1GNL,6ELQ,4UDX,6B6X,1E1D


Conserved Protein Domain Family
Prismane

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pfam03063: Prismane 
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Prismane/CO dehydrogenase family
This family includes both hybrid-cluster proteins and the beta chain of carbon monoxide dehydrogenase. The hybrid-cluster proteins contain two Fe/S centers - a [4Fe-4S] cubane cluster, and a hybrid [4Fe-2S-2O] cluster. The physiological role of this protein is as yet unknown, although a role in nitrate/nitrite respiration has been suggested. The prismane protein from Escherichia coli was shown to contain hydroxylamine reductase activity (NH2OH + 2e + 2 H+ -> NH3 + H2O). This activity is rather low. Hydroxylamine reductase activity was also found in CO-dehydrogenase in which the active site Ni was replaced by Fe. The CO dehydrogenase contains a Ni-3Fe-2S-3O centre.
Statistics
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PSSM-Id: 397266
Aligned: 159 rows
Threshold Bit Score: 300.601
Threshold Setting Gi: 501258249
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GNL_A                4 MFCyQCQetvgNKGCTQV-------------GVCGKKPETAALQDALIYVTKGLGQIATRLRAEgkavdhridrlvtgnl 70  Desulfov...
WP_009246088         49 ICCrICT----MGPCRITkka--------prGICGCDVHGIVGRNYLKFTAGGAATHSDHGREIchtlye---------- 106 Lachnosp...
WP_012063158         46 VCCrICG----MGPCRVSpvagk----gaqkGICGATADTIVARNFARMVAAGTASHSDHARDIahvlh----------m 107 Alkaliph...
Q189R4               45 VCCrICG----MGPCRISpkt--------prGLCGADEHTIVGRNFARMVAGGTAAHSDHARDIahtla----------l 102 Clostrid...
ETI95811             56 VCCrNCG----MGPCRISpkt--------prGLCGADEHTIVGRNYARMCAGGTAAHSDHARDIthtlgl---------- 113 Intestin...
WP_012301969         30 SCCrVCA----MGPCRVTesgk-----garvGVCGATPDTIAARNLCRMIAAGTAAHSDHAREVvqtfca--------va 92  Candidat...
goetting:HRM2_16670  62 ICCkNCS----MGPCRLPlpkggiegkdtrkSLCGATPNTIAARNFIRMIAGGASAHSDHGRGVaevfla--------aa 129 Desulfob...
jgi:Sfum_2566        63 SCCkHCF----MGPCRLNprdp-----ysrvGVCGATIDTIAARNFSRMVASGGAAHTDHGMGMldvfre--------vv 125 Syntroph...
ACL04072             55 ACCkHCS----MGPCRLNakdp-----ygkvGVCGATIDTIQARNFARMVASGAAAHTDHGMSIlhlfge--------vv 117 Desulfat...
WP_012174881         55 ACCkHCS----MGPCRLNskdp-----ygkvGVCGADIDTIMSRNFARMVASGAAAHTDHGMSMldlfre--------vv 117 Desulfoc...
1GNL_A               71 fatITNANFDDDILAERVRMTCAAKkelaasltdksglsdaalweaseKSAMLAKAGtvgvmat-tdddvrSLRWLITFG 149 Desulfov...
WP_009246088        107 asadgcYKVKDPEKLIRIAKEWGMEteg------------------kdIYELAHEVAleglmeygkpfgtqRFLKRAPES 168 Lachnosp...
WP_012063158        108 asrDGNYQVQDEKKLIALAQEWEVPteg------------------rdIYDVAHEVAeialnefgkpfgtlRFPDRAPAP 169 Alkaliph...
Q189R4              103 adpNGNYKIRDEAKLITLAKEWDVEteg------------------rdIYDVAHEVAeialmefgkpfgtlRFIKNAPEP 164 Clostrid...
ETI95811            114 ttpggaYQVTEPEKLKEFAQFMGVDpeg------------------kdIYELAHEVSevclmefgkphgvsKLLARAPKV 175 Intestin...
WP_012301969         93 rgtaPGFELCDREKLSRLAAQLGCGka-------------------edPAVLAREVGklflgefgrqegelALAALAPPR 153 Candidat...
goetting:HRM2_16670 130 rketDAYQIKDTVKLKALAPTLGVAttvevdg----------etqdrdIYEIAVEVGeaalnewgkpegelLNLKRAPEA 199 Desulfob...
jgi:Sfum_2566       126 rgnIKGYKIKNEKKLFEVAKSIDIKvdg------------------rsVKDVATDLYtelertytqvegeiPFMKRVPPK 187 Syntroph...
ACL04072            118 kghnKDYEIKDTQKLLQVAQTLEIEtdg------------------raYQDIGLDIYeelmktytqvegefPFAKAVPEK 179 Desulfat...
WP_012174881        118 nghiKEYGIKDVKKLMEVAQSVGIEtds------------------reVSDIAMDLYnelektytqiegeiPFAKRVPPK 179 Desulfoc...
1GNL_A              150 LKGMaayakhADVLGKHENSLDAFMQEALAKTLDDSLSvadLVALTLETGKFG-VSAMALLDAANTGTYGHPEI--TKVN 226 Desulfov...
WP_009246088        169 QQKLwe--enELAPHAIDREVSRSLHMAHMGCSSKPEA---LVKQSIRAGLSDgWGGSMMGTEFSDILFGTPKPieTEAN 243 Lachnosp...
WP_012063158        170 RRKIwe--elNIMPRAIDREIATIMHSTHMGCTSDAES---LLRLSMRTSLANgWGGSMLGTELSDIVFGTSTPrmTEAN 244 Alkaliph...
Q189R4              165 RQKIwk--eyAIEPRAIDREIATIMHSTHIGCTGDIDS---LIHMSLRTSMADgWGGSMIGTRLSDILFGTPVPrrTEAN 239 Clostrid...
ETI95811            176 RQDVwk--eyGIEPRAIDREIATVMHSTHIGCCADIDA---LVHMAFRCSMADgWAGSMIGTMLSDILFGTPKPvhTEAN 250 Intestin...
WP_012301969        154 RLERwr--rlGLVPRGIDREVVESLHRTHMGVDQEALH---LLHQGTRTALADgWGGSVIATAVRDVLFGTPRPvrSRVD 228 Candidat...
goetting:HRM2_16670 200 LYEKwk--klGVLPRNIDREIVEIMHRTHIGVDQDYKN---LMKQGTRAAIADgWGGSMLATDLQDVLFGTPFPiqSEAN 274 Desulfob...
jgi:Sfum_2566       188 TLELwr--kaGIVPRGAMREIMEIMHRSHMGVDQDYEN---IVKQCSRTALADgWGGSMVATELGDIMFGSPEPkkAGVN 262 Syntroph...
ACL04072            180 TLETwr--khNIVPRGAMREIMEIMHRTHMGVDQDYEN---IVNQCSRTALSDgWGGSMVATEISDIMFGTPRPvmAEVN 254 Desulfat...
WP_012174881        180 TLETwr--kqGIVPRGAMREIMELMHRTHMGVDQQYEN---ITRQISRTALADgWGGSLVATEISDILFGTPSPvqVEVN 254 Desulfoc...
1GNL_A              227 IGVG-SN-PGILISGHDLRDLEMLLKQTEGTGVDVYTHse-----mLPAHYYPAFK-KYAHFKGNYGNAWWKQKEEFESF 298 Desulfov...
WP_009246088        244 LGVMvEEnVNIVVHGHDPSLSEMICEVADSPEMIAYAKeqgakgitISGVCCTSNEvAMRRGIPMAGNFLQQENVVLTGA 323 Lachnosp...
WP_012063158        245 LGVLeEKqVNILLHGHDPCLSEMIVAAAQDPEMIKLTEevgaeginLAGMCCTGNEvTMRHGVKIAGTFYQQELAVLTGA 324 Alkaliph...
Q189R4              240 LAVLeENkVNIILHGHEPALSEMIVLASEEPDLVALAKevgadginLAGMCCTGNEiTMRHGVKIAGDFHQQELAIITGA 319 Clostrid...
ETI95811            251 LNVLdGNnVNIILHGHEPTLSEMIVLASELPEMQDLAKevgadgitLSGICCTGNElTMRHGIKIAGDFHQQELAIITGA 330 Intestin...
WP_012301969        229 LGVLkPDcVNIVVHGHEPLLPEVLVRLAADGEMTARARavgaagvnIAGMCCTANEiLMRHDVPVASHFLQQELAIITGA 308 Candidat...
goetting:HRM2_16670 275 LGVMkEDhVNLILHGHEPILSEIVVSVAQSQEMIDYAKtkgakgiqLSGICCTANElLQRHGIPTAATFLQQELAIITGA 354 Desulfob...
jgi:Sfum_2566       263 MGFLkEDqVNIIVHGHEPLLFEAMIVASSDPENLKKAEaagakginLLGMCCSGAEvLGRHGVPHAGNFLSTEPVLATGA 342 Syntroph...
ACL04072            255 MGVLkEDhVNIIVHGHEPNLFESIMVSTSDATMVEAAKaagakginLVGMCCSGAEmMSRHGVPHAGNFMSTEAVLVTGA 334 Desulfat...
WP_012174881        255 MGVLkENmVNIIVHGHEPNLFESMLVSVNAPVLVEAAKaagadginLVGMCCSGAEmLVRHGIPHAGNFMSTEAVLVTGA 334 Desulfoc...
1GNL_A              299 NGPVLLTTNCLVPP--K-DS-YKDRVYTTGIVGF---TGCKHIP---GEIGehKDFSAIIAHAKTCPAPTEI----ESGE 364 Desulfov...
WP_009246088        324 CEAIVVDVQCIFPAlgPlSKcFHTKFITTSPIAQm--PDSEFVRfdaHTAL--EKATQIVKMAIENFKNRKPelvhIPQM 399 Lachnosp...
WP_012063158        325 IEAVIVDVQCIFPSlaPiTDcYHTKFITTSPKAKi--TGATHIEfneEKAL--ESAKVIVREAIENYKNRKQdkvfIPQS 400 Alkaliph...
Q189R4              320 VEAVIVDVQCIFPAlaRvADcYHTKFVTTSPKAKi--TGSTYIEfreEQAL--DDAKAIVKEAILNFKNRDKskvlIPEL 395 Clostrid...
ETI95811            331 VEAMIVDVQCIFPAlaEvAThYHTKFITTSPKAQi--TGSTYMEfheETAL--EDAKTIVREAILNFKNRDAskvmVPEL 406 Intestin...
WP_012301969        309 VELMLVDVQCVMQGlaAvAAcYHTRLVTTSEKARi--KGARHVEfspATAL--DTARELLYAAIDNFPNRrr--vdIPPQ 382 Candidat...
goetting:HRM2_16670 355 CDAMVVDIQCIMENiaNvAEcFHTKIITTHPIARmeeQSVLHIEfdeHHAV--EDAKRIVKIAIDNFENRNRev-mIPSQ 431 Desulfob...
jgi:Sfum_2566       343 VDAMAVDVQCIMTGlnTmSKcYGTRFFTTNRKAMi--EGAEHVEfdeHDTE--KCTNQIIDMAIERFRNR-PvqveIPQR 417 Syntroph...
ACL04072            335 VDAMAVDVQCIKQGlgKvADcYGTELFTTNPRCHi--EGVKHIEfdeDDPM--ACTDEVVIKAISRFKNR-KgdiqIPKN 409 Desulfat...
WP_012174881        335 VDAMCVDVQCIKQGlaKvADcYNTPLFTTNTRCHi--EGAVHIDfneHKPL--DCTDEIVIKAISRFKNR-TaaieIPQI 409 Desulfoc...
1GNL_A              365 IIGGFA-----------------HNQVLALADKVIDAVKSGAIKKFVVMAGCDGRAKSRS-YYTDFAEGL-PKDTVILTA 425 Desulfov...
WP_009246088        400 KQKATVgysteaivkvldgvtnsQVDETGTTKPLLQCITSGVLRGAVAMVGCNNPKVRPDvAHIELMKKLvANDIIIIAS 479 Lachnosp...
WP_012063158        401 KAQAITgysneavikqldrvvnsNIDPQGTVKPLADVIKAGVLRGAAGIVGCNNIKTKHEySHIEIMKKLiANDVIVVTT 480 Alkaliph...
Q189R4              396 KSGATVgysveavvnqldrvvnsHIDPAGTVKPLTDCLKSGVLRGAAGVVGCNNAKGVSNeAHVTIMKELiKNDIIVVTT 475 Clostrid...
ETI95811            407 KSEAMVgyaeeaivgqlnnvvntQIDDMNTLKPLIDVLASGVIRGVVGVVGCNNARTPSNyNHLTIMKELiKNDYLVVTT 486 Intestin...
WP_012301969        383 AVELVTgfgqes------irhalGGRFRGSYRMLNENIINGWIRGVAGVVGCTNPRAASGaSHGVLVRELvANDVLVLVT 456 Candidat...
goetting:HRM2_16670 432 KATQIAgfgves------iqyhlGGTFRGSYYTLNDNIINGRIRGIAGVVGCNNARTKHNdGHVRVVKELiKNDVIVLTT 505 Desulfob...
jgi:Sfum_2566       418 QDWGIHgfsmey------isymlGGTFRSSYVPLNDNIINGRIRGVAGVVGCTNPRVKQDyIHVELVKELiKNNVLVVQT 491 Syntroph...
ACL04072            410 KNVGIHgfskey------igymlGGSFRESYVPLNENIINGRIRGVAGVVGCTQPRTKQDyMHVELVKELiKNDVLVLQT 483 Desulfat...
WP_012174881        410 INKGVHgfsyey------inymlGGSFRSGFTPLNENIINGRIRGVAGVVGCTNPRVRQDwVHVELVKELiKNDVLVLQT 483 Desulfoc...
1GNL_A              426 GCAKYRYNKLNLGDI-------G-Gip---------rVLDAGQCNDSYSLAVIALKL--KEVFGLeDVNDLPI-VYNIAW 485 Desulfov...
WP_009246088        480 GCSAQAAAKAGLMDKrak-dicGdGlkrvceladippVLHMGSCVDISRMLVLAATL--AKDSGL-RISQLPVvGCAPEW 555 Lachnosp...
WP_012063158        481 GCAAQAAAKAGLLSKdai-klaGkGlqavcelvdippVIHLGSCVDNTRIIRLVSAV--SEHLGV-DNSDLPVvGVAPEW 556 Alkaliph...
Q189R4              476 GCGASAAAKFGLMESdaaekyaGkGlatvcklvgippVLHMGSCVDISRILDLVGAA--ANYLDM-DMCDLPVvGIAPEW 552 Clostrid...
ETI95811            487 GCGASAAAKNGLMLKenaakyaGkGlatvcqlvdippVIHLGSCVDNSRILNICSLV--ANALDM-DIADLPVaGCAPEW 563 Intestin...
WP_012301969        457 GCAALACARDGLLVPeaa-dsaGpGlrevcealgippVLHCGSCVDNSRILMMAAEMvrAGGLGE-DLSDLPVaGCAPEW 534 Candidat...
goetting:HRM2_16670 506 GCNAIACAMEGLLTPeaaavhcGpGlaevcetvgippVLHLGSCVDNSRILLAATEVvkAGGLGH-DICDLPVaGSAPEW 584 Desulfob...
jgi:Sfum_2566       492 GCSQIALAKAGLMKPdaa-vlaGdGlqevcetvgmppVISLGSCVDNSRILTACAEMvrTGGLGD-KLSDLPVaGCAPEY 569 Syntroph...
ACL04072            484 GCSQIALAKAGLLIPeaa-hlaGdGlaevcetvgmppILGLGSCVDNSRILTAASEMvrTGGLGH-SIADLPAaGAAPEW 561 Desulfat...
WP_012174881        484 GCSQIALAKAGLTTPeaa-vlaGpGlqevceavgmppVLGLGSCVDNSRILIAAAEMvkTGGLGE-SIADLPAaGAAPEW 561 Desulfoc...
1GNL_A              486 YEQKAVIVLLALLSLGVkNIHLGPTLPAFLSPNVAKVLVEQF--NIGGITSPQDDLK 540 Desulfovibrio desulfuricans
WP_009246088        556 MSEKAVSIGNYVIGSGL-DTYLGVDPYASGSSEMVEILTNGTreWCEAAFTVEKDID 611 Lachnospiraceae bacterium 6_1_6...
WP_012063158        557 MSEKAVAIGTYVVSSGI-DVFLGITPPVTGSPEFVDLLTNKIedMTGAKFFIDENPL 612 Alkaliphilus metalliredigens
Q189R4              553 MSEKAVAIGCYVVASGI-DTYLGIMPPIAGSSRAVDILTSELkdKVGATFTVNTNPK 608 Clostridioides difficile 630
ETI95811            564 MSEKAIAIGTYVVGSGI-ETFLGVMPPVTGSSRAVEILCGSIkdKVGACFHVNEDAE 619 Intestinibacter bartlettii DORA...
WP_012301969        535 MSEKALAVGQYFIGSGI-SVGLGVYFPGADSKEFAAQVFEGLtqDYGAAWFFEPDPQ 590 Candidatus Desulforudis audaxvi...
goetting:HRM2_16670 585 MSEKAISIGHYFVASGV-YTVFGVTLPTSGAPVFHDYLCKQFegLTGGMWDLEIDPI 640 Desulfobacterium autotrophicum ...
jgi:Sfum_2566       570 MSEKAICIGQYFVASGV-YTVFGVTFPSVEGTKFHKLLFEGLeeQGFGKWGFATDPY 625 Syntrophobacter fumaroxidans MPOB
ACL04072            562 MSEKAISIGHYFVASGV-YTVFGTTFPITEGTKFHKHLFEELeeMGLGKWGFSNDPI 617 Desulfatibacillum aliphaticivorans
WP_012174881        562 MSEKAISIGHYFVASGV-YTVFGVTFPVVDGTRFQKLLFEELeeKGMGKWGFAVDPY 617 Desulfococcus oleovorans
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