2F0X,1VPM,1NJK,2O6T,3QY3,2PZH,1S5U,5V10,4K00,2EGI,5WH9,2FS2,3S4K,4QDB,4K4C,1SBK,2B6E,4K02,3NWZ,1ZKI,2HBO


Conserved Protein Domain Family
4HBT

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pfam03061: 4HBT 
Click on image for an interactive view with Cn3D
Thioesterase superfamily
This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyzes the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyze palmitoyl-CoA to CoA and palmitate, they also catalyze the hydrolysis of other long chain fatty acyl-CoA thioesters.
Statistics
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PSSM-Id: 397265
Aligned: 127 rows
Threshold Bit Score: 39.9262
Threshold Setting Gi: 75180728
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2F0X_D  52 IGTLHGGLT----ATLVDNISTXALLCTERG----------APGVSVDXNITYXSPAKLGeDIVITAHVLKQGKTLAFTS 117 human
O07408  31 FGHLNNAVY----YQLFDTAINAWINTSTGVdpl----ampVLGIVAESGCRYFSELRFPeSLMVGLAVTRLGRSSVTYR 102 Mycobacterium tubercu...
Q9DCP4  76 NSHVNNAVY----YSYFDTVISHYLIRYCGLktsl--ltspQVGFMVTNQCKFHTPISFPqTPLAALAVEKVGRSSVCYR 149 house mouse
2O6T_I  30 YGHVNNVTY----YAFFDTAVNTYLIERGGLdiq----ggeVIGLVVSSSCDYFAPVAFPqRIEMGLRVARLGNSSVQYE 101 Pseudomonas aeruginosa
Q9HTM6  26 QGIVFNGNY----LTYLDVATTEYYRQLGMSypadl-lrggGDLFAVKSTLEYRAPAHFDdWLDIGTRVARLGRSSLVFE 100 Pseudomonas aeruginosa
Q0KBD3  22 qSIVFNAHY----LTYCDICVTEYWRALGIRypedvlhahgVDIFVVKSTLEYHASARFDdELEIRGRMSRLGRSSMLFR 97  Cupriavidus necator H16
Q9I4Y1  19 EGIVYTPRFsyfvLEAVQEALGVWLGGPGLRtll----gfrILPPARAFSLEFLHPVTWDdELTMQVGVSNVGTHSFSFS 94  Pseudomonas aeruginosa
Q9L110  29 LGLLHNARY----PVMVERAWTELWAGHGVRfegdweaagdACNAVRELTIGYEAPVTRPgAYAVHLWLDRLGTTGLTYG 104 Streptomyces coelicolor
Q97MC7  18 MGIVYHANY----YVYFEAAREDLIEGAGIKysdm--edigIMMPLVETKCKYHEGAKYGdYILVETTLGKLSPIKVEIN 91  Clostridium acetobuty...
2EGI_I  17 QGIVHHSNY----FRYFEEARGEFLRSKGFPyskm--rdmgLEVVLLNAYCEYKKPLFYDdVFEVHLNLEELSRFTFTFS 90  Aquifex aeolicus
2F0X_D 118 VDLTNKATGKLI 129 human
O07408 103 LGVFKEPDDAGV 114 Mycobacterium tuberculosis
Q9DCP4 150 LALFPPKPTKEL 161 house mouse
2O6T_I 102 LALFLEGQREAC 113 Pseudomonas aeruginosa
Q9HTM6 101 LGIWRDEQLLTV 112 Pseudomonas aeruginosa
Q0KBD3  98 VEMFRGDEHLIt 109 Cupriavidus necator H16
Q9I4Y1  95 VEGRLSPDVVAF 106 Pseudomonas aeruginosa
Q9L110 105 FRFCSADGATTY 116 Streptomyces coelicolor
Q97MC7  92 YRVLRESDGKLL 103 Clostridium acetobutylicum
2EGI_I  91 YIVFKEDIAVAK 102 Aquifex aeolicus
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