4PN0,1D8I


Conserved Protein Domain Family
mRNA_triPase

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pfam02940: mRNA_triPase 
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mRNA capping enzyme, beta chain
The beta chain of mRNA capping enzyme has triphosphatase activity. The function of the capping enzyme also depends on the guanylyltransferase activity conferred by the alpha chain (see pfam01331)
Statistics
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PSSM-Id: 397201
Aligned: 17 rows
Threshold Bit Score: 180.606
Threshold Setting Gi: 74610719
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4PN0_C     55 VPDTTKVISNFLTh---------------yLITEPvEHVEIEAKLGTLIDLE----TQNRFEFPVMNETILNPEf-nLRT 114  fission yeast
Q5KEQ1    151 RNPFTSVVGDFIM-----------------NAAMGhSNVEIELKLGTFMTPSmpgqQPRRINMPTLSEMIIPHDy--PNG 211  Cryptococcus neof...
KIS67575   18 LDDFVTIVGDWIY-----------------TKGRGrSNLEIEAKIGQIISQE----TGERIHLPVRNETIVDLS----HT 72   Ustilago maydis 521
Q2UGU4    464 HEEVTKTVCDFLFqhvvmrndataapagatATGQG-AMIEVEAKLGQLVDMD----RGERLLLPISTEGIVNKEntrLRT 538  Aspergillus oryzae
Q5BCN3    479 FEEITKTICDFLFqhvvlrndaiagppgatAQGQG-AIVEVEAKLGHIIDLD----RGERLRLPIMTESIITREr--IRT 551  Aspergillus nidulans
Q2GQC7    526 NSTLVKSKAaa-----------------ssLRSK--------AKLGMLVDKS----TNQRVELPVQSECVLSDNg--NWL 574  Chaetomium globos...
Q7S0G4    767 QDTMAKVMADFFFhyivln------enmgeIQSRG-IQFEIEAKFGELIDRN----TNQRIDLGVLSPAILKEDd--YVY 833  Neurospora crassa
Q4N969     58 NNHFIKSGYNMNSg---------------sVFSKPeCQLEVEVRLGFIQNIR----SEHRFTLPVTTDTLLASR---APV 115  Theileria parva
Q6BND2    192 PPSVTRTIAEWIYanf------------teIPDDQrKYVELELKFGTIIDKR----AGHRIDINVSTECIFTDN---SNT 252  Debaryomyces hans...
O93803    260 PSSITRKIAEWVYanf------------snVEEKSkRNVELELKFGKIIDKR----SGNRIDLNVVTECIFTDH---SSV 320  Candida albicans ...
4PN0_C    115 RFESDMTASEHKYLNEFLNQaFR-----------DSQKPGRLPFAYKHTKQVDLFYETE------------------DNS 165  fission yeast
Q5KEQ1    212 PFVSTINHLHHRTLNELLNRaVE-----------SQSTHPTGRLYFSRSKLADSFYDHS------------------EHG 262  Cryptococcus neof...
KIS67575   73 RFESQMSASQHAHYNRILNSlALr---------sSEGSYTGAKISYHRRKEIDYFH---------------------PAP 122  Ustilago maydis 521
Q2UGU4    539 AFESTMTIAQHQAMNNFLNE-AVkm-------smPQANPGRIPLSYTHKKERDTFYEISpselppv-----irqnlnPRH 605  Aspergillus oryzae
Q5BCN3    552 SFESNMTLAQHRAMNNFLNE-AVkn-------smPQANPKRIPLSYAHKKERDSFYEVSpaelppv-----irqnlnPRH 618  Aspergillus nidulans
Q2GQC7    575 GFRSSMTEVQHKSFNGFLNF-LVqqthpgnkaanAALPRPRLPIDYRHRREVDKFFELPasvrdrllpvcvakpiaaKGH 653  Chaetomium globos...
Q7S0G4    834 PFRSIMTEAQHRSYNEFLNH-QVvvskn--pksnIGRERPRVPISYEHKYEIDRFYAIPpqirdkhlpvtvanllasKGR 910  Neurospora crassa
Q4N969    116 KFVPGVTEDQYNAARNFLIEtS------------EEDDPKNEWTTCLNSCTINRFFEIQg-----------------YDE 166  Theileria parva
Q6BND2    253 YFDMGVHEVGWNDMCKFLDDlEKsyqdelrrspqANSNSPKRKFNILESDITDNFYQITs----------------rNEQ 316  Debaryomyces hans...
O93803    321 FFDMQVEEVAWKEITKFLDElEKs----------FQEGKKGRKFKTLESDNTDSFYQLGr----------------kGEH 374  Candida albicans ...
4PN0_C    166 RDKIRVSKNQS---DNQVLAC---VKKRRVADLFLYCPNDAF---------------DIRISISDELPv---------sM 215  fission yeast
Q5KEQ1    263 HGKVRVSRDMD---NGHVVQA---VEKRRIADLNVYCPGMAY---------------DFRISVNTETP-----------C 310  Cryptococcus neof...
KIS67575  123 KGKVRVTRDA----ETLAIKPdgiIQKQRIADLDIYCPYRLF---------------DYRISINVELP-----------A 172  Ustilago maydis 521
Q2UGU4    606 KPKVRVTLDQR---TGEVLAK---IVKCRIADLDVYSPRTCV---------------DWRISVNLEMSyegdv--shlpV 662  Aspergillus oryzae
Q5BCN3    619 KPKVRVTVDQR---TGEVLAK---IVKCRVADLDIHSPLTAV---------------DWRVSVNLEMNydgdi--shltP 675  Aspergillus nidulans
Q2GQC7    654 SVKVRVSYDQK---TNKVLDK---IIKARIADLSMHFPDLPL---------------DCRISVNLEMDwdgtvedlekmA 712  Chaetomium globos...
Q7S0G4    911 DAKVRVSYKENkdgSREQIAK---IVKARLKDLSIHFPEHRL---------------DCRISINLEMPwegpleeleayA 972  Neurospora crassa
Q4N969    167 LVRISVSNDSNspvNRQQKEPvdaIRKVNLLTWNISSGSTEEpseeseefstgleglDYRIAVNLEYKvp-------ltN 239  Theileria parva
Q6BND2    317 PKSIRISKDNLl--DPPRYTA---INKQRLSSLFIHNPSSMY---------------DLRLSLSYENPiadn----nidG 372  Debaryomyces hans...
O93803    375 PKRIRVTKDNLl--SPPRLVA---IQKERVADLYIHNPGSLF---------------DLRLSMSLEIPvpqg----nieS 430  Candida albicans ...
4PN0_C    216 PSGNQQPSLTRLKDRVGYVHQE--IKIDLTKTTq----NDPVy----DTTERHELEVEF 264  fission yeast
Q5KEQ1    311 EVPTGNAKSVRYKDRACYRHQV--CRVDLTSVF-----SSNPrnadvPPSRSFELEIEV 362  Cryptococcus neoformans var. neoforman...
KIS67575  173 PEPTSDHVSIREKNRLSYAHQN--FIVDLTQVtlp----------ekPSDHINELEIEI 219  Ustilago maydis 521
Q2UGU4    663 VDPGRGRGGERNKDRMSYRHLA--YQIDLTQVAk----SEPPs----KGEFEHELEVEI 711  Aspergillus oryzae
Q5BCN3    676 ADTGRGRASDRNKDRMSYRHLA--YQVDLTQVAr----SEPSa----KGEFEHELEVEV 724  Aspergillus nidulans
Q2GQC7    713 SSTGRPPIPARMKDRLSYKHGC--YQIDLTQVTq----SVAGvtntqRTEKDHELEVEI 765  Chaetomium globosum CBS 148.51
Q7S0G4    973 TSANKGQSPDRRKNRLSYGHCS--YQFDLTQVVe----NVSG-----RDEKKHELEIEL 1020 Neurospora crassa
Q4N969    240 LPTTSNAKYCRRRLRDSFIHTEskMRFDLSKV-------EDVtenkdPTTSKFEIEIEL 291  Theileria parva
Q6BND2    373 IIKKNQPTLTRIKKRNSWTHRPtvTRFDMTRVLspresKNKSgkkivEQDQSFEVELEV 431  Debaryomyces hansenii CBS767
O93803    431 IITKNKPEMVREKKRISYTHPPtiTKFDLTRVig------------nKTEDKYEVELEA 477  Candida albicans SC5314
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