4DKT,5HP5,4N2C,6CE1,9FMN


Conserved Protein Domain Family
PAD

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pfam03068: PAD (This model is not part of the current CDD release)
Protein-arginine deiminase (PAD)
Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyze the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognised (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen.
Statistics
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PSSM-Id: 515368
Aligned: 49 rows
Threshold Bit Score: 427.799
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4DKT_A       288 VVFQDSVVFRVAPWIMTPNTQPPQEVYAcsIFEN-----EDFLKSVTTLAMKAKCKLTICPEEENmdD---QWMQDEMEI 359 human
EMR72151     195 ETASDAVALKVAPVLTHHPLQRVETLVStdANDTdp-iqQYFVAQLDDAREKVGIEDPMFLFNQSs-D---IWAQDIVEP 269
EQB54248     194 TILSDAVELKVAPVLTHHHLQRVDTLIStaANDSdp-vqLEFIRQLDAGRAAAGLQTPLYLFNQSs-D---IWAQDFIEP 268
XP_018242344 196 MTTYDAVAMKQAPVLFHHHLQRVQEVLSvkGNETsspvqNKFVRGLEDALMNVVETPALHLLNGTd-E---IWAQDFMEP 271
XP_008600798 206 RSGSDFVAMRQAPVLLHHHLQSMDAVVTmqTEESkw--qGAFVNSLRDAIHELAPAVTLLLLNSSr-G---IWAQDFMEP 279
XP_008602913 206 RSGSDFVAMRQAPVLLHHHRQSMEAVVTmqTVESkw--qGAFVNTLGAIIHKLKPAVPLITLNDSr-D---VWAQDLMEP 279
XP_003044046 193 TTASDTVAMKQAPVLIHHHLQAPEVVLStdGSITtstwqTGFINSVQNALENLDQDIPLFLFNETd-D---IWAQDFLEP 268
TDZ15788     261 VISTDDVMLRVAPVLTHHHLQDVETVLAanSRPGqnaleR-FNEHFERVLKWARIEEETFFVDESt-ErtsASVQDFVEP 338
EMR61982      89 ESSHDIVRLRVAPILTFHHLMTVSEVLAtnGNESmslyqAQFVSELRDILDAPSISKPLWLFNHSd-D---VWAQDIVEP 164
XP_003045412 207 DYVRDSVALKVAPVLTHHPLQRVETLVStfANDSep-iqQYFVQQLDDARSVAGIENPLWLFNQSs-D---IWAQDIVEP 281
4DKT_A       360 GYIQAPHK-T---LPVVFDSPR-----NRGlkefPIKRVMGPDFGYV--------TRGPQtggisglDSFGNLEVSPPV- 421 human
EMR72151     270 AYASMPGPdGpiaIRVMMRSAQstrtgGRQ----IFEQLRGAGVGGFqp-----gGATGTgfgyntiDSYGNLETIPPHr 340
EQB54248     269 AYASMPGPnGpvsIRIVLRSAQstrtgGRQ----VFEQLRGKGVGGFqp------eGGRRgfghleiNSFGNLETIPPYt 338
XP_018242344 272 GFASMPGPeGpisLRVLVRSAQstrvaGRQ----VFESFRGNRVGGHql-------sLGSgfgheeiDSGGNIEIIPPYv 340
XP_008600798 280 AFASMPGPhGpisIRVLLRSAQssrsnGRL----VFEKLRGAGVGGWqp-------gSGSgfgweeiNSGGNIETIPPYt 348
XP_008602913 280 AFASMPGRnGpisIRVLLRSPQstrpnGRL----VFEQLRGAGVGGWqp-------gPESgfgweeiNSGGNIETIPPYt 348
XP_003044046 269 GYASMPGPnGpisIRVLLRSPQsgraaGRQ----VFSLLRGPEIGGFqp-------gLGSgfgheeiNSGGNFETIPPYt 337
TDZ15788     339 GYVSMPTGiGivsLRIMICSAQaarsdGVK----VFTEFRNTGIGAVqhr---gdRPAAEspfieaiNGAGNIETIPPY- 410
EMR61982     165 GYTSIPGSsEpitLEVMIRSSQgsrvaGRQ----VFEYLRKTGRGAVystgg----------trdeiDSMGNLETIPPY- 229
XP_003045412 282 AYASMPGPnGpiaIRIMLRSAQstrtgGRQ----VFEQLRGPGIGGFqpadgpgiGFSSSgfgyhtiNSYGNLETIPPHr 357
4DKT_A       422 TVRGKEYPLGRILFGD--SCYPsndsrQMHqalqDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDR-KGFRLLLAS 498 human
EMR72151     341 SKRGVLFKAGRAIFGKhyDTLTs---qPVR----DLLFGQGVQTPLVLETGWLRVGHVDEFVQFVPFDND-LGFTIAIAD 412
EQB54248     339 SKSGIRYPVGRIIQGKhfEKMPa---eSMT----KFLDGQKLQKPLMLETGWLLIGHVDEFVQFLPSNNTgLGFTIGIAD 411
XP_018242344 341 SKNGTSYKHGRVIMGKhfDKHPa---kSMT----SLIEAQIYQSPLILEAGWLVIGHVDEFVQFLPYQND-LGWTIAIAD 412
XP_008600798 349 SRSGVSYKNGRVVLGKhyDKYPa---aSLT----KFLEAQREQTPLYLEAGWLVAGHVDEFVQFLPYNNT-IGFRVAVPD 420
XP_008602913 349 SRSGVSYKNGRVVLGKhyDKYPa---aSLT----KFLEAQREQTPLYLEAGWLVAGHVDEFVQFLPSNNT-IGFRVAVPD 420
XP_003044046 338 SRAGVEYKSGRVITGKhfDKYPa---eSMI----KFLEAQGVQKPLVLETGWLAVGHVDELVQFVPYDNE-LGFTIAVVD 409
TDZ15788     411 THKRESYPAGRIVIGGhgSHVP-----DLF----HLLLAQETQQPILLETDWLQVSQVDQFLQFLPANNS-RGWAMQVDD 480
EMR61982     230 EYGGKSFPAGRVIEGShaESYPpf--pHVY----DYMRAQETQDPLILDTDWLAVGHVDEMVQFLPANGTlHGWALYIAD 303
XP_003045412 358 SKDGTLYKAGRVIQGKhfEEFPa---qAVR----NLIFGNGVQSALFLETGWLVVGHVDEFVQFLPFDND-LGFTIGIAS 429
4DKT_A       499 PRSCYKLF---------------------------------QEQQNEGHGEALLFEGIKKK------KQQKIK------- 532 human
EMR72151     413 TRSAMQVL---------------------------------RDVAGAGHGHIEAISFNASVat--efGKTAPDqvnmtva 457
EQB54248     412 TVSALEIL---------------------------------RNASTAGHGGVRAVSFNGSLdn---aFSTSAEelattin 455
XP_018242344 413 TQAPLALL---------------------------------KKAKDSGHGSTLVTSYPDLRqpe-gfSFYDSSlenltin 458
XP_008600798 421 TRSAMRIL---------------------------------NRINETGHGAVPFLTYTGDItsdpwaIFADHDlpnktve 467
XP_008602913 421 TRSAMRIL---------------------------------KHVNETGHGTVPFLSFKGNLtddnwpIFADHDlpnktve 467
XP_003044046 410 TASAFSLL---------------------------------QEAWKDGHGDTKVISYDGDMtpdnetIFIDPEvrnltik 456
TDZ15788     481 PREGIELLtmiqtlaelyrsemdvselevaiqrwdtvsgacNQTKQACHRvdnt-----------------------sva 537
EMR61982     304 PMGGIEIL---------------------------------QKAQQEGHGYDPAFSRPNGTi-----PGIAGDvpgltin 345
XP_003045412 430 PDVGIKIL---------------------------------SDAQAAGHGNASAISFDAQPqme-rfDAEEPPflnlsvs 475
4DKT_A       533 NILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKL---------------KEFSK--------AEAFFP 589 human
EMR72151     458 EVLANQTFLDVNAYGQKHIDSNLDILLGEIPLDRGDVIRVPALFRDrsqgppf--vrpdglPVYWQpvmkneyqLGAFSP 535
EQB54248     456 QILANETFHQVNAYAQKHIDANLETLLSEIPIAREHVVRVPVLFKDlnmgqggfsrsddglPSHTDtvmadeflVASFSP 535
XP_018242344 459 ALLSDDDFLQTQKYAQKYIDHNLKLLLEEVPLPHNQVLRVPALFKNvtypwp---snldgiPPRLHrvapgqrqLIAFLP 535
XP_008600798 468 MLLAEKDFANTNEYAQKFIDRNVELLREELPISDADVLRVPALWRDvtydwv---adpdglPARLHhtipgerqLQGFFP 544
XP_008602913 468 ALLAEESFVKTNAYAQKFIDRNVEILLEELPISDADVLRVPALWRDqtydwl---adpdgfPARLHhtipgerqLQGFFP 544
XP_003044046 457 DLLSDKDFVAINAYAQSFINDTLDLLLEEVPLTESDILRVPTLWKDvtypwp---ktpdghPLRLNrappgerqVKSFFP 533
TDZ15788     538 ELLADDALIKANLQAADKIERNIVTIKEATGLSEKEIIRVPAFYKFad-----------ksHDASK--------LTSFFP 598
EMR61982     346 EILTDK-LIEDNKRFAQHVDGVQAVLQSETGITEGDIHQVPMIFTTgvcwgpdegvspdrnCSTTH--------AAALYP 416
XP_003045412 476 NLLDNKTFIEVNRYAQKWIDYNLDILLSEIPLDREDVIHVPALYRDqsgygpw--irpdglDYYWPpvhkdeyqLGAFIP 553
4DKT_A       590 NMVNMLVL--GKHLgIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPfSFKWW 664 human
EMR72151     536 SAINGIIIg-SQYL-SPKPWGPVVDGVDVLAEAVEAAYARAGMNVTFIDDYMSHHMNGGEIHCGSNTLRQT-DIEWW 609
EQB54248     536 AAINGIVLg-EHYL-SPKPWGPVVDGKDLFEERVRAVYGATGMDVGFVDDFLSHHVGLGEIHCGSNTLRET-DVKWW 609
XP_018242344 536 AVINGVVIg-SDYL-AAKPWGPIVDGQDIFEEAVRDVYGQAGMKVHFVDDFMSHHVNGGEVHCGTNTLRDA-TVEWW 609
XP_008600798 545 LAVNGLLLd-QHYI-APKPFGPQVDGVDVFEREIRKVYTDAGLNVVFIDDYMSHHVRGGEVHCGTNSLRRT-DIEWW 618
XP_008602913 545 LAVNGLVLd-QHYI-CPKPFGPRVDGVDVLEREIGKVYTEAGFNVVFIDDYMSHHVRGGEVHCGTNSLRHT-NVEWW 618
XP_003044046 534 QSINGLVLg-HDCL-APKPWGPVINGRDILEDAVKDVYARANMTVWLIDDYMSHHVRGGEVHCGTNTLREK-DVAWW 607
TDZ15788     599 GVVNSLVLsgSDVLvAPEPW------NSALAEIMEDLYKKIGLDVLYIDDWRSHHVNGREVHSGTNTVRDM-SDPWW 668
EMR61982     417 GVLNGVVLndRSYL-CPKPWGPVINNKDIMVEATDQVYGEVGMEVIYIDDWYSHHKGGGEVHCGTNTIRIP-KQPWW 491
XP_003045412 554 APINGIVIg-NHYL-SPNPFGPIINGVDVIARAVTEAYARAGMNVTFVDDYYSHHMRGGEIHCGSNTLRET-AVEWW 627
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