Conserved Protein Domain Family

pfam02986: Fn_bind 
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Fibronectin binding repeat
The ability of bacteria to bind fibronectin is thought to enable the colonisation of wound tissue and blood clots. The fibronectin binding repeat is found in bacterial fibronectin binding proteins and serum opacity factor. Bacterial fibronectin binding proteins are surface proteins that covalently link to the bacterial cell wall, mediate adherence of the bacteria to host cells and trigger the fibronectin/integrin-mediated uptake of bacteria by host cells. Each fibronectin binding repeat is an array of short motifs that bind to fibronectin type I domains. Fibronectin binding repeats are natively unfolded in the absence of fibronectin and are thought to adopt a well-defined conformation (tandem beta-zipper) upon binding.
PSSM-Id: 397232
Aligned: 33 rows
Threshold Bit Score: 29.109
Threshold Setting Gi: 31615769
Created: 20-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1O9A_B                          1 EE-S----LPTEQGQSGST---TEVEDSK---PKLSIHfDNEW 32   Streptococcus dysgalactiae
P72416                        516 SEdT----QPGMSGQSGGT---TIVEDTKkptPK--PK-PAPA 548  Streptococcus equi
Q93T51                        853 TEdT----QPGMSGSNDAT---VVEEATT---PQRPDIlVGGQ 885  Streptococcus pyogenes
Q06556                        992 VEdT----LPGMSGSNEAT---VVEEDTR---PKLQFHfDNEE 1024 Streptococcus dysgalactiae
Q5XE71                        541 TKdT----QTGMSGFSETA---TVVEDTR---PKLVFHfDNNE 573  Streptococcus pyogenes serotype M6
Q76K22                        376 TEnT----QEGMSGSNNGQ---TFEEDTR---PKLEFHfDNEV 408  Streptococcus equi subsp. zooepide...
Q93T53                        891 TEdT----QPSVSGSNDAT---VVEEDTA---PKRPDIlVGGQ 923  Streptococcus pyogenes
hbprmlniaid:MGAS9429_Spy1736  510 TEdTitdaPPTVSGHNASTqpqSVVEDTA---PQRPDVlVGGQ 549  Streptococcus pyogenes MGAS9429
Q9S4K0                        795 TEeSiy-rLPLEHGSNAPDtqvTIEEDTV---PQRPDIlVGGQ 833  Streptococcus pyogenes
CAL51043                      259 EEdT----LPKVSGQNEGQq--TIEEDTTp--PIVPPT----P 289  Staphylococcus aureus
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