Conserved Protein Domain Family
Perilipin

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pfam03036: Perilipin (This model is not part of the current CDD release)
Perilipin family
The perilipin family includes lipid droplet-associated protein (perilipin), adipose differentiation-related protein (adipophilin) and TIP47, also known as perilin-3, altogether form the PAT family of proteins. They predominantly localise to the surface of intracellular neutral lipid droplets. Perilipin is a modulator of adipocyte lipid metabolism and adipophilinis and are involved in the development and maintenance of adipose tissue. This family appears to share some similarity with pfam08618.
Statistics
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PSSM-Id: 515350
Aligned: 32 rows
Threshold Bit Score: 308.468
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006640158  21 GSREQQS---VVTRVASLPLVSSACGALSSAYSSAKESAPYLRGVMDAAESGARTLGAAAASGSRPLLDRLEPQLTVVNE 97 
XP_012397482  17 EQQPQAQdrdLVSRVINLPLVSTTFARASAAYSSVKENHPYLNSLCGLAERSLQGLTTRAAQGAQPLLNLLEPQITSVNK 96 
M0R7Z9        30 GELDQHN---VVKRVVALPLVRATCTAVSGAYNSAKDRHPLLGSACRFAEHCVCSVATCALDHAQPLLEHLQPKLATVND 106 Norway rat
A8WHP8        13 QQAQAQS---YYDQVLGNAYVQTAIN----AYTKTKEFHPLLNSTLNSAEEKVSTVGNYAAQKA----------YDGYNS 75  Caenorhabditis ...
2_pfamImport   1 TFITNDN---ALNRVASLPIVASTWNAMQSYYATVKKTYPNVSPYLEAAENLTVSAANLALETSRPVVDRFG---NTVNS 74 
XP_012397830  13 NHPEQEN---VLQRVFQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFSAANE 89 
6_pfamImport   1 DFPEQES---VLQRVLQLPVVSGTCECVQKTYTSTKEVHPLVASMCNAYERGVQGASSFAAWSMEPVVRRLSTQFTAANE 77 
Q8CGN5        13 DLPEQEN---VLQRVLQLPVVSGTCECFQKTYNSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANE 89  house mouse
8_pfamImport   1 TRDDRLC---VIKKVAELPLVSSTYEMVSATYTSAKKSHPAIQAVCDMAEVGVKAIATTAASGAQPFLDKLEPQIAAVDT 77 
XP_003220893  30 KEAGQEN---VLRRVANMPLVSSTYDMAATAYSSTKDSHPYVKSILDVAEKGVKTITEVAVNTAQPILNKLEPQIATANE 106
XP_006640158  98 YACKGLDRLEEKLPILQQPTEKVVADTRELvssvqqsvsqsvsgarqaVTGAVTGAVGVAKGA-----VQGSVDVTRAAV 172
XP_012397482  97 YACKGLDKLEEKLPFLRQPSQEVVTSAKDA------------------VTSSVTGVVGLAQKG-----RRWSVDLTRSVV 153
M0R7Z9       107 LACRGLDKLEEKLPFLQQPSDTVVTSAKDA------------------VAKSVTGVVDLAQRG-----RRWSGELRRSVS 163 Norway rat
A8WHP8        76 YYVKPKNTAYEAVSYGTERAKTAVESGKQAaivgg---------tfgiGAAVVLTQFSLALSAggaalVLEQVDSAKKLG 146 Caenorhabditis ...
2_pfamImport  75 YANKGLDTLESKVPIITKEPEEVLFQFdvish------------lcnkIVVYINAKVSI--GS-----CLNECERHVLHC 135
XP_012397830  90 LACRGLDHLEEKIPALQYPPEKIASELKDTistrir-------sarnsFSVPIASTSDKILGA-----ALAGAELAWGMA 157
6_pfamImport  78 LACRGLDHLEEKIPALQYPPEKIASDLKDTistrlr-------sarnsISVPITSTSDRVLGA-----ALSSCELAWEVA 145
Q8CGN5        90 LACRGLDHLEEKIPALQYPPEKIASELKGTistrlr-------sarnsISVPIASTSDKVLGA-----TLAGCELALGMA 157 house mouse
8_pfamImport  78 LACKSLDVLQERFPVVQQTVEKVVSNAKGL------------------LTESLAPVYTKVTEA-----AQESIEMASSTV 134
XP_003220893 107 YASRGLDTLEEKLPILHLTADEIASSTKEMvsna-----------keaIANKLSGVVDMTKDA-----VQTGMDATRSAI 170
XP_006640158 173 SGGVS-------------TMMGSRVGQMLSSGVDLALSRSEEWVEQLLPLSHRELAALSEP--VSGGEAGP---PAAQQS 234
XP_012397482 154 TSGVD-------------TVMGTRMGQMVTNGVDVMLDKSEELMDHFLPMTDEELDELAAA--AEGGTLAPg-dDQHETS 217
M0R7Z9       164 ------------------QAMDTVLRRSVSQAMDTVLGKSEELVDHFLPMTEAELVALATE--SQGPEVGSveeQRQKQG 223 Norway rat
A8WHP8       147 SSAIStik-------eaeLAVEHRIFSALHQAQRIAMVPVEKITENTNSLLD---ILDGAV--QKGLNIEVppsVNLTIG 214 Caenorhabditis ...
2_pfamImport 136 YKSLNqieflynyfkwmyNITKSTATSLINNKVEGALEVTERYVEYYLPKDEDEEEDEEGE--ENDPEA------KKQPS 207
XP_012397830 158 QDTAD-------------YASSTRVGQLAAGGADLALSNVEKVVNYLMPAPKENP---APV--LEHPSPSQvqqKLPKPS 219
6_pfamImport 146 KGTAE-------------YATNTRVGRLASGGADLALGGIEKVVEFLLPPAEEDSDPYPAP--AVGCQPAQk-pSKAKLS 209
Q8CGN5       158 KETAE-------------YAANTRVGRLASGGADLALGSIEKVVEFLLPPDKE-----SAP--SSGRQRTQk-aPKAKPS 216 house mouse
8_pfamImport 135 RNGVH-------------TVMETSMGQMVSNGVSEMINKSDIWIDKYLPITDSELAALAASaaLEVSDMPPliiQTKDQK 201
XP_003220893 171 SHSVS-------------TVVESRVGQIAVSGAEAILDSAEELIDDYLPMTEEELAELARA--VRNGDLVAm-qHNEREE 234
XP_006640158 235 YFVR-LGTLSAK-VRQRALELSLGRARRAHESALSTLASLTTTLDLIERTKAALSsatDRLGGAQEQLLQHWAEWKegq- 311
XP_012397482 218 YFVR-LGSLSSR-LRQRAYQHSLGKLRQKKHQAQESFSQLHDTLEMIHYMKHGSN---HNFQGGEGRLQKLWQEWS---- 288
M0R7Z9       224 YFVR-LGSLSAR-LRHLAYQHSLGKLRESKHRTQEMLAQLQKTLELIQHMQSRAS---PTPTFHHPKVQELCGDWSpcl- 297 Norway rat
A8WHP8       215 QRVKnLASLIVQgVSNKLFKAHDHVIDPINERARNYLEQLSQSFVLLDIVREKKT----WVIEKSNELSTSVFDFKktl- 289 Caenorhabditis ...
2_pfamImport 208 --DR-IREISNK-VRQRSYKRAMRKLHGVQTRSKEALSKLSFTVDLIQYAQSGLNstsAGIMDSANRANESVQNGMnv-- 281
XP_012397830 220 FLQR-IGTLTNN-ISQHTFHTTIQTLRWG----HALAKWIPGVAPLSSMAQWGVSaalEVVSRPRSTSRGNWQYNQaqd- 292
6_pfamImport 210 LMSR-VGALTHT-LSQHTVQTTAWALKQG----HALAMWIPGVAPLSGLAQWGVSvamQVVSQQKNEVQAPWLHKLttaq 283
Q8CGN5       217 LVRR-VSTLANT-LSRHTMQTTAWALKQG----HSLAMWIPGVAPLSSLAQWGASaamQVVSRRQSEVRVPWLHNLaasq 290 house mouse
8_pfamImport 202 YYVR-LGSLSAK-LRSRAYHHSLEKVQRVKQTFDMALFHLEQFMHLLRFTKQTWE---YKIQQGQEKLRQMWLEWIrgq- 275
XP_003220893 235 YLVR-LGSLSAK-FRNRAYRHSVDKLKKTRQRIQSSLAQIEQTIRLLEYMKNEAG---QKLNEHQEKLRQMVLEWSkgt- 308
XP_006640158 312 -pggKEAEedkgqmqSDDHVELEGRA-LSMARGLSAQLRAACSG------VVSTAQGLPV--SVQEQVAAALRAAEELQA 381
XP_012397482 289 ----HQDK-------ESYQSQVESQT-LDLSRDLTQELQATCET------LAASVQGLPP--AVQAKVLEVQQSVEELHR 348
M0R7Z9       298 -------------enGYRHSQVELET-LALSRSLTLELQSAVDA------LAGCVRGLPP--SAQAKVAEVQRSVDALQA 355 Norway rat
A8WHP8       290 -eeeAQKY-------KVAPEEMLMKHiQSTSEQLSTQLQSLREK-------GQNVFGDGT--KIDSTIDYL----ENLKK 348 Caenorhabditis ...
2_pfamImport 282 --akSNLQvv----tDSINKQVEENV-LNRARILSRQLSDTCQW------SIRYIQNSPQlqPLLKKANQVKDASDDLYQ 348
XP_012397830 293 -eeeDEEE-------EEEEEEEEDEE-NLEMRKEENKLNETMPSnq--slLGSVVHTLQS--AYLTTVSTVKWAPFAIWN 359
6_pfamImport 284 -edhDDQT-------DTEEEETEEEE----LKAEENKFSEVALPspr-glLGSVAHTLQK--TLQSTISAVTWAPVAVLG 348
Q8CGN5       291 deshDDQT-------DTEGEETDDEEeEEESEAEENVLREVTALpnprglLGGVVHTVQN--TLRNTISAVTWAPAAVLG 361 house mouse
8_pfamImport 276 -pgqSAIS-------EPSQAEMESQA-LQVSQTITRQMQANCLK------LLTDMEGLPD--ALKEKVQEAYSSLEEVQS 338
XP_003220893 309 --sdDKAE-------ACVCVEVDLRA-ISMFRSMIQQLQTTFQT------LTSSIQGFPS--SLQDKMHQIHENTKELQA 370
XP_006640158 382 SLGGATSFSNP---LLAQSRAR--MAQVRQSVDATMEYLLNNTPLNWLVG-----PFSPQI 432
XP_012397482 349 AFSTARSFHDLppaVLAKGRGH--MMQAHTTVDELLEFVIQSIPLPWLVG-----PFSPLI 402
M0R7Z9       356 TFADAHCLGDVaptALAEGQDS--VAQAHACVDEFLDLVLRAMPLAWLVG-----PFAPIL 409 Norway rat
A8WHP8       349 NFTDAEDVYKVrdeVLNEGRQR--IAELSTWTTSLLIISAE-----W--------QFEPED 394 Caenorhabditis elegans
2_pfamImport 349 MFANKTSLSQLpttLMVSARPK--IQFVEESLLQILQKMSDQPPIAWLTPrvdfdPFAELS 407
XP_012397830 360 NTAGRLLHLTSgqeTFAKGRAMslSDALKGVTDNVVDTVVHYVPLPRLS------LMEPES 414
6_pfamImport 349 TAGRVLHLTPAravPSTKGRAMslSDALKGVADNVVDKVVHYVPLPRLS------LMEPES 403
Q8CGN5       362 TVGRILHLTPAqavSSTKGRAMslSDALKGVTDNVVDTVVHYVPLPRLS------LMEPES 416 house mouse
8_pfamImport 339 ALSNAQTFQDIpsgILSQSPEK--IGKAQHAVHEVMEYVTRTPPVTWVAG-----PLSAGV 392
XP_003220893 371 SLSNTGSFQELsnvVLAQSYQT--VQKAQEYMEELREYISHQTPLSWLVG-----PFTRSP 424
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