Conserved Protein Domain Family
GCS

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pfam03074: GCS (This model is not part of the current CDD release)
Glutamate-cysteine ligase
This family represents the catalytic subunit of glutamate-cysteine ligase (E.C. 6.3.2.2), also known as gamma-glutamylcysteine synthetase (GCS). This enzyme catalyzes the rate limiting step in the biosynthesis of glutathione. The eukaryotic enzyme is a dimer of a heavy chain and a light chain with all the catalytic activity exhibited by the heavy chain (this family).
Statistics
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PSSM-Id: 515372
Aligned: 91 rows
Threshold Bit Score: 416.548
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEQ41744     243 VYMDSMGFGMGSSCLQVTMQAANMAQARYLYDALAPLTPVMLAVSAAAPIFKG-FLVDQDVRWNVISGAVDDRTFAERDE 321
8_pfamImport   1 IYMDAMGFGMGNCCLQVLAQVC-VSALKSIFMKSNGCIPVILSSSSAGPGYSGiWVTSFTFFWPVLTRVKNLKKIKEKGA 79 
EDO46274     238 IYLDAMGFGMGCSCLQMTFQACSIEEGRHLYDQLAAVTPIVMALSAGTPVFRG-YLGDLDCRWSVIAGSVDDRTPEERGL 316
XP_002114199 235 IYLDAMGHGMGCSCLQVTFQACSIDEARLLYDQLCPICPIVLALSAASPIYRG-FLADVDCRWNIIVGSVDDRTKEERGL 313
XP_001605407 239 VYMDAMGFGMGCCCLQLTFQACNIEEARTLYDQLTPLCPIMLALTAASPFYRG-YVTDVDCRWNVISCSVDCRTEEERGL 317
XP_002425007 239 VYMDAMGFGMGCCCLQLTFQACNIQEARTLYDQLTPLCPIMLALTAASPFYRG-KICDVDCRWNVISESVDCRTPEERGL 317
XP_966349    232 VYMDAMGFGMGCCCLQLTFQACNITEARTLYDQLTPLCPIMLALTAASPLHRG-FVTDVDCRWNVISCSVDCRTKEERGL 310
XP_038118758 230 VHMDAMGFGMGCCCLQLTFQACNITEARTLYDQLTPMCPIMLALTAASPAYRG-YLTDVDCRWNVISASVDCRTREEKGE 308
1_pfamImport   1 VYMDAMAFGMGCCCLQMTFQACCIKEARTLYDQLTPLCPILLALTAASPVFRG-YLTDVDCRWNVISGSVDCRTRQERGL 79 
XP_015792538 241 VYMDAMGFGMGCCCLQVTFQASNLDEARILYDQLTPLCPIMMALSAASPIQRG-YLCDLDCRWSVISQAVDDRTKEELGE 319
EEQ41744     322 EPyagyeffggldvpeeVKShfqalgggrglngdavvnkfgdtgvktvdgrsvqK-IPKSRYDSIDSYLgdeayrreGFF 400
8_pfamImport  80 SCy--------------LRN----------------------------------NfHKSAQFPPVNLFS--------GTL 103
EDO46274     317 KP---------------LKEn--------------------------------rFvIPKSRYDSISCYL--------SPE 341
XP_002114199 314 EP---------------LKNn--------------------------------kHrIPKSRYDSVDYYL--------CPE 338
XP_001605407 318 KP---------------LKEn--------------------------------kFkISKSRYDSIDSYL--------SEQ 342
XP_002425007 318 VP---------------LKNn--------------------------------rFvIPKSRYDSIDSYL--------SEH 342
XP_966349    311 AP---------------LKNd--------------------------------kFvIKKSRYDSIDSYL--------SPQ 335
XP_038118758 309 IP---------------LKNd--------------------------------rFrINKSRYDSIDSYL--------SPA 333
1_pfamImport  80 EP---------------LTTd--------------------------------kFvIPKSRYDSTTLYL--------SSQ 104
XP_015792538 320 EP---------------MKFc--------------------------------kFrINKSRYDSIDSYI--------SAD 344
EEQ41744     401 RPAYNDINSPLNGAV--YERLVSEKFDEPLARHFAHLFVRDPLVIFNERVAQDNLSDNDHFENIQSTNWQTLRFKPPAly 478
8_pfamImport 104 ATAYYALNWVLDKRLrqFQAVRQQ-VEGLVPGPVDHTSVYAPVAQILKI-KLSDLGSQS---GIQPSRWQR--------- 169
EDO46274     342 GTKYNDIELVMDQEI--YQQLVENGIDDALARHYAHLFIRDPMTLFKEHVDEDDEQYSDHFENIQSTNWQTMRFKPPP-- 417
XP_002114199 339 GQAYNDIELVYDKEF--CEQLEKAGVDSILAHHVAHLFIREPVSVFKELLEQDDVKDSDHFENIQSTNWQTMRFKPPP-- 414
XP_001605407 343 GDRYNDVPLTYDKDI--YKQLLDNGIDKLLAQHIAHLFIRDTVSLFSEKVHQNDLEDTDHFENIQSTNWQTMRFKPPP-- 418
XP_002425007 343 GRHYNDVPLIYDEAI--YKRLRDADIDDLLAQHIAHLFIRDTVSLFSERIHQNDNEDSDHFENIQSTNWQTMRFKPPP-- 418
XP_966349    336 GEKFNDVPLIYDPKI--YQQLVDNDIDHLLAQHIAHLFIRDSVSLFSEKINQNDEEDTDHFENIQSTNWQTMRFKPPP-- 411
XP_038118758 334 GEKYNDVPLVMDEAL--YKRLREGDIDHLLAQHIAHLFIRDSVSLFSEKVHQNDKEDTDHFENIQSTNWQTMRFKPPP-- 409
1_pfamImport 105 GEKFNDVPLVYDETI--YNKLKSADIDHQMAQHVAHLFIRDTVSLFNEKVHQDDTVEMDHFENIQSTNWQTMRFKPPP-- 180
XP_015792538 345 GDKYNDIPLIYDQVY--YDKMVKSGVDPLIAKHIAHLFIRDPVTLYREKLDQDDENDMDHFENIQSTNWQTMRFKPPP-- 420
EEQ41744     479 kdatPEelARtPG-----WRVEFRPLEIQLTDFE--NAAFSVFIALAGAAILAYNPDWYIPISKIDANMKTAHKVDAATK 551
8_pfamImport 170 --------NEkLKhgkllWKVQC------LCNLElkNSLYQKFQVILT------KLDRLLGLK-VDENMKVAQKRDAVLQ 228
EDO46274     418 ----PN--SP-IG-----WRVEFRPTEVQLTDFE--NAAFVTFIVLLSRVILSFDLNLLMPISKVDANMQTGQMRDAVRQ 483
XP_002114199 415 ----PN--SD-IG-----WRVEFRPCEVQLTEFE--NAAFAAFIVLLTRVILTYGLNFYMPMSKVDENMQTAQKRDAVRN 480
XP_001605407 419 ----SN--SS-IG-----WRVEFRPCEVQITDFE--NAAIVCFVVLLTRVILSYKLNLLIPISKVDENMARAQKRDAVKT 484
XP_002425007 419 ----FN--SS-IG-----WRVEFRPCEVQITDME--NAAIVCFVVLLTRVILSYQLNFIIPISKVDENMQKAQRRNALRE 484
XP_966349    412 ----PN--ST-IG-----WRVEFRPCEVQITDFE--NAAIVCFVVLLTRVILSYNLDFLIPISRVDENMQNAQKRNACME 477
XP_038118758 410 ----PN--SP-IG-----WRVEFRPCEAQLTDFE--NAAIVCFVVLLTRVILSYQLDFLIPISKVDENMQTSQKRGAVLT 475
1_pfamImport 181 ----PK--ST-IG-----WRVEFRPCEVQLTDFE--NAAIVCFVVLLTRVILSYQLNFLIPISKVDENMSKAQKRSAALT 246
XP_015792538 421 ----PS--SPgIG-----WRVEFRPMEVQITEFE--NAALVVFIVLLTRIILTYRLNLLLPISKVDENMKEAQKRDAVQR 487
EEQ41744     552 EKFWFRNpttcglrnddfkaydlswfdRFTTPGNDASAAYTNGyvtq----------devSSNVTDVKMTANEIVNGT-- 619
8_pfamImport 229 GMFYFRK--------------------DICKGGNAVVDGCGKAqqsa---------elaaEEHEEYALMSIDTIINGKe- 278
EDO46274     484 GKFYFRK--------------------TLKNCKPICAGKPCRPggfn---------gmecIPCDELNQMSIDAIINGKnd 534
XP_002114199 481 GMFYFRK--------------------DLGKGKRFRITTYLNNs---------------pPDESEYELMSINTIINGKa- 524
XP_001605407 485 EKFWFRR--------------------DITCNTQQGDIKD------------------------EYTEYTIDEIVNGKe- 519
XP_002425007 485 QLFWFRK--------------------DILTCVSPPEAASRCKn----------------TSGDIYQPMSINHIINGKe- 527
XP_966349    478 QKFWFRK--------------------EVTTQISPPEANECCKkgtt---------ncepKNCDVYTCMTVNEIINGKd- 527
XP_038118758 476 EKFWFKK--------------------NINGAKENNHSNESNG------------------LDAEYELMTIDQIINGK-- 515
1_pfamImport 247 EKFWFRK--------------------NIAASTSKTANVNVNSs----------------NDDASYTQMSINEIINGKt- 289
XP_015792538 488 CRFWFRK--------------------RIITQTSPPEASACLRaastndikncdediidnDIDESCVLLTIDEIINGKs- 546
EEQ41744     620 -DSFPGLIRMIVRYVAA---ELapkakvSELVTLQSYLQLVSMRAAGKIPTTARFLRNFVLDHPAYQRDSKVSDAINYDL 695
8_pfamImport 279 -GVFPGLIPILNCYLENmevDV------DTRCSILNYLKLIKKRASGELMTVAKWMREFIANHPDYKQDSVITDQINYSL 351
EDO46274     535 eGEFPGLIPLINKYLSDvdvDI------DTRCTISQYLKLISRRASGELMTTARWMREFIQSHPDYKHDSVVSERINYDL 608
XP_002114199 525 -DGFPGLVPLINDYLASlsiDF------NTRCSLYRYLSLIQKRASGELKTTAKWMRDFVASHPDYKKDSVVSEKINYDL 597
XP_001605407 520 -GTFPGLIPLVNSYLSSmdaDA------DTHCTIQRYIKLIQRRASGELLTTAKWLRQEVLTHPEYKQDSRISQRINYDL 592
XP_002425007 528 -GVFPGLIPLINGYLSGmdvDA------DTHCTIQQYLKLIQRRASGELKTTAAYLRDYVANHPDYKKDSNISEKINYDL 600
XP_966349    528 -GEFPGLIPLINTYLSGmdvDA------DTHCTIQQYLKFIQRRASGEILTTASWLRKFVTEHPSYNKDSKVTEEINYDL 600
XP_038118758 516 -GCFPGLVPLINSYLGSmdvDA------DTHCTIQQYLKLIQKRASGELLTTASWIRKEITEHEEYKHDSVVSERICYDL 588
1_pfamImport 290 -GEFPGLIPLIHSYLSSmevDT------DTHCTIQQYLKLISRRASGQIDTTASWIRRFVQDHPAYKRDSVVSDEINYDL 362
XP_015792538 547 -GMFPGLMPLLRHYLLSveiDA------ETHCTINQYLNLISCRASGKYLTPAQWIRKFVQNHSDYKKDSVVSDKINYDL 619
EEQ41744     696 VAETVAI 702
8_pfamImport 352 ILKCNQI 358
EDO46274     609 LNTCNKI 615
XP_002114199 598 LYACNEI 604
XP_001605407 593 LKKIHDI 599
XP_002425007 601 LNHVKDI 607
XP_966349    601 LQTIKGI 607
XP_038118758 589 LKKGKDI 595
1_pfamImport 363 LMTADGI 369
XP_015792538 620 LKTIKKI 626
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