8B7H


Conserved Protein Domain Family
DAN
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pfam03045: DAN (This model is not part of the current CDD release)
DAN domain
This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.
Links
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Statistics
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PSSM-Id: 515355
Aligned: 33 rows
Threshold Bit Score: 104.697
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8B7H_A        26 EEVLESSQE-ALHVTERKYLKRDWCKTQPLKQTIH-EEGCNSrTIINRFCYGQCNSFYIPRHIRKEEG------------ 91  human
Q4H3R0       115 HNILKTSAK-AKTITERKYLKRDWCKSQPVRQYIRtADGCKG-ELINQFCYGQCNSFYIPKDIEIDERdgei-------- 184 vase tunicate
3_pfamImport   1 KEVLASSQE-ALVVTERRYLRSDWCKTQPLRQTVH-EEGCHSrTVLNRFCYGQCNSFFIPRPGGGSWG------------ 66 
XP_001492621  50 KEVLASSQE-ALVVTERKYLKSDWCKTQPLRQTVS-EEGCRSrTILNRFCYGQCNSFYIPRHVKKEEE------------ 115
XP_005158738  65 HDMLSSSRE-ALVVTERKYLKSDWCKTQPLRQTVS-LEGCLSrTVINRFCYGQCNSFYIPRHLTSQSShrsrkta--stp 140
XP_015196201 151 DEILDADKVvALFVTERRFVRRDWCESRPLVHTVR-VQGCLSrAVIVRFCYGQCNSFYIPGVGGDGGG------------ 217
XP_005987980  55 DDVLDSNQA-ALIVTERRHVRRDWCKSHPLVQTLH-EEGCLTrTVINRFCYGQCNSFFIPSQTNGAE------------- 119
EFA02797     126 RKLLKSSKN-ALFVTKKEYLQRDWCKTEPLIQKVK-EEGCLTrTVINRFCYGQCNSFYIPKNPKKRHRhipvseeteded 203
2_pfamImport   1 RKILKSSKN-ALIVTKKEYLKEDWCKTEPLVQKIR-EPGCIPtTVINKFCYGQCNSFYIPKGPRRRDNsdr--------- 69 
XP_011610424  66 DEVLESSQE-ALHVTERRYLRLDWCKTQPLKQTIH-EEGCLSrVIINRFCYGQCNSFYIPRHTYQDGG------------ 131 torafugu

8B7H_A        92 ----SFQSCSFCKPKKFTTMMVTLNC--PEl--QPPTKKKRVTRVKQCRCI 134 human
Q4H3R0       185 -etdYFRFCAFCKPKTEEWISVRLRCrrKGrkkRGRYVIKRVKRVKGCTCI 234 vase tunicate
3_pfamImport  67 ----SFQSCAFCRPQRAAALLVELQC--PGr--DPPFHLRKIQKVKQCKCM 109
XP_001492621 116 ----SFQSCAFCKPQRVTSVLVELDC--PGl--DPPFRLKKIQKVKQCRCM 158
XP_005158738 141 dhttSFQSCAFCRPSRITTVTVRLHC--PGl--QPPYRQRKVQRIKQCKCV 187
XP_015196201 218 ----AFRSCSYCQPRQLGTLAVTLTC--PTl--RPPTRLQRLTVVRECRCT 260
XP_005987980 120 ----PFRSCSFCKPRNFNTVVVTFNC--PGm--SPPAKHRRIQLVKECRCI 162
EFA02797     204 qngpAFKACAFCRPSKFTWISVTLKC--PSl--MPPFRKKRIQRIKQCKCI 250
2_pfamImport  70 -pqpAFKSCSFCRPKNFTWITVTLRC--PGq--NPPFRRKRLQKIKQCKCI 115
XP_011610424 132 ----VFQSCSACKPKTFSSVTYTLFC--PGq--TPSTKKKRVQRVKQCRCt 174 torafugu
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