3VKG


Conserved Protein Domain Family
Dynein_heavy

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pfam03028: Dynein_heavy 
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Dynein heavy chain and region D6 of dynein motor
This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Statistics
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PSSM-Id: 397251
Aligned: 390 rows
Threshold Bit Score: 84.8063
Threshold Setting Gi: 972951895
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3VKG_A       2642 KSSSPLLLCSVPGYDASSKVDDLALQLH---K--QyKSFAIGSPEGFeLAEKSIYAAAKSGTWVLLKNIHLAPQWLVQLE 2716 Dictyostelium...
EEN67527      158 TATEPILIIISPGADPSQELQELASATVgadR--Y-HQVAMGQGQAD-IAMQLLHECARNGEWMCLKNLHLVTAWLPVLE 233  Florida lancelet
XP_005038274 3716 LEIEPILIIISPGADPSQELQELASVERnteC--Y-HQIAMGQGQAD-LAIQTLRECAQNGEWLCLKNLHLVTSWLPVLE 3791 Collared flyc...
XP_007665027 3710 LEIEPILIIISPGADPSQELQELANAERsgeC--Y-HQVAMGQGQAD-LAIQMLKECAQNGEWLCLKNLHLVVSWLPILE 3785 platypus
PNJ86626     3718 LEIEPILIIISPGADPSQELQELANAERsgeC--Y-HQVAMGQGQAD-LAIQMLKECARNGDWLCLKNLHLVVSWLPVLE 3793 Sumatran oran...
XP_015197180 3726 LEIEPVLIIISPGADPSQELLELASETVgkeS--Y-HEVAMGQGQAD-IAIQALKECARNGEWLCLKNLHLVTAWLPLLE 3801 spotted gar
XP_022527179 3719 VETEPVLLIISPGADPSQELLELASDTV---GrdNyHELAMGQGQAD-VALQVLRECVRSGEWLCLKNLHLVTAWLPLLE 3794 Mexican tetra
XP_025753905 3706 MEWEPVLIIISPGADPSQELAELAAETVgrdN--Y-HEISMGQGQAD-VALATLRECSRNGDWLCLKNLHLVTAWLPLLE 3781 Nile tilapia
XP_026693268 2919 HAAEPILIVLSAGADPSQELQELASSVVgeeN--Y-FQVAMGQGQSD-VAMQLVRECSRNGQWLCLKNLHLVTSWLPVLE 2994 vase tunicate
ESN99131     3630 HCREPILFIISQGADPSQELEDLAKKTVgldK--Y-NQVALGQGQTD-TAIQLLKSCANKGEWLCLKNLHLSISWLSVLE 3705 Helobdella ro...
3VKG_A       2717 KK-----LHSlsphpSFRLFMTSEIHPALPANLLRMSNVFS 2752 Dictyostelium discoideum
EEN67527      234 KElnslqPHQ-----DFRLWMTAEVHSQFPTILLQSSLKIT 269  Florida lancelet
XP_005038274 3792 KElntlhPQP-----NFRLWLTTEVHPKFTPILLQSSLKIT 3827 Collared flycatcher
XP_007665027 3786 NElntlqPKE-----NFRLWLTAEVHPKFTPILLQSSLKIT 3821 platypus
PNJ86626     3794 KElntlqPKD-----TFRLWLTAEVHPNFTPILLQSSLKIT 3829 Sumatran orangutan
XP_015197180 3802 KElnalqPKA-----SFRLWLTAEVHPKFTPILLQSSLKIT 3837 spotted gar
XP_022527179 3795 KElnsmqPKA-----GFRLWLTAEVHANFTPILLQSSLKIT 3830 Mexican tetra
XP_025753905 3782 KElnvlrPKA-----GFRLWLTAEVHPRFPPILLQSSLKIT 3817 Nile tilapia
XP_026693268 2995 KElnalvPDN-----NFRLWLTSEVHSKFPPILLQSSLKIT 3030 vase tunicate
ESN99131     3706 KEfkslePHE-----NFRLWLTSEAHQNFPAVFLKTCLKVT 3741 Helobdella robusta
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