pfam02926: THUMP (This model is not part of the current CDD release)
THUMP domain
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. This domain is found in many tRNA modification enzymes classified into five types, namely 4-thiouridine synthetase, deaminase, methyltransferase, a partner protein of acetyltransferase and pseudouridine synthase. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains and was first predicted to function by delivering a variety of RNA modification enzymes to their targets. Studies performed in tRNA 4-thiouridine synthetase, tRNA methyltransferases and tRNA deaminase suggest that the THUMP domain captures the 3'-end of RNA but in some cases this is not applicable due to the modification patterns observed in tRNA. Several THUMP-related proteins are also involved in other RNAs modifications, such as rRNA modification.
Jiyao W et al.(2023). "The conserved domain database in 2023.",