4OU8,5U8Y,6OJR,3NPE,7QR6,3KVC,3KVC,7WH0


Conserved Protein Domain Family
RPE65

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pfam03055: RPE65 (This model is not part of the current CDD release)
Retinal pigment epithelial membrane protein
This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein. The family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.
Statistics
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PSSM-Id: 515360
Aligned: 458 rows
Threshold Bit Score: 231.74
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4OU8_A        24 YQSQPQEWD-Yw------V--EdvE--GSIPPDLQGTLYRNGPG-LLeIG---------------DRPLK-HPFDGDGMV 75  Synechocystis s...
XP_009225893  37 GLIGLKEERgPi------E--Lkv--sGEIPAWAAGSLFRTGPGdSE-IRdtp----------ngTLKIS-HWFDGLGHA 94 
CCE29580      42 AFDGLDNQReSv------Q--Lgv--nGHIPSWAAGTFYRTGPGqSV-IEnts----------rgTHHVS-HWFDGFAQV 99 
XP_025172812  48 GFSNAGETLtP----------VelKvsGELPSWLSGELYTVGPGtYD-IKytrmieseggfesatETFSMgHWFDGLPLV 116
EPB84051     170 GFQNFHDSDkI----------DdlNvtGQLPEWLVGEHFTIGPStFD-IKytrkieidgelqnasAFYTFgHWFDALPLV 238
EPB85659      76 GFYNAKDSKdV----------VdlVvdGQLPEWLTGEYYTIGPGtYD-VRysrkievdgmlqsatATFTLgHWFDALPLV 144
XP_067522533  69 GFCNTTDSKqV----------VdlEvdGQLPDWLASEHYTIGPGtYD-VKytrkieidgilqsatATFTLgHWFDA---- 133
EPB86031      20 GFKNVPSVEsP----------VtlKldGQIPSWVNGVMYRSGSGrYN-VLldn----------gdTFHIG-HPFDGLAML 77 
XP_067512199  30 IQSMQKPVMlGntpecqdRitLekVs-GQLPSWLNGVMYRVGPGvFN-IKqkn----------giTYTIR-HAFDGLPMV 96 
EPB91835      40 KLSNTPEVQdPv---------VlqLqsGQIPSWLNGIMYRIGPGrFN-IQqnd----------gsTFSIR-HAFDGLPFM 98 
4OU8_A        76 TAFKFPg-----------------------D-GRvHFQSKFVRTQGYVEEQKAGK------------------------- 106 Synechocystis s...
XP_009225893  95 HRFDIIpafpapgpnepqdgdsqnqqsqktRv---VYTSRR-QSDDLVNWIKSNGddrlfsfaqrs-------------- 156
CCE29580     100 HKFDLIpslld---------------etncSv---TYTSRF-QSEEYIKFVRRKGwradlsfgqrs-------------- 146
XP_025172812 117 NRFEFDg-----------------------KdGKiKYRSRITSRKYEIKIRDHHGivtrhp------------------- 154
EPB84051     239 NRFDLNg-----------------------SrNSvTYRHRSTSRRLVEKIREHHGyapqhp------------------- 276
EPB85659     145 NRFDLNg-----------------------ErNTiTYRNHLVNKKLGEKIRDHHGyapnyp------------------- 182
XP_067522533 134 ---------------------------------------------------DHHGyapnfp------------------- 143
EPB86031      78 HRFEISg-----------------------EtQSvKYNSRHTSHGVE---RRIGQrdptlltfgpdpcktifgriqsvyh 131
XP_067512199  97 HRFQLNg-----------------------StQTvTYNSRHTAKSLE---KEISS------------------------- 125
EPB91835      99 HRFEVNg-----------------------StQTlKYNSRMLAKSLE---TEIKN------------------------- 127
4OU8_A       107 ---------------MIY-------------RGVFGSQPag---------------gwL-K-------TIFDLRLKNIAN 135 Synechocystis s...
XP_009225893 157 ----dpcvglfgkvmSTFkrarfgrtsqvsrG-------------------------------------------LENIA 189
CCE29580     147 ----dpcvglfakfmSLFtp------------------------------------------------------rQINNN 168
XP_025172812 155 -----------------------------------------------------------------------ftlfkTHAN 163
EPB84051     277 -----------------------------------------------------------------------nalymSNTN 285
EPB85659     183 -----------------------------------------------------------------------aglfkTNAN 191
XP_067522533 144 -----------------------------------------------------------------------aglfkTHPN 152
EPB86031     132 hiskfganaalqendAEF----------------------------------------------------------DMVN 153
XP_067512199 126 -------------------------------GADKGLVFfghvpevsfltwlinwivrLnNlvlrpkpIHLTKPDGRSVG 174
EPB91835     128 -------------------------------KSFKGLIFfghipemtfpqwlynfyvrFnNlilspkpRHDGRPDGQSVG 176
4OU8_A       136 TNIT-------------------------------YWGDRLLALW-EGGQPHRLEPSNLATIGLDDLggilaegqPL--- 180 Synechocystis s...
XP_009225893 190 VTVVtqppvqlerednlvqanssdpnpgepatsghQ-SNTIWMLT-DTSSISLVDKTTMERVGISTQk-------QLhpe 260
CCE29580     169 VTVLpnipgmmqd-------------tdtshkdfqNEPSNLYVCT-DNATLQKLDPITLEPLGKATQr-------SLhpd 227
XP_025172812 164 QTPLaklfgqkrtdkpeme-pcsvnistkfpfyksGEKPKVFCQN-HASQVVELDAHDLAPSRVYSWnd-----iNPlfr 236
EPB84051     286 QTVLskflgsskaskpd-----aepcaarilanipGLEGRLFAQN-YANHVQELDPFDLKPTRLLQWne-----iNPkfk 354
EPB85659     192 QTMLikflnngkalkpd-----ripcgqrittrlpGIDGRLFCQD-FANHIQELDPFDLTPTRVETWne-----lNPelk 260
XP_067522533 153 QTMLikflnngkkpkpd-----rvpcnqrimtqvpGLDGRLFTQN-FANHIQELDPFDLTPTQVQTWde-----iNAdfk 221
EPB86031     154 VTVTpnfplga-----------------dleqetgVKRGEALVVKrDANTLQVVDPETLKPLKMFtyahvsk-------k 209
XP_067512199 175 VTVTpnytlpa-----------------rvsmnndLSKKSLVAKT-DANVLQKLHAETLVPeiifsykny-------dph 229
EPB91835     177 VTVTpnfplp-------------------arikkaDGENVLVSKT-DANVLQKIHAETLEPqnifnytsy-------dar 229
4OU8_A       181 ------SAHPRIDPAStfdggqPCYVTFS---IKsslsStLTLLELd-P--QGK-------------------------L 223 Synechocystis s...
XP_009225893 261 lagpfsCAHAARDPVT------GDIYNYN---LEvg-pNp-TYRIFriDaaSGTteim------------------arfA 311
CCE29580     228 lkgpmsCAHAQRDPET------GDLFNFN---LEpg-rTa-TYRIFrvNaaSETvdil------------------atiA 278
XP_025172812 237 g--dhaSPHPHYDDNT------GELINFNmev----yaLgTKYNFFsiTekNPNgefi------------------asiS 286
EPB84051     355 g--tssCPNGKYDSRT------GEYINFSmev----gyQsVKYNFFsiSdkNPKgsl-------------------lasV 403
EPB85659     261 g--yssCPNGQFDTET------GEYINFTmei----gyRsTKYHFFsiSeqHPKgepi------------------atiW 310
XP_067522533 222 g--yssSPNGQVDPET------GEYINFTmei----gyRtTRYHFFsiSnqEPKghpi------------------ttiW 271
EPB86031     210 lqgqlcASHHQYDEET------DEYINFMvklG-----PfPTFQTFslGpyLPSppgekeampapeprlhqpiwrhlgaW 278
XP_067512199 230 lngpfsAAHHQFDPET------NEIFNFSlhlF-----PkSKMTVFktSkeGQTtllae----------------ithrK 282
EPB91835     230 ikgqlsAAHHQYDPNT------KEIFNFAlttG-----PvPRLVVFstTeaGKVtila-----------------dfthR 281
4OU8_A       224 lrqktetfpG------FAFIHDFAITPHYAIFLQNNVTLNglpYl------fGLrgAGECV-QFHPDKPAQIILVPRD-- 288 Synechocystis s...
XP_009225893 312 hrs-----------lgPTYMHSFFLTERHVILCLPVAQMG---YkgaammvyGn--VVESLvPFDPSQTTKWIFIDRTa- 374
CCE29580     279 dke-----------laAAYIHSFFLTDNHVILCVPTSHYG---WnglkvlweRn--IIEAIkPFDTNEDCKWLVVDRRh- 341
XP_025172812 287 a--------------kASYVHSFAVTQRFIILVVFPFHGK---Nagi--nfkWSdnILDSL-TYRPEESTLFYVISRAe- 345
EPB84051     404 ta-------------pMAYVNNFSITPKYIIFVICPILAN---Aggv--kynWNesIMDSF-SFRPSEPTLFYVISREk- 463
EPB85659     311 na-------------pTGWVNNFALTPNYIVMVIHPMLAN---Sgav--rfaWSesILDSF-NFYPSEPTLFYVVSRKd- 370
XP_067522533 272 na-------------pTGWVNGFALTPNYIVMVIHPMLAN---Sgav--rfaWNesVLDSF-TFYPSEPTLFYVISRVd- 331
EPB86031     279 ---------KtmealkPSYIHSFSMTKNYIIIPNFPYYysfgg-----lsaiYYssAYQTF-YWDETRHTLFHVIDRH-- 341
XP_067512199 283 ---------GdhsefrASYIHSFYLTKNYVIIPESPLVygdqg-----lnslLQgaVLSSM-HWIDQAPLYFHVIHRNe- 346
EPB91835     282 ---------TdkspiqAPYIHSLWLTENYVIIPESPMVlkdrg-----anmlMNgsFLSSI-SWVKDAPTYCHVIARHpv 346
4OU8_A       289 ---G-Ge---iKRIP---V--QAGF-VFHHANAFEengkiildsicynslpqvd-------------------------- 329 Synechocystis s...
XP_009225893 375 ---ArrgviavrETP-------AMF-FFHTINAWEdydasrsggqqestpaepkgreteehdaaksagdagtaskddaiw 443
CCE29580     342 ---Grgvv-arfSTP-------ASF-FFHTINAFEekikdengnqvtelymdcieyentnimhm---------------- 393
XP_025172812 346 ---KqHva--tyRSE-------PCF-AFHHINAFEddddnlyldivcydnteicy------------------------- 387
EPB84051     464 ---GdVva--tyRSD-------PCF-VFNHINAFEddrdgvyldmicypddtiarql----------------------- 507
EPB85659     371 ---KdVia--cyRSA-------ACF-SFNQVNAFEdvhgnvvidmvcyendtiaqq------------------------ 413
XP_067522533 332 ---KeVia--cyRSN-------ACF-SLNQVNAYEdvhgnvtvdmvcyeddtivh------------------------- 373
EPB86031     342 -----------TGHHvatYeaDPCF-SFHTANAWDedvelpggrkerviymdycmyentdivdasfelgk---------- 399
XP_067512199 347 ---GgLvas----------ipaPAFyTFHVANAFEevsldgelllhldssafsdgdiiyqvqnfgg-------------- 399
EPB91835     347 qqkEgLvas---------ipvNPGFfTFHVANAFEtkdnsgetiltldcasfsdgdimhqlhsfgtp------------- 404
4OU8_A       330 -----------------------------tdgdfrstnfdnldpgqlWRFTI-DPAAATVek------------------ 361 Synechocystis s...
XP_009225893 444 hvtcdminydsrdildglyfdvilnrdgagdafwrdperransqptlSRYTF-SIPASGPgtnqagvaittpciwpsres 522
CCE29580     394 ------------------lyydilmdrngaaaqglakcglesaqmylVRHKF-TMQNLPMphdknmys------------ 442
XP_025172812 388 ---------------------------dlslenlrtglvvelplaevRRYVLqNIQVESIkfskipqatqletlqntvv- 439
EPB84051     508 --------------------------tteylrnpstmqpsrlvasevRRYLLaNIEEEKItymannslipsktsvttrif 561
EPB85659     414 ---------------------------lstenlrhpetmgklafsqvRRYTLnQPQQDAHktyvannsfipsaisitsri 466
XP_067522533 374 ---------------------------rfatekmrdadmerlpssevRRFVLaNPRHEANkiyldnnsyipsaisvtsri 426
EPB86031     400 ------------tptgkldldlvqparyvfdkntahkeehqiapsqfRRYRLgQVPVAKPgadtwtpswsnafs------ 461
XP_067512199 400 -----------------tflqddlslkrtkfhgftfppaqqvsfghlTRHTL-NLNQRTAvf------------------ 443
EPB91835     405 ----------------hrkgpaaekaaqttlngisyppqqqsgfgdlVRYKL-NLDQSTTls------------------ 449
4OU8_A       362 -----------------------------------qLMVSRCCEFPVVHPQQVGRP-YRYVYM----------GAAhHSt 395 Synechocystis s...
XP_009225893 523 hq------------gldvksrldpawpgmaggrvlrVPSPRVGELPVINPAKATRP-HRYVWS----------QATrGL- 578
CCE29580     443 ----------------------------qraeqvfsIPGPHVGELPAINPDRAGKA-YRYAYG----------VGNgGR- 482
XP_025172812 440 -----------------glfknvqpvtyplpvanyvRCLDSTLELPRINPKFHGQK-YRYVYG----------IGLsAKa 491
EPB84051     562 glfgkkqtpassdleynnqdqdmnkwyswmpiatydKRVQPSIELPQINPKFSMHK-HTIMYG----------LGFsAAs 630
EPB85659     467 gsvwnyv---sggsnqpenavgssgwhawmpvigfdTLVETTLELPQVNPNYKMKD-YTYIYG----------LGFsATs 532
XP_067522533 427 gtvwnyv---tgqagqpenatgsagwhawmpvvkyeRISEATLELPQVNPLYKMRK-YSFAYG----------LGNtGNs 492
EPB86031     462 -----------------------nltkfnkrrvasyAVIGHDLEMPRFNPRYNMKP-YRFCWGvcesrhapsyASGsVV- 516
XP_067512199 444 -----------------------------------aHTLAENIEFPRFHQELIGKP-YKFVYG----------CRVlDDk 477
EPB91835     450 -----------------------------------iDTLAKNVEFPRFNQDYALKKkNRFVYG----------CQLqGFt 484
4OU8_A       396 -G-----NAPL-QAILKVDLESGTETlrSFAPHG----------F-AGEPIFV--Prpg--------------------- 434 Synechocystis s...
XP_009225893 579 --------NTIiDALVKTDMEAEYAG--RPGATFwenp---hghT-PGEPIFLprPrgapplvkpvaggpatqqssssss 644
CCE29580     483 --------GMFmDCLVKTDLQTRE------ALIWngp----vghS-PGEPMFIprPgg---------------------- 521
XP_025172812 492 aTqdgqiW----DSLIKCDLDTKE------VIAMwse----edcY-PSEPVFVpvPgn---------------------- 534
EPB84051     631 sLkdgaiW----DSIVKTNMDTKQ------IEASwhq----dfcY-PSEAVFVprPsigp-------------------- 675
EPB85659     533 sIqegkiW----DSITKINVQSQT------VVASwhe----encY-PSEAQFIpkPikagd------------------- 578
XP_067522533 493 -Km----W----DSIIKLDVNNST------VVASwhe----ancY-PSEAQFIpkPkdqaa------------------- 533
EPB86031     517 ------------NGLIKLDLNNVYLG--PNTDQNssakiwdepgcsCAEPIFI--Pnpd--------------------- 559
XP_067512199 478 ------rS----TGLAKVDVSNQ--------SVIqhq----esgYaYSEPIFV--Phpq--------------------- 512
EPB91835     485 eKkd--eT----GGLIKVDLTGQ--------SGPltfy---eegFnCSEPIFV--Pspt--------------------- 524
4OU8_A       435 ---------------------------gvAEDDGWLLCLIY------KaDLHRSELVILDAQDITApaIATLKLKHHIPY 481 Synechocystis s...
XP_009225893 645 sssssssssssssasdadpavagaadaepEEDDGCLLSVVLn------gHKGTSYLVCLDAKTMVE--VGRAELDfPVGI 716
CCE29580     522 ----------------------------aREDDGVIMTLVLd------sNGQKSYLLCLDAENLEE--LGRAETDfPIAF 565
XP_025172812 535 ---------------------------ddDEDDGVLLSVIFeg------qkVKSYLVVLDAKTLLE--KARVDLPQVIPL 579
EPB84051     676 -------------------------edevGEDEGVLISVVMns------akSTSFLLILDAGSLNV--LATADLERLVPL 722
EPB85659     579 -------------------------dkvaEEDAGVLISIVMds------arATSFVLVLNAKDLSV--LARVELNKLIPL 625
XP_067522533 534 -------------------------ekdeEEDSGVLISVVMda------arNTSFLLVLNAQDLSV--IAKSQLNKLIPL 580
EPB86031     560 ---------------------------gqDEDDGVVMSIVNttlqdgS---ESCFLLILDACSFTE--IARTTIGAFNAV 607
XP_067512199 513 ---------------------------akSEDDGVLLSLANh--------tECCYLVILNAMDMKE--LARFKIGQFTAI 555
EPB91835     525 ---------------------------gtKEDDGVLLSLVNn--------fDCCYFIVFDASNLKE--LARVKIGQFIAV 567
4OU8_A       482 PL-HGSWA 488 Synechocystis sp. PCC 6803 substr. Kazusa
XP_009225893 717 GF-HGAHV 723
CCE29580     566 TL-HGSRI 572
XP_025172812 580 SFgHGSFR 587
EPB84051     723 SFaHGSYR 730
EPB85659     626 SFaHGSYR 633
XP_067522533 581 SFaHGSYR 588
EPB86031     608 TL-HGSFV 614
XP_067512199 556 TF-HGSFV 562
EPB91835     568 TF-HGSYV 574
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