGslsqFGFGGP 382 Gloeobacter violaceus
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