6HUG,3JAD,5KXI


Conserved Protein Domain Family
Neur_chan_LBD

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pfam02931: Neur_chan_LBD 
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Neurotransmitter-gated ion-channel ligand binding domain
This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
Statistics
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PSSM-Id: 397192
Aligned: 81 rows
Threshold Bit Score: 144.71
Threshold Setting Gi: 74962606
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6HUG_A  23 FTRILDRLLDG--YDNRLRPG---LGER----VTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFK-----GP 88  cattle
Q9VVH4  44 QTQLIQRLTHvcrYDRLERPFe--YDSDgkrlPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKafnrsDN 121 fruit fly
Q9V9Y4  72 LMELLTRLTAPcrYDRMVPPVvhnKDGEe--vPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSsy--lpN 147 fruit fly
Q9W4G1  36 QTQLLDRLTHGcrYDRLERPItysETGQr--lPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRnv--spK 111 fruit fly
P41849  32 LGKLIDTLLTD--YDTHLLP-----EAE----GVNVTIELHVQGVSGISEITGDFSLDVMYSEIWQDPRLSFKhl--nVC 98  Caenorhabditis elegans
P91985  71 EAQLMEKLLKGsgYSKHKIP----RENG-----ITVSVEFWIQEINSISEMTNDFELELFINEMWTDPSLRFPhl--gAC 139 Caenorhabditis elegans
Q9U358  52 DDAIIAQILDG--YNKLDLP----GGGH-----VVVSIEIWVQEVSKIIEITSEFELDIYVTERWTDPSLAYShl----n 116 Caenorhabditis elegans
Q21420  54 QPAIIDKLLNGtgYNKFRIP----NENG-----VPVQVEFWVQAITSINEITNDFEMDIYINEMWLDPALKFDhl----n 120 Caenorhabditis elegans
Q18812  50 DTDIIDRLLNGtgYNKFRIP----QEEG-----MTVVVEIWIQAITSIDELTNDFDMDIYITETWLDPALNFQtm----t 116 Caenorhabditis elegans
P48167  56 TSNILNRLLv--sYDPRIRPN---FKGI----PVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPsd--fRG 124 human
6HUG_A  89 MTVLRLNNLma---sKIWTPDTFFHNgKKSVAHNMTmPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKF 165 cattle
Q9VVH4 122 ILGQKHLSE------RLWLPHIFFANeRESSILGTDeKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVL 195 fruit fly
Q9V9Y4 148 RRQPIMGESel--kkMLWVPHIFLTNeQASTVLGTSaKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTL 225 fruit fly
Q9W4G1 112 RRQPILGEEhl--rnSLWMPHIFLANeRDSSILGLTeKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVL 189 fruit fly
P41849  99 ATNITLKSDfr---kKIWTPDTCIINsKSSSIHSSPsENTFVILYENGLVWSNFRLNVKTPCSVNLKMFPFDSLSCEIVL 175 Caenorhabditis elegans
P91985 140 KANLTLDQQtl---tKLWTPNTCFVNsKFAEIYESSfQNVFLTLFDNGTVWVNYRVRVKGACNMDLVDFPMDTQSCRLNY 216 Caenorhabditis elegans
Q9U358 117 PCKSNMSVDgatilnKIWNPHACFVNsKLANIHESPfKNIFLQIYSNGSIWHNYRIKLTGPCSSTLRTFPIDQQRCMLFY 196 Caenorhabditis elegans
Q21420 121 PCKQNLSVShqv-leQLWTPNSCFVNsKFAEIHDSPfKNVFLMIYPNGTVWVNYRVNVKGPCDLSLELFPLDIQECHLIY 199 Caenorhabditis elegans
Q18812 117 PCKGNLSLNhqv-ldRLWTPNSCFINsKVAQIHNSPfRSVFLMLFPNGTVMVNYRVRVKGPCSLDLSNFPLDLQKCSLIY 195 Caenorhabditis elegans
P48167 125 SDALTVDPTmy---kCLWKPDLFFANeKSANFHDVTqENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQL 201 human
6HUG_A 166 GSYAYTRAEVVYEWTRepars--vvvaeDGSRLNQYDLLGQTVDSG----IvqSSTGEYVVMtTHFHLKRKI 231 cattle
Q9VVH4 196 ESWMYNTSDLILEWEPhtpisfdpemrlTEYNMAQFWHNTTIVQSDgdnlRhgAFAGNYSSLsFTVNLKREI 267 fruit fly
Q9V9Y4 226 ESWMYNTTLVQLHWETdnpvsfdkqlqlTEYNLIGSLYNESIRVSNesymShgSLEGNYSIIsFTVLLTREV 297 fruit fly
Q9W4G1 190 ESWMYNTSELVLHWEQkrpitydgalhlTEFVLQRSWSNETVINADlsdlRhgAFAGNYSSLsFTVHLTRVV 261 fruit fly
P41849 176 ESYSFNTDEVRLMWHDvpi------tmmEKVELPDFDLIGWSTDHQ----RleYPNGIWDRAkVKFTFARRY 237 Caenorhabditis elegans
P91985 217 QSFTYNNEEVRLQWNSqrsp----vfalQEIRIADFWLKDITPAVI----KrdYPAGLWDELvVTFVFERRY 280 Caenorhabditis elegans
Q9U358 197 ESFTHNTDQVKMEWITtvppi---tilkGNITLPDYVLVDFSSSSE----LrlYPPGIFNEliATFTFQRLY 261 Caenorhabditis elegans
Q21420 200 ESFNYNNQEVRMRWNEksaep---vsvtNKIRLPDFELIKIESTRI----SapYPAGMWDElhVKLVFERRY 264 Caenorhabditis elegans
Q18812 196 ESFNYNRQEVEMRWSDaehp----vfnlSKIMLPDFDLFEIQTERR----QepYPAGMWDElhVTIIFERRF 259 Caenorhabditis elegans
P48167 202 ESFGYTTDDLRFIWQSgdp------vqlEKIALPQFDIKKE-DIEYgnctKyyKGTGYYTCVeVIFTLRRQV 266 human
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