Conserved Protein Domain Family
Pox_G9-A16
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pfam03003: Pox_G9-A16 
Pox virus entry-fusion-complex G9/A16
Pox_G9-A16 is a family of two of the eight entry-fusion complex proteins of pox viruses. the viral fusion proteins are components of the mature virion, MV, membrane. Extracellular enveloped virions (EVs), the infecting particles are MVs with an additional membrane that is opened or removed prior to the fusion of the MV and cell membrane during virus entry. G9 and A16 interact closely with each other and each is required for membrane fusion and virus entry as well as for interaction with A56/K2.
Links
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Statistics
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PSSM-Id: 281058
Aligned: 30 rows
Threshold Bit Score: 93.9226
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9EMT1 233 LSNWCKNNSNNSLCFCYNPPTEFIpDVEEVLGPKECWLAPCTvsYSGQKWLTTNQMNIKKNCNIQSCIITIGSLLTRgNN 312 Amsacta moorei entomo...
Q9EN13 206 VL---NAQTDKTNLKCAFSPSYITdTQNRLNVPKECWYRECA--FSPNYLLLTDNITLKNNCSLSECNINIGNLDIVsAS 280 Amsacta moorei entomo...
Q98236 214 VLAQQDPEFKRTHMACSYPSHRSLeLARRVAEPRECWDPQCQ--RANPNFLLSENYHALAGCHIYRCNVSIGTLLMDkRS 291 Molluscum contagiosum...
Q070H0 202 VLMRQPASFKSARMRCSFPSAATLtVAARVIEPRECWDPNCV--NGNANFFLSENYRNLSLCSIYRCNIDIVSLRMDpKS 279 Crocodilepox virus
P0DTB1 203 VLMQQTPEFKEKYMKCSFPSHNTVfLADRVIEPRECWDQECI--TSNVHFLLSKNYHNLTLCHIYRCNISINNLLIDgKS 280 Fowlpox virus strain ...
Q6TVS4 203 VLSVQSPEFKSKHMRCSYPSPATLaMAANVDEPRECWDPECV--AGNVDFMLSDNYTNLGLCRLSRCSVGVTHLRMDaRS 280 Orf virus
P07611 208 ILRQQSADFKQKYMRCSYPTRDKLeESLKYAEPRECWDPECS--NANVNFLLTRNYNNLGLCNIVRCNTSVNNLQMDkTS 285 Vaccinia virus WR
Q08FT4 205 ILYLQSDDFKNTYMRCSYPSTKTLeESLRYSEARECWDPECA--NANVNFLLTRNYKNLGLCTINRCNVSINHLNIDnKS 282 Deerpox virus W-848-83
Q6TUV4 202 ILYQQSDDFKNNFMKCSFPSEDKInESLKSLEPRECWDPECE--NANVNFLLTENYNNLGLCTINRCNVSINHLDVDsVS 279 Yaba monkey tumor virus
Q9Q917 202 LLMAQKDDFKSKYMRCSFPTKEKMeESLKYSETRECWDPECA--NSNVNFLLTENYRNMGLCTINRCNVDINHLNMTpAS 279 Rabbit fibroma virus

Q9EMT1 313 KIDLINNCINNlnaSTVINSENLS-------NVTDIKINQtwgvffdpVIFILIIFIFI 364 Amsacta moorei entomopoxvirus
Q9EN13 281 EVTITCN---NnksNTVSSRQKLDillreseDYRFLLTNN--------ILILILLFIFL 328 Amsacta moorei entomopoxvirus
Q98236 292 KLRISCHd-----pSTRVQLNKLGvvqdnvrRAPRVRTHL--------LAALALFLVWV 337 Molluscum contagiosum virus subtype 1
Q070H0 280 RLMVSCHd-----pLKDAGAKKIDvvrenvaRSFPLNRSY----------FLLVFVVIL 323 Crocodilepox virus
P0DTB1 281 SVKISCHDENIsnkDKPKARNKAKfiddilgSSFNINFG---------FFFVIFIMIAL 330 Fowlpox virus strain NVSL
Q6TVS4 281 RLRMRCA--GAlagLTKAPVNQTVvvgdnlaRAFEPRVET--------LGVLALCVVYL 329 Orf virus
P07611 286 SLRLSCG-LSNsdrFSTVPVNRAKvvqhnikHSFDLKLHL--------ISLLSLLVIWI 335 Vaccinia virus WR
Q08FT4 283 KLRMACN---NldlTSPYPINREKvilhnidNSFELKIHC--------ITILSILVIWL 330 Deerpox virus W-848-83
Q6TUV4 280 SVHMSCN---GnnlISPSPVNREKvildninSSFNLKINL--------ITILSLLIIWI 327 Yaba monkey tumor virus
Q9Q917 280 KLRMTCG---TeslYNPLPVNKEKvikhnvdNSFQLHVYE--------ITILFVLVIWI 327 Rabbit fibroma virus
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