1RCW,3HML,1TYH,3RM5


Conserved Protein Domain Family
TENA_THI-4

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pfam03070: TENA_THI-4 
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TENA/THI-4/PQQC family
Members of this family are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. In Bacillus subtilis, TENA is one of a number of proteins that enhance the expression of extracellular enzymes, such as alkaline protease, neutral protease and levansucrase. The THI-4 protein, which is involved in thiamine biosynthesis, is also a member of this family. The C-terminal part of these proteins consistently show significant sequence similarity to TENA proteins. This similarity was first noted with the Neurospora crassa THI-4. This family includes bacterial coenzyme PQQ synthesis protein C or PQQC proteins. Pyrroloquinoline quinone (PQQ) is the prosthetic group of several bacterial enzymes,including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria. PQQC has been found to be required in the synthesis of PQQ but its function is unclear. The exact molecular function of members of this family is uncertain.
Statistics
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PSSM-Id: 397272
Aligned: 18 rows
Threshold Bit Score: 161.755
Threshold Setting Gi: 13815374
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RCW_A  10 DQLDLIIQNKHXleHTFyvkWSKGEltKEQLQAYAKDYYLHIKAFPKYLS---AIHSRCDDLEARkLLLDNLXDEENGYp 86  Chlamydia trachomatis
Q96XA8  69 IRKRFIEKFYGEnpHPFilaMQKPT--RGVLLGYVIEHQHFLKNWVKVLSs--IVFKTDKDEVVEyELENIAVEFIGYKg 144 Sulfurisphaera tokodaii
Q9HJM8  70 ARMEFIAKFYAHp-HPFmeaMQKPTv--pVLLGYVIEHRFFLKNWIRTLSm--VIHSTTSDDAFEyEVENVATEYIGLNg 144 Thermoplasma acidophilum
Q9I2C2  13 RALRDKGR-YYHihHPFhvaMYEGRasREQIQGWVANRFYYQVNIPLKDA---AILANCPDREVRrEWIQRILDHDGAPg 88  Pseudomonas aeruginos...
3HML_A  14 EALRAKGDFYHIh-HPYhiaMHNGNatREQIQGWVANRFYYQTTIPLKDA---AIMANCPDAQTRrKWVQRILDHDGSHg 89  Klebsiella pneumoniae...
Q9EXV0  12 ARLLEIGKERYHdkHPFhamLHGGGctTTQVRAWVINRYYYQSRIPMKDA---AFLSRCDDPDMRrAWRSRIEDHDGGVe 88  Sinorhizobium melilot...
Q9L3B2  11 AQLRQIGAERYHnrHPFhrkLHDGKldKAQVQAWALNRYYYQARIPAKDA---TLLARLPTAELRrEWRRRIEDHDGTEp 87  Gluconobacter oxydans...
Q8P6M9  12 ADLRAIGARLYHdqHPFhalLHHGKlnRGQVQAWALNRFEYQRCIPLKDA---AILARMEDPALRrIWRQRILDHDGNSp 88  Xanthomonas campestri...
Q9SWB6  20 KKHRLLYNGATR--HPLiisIRDGTinTASFKTWLAQDYLFVRAFVPFVAsvlIKAWKESDCSGDmEVILGGMASLEDE- 96  soybean
O94265 299 PSITPKWLSIVN--HPFveqLKAGTlsRLPFQKYLVLKYHMLINNAQAAG---MMAFSSSSISAI-EHSAKIIQAIKEE- 371 Schizosaccharomyces p...
1RCW_A  87 n--hIDLWKQFVFALGVTPEE-LEAHEPSEAAKAKVATFXRW-CTGDSLAAGVAALYSYESQIPRIA---REKIRgltey 159 Chlamydia trachomatis
Q96XA8 145 rpshYELLLRMGESLGMPREK-ILNTQPLPDTQFAINTWRRI-AEEKHWLITMASMHSLELVADRSLrnyGAKLHyfdpq 222 Sulfurisphaera tokodaii
Q9HJM8 145 kpshLELLLRMGEALGMSRKR-IMEYSPLPETSQAIEVWYGI-SNRYSWIDTMGAMHVLELVADRTLvddGSPIHyfnpe 222 Thermoplasma acidophilum
Q9I2C2  89 eaggIEAWLRLAEAVGLEREQvLSEERVLPGVRFAVDAYVNF-ARRASWQEAASSSLTELFAPQIHQsrlDSWPRh---- 163 Pseudomonas aeruginos...
3HML_A  90 edggIEAWLRLGEAVGLSRDDlLSERHVLPGVRFAVDAYLNF-ARRACWQEAACSSLTELFAPQISQsrlDSWPQh---- 164 Klebsiella pneumoniae...
Q9EXV0  89 egggIRRWLRLAEAVGLDPAYvGSARGVLPSTRFAVDAYVSF-VREKPLLEAVASSLTELFAPKIHSeriAGLLEh---- 163 Sinorhizobium melilot...
Q9L3B2  88 gtggVARWLMLTDGLGLDRDYvESLDGLLPATRFSVDAYVNF-VRDQSILAAIASSLTELFSPTIIServSGMLRh---- 162 Gluconobacter oxydans...
Q8P6M9  89 sdggIARWLHLTDALGLPRELvESGRALLPGTRFAVQAYLHF-VREKSLLEAIASSLTELFAPNIIGqrvAGMLQh---- 163 Xanthomonas campestri...
Q9SWB6  97 ----ISWFKTEANKWGISLSD----VVPQQANKNYCGLLESLmSPDAEYTVAITAFWAIETVYQESFahcIEEGSktpp- 167 soybean
O94265 372 ----NVTHLRICEQYGLSASQ-ITKSKPE-IVKSHSLFIHDT-AQQDGLRGIQIAMLPFVFMIQEVVsqiSasdg----- 439 Schizosaccharomyces p...
1RCW_A 160 fgfsnpedyAYFTEHEEADVRHAREE-KALIEXLLKDDADKv-LEASQEVTQSLYGFLDSFLdPGTCC 225 Chlamydia trachomatis
Q96XA8 223 il-vsneypQAVKDFLREGYEADVSHaGEALYLVEKYAKGM--EEEIQVNVLKSFDAFSKYLfARLER 287 Sulfurisphaera tokodaii
Q9HJM8 223 il-kgsdypEAVKNFLMEGYEADVGHaGEALKIVQAATMD---DLTTRSIMLRSMDAFYVYLnARMRR 286 Thermoplasma acidophilum
Q9I2C2 164 --------yPWIEAAGYEYFRSRLAQaRRDVEHGLRITLEHyrTREAQERMLDILQFKLDVL-WSMLD 222 Pseudomonas aeruginosa PAO1
3HML_A 165 --------yPWIKEEGYFYFRSRLSQaNRDVEHGLALAKAYcdSAEKQNRMLEILQFKLDIL-WSMLD 223 Klebsiella pneumoniae subsp. pneu...
Q9EXV0 164 --------yAFADDAALAYFRQRLAEvPRDVEFGLAYVLDHadTREKQDAAAQALTFKTDVL-WAQLD 222 Sinorhizobium meliloti 1021
Q9L3B2 163 --------yDFVSEKTLAYFTPRLTQaPRDSDFALAYVREKarTPEQQKEVLGALEFKCSVL-WTMLD 221 Gluconobacter oxydans 621H
Q8P6M9 164 --------yDFVSPEALAYFEHRLTEaPRDSDFALDYVKQHadTIEKQQLVKAALHFKCSVL-WAQLD 222 Xanthomonas campestris pv. campes...
Q9SWB6 168 ------elkETCVRWGNEAFGKYCQSlQNIANRCLQKASDEe-LKKAEVMLLSVLEHEVEFW-NMSRG 227 soybean
O94265 440 -----ypyvAWVEHCKDKSATSHIETlLESLETNSQIISLSk-VQHLLGILEKSLDFERLVLdTSSSN 501 Schizosaccharomyces pombe 972h-
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