5LX9


Conserved Protein Domain Family
HlyIII

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pfam03006: HlyIII 
Haemolysin-III related
Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.
Statistics
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PSSM-Id: 397239
Aligned: 38 rows
Threshold Bit Score: 130.86
Threshold Setting Gi: 6136493
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5LX9_A  61 FRIHTETGNIWTHLLGCVFFlcLGIFYMFRPNISFvapLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSE-GVSRLFSKL 139
Q8SV70   1 MAKQKPMLRGRIHQIAFYLTigKALMYGICCLh-----GKGNLGIMIYLLSQLILFGVSSTYHITSW-KDeKTKALFQRL 74  Encephalitozoon cuniculi
O51144  19 KIPKNELFSSISHLFGIILSiiGTTILVTISTLKKk--DLHVVVFLIYGFSMTLLYVMSTLYHI--FPKGsKIKKIFRKF 94  Borreliella burgdorfe...
Q834G8  13 YLIVNEVLNAVTHGIGAGLSiaGLVILLVKGARLGs--PIHVVSYAIYGSMLILLFLSSTLFHS---LIFtRAKKVFQVF 87  Enterococcus faecalis
Q9CI69  10 YQILNEIFNAVTHGAGTGLAiaALVLLVIKGAASGs--ALEVVAFTIYGASLVILFLCSTLAHG---LHFtKAVKVFRVF 84  Lactococcus lactis su...
Q86A98  25 QTYSEEVLNSLSHGIGLLLCipAVFFLLSLARMKGs--KWHVVSCTIYGITLMTMYFCSTLYHSVDIIHLqKYRNFFKDL 102 Dictyostelium discoideum
Q8A6A2  19 YNNVEEWANTLSHGAGILLGviAGYFLLAKAAAGAe-pKWAVACVTVYLFGMLSSYVSSTWYHG---SRPgKLKELLRKF 94  Bacteroides thetaiota...
Q8XKC6   3 NTFFREPINGFTHLFGAILSifALVALTAKATYIYg-iGLPLLSVILFGFSLVLLYSASAIYHL--VNAKeKTIAFLRRL 79  Clostridium perfringens
Q81JK3   2 NTYIREPVNAFTHLGGAVLSfiALLAMLVKVSIKMp-sFAAITAIILFGIGMMVLYTASAVYHS--VVASeRVIYFFRKL 78  Bacillus anthracis
Q97KN5   2 FSKLKDPVSGITHLVGAVLSiiALVCMVHHSIVADs--KISIAASIIFGVSLIFLYSASASYHL--INVSrRLTTILRKI 77  Clostridium acetobuty...
5LX9_A 140 DYSGIALLIMGSFVPWLYYSF------------------------------------YCnpqPCFIYLIVICVLgiAAII 183
Q8SV70  75 DHISIFLLISGTQTSVALLLL-------------------------------------PegpYTKHILMTTWTIslAGIL 117 Encephalitozoon cuniculi
O51144  95 DHISIFILIAGTYTPACAILV-------------------------------------Pn-kSGLIILCIVWSLaiIGII 136 Borreliella burgdorfe...
Q834G8  88 DHSSIFLLIAGSYTPFCLISI-------------------------------------Gg-wLGWTLFSLVWLIaiVGIV 129 Enterococcus faecalis
Q9CI69  85 DHNGIFFLIAGTYTPYCLVAL-------------------------------------Nn-wLGWIVLAVIWICsiLGIV 126 Lactococcus lactis su...
Q86A98 103 DHCAIYMLIAGTYTPLTLINLvynnlnhnnnnsssssnqpminggqqqqqqkiktpiAKavkIGWAMFVLIWAMcvLGVG 182 Dictyostelium discoideum
Q8A6A2  95 DHGAIYLHIAGTYTPFTLLVM------------------------------------RHaggWGWGIFSFVWLSaiVGFI 138 Bacteroides thetaiota...
Q8XKC6  80 DHSMIFILICGSYMPYCLIGL-------------------------------------Eg-kAQIFITSLIVILtvLGIL 121 Clostridium perfringens
Q81JK3  79 DHSMIFILIAGTYAPFCLITL-------------------------------------Hs-aNGLLLFCLVYATaiCGIV 120 Bacillus anthracis
Q97KN5  78 DHMMIFVLIAGTYTPICLITL-------------------------------------Ng-kIGNIILFLIWAVaiLGIV 119 Clostridium acetobuty...
5LX9_A 184 VSQWDMFATPQY--RGVRAGVFLGLgLSGIIPTLHyVISEGfLKAATiGqIGWLMLMASLYITGAALYAARiperfFPGK 261
Q8SV70 118 KIILMK---KLH--MYFDLMVYILHgVSVVPFFHIiMKSVPvSD------ISLFILGGVIYIVGGLIYGME-----KPNP 181 Encephalitozoon cuniculi
O51144 137 FKIIFT---NSP--GWFNGSIFIIMgWIIIFKIKPiYKALSgKG------FFWLVFGGIVYTIGGIVYILS-----KKFN 200 Borreliella burgdorfe...
Q834G8 130 YKSLTLHKQETV--KNISTIIYIVLgWLCIIAARPlYESLGfTG------TALLVAGGVSYTLGAAFYSLK------NVR 195 Enterococcus faecalis
Q9CI69 127 LTSIYLPKWGKT--PKLSTVLYVVLgWMILIVIYPlWNALDpVG------FWLLVAGGVVYSVGALIYHFK-------FP 191 Lactococcus lactis su...
Q86A98 183 SKLVLG---ANGvpDIISNSFYLLMgWVSVIGLKDlIKNLPqKG------LKLLVSGGITYTGGVGFLIWE------TAP 247 Dictyostelium discoideum
Q8A6A2 139 LSFKKL---KEH--SNLETACYIAMgACILVAMKPlMDHLAeMGAGP-A-FWWLIGGGVSYIIGAVFYSLR-------KP 204 Bacteroides thetaiota...
Q8XKC6 122 FKMVWF---NCP--RILSTLMYIGMgWISLGAIPF-FKNIPaLA------LIWLAIGGVIYTIGGIIYALK-----PKFL 184 Clostridium perfringens
Q81JK3 121 FKMFWF---NCP--RWLSTAIYITMgWLIVLFFAPlAANLStGG------MVLLVLGGILYTIGGFIYGTK-----PKWL 184 Bacillus anthracis
Q97KN5 120 LKLVWF---NAP--RWLYTLFYIAMgWIVVFAFAPiSRIMAlPG------IIFMVLGGIVYSMGGIIYALK-----WPVR 183 Clostridium acetobuty...
5LX9_A 262 CDIWFHSHQLFHIFVVAGAFVHF 284
Q8SV70 182 YPQVFGYHEIFHVMTVLANWCFL 204 Encephalitozoon cuniculi
O51144 201 PTINMKMHDVFHILIIIASASHF 223 Borreliella burgdorferi B31
Q834G8 196 F-----MHVVWHLFVMLAAILMY 213 Enterococcus faecalis
Q9CI69 192 F-----AHVVWHLFVLLAAMLMF 209 Lactococcus lactis subsp. lactis
Q86A98 248 F-----NHAVWHLFVSAGTLFHY 265 Dictyostelium discoideum
Q8A6A2 205 Y-----MHATFHLFCLGGSIGHI 222 Bacteroides thetaiotaomicron
Q8XKC6 185 EFNNLGFHEIFHIFILLGSLCHF 207 Clostridium perfringens
Q81JK3 185 EFKYMGHHEIFHVFVLLGSLAHF 207 Bacillus anthracis
Q97KN5 184 NAKYFGFHEIFHLFVMAGSLFHF 206 Clostridium acetobutylicum
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