5N0Y,5HP5


Conserved Protein Domain Family
PAD

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pfam03068: PAD 
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Protein-arginine deiminase (PAD)
Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyze the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognized (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localization. The expression of type I PAD is known to be under the control of oestrogen.
Statistics
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PSSM-Id: 397270
Aligned: 58 rows
Threshold Bit Score: 385.811
Threshold Setting Gi: 493669442
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5N0Y_A       293 QDSVVFRVAPWIMTPNTQPPQEVYACSIFEN-----EDFLKSVTTLAMKAKCKLTICPEEENMdD---QWMQDEMEIGYI 364 human
XP_018244738 199 yDAVAMKQAPVLFHHHLQRVQEVLSVKGNETsspvqNKFVRGLEDALMNVVETPALHLLNGTD-E---IWAQDFMEPGFA 274 Fusarium oxyspo...
EJP63553     209 sDFVAMRQAPVLLHHHLQSMDAVVTMQTEESkw--qGAFVNSLRDAIHELAPAVTLLLLNSSR-G---IWAQDFMEPAFA 282 Beauveria bassi...
XP_008602913 209 sDFVAMRQAPVLLHHHRQSMEAVVTMQTVESkw--qGAFVNTLGAIIHKLKPAVPLITLNDSR-D---VWAQDLMEPAFA 282 Beauveria bassi...
XP_003044046 196 SDTVAMKQAPVLIHHHLQAPEVVLSTDGSITtstwqTGFINSVQNALENLDQDIPLFLFNETD-D---IWAQDFLEPGYA 271 [Nectria] haema...
ENH76503     264 TDDVMLRVAPVLTHHHLQDVETVLAANSRPGqnaleR-FNEHFERVLKWARIEEETFFVDEST-ErtsASVQDFVEPGYV 341 Colletotrichum ...
EEH07995     191 ADSVKLRVAPILTYHHSQSVQQIFATAGNDTsnffqRKFVSALEASLAEMDVNYPLFKFNASD-D---IWAQDFFEPGYT 266 Histoplasma cap...
XP_007798908  92 hDIVRLRVAPILTFHHLMTVSEVLATNGNESmslyqAQFVSELRDILDAPSISKPLWLFNHSD-D---VWAQDIVEPGYT 167 Eutypa lata UCREL1
XP_013952202 192 SDAVRLRVAPVITFHHLMPVSQVFVTNGNKSetpfqEQFVSDLRQILDRPDMRKPLFTFDHSD-D---IWAQDILEPAYT 267 Trichoderma vir...
XP_003045412 210 RDSVALKVAPVLTHHPLQRVETLVSTFANDSep-iqQYFVQQLDDARSVAGIENPLWLFNQSS-D---IWAQDIVEPAYA 284 [Nectria] haema...
5N0Y_A       365 QAPHK-T---LPVVFDSPR-----NRGlkefPIKRVMGPDFGYV--------TRGPQTGGISGLDSFGNLEVSPPV-TVR 426 human
XP_018244738 275 SMPGPeGpisLRVLVRSAQstrvaGRQ----VFESFRGNRVGGHql-------sLGSGFGHEEIDSGGNIEIIPPYvSKN 343 Fusarium oxyspo...
EJP63553     283 SMPGPhGpisIRVLLRSAQssrsnGRL----VFEKLRGAGVGGWqp-------gSGSGFGWEEINSGGNIETIPPYtSRS 351 Beauveria bassi...
XP_008602913 283 SMPGRnGpisIRVLLRSPQstrpnGRL----VFEQLRGAGVGGWqp-------gPESGFGWEEINSGGNIETIPPYtSRS 351 Beauveria bassi...
XP_003044046 272 SMPGPnGpisIRVLLRSPQsgraaGRQ----VFSLLRGPEIGGFqp-------gLGSGFGHEEINSGGNFETIPPYtSRA 340 [Nectria] haema...
ENH76503     342 SMPTGiGivsLRIMICSAQaarsdGVK----VFTEFRNTGIGAVqhr---gdRPAAESPFIEAINGAGNIETIPPY-THK 413 Colletotrichum ...
EEH07995     267 SMPGPsGpvtLQVMIRSAQddrvaGRQ----VFEYLRGSGTGAVqd----------rGGSRDEINSMGNLETIPPH-NFN 331 Histoplasma cap...
XP_007798908 168 SIPGSsEpitLEVMIRSSQgsrvaGRQ----VFEYLRKTGRGAVys----------tGGTRDEIDSMGNLETIPPY-EYG 232 Eutypa lata UCREL1
XP_013952202 268 SMPSPqGpiiLEIMIRSPQgsrvaGRQ----VFEYLRNGTRGAIyt----------tGGIRDEIDSTGNVETIPPY-SYG 332 Trichoderma vir...
XP_003045412 285 SMPGPnGpiaIRIMLRSAQstrtgGRQ----VFEQLRGPGIGGFqpadgpgiGFSSSGFGYHTINSYGNLETIPPHrSKD 360 [Nectria] haema...
5N0Y_A       427 GKEYPLGRILFGd--SCYPsndSRQMHqalqDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDR-KGFRLLLASPRS 503 human
XP_018244738 344 GTSYKHGRVIMGkhfDKHP---AKSMT----SLIEAQIYQSPLILEAGWLVIGHVDEFVQFLPYQND-LGWTIAIADTQA 415 Fusarium oxyspo...
EJP63553     352 GVSYKNGRVVLGkhyDKYP---AASLT----KFLEAQREQTPLYLEAGWLVAGHVDEFVQFLPYNNT-IGFRVAVPDTRS 423 Beauveria bassi...
XP_008602913 352 GVSYKNGRVVLGkhyDKYP---AASLT----KFLEAQREQTPLYLEAGWLVAGHVDEFVQFLPSNNT-IGFRVAVPDTRS 423 Beauveria bassi...
XP_003044046 341 GVEYKSGRVITGkhfDKYP---AESMI----KFLEAQGVQKPLVLETGWLAVGHVDELVQFVPYDNE-LGFTIAVVDTAS 412 [Nectria] haema...
ENH76503     414 RESYPAGRIVIGghgSHVP-----DLF----HLLLAQETQQPILLETDWLQVSQVDQFLQFLPANNS-RGWAMQVDDPRE 483 Colletotrichum ...
EEH07995     332 GKNYTAGRIVLGthgARKP-----YIL----KYMLAQEIQDPLLLDTNWLAVGHVDEMLQFLPANNS-LGWAMLVPDPQA 401 Histoplasma cap...
XP_007798908 233 GKSFPAGRVIEGshaESYPp--FPHVY----DYMRAQETQDPLILDTDWLAVGHVDEMVQFLPANGTlHGWALYIADPMG 306 Eutypa lata UCREL1
XP_013952202 333 EKSYPAGRIIQGshgKSLP-----HLY----DYLKAQEIQSPIILDVDWLAVGHVDEIVQFIPFESSpYGWALYIADPIG 403 Trichoderma vir...
XP_003045412 361 GTLYKAGRVIQGkhfEEFP---AQAVR----NLIFGNGVQSALFLETGWLVVGHVDEFVQFLPFDND-LGFTIGIASPDV 432 [Nectria] haema...
5N0Y_A       504 CYKLF---------------------------------QEQQNEGHGEALLFEGI------------------------- 525 human
XP_018244738 416 PLALL---------------------------------KKAKDSGHGSTLVTSYPdlrqpe--------------gfsfy 448 Fusarium oxyspo...
EJP63553     424 AMRIL---------------------------------NRINETGHGAVPFLTYTgditsdp-------------waifa 457 Beauveria bassi...
XP_008602913 424 AMRIL---------------------------------KHVNETGHGTVPFLSFKgnltddn-------------wpifa 457 Beauveria bassi...
XP_003044046 413 AFSLL---------------------------------QEAWKDGHGDTKVISYDgdmtpdn-------------etifi 446 [Nectria] haema...
ENH76503     484 GIELLtmiqtlaelyrsemdvselevaiqrwdtvsgacNQTKQACHR--------------------------------- 530 Colletotrichum ...
EEH07995     402 GLAIL---------------------------------RKTQSAGYGNIRAFSRQndtegnpsd---------lfgipwg 439 Histoplasma cap...
XP_007798908 307 GIEIL---------------------------------QKAQQEGHGYDPAFSRPngti------------------pgi 335 Eutypa lata UCREL1
XP_013952202 404 GINIL---------------------------------EQAKKDGYGHLPAFSRPsgvlmerllgdnygklrsysrsnip 450 Trichoderma vir...
XP_003045412 433 GIKIL---------------------------------SDAQAAGHGNASAISFDaqpqme--------------rfdae 465 [Nectria] haema...
5N0Y_A       526 -KKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKL---------------KEFSK---- 585 human
XP_018244738 449 dSSLENLTINALLSDDDFLQTQKYAQKYIDHNLKLLLEEVPLPHNQVLRVPALFKNvtypwp---snldgiPPRLHrvap 525 Fusarium oxyspo...
EJP63553     458 dHDLPNKTVEMLLAEKDFANTNEYAQKFIDRNVELLREELPISDADVLRVPALWRDvtydwv---adpdglPARLHhtip 534 Beauveria bassi...
XP_008602913 458 dHDLPNKTVEALLAEESFVKTNAYAQKFIDRNVEILLEELPISDADVLRVPALWRDqtydwl---adpdgfPARLHhtip 534 Beauveria bassi...
XP_003044046 447 dPEVRNLTIKDLLSDKDFVAINAYAQSFINDTLDLLLEEVPLTESDILRVPTLWKDvtypwp---ktpdghPLRLNrapp 523 [Nectria] haema...
ENH76503     531 ---VDNTSVAELLADDALIKANLQAADKIERNIVTIKEATGLSEKEIIRVPAFYKFad-----------ksHDASK---- 592 Colletotrichum ...
EEH07995     440 lHGVPSYTIDDLLSQSQIIEANANFARSIRGTVNLLKRETGITNADIHGVPAVFRTgltfppnggirpernNNSEL---- 515 Histoplasma cap...
XP_007798908 336 aGDVPGLTINEILTDK-LIEDNKRFAQHVDGVQAVLQSETGITEGDIHQVPMIFTTgvcwgpdegvspdrnCSTTH---- 410 Eutypa lata UCREL1
XP_013952202 451 mRSIPDVTINDILTDR-LIEENKEFAMSISKVQKILERETGIPKEYIHHVPMVFETgfcfppdegvlpernCSSEH---- 525 Trichoderma vir...
XP_003045412 466 ePPFLNLSVSNLLDNKTFIEVNRYAQKWIDYNLDILLSEIPLDREDVIHVPALYRDqsgygpw--irpdglDYYWPpvhk 543 [Nectria] haema...
5N0Y_A       586 ----AEAFFPNMVNMLVL--GKHLgIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRK 659 human
XP_018244738 526 gqrqLIAFLPAVINGVVIg-SDYL-AAKPWGPIVDGQDIFEEAVRDVYGQAGMKVHFVDDFMSHHVNGGEVHCGTNTLRD 603 Fusarium oxyspo...
EJP63553     535 gerqLQGFFPLAVNGLLLd-QHYI-APKPFGPQVDGVDVFEREIRKVYTDAGLNVVFIDDYMSHHVRGGEVHCGTNSLRR 612 Beauveria bassi...
XP_008602913 535 gerqLQGFFPLAVNGLVLd-QHYI-CPKPFGPRVDGVDVLEREIGKVYTEAGFNVVFIDDYMSHHVRGGEVHCGTNSLRH 612 Beauveria bassi...
XP_003044046 524 gerqVKSFFPQSINGLVLg-HDCL-APKPWGPVINGRDILEDAVKDVYARANMTVWLIDDYMSHHVRGGEVHCGTNTLRE 601 [Nectria] haema...
ENH76503     593 ----LTSFFPGVVNSLVLsgSDVLvAPEPW------NSALAEIMEDLYKKIGLDVLYIDDWRSHHVNGREVHSGTNTVRD 662 Colletotrichum ...
EEH07995     516 ----AGSLYPASINGQVLssTQYL-APNPWGPVVDGRDIMADAVSEVYGRLGFKVNFVDNWNSHHTWGGEVHCATNTIRN 590 Histoplasma cap...
XP_007798908 411 ----AAALYPGVLNGVVLndRSYL-CPKPWGPVINNKDIMVEATDQVYGEVGMEVIYIDDWYSHHKGGGEVHCGTNTIRI 485 Eutypa lata UCREL1
XP_013952202 526 ----AVALYPGVLNGVVLsdSQYL-SPNPWGPVIDGIDIMAQATDKVYGKAGMDVIYIDDWYSHHEGGGEVHCGTNTVRL 600 Trichoderma vir...
XP_003045412 544 deyqLGAFIPAPINGIVIg-NHYL-SPNPFGPIINGVDVIARAVTEAYARAGMNVTFVDDYYSHHMRGGEIHCGSNTLRE 621 [Nectria] haema...
5N0Y_A       660 PfSFKWWN 667 human
XP_018244738 604 A-TVEWWs 610 Fusarium oxysporum f. sp. lycopersici 4287
EJP63553     613 T-DIEWWK 619 Beauveria bassiana ARSEF 2860
XP_008602913 613 T-NVEWWK 619 Beauveria bassiana ARSEF 2860
XP_003044046 602 K-DVAWWe 608 [Nectria] haematococca mpVI 77-13-4
ENH76503     663 M-SDPWWK 669 Colletotrichum orbiculare MAFF 240422
EEH07995     591 G-NYRWW- 596 Histoplasma capsulatum G186AR
XP_007798908 486 P-KQPWWD 492 Eutypa lata UCREL1
XP_013952202 601 P-AYGWWE 607 Trichoderma virens Gv29-8
XP_003045412 622 T-AVEWWQ 628 [Nectria] haematococca mpVI 77-13-4
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