6ELQ,6VWY,1JQK,7ERR,1GNL,1GNT,7B7T


Conserved Protein Domain Family
Prismane
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pfam03063: Prismane (This model is not part of the current CDD release)
Prismane/CO dehydrogenase family
This family includes both hybrid-cluster proteins and the beta chain of carbon monoxide dehydrogenase. The hybrid-cluster proteins contain two Fe/S centres - a [4Fe-4S] cubane cluster, and a hybrid [4Fe-2S-2O] cluster. The physiological role of this protein is as yet unknown, although a role in nitrate/nitrite respiration has been suggested. The prismane protein from Escherichia coli was shown to contain hydroxylamine reductase activity (NH2OH + 2e + 2 H+ -> NH3 + H2O). This activity is rather low. Hydroxylamine reductase activity was also found in CO-dehydrogenase in which the active site Ni was replaced by Fe. The CO dehydrogenase contains a Ni-3Fe-2S-3O centre.
Links
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Statistics
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PSSM-Id: 515364
Aligned: 147 rows
Threshold Bit Score: 290.22
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6ELQ_X        45 LCCrHCVQGPCRIDpfge---gpqaGICGATAEVITARNLLRQVTAGAAAHVDHAYDVlevle-qiaqGTeSYSIKDQEK 120 Carboxydothermu...
WP_012301267  55 DLCcLCNFGKCDLTqd-------rkGACGIDMATQQARMILIACLMGAAAHGAHGRHLiehl----------iekHGEDY 117 Candidatus Desu...
Q8THW2        73 DQCcYCTYGPCDLSgn-------krGACGIDMAGQTGREFFLRVITGTACHAAHGRHL---------------------- 123 Methanosarcina ...
WP_012675684  47 RCCtLCPDGPCRIKrra------pkGKCGIDADGLAARNLLRLVNQGGAAYTHDFKTTlktlka-iaegksPFRVSDRNK 119 Persephonella
O28429        47 LSCqLCSMGPCRISkdk------ptGACGIDAAGMVVRNFTHKNMLGTEAYTYHAIEAaktlka-taegktIYEIKDVEK 119 Archaeoglobus f...
A0B8H1        66 TRCdLCSNGPCRADask-----drrGVCGISADGMAMRMMLLRNVMGASTYHYHAEQTirtlra-talgrtPFRIVEQKK 139 Methanothrix th...
WP_013179588  44 MSCqLCSNGPCRITpvidgvrkidsGACGIGPDAMAMRYMLLRNVMGTSTYTYHAKEAfrtlks-taegrtPFEIQDITK 122 Methanococcus v...
Q3AG28        45 VSCqLCSNGPCRINekvg----atlGVCGINADGMAMRYMLLRNVMGTSTYTYHAYEAyktlkm-talgntPFTITDKDK 119 Carboxydothermu...
WP_012047757  69 lSCqLCSQGPCRINekgp----qkkGVCGIGPDAMAMRNFLLKNIMGAGTYSHHAYEAfrtlka-taegktPFTIKDVNK 143 Clostridium bot...
7B7T_A        45 VSCqLCSNGPCRINekvg----atlGVCGINADGMAMRYMLLRNVMGTSTYTYHAYEAyktlkmtalgNT-PFTITDKDK 119 Carboxydothermu...

6ELQ_X       121 LKQVAFTLGIDtanktEQEIVEEMCqiiyrdfansgatpmtYLKANSPRERLETweklGVLP-RNPDREIREALHQTTMG 199 Carboxydothermu...
WP_012301267 118 PLVLGDQVNVEapi-------------------------irTVLGLKPQTLGDL----RKAV-EYVEREFIHLVAATHTG 167 Candidatus Desu...
Q8THW2       124 LDHVIEVFGedlplnlge---------------snvltpnvTICTGLSPKTLGE----CRAPmEYVEEQLTQLLATIHAG 184 Methanosarcina ...
WP_012675684 120 LLWFAGSLGLDte-gtDEEIIGRLAdflerefmkdlnepltLIEKLAPESRVEIwkslGIIPgGYIFES-HEASAKVMPN 197 Persephonella
O28429       120 LKWFAKLLGIEge--dVNELAAKVAdfvisdl--ssleksrLVEIFAPEKRKELweklGIFP-SGVFQELLTMGSSAMTN 194 Archaeoglobus f...
A0B8H1       140 LRRLASMLDIDts-gsPEDTALRLCdaveadfnrsyyqesqIVEAFAPAERKDLwralGIFP-GGIHGEILLATGSCLTN 217 Methanothrix th...
WP_013179588 123 LKTFANACGLKvt--sVNETAINLAkflyeqt--ytskpsiMVERFAPKPRKDLwnklDLFP-AGPQEEMLISTSSCLTN 197 Methanococcus v...
Q3AG28       120 LYQMAKDLELNte-gkPEDVAVRLSdfliwelyrdydepgkMIEVYAPLKRKEVwrklGIYP-AGPLHELKDAAASCLTN 197 Carboxydothermu...
WP_012047757 144 LKWMCENLGIDtn-kdTNQMAIELAdlleeqqkidvedknlMVEAFAPKKRKELwrklNIYP-AGTVHEEQNCVASCLTN 221 Clostridium bot...
7B7T_A       120 LYQMAKDLELNte-gkPEDVAVRLSdfliwelyrdydepgkMIEVYAPLKRKEVwrklGIYP-AGPLHELKDAAASCLTN 197 Carboxydothermu...

6ELQ_X       200 MDADPVNLILKTIRLGLVDgFAGLKLATDLQDIIFGTP----QPvvTEANLGVLkEDyVNIIVHGHVPLLSEKIVEWSRK 275 Carboxydothermu...
WP_012301267 168 QEGSNLDYESKAFHCGMLD-HVALEACDLAQITGFNYPtsvvETplVELGWGTIdRTkPVILLVGHNAAAANSMTDYLRK 246 Candidatus Desu...
Q8THW2       185 QESAEIDYDSKALFSGSLD-HVGMEVSDIAQVSAYDFPkadpEAplIEIGMGSIdKSkPLIVAIGHNVAGVTYIMDYMEE 263 Methanosarcina ...
WP_012675684 198 IDTDYIDLALTSLRLGLSAgFLANIATTVIRDIIFGSP----DIteGYADIGVLdKDyVNIVVHGHVPWMGSIVAKKAKT 273 Persephonella
O28429       195 VDSNYVSLAKKSMSMSIATcMAAQIALETIQDILFGTP----MPheSHSDLGILdPEyVNIAVNGHEPFVGIALIKLAER 270 Archaeoglobus f...
A0B8H1       218 VDGSYESLAMKAMRLSIAMaYQSQMVLEHCQDVLFGVP----RPhkMMVDLGVLdPDyVNVVVNGHEPFMGFAMIMLARQ 293 Methanothrix th...
WP_013179588 198 VDSDYVSLALKAMRLGISCiYGAQIGLEMVQDILYGTP----MPhkVDVDLGIVdPNyINIVVNGHEPFVGAALIDMARS 273 Methanococcus v...
Q3AG28       198 VDGDYVSLATKGLRLGLSCiYGAQIGLELVQDILFGTG----MPheMDVDLGIFdADyINIVFNGHEPFVGVALILAAKE 273 Carboxydothermu...
WP_012047757 222 VDGNYKSLAAKALRLGIATiYNSQIGLEMVQDILFGTP----MPheVNVDLGIMdPEyVNIVFNGHQPWGGVATIQKAKM 297 Clostridium bot...
7B7T_A       198 VDGDYVSLATKGLRLGLSCiYGAQIGLELVQDILFGTG----MPheMDVDLGIFdADyINIVFNGHEPFVGVALILAAKE 273 Carboxydothermu...

6ELQ_X       276 LEDEAKKAgak--ginLAGICCTGNEv-LMRQ------GVPLATNFLAQELAIITGAVDLMVVDVQCIMPSLAEiAAc-- 344 Carboxydothermu...
WP_012301267 247 NNLLDQVE--------LAGICCTALDatRYNA------GAKVVGPLAQQRFFLKTGLADVIVTDEQCVLTDIPAlAGe-- 310 Candidatus Desu...
Q8THW2       264 NNLTDKME--------IAGLCCTAFDmtRYKEadrrapYAKIVGSLAKELKVIRSGMPDVIVVDEQCVRGDVLSeSMk-- 333 Methanosarcina ...
WP_012675684 274 AKFQNIARsagakgikVYGSLCTGQEl-LQRPeta-kyLDGQVGNWLTQEFVAATGAVDAFLMDKNCAAPGMANlVQslk 351 Persephonella
O28429       271 EEIQEKARkagakglrIIGFIETGQEi-LQRVds--pvFAGIVGNWIVQEYALATGCVDVFAADMNCTLPSLPEyQR--- 344 Archaeoglobus f...
A0B8H1       294 PEWQERARsagarglrIIASIETGQEi-IQRWsmd-evLGGFTGNWISQEPMMATGSIDLMACDMNCSLPLDPEyARr-- 369 Methanothrix th...
WP_013179588 274 SQIQERARaegakglrIVGSIETGQEl-IQRYdmd-dvFVGLTGNWITIEPLLATNAVDVFAMDMNCSLPRLNEySKk-- 349 Methanococcus v...
Q3AG28       274 AVNQDKAKaagakslrIYGSIESGQEv-VQRFqkd-evFRGLTGNWLTIEPMLATGAVDVLAMDMNCSPPNLGPlAEk-- 349 Carboxydothermu...
WP_012047757 298 AEVQQKAKaagakglrIVGSIETGQEl-LQRFevd-dvFVGLMGNWLAIEPLLATGTVDVMAMEENCSPPAIDHyAEk-- 373 Clostridium bot...
7B7T_A       274 AVNQDKAKaagakslrIYGSIESGQEv-VQRFqkd-evFRGLTGNWLTIEPMLATGAVDVLAMDMNCSPPNLGPlAEk-- 349 Carboxydothermu...

6ELQ_X       345 YHTRLVTTMPIVKi--PG-AEH-V---Pft----------tETA-----DEASQQIVRMAIESYQKR-NPak--vyIPRE 399 Carboxydothermu...
WP_012301267 311 TGAALIAWSDKIC---YG-LDN-VtekEtdeivkmivagekKQVlvldsDKAAEVAVKVALALAPARkk-----fiLSPA 380 Candidatus Desu...
Q8THW2       334 LKIPVIASNEKIMmglPD-RTD-A---DvdsiveeiksgaiPGCvmldyDKLGELIPKIAEVMAPIR-DAegi-taIPTD 406 Methanosarcina ...
WP_012675684 352 LHTKLIPVSSVVRl--KDvEAR-S---Dfmy--------dpVKA-----EEQAERLIMEAIDAYKNRrKTyk--ihIPER 410 Persephonella
O28429       345 YGVKIVPVSRLVRl--KGiDEG-LdyeP-------------EKA-----EEIAMKLIDMAIENFKQR-DKsk---aVKVE 399 Archaeoglobus f...
A0B8H1       370 YGFRLVPVSELVAf--EGiSDR-LnyvP-------------EQV-----EHQAAKLLEMAISNYPSR-RSge--khVRDL 425 Methanothrix th...
WP_013179588 350 YNSTLVSVSKLVKl--PHvSIN-M---D-------------YEPhk--vEKMAEDIINIAFKNYKIR-KStk--syVPAK 405 Methanococcus v...
Q3AG28       350 YGATLVSVSRLVRf--PG-IHH-F-----------------LDYkpsevREIAQKIIDIAVDSFKNK-RHgki-tpKIPA 406 Carboxydothermu...
WP_012047757 374 YGATLVSISTIIDi--PG-LQHkI---Pyn----------pEKV-----DVMADSLIDLAIENFKKR-KDkv---kPMVP 428 Clostridium bot...
7B7T_A       350 YGATLVSVSRLVRf--PG-IHHfL---Dyk----------pSEV-----REIAQKIIDIAVDSFKNK-RHgkitpkIPAN 407 Carboxydothermu...

6ELQ_X       400 KAKVVAgfsv----------------------------------------eaiVKALAklnpdDPLKPLIDN-------- 431 Carboxydothermu...
WP_012301267 381 QAVEIAgrcrekcekchq-----------------------ncanllpvgtavSRAGE-----GDLEPLAKLfrkcvgcg 432 Candidatus Desu...
Q8THW2       407 EEFKVYidkcvkcgecmlacpeeldipealeyaakgsyeylealhdvcigcrrCEQVC-----KKEIPILNVlekaaqks 481 Methanosarcina ...
WP_012675684 411 KTHYIAgfgi----------------------------------------esiLKVLG-----GTPDPLFEA-------- 437 Persephonella
O28429       400 QKKKIVvgfs---------------------------------------peaiLKALN-----GDLNVLLDA-------- 427 Archaeoglobus f...
A0B8H1       426 PAGEATvgfs---------------------------------------tesiLELLG-----GSLDPLLNA-------- 453 Methanothrix th...
WP_013179588 406 KTGAIVgist----------------------------------------eaiLHILG-----GSLDPLLNA-------- 432 Methanococcus v...
Q3AG28       407 NIQKAItgft---------------------------------------peaiLKALG-----GSINPLIEV-------- 434 Carboxydothermu...
WP_012047757 429 KITQKAiagfs--------------------------------------teavLEALG-----NKLDPLVDV-------- 457 Clostridium bot...
7B7T_A       408 IQKAITgftp----------------------------------------eaiLKALG-----GSINPLIEV-------- 434 Carboxydothermu...

6ELQ_X       432 ---------------------------------------------IVSGNILGVVATVGCNNVKVKHDw-F-HIELVKEL 464 Carboxydothermu...
WP_012301267 433 kceevcdfnlpilklmaaaasaekykvrvgrgpihdveirkvgspIVLGTIPGVVLFAGCSNYPDIGD----VAWMAEEL 508 Candidatus Desu...
Q8THW2       482 iseekgwvr-------------------sgrgqasdaeiraeglnLVMGTTPGIIAIIGCPNYPAGTK--D-VYNIAEEF 539 Methanosarcina ...
WP_012675684 438 ---------------------------------------------IQDGTIKGVVGLVSCTTMKNGHGt-F-TYDFVKEL 470 Persephonella
O28429       428 ---------------------------------------------IKKGDIKGVVALVSCTTLKNGPHdsS-TVTIAKEL 461 Archaeoglobus f...
A0B8H1       454 ---------------------------------------------LKSGQIRGIVGLVSCTTLRDSGQdvH-SVALAKEL 487 Methanothrix th...
WP_013179588 433 ---------------------------------------------IKDGDIKGVVALISCTSIHGHGHdmN-TVAIAKEL 466 Methanococcus v...
Q3AG28       435 ---------------------------------------------IKAGKIKGAVGLINCTTLKNGPQdyV-TVNLAKEL 468 Carboxydothermu...
WP_012047757 458 ---------------------------------------------IAAGKIKGVVALANCSTLRNGPQdwN-TVNLTKEL 491 Clostridium bot...
7B7T_A       435 ---------------------------------------------IKAGKIKGAVGLINCTTLKNGPQd-YvTVNLAKEL 468 Carboxydothermu...

6ELQ_X       465 iKNNVLVVTTGCSAHAL---AKAGLMDPaaa---ewaGeGlravltaigtandlggplppVLHMGSCVDNSRIGDLVIAV 538 Carboxydothermu...
WP_012301267 509 aRRKYIVCLSGCAAMAAgmyKDAEGRTIyekyppsfdAgG--------------------VLNVGSCVSNAHVVGAAIKI 568 Candidatus Desu...
Q8THW2       540 lKRNYLVVVSGCSAMDIgmyKDDDGKTLyerypgtfsGgG--------------------LLNTGSCVSNAHITGAAEKV 599 Methanosarcina ...
WP_012675684 471 lKRDILVLIAGCASSLA---QVEGFTNSkgrk--efaGpGlralce--------aldippVLNFGSCLDTGRMALLIIAL 537 Persephonella
O28429       462 iKRDILVLSMGCGNAAL---QVAGLTSMeav---elaGeKlkavck--------alnippVLSFGTCTDTGRAAYLVRLI 527 Archaeoglobus f...
A0B8H1       488 iKRDVLILSMGCGNAAM---QLAGLCRKeaa---alaGsGlegics--------slgippVLSYGTCTDVGRLSELLRSV 553 Methanothrix th...
WP_013179588 467 iKKDILILSAGCGNAAL---QVAGLTSLdai---dlaGsKlagvck--------llkippVLSFGTCTDTGRISMVVSEL 532 Methanococcus v...
Q3AG28       469 iKRDILILSGGCGNHAL---EVAGLCNLdai---nlaGpGlsevcr--------nlnippVLSFGTCTDTGRISLVVTAL 534 Carboxydothermu...
WP_012047757 492 iNKDILVVSGGCGNHAL---EVAGLCTLeaan--tiaGeGlkevcn--------llkippVLSFGTCTDTGRISMLVTAL 558 Clostridium bot...
7B7T_A       469 iKRDILILSGGCGNHAL---EVAGLCNLdai---nlaGpGlsevcr--------nlnippVLSFGTCTDTGRISLVVTAL 534 Carboxydothermu...

6ELQ_X       539 ANYL------K-V-SPKDLPIa----ASAPEY--QHEKALSIGTWAVAMGIMTHLGVVPPVVGSSKVTRILTQD----Ae 600 Carboxydothermu...
WP_012301267 569 ANIFanlpsrAnYeLIADYILnrvgaCAVV-WgpYSQKALAIGTGAIRWGIPLLLGPHGAKYRRLFMSKKEYDDwt-vId 646 Candidatus Desu...
Q8THW2       600 AGIFaqrtlaGnLaEVADYTLnr-vgACGLAWgaYSQKAASIGTGCNIYGIPAVLGPHSSKYRRALIAKTYEEDkwkvFd 678 Methanosarcina ...
WP_012675684 538 SEYL------G-V-DPSALPVv----AAAPEY--YNNDALIDGLLAVSLGINTYVNPVPPIVGGPGFTRLLTRD----Le 599 Persephonella
O28429       528 ADAL------G-V-DVPQLPVa----VTAPEY--MEQKATIDAVFAVAYGLTTHVSPVPPITGSEDAVKLFTED----Ve 589 Archaeoglobus f...
A0B8H1       554 SEML------G-V-PVKDLPVa----AAAPEY--MEQKATIDAIFALAFGLYTYVNPVPTITGAPRLLDLLLRG----Cr 615 Methanothrix th...
WP_013179588 533 ANAL------N-V-DTKDLPIa----VSAPEY--MEQKATIDALFALGFGLYTHVSPLPPVTGGDSLVKLLTND----Le 594 Methanococcus v...
Q3AG28       535 ANAL------N-V-DTADLPVa----VTAPMY--MEQKATIDALFALAYGLYTHVAPDPPVMGAPNLVKLLTRD----Lp 596 Carboxydothermu...
WP_012047757 559 ADHM------N-L-DVSDLPIa----VTAPEW--MEQKATIDGIFAVAYGAYTHLSPVPFMTGAPELVKLLTEE----Ve 620 Clostridium bot...
7B7T_A       535 ANAL------N-V-DTADLPVa----VTAPMY--MEQKATIDALFALAYGLYTHVAPDPPVMGAPNLVKLLTRD----Lp 596 Carboxydothermu...

6ELQ_X       601 aLIGGKF-YVETDPY 614 Carboxydothermus hydrogenoformans
WP_012301267 647 gRTEQLVdTREPTPE 661 Candidatus Desulforudis audaxviator
Q8THW2       679 aRDGSEM-NIPPAPE 692 Methanosarcina acetivorans C2A
WP_012675684 600 nLLGARF-MVEPDAV 613 Persephonella
O28429       590 kLTGGKV-VVEEDPL 603 Archaeoglobus fulgidus DSM 4304
A0B8H1       616 eVTGGVI-SVEKDPV 629 Methanothrix thermoacetophila PT
WP_013179588 595 nLTGAKL-NVDTDMI 608 Methanococcus voltae
Q3AG28       597 sITGGRI-AVGSDPV 610 Carboxydothermus hydrogenoformans Z-2901
WP_012047757 621 nITGGKV-ALGDDPV 634 Clostridium botulinum
7B7T_A       597 sITGGRI-AVGSDPV 610 Carboxydothermus hydrogenoformans Z-2901
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