6VXC,2F3O,6ND3,2YAJ


Conserved Protein Domain Family
PFL-like

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pfam02901: PFL-like 
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Pyruvate formate lyase-like
This family of enzymes includes pyruvate formate lyase, choline trimethylamine lyase, glycerol dehydratase, 4-hydroxyphenylacetate decarboxylase, and benzylsuccinate synthase.
Statistics
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PSSM-Id: 427048
Aligned: 123 rows
Threshold Bit Score: 391.994
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6VXC_G         22 ARgtfERTKK----LREES-IN-AEPH-I-S---------IERAVLMTEAYKKy-----EGSvEIP--VLRALSfk---- 73   Clostridioide...
WP_006069341    1 MS---SKIENnpsqVDVNKkIPcEKPAiM-Q---------LEIMEAYTRAHQS----------EENlyKREVACls---- 53   Vibrio medite...
WP_011966617    5 NV---EGAQN----VEISKkLPcEKPLiV-Q---------LEIMERYTAVHKA------CAAlPKE--IREVEClk---- 55   Parabacteroid...
Q2HBR9        360 PSr---RLLSlmarTFSHWrDSwMKKQvFpR---------LPHLSKLLSEDQKg----tLATiPIA--VRKGLAnqktla 421  Chaetomium gl...
Q8XZ58        495 LRq---QLEH----FFADPsHAtERDAlL-AeaggdvkgpTPQARAADHVMRQ----------PVAlrAAWAARllcnla 556  Ralstonia sol...
EDO62661        3 LS---ERMER----LFSYAkSTwKDPPpC-P---------FNRDFQYAAVNLF------SDK-EVW--ERAALSfa---- 52  
2YAJ_C         40 LM----DIYY----TLKVT---------A-D---------MEAAYWYNRTWWEn-----DGE-VIE--VRRAKAva---- 80   Clostridium s...
WP_005426151    1 MMag-yRFNKee-yFKETKaVYsNYPTdV-S----------RMEKELDRLQKE---------------NPKASSfq---- 48   Blautia obeum
Q8A3J9          4 YEq---KIAN----LRMRKlAQtQEKI---EkeglldeddYGRVVPPENLWNIipn-hpDGSfYGF--DAWADNfc---- 66   Bacteroides t...
EDO60733       16 YDd---RIRI----LKQRKlEEtQAKS---KmkvyqdgddYGSIPAPENYQFHcipnheNGSwYGY--DGWSKNfh---- 79  
6VXC_G         74 hYIENR---------TLSINDGELIVGEK-GDSPNGAPTY--PEICCHT-------MED--LEVmhnr------------ 120  Clostridioide...
WP_006069341   54 eLYPVL---------FRQIESEDIVVGRL-DALPIGFGSV----------------TSVggVGHycnf------------ 95   Vibrio medite...
WP_011966617   56 vLYPTL---------FRKITNQDLIAGRT-DFLPIGFGCV----------------TSLggVGHycvf------------ 97   Parabacteroid...
Q2HBR9        422 eLLSNPrsqiaqengLLRIEAKELIVGVI-------------PDFT----------LGRgkEVV---------------- 462  Chaetomium gl...
Q8XZ58        557 aRLDGVgrrgnggmdTCDIHPLDLLAGSM-------------PAQS----------LAEgrYVI---------------- 597  Ralstonia sol...
EDO62661       53 yALRRA---------PVIITDDDRIIGRAyQVRFAEPDCYd-PE------------LKDysLQS---------------- 94  
2YAJ_C         81 aSLSHM---------TPTILPYEKLVMNK-TKNVRGAFPF--PWVCASFfnaqaeaLMNe-VDApaeneadsvsvvgagg 147  Clostridium s...
WP_005426151   49 kKTWIY---------RTAARDAEVILFPS-------SPFY--AEIDTGR-------EQNs-VTAsfpp------------ 90   Blautia obeum
Q8A3J9         67 sLMNIH---------PVYIDADDAFAGRWmYFMSKMRPNKwnPDYSyd-------------------------------- 105  Bacteroides t...
EDO60733       80 kLMSEH---------PVYIDPVDAFSCRWmFSMIWFEEKS--PEKGLHW------------------------------- 117 
6VXC_G        121 ------------diiNFSV-SEEARKIHKEeii--pfwKKRQTRDKIINAMTPEW-------LAAYEAGMFT-EFMEQRA 177  Clostridioide...
WP_006069341   96 -----------dkleAFKTeLSPEEHSRVDvll--dywKERDTRSIYFRQTLTEAtlgkfvdVNy--------PAIATAR 154  Vibrio medite...
WP_011966617   98 -----------kklrAFQLqLDETERKRVDaly--dywLDHDLKTQFNKEVLTEDtlgmfidCEy--------PMIATAR 156  Parabacteroid...
Q2HBR9        463 ---------------PYLS-DEETMAAWLKg------------------------------------------SLNEWSA 484  Chaetomium gl...
Q8XZ58        598 ---------------DYTRdDDDEAERFRWfn----------------------------------------lSLSPTSG 622  Ralstonia sol...
EDO62661       95 --------------------------------------PGFESGEAVYKGYTD-----------LAELHLVT-----EPA 120 
2YAJ_C        148 gnvtesygnvisiakKFGM-RKEEIPVLVKtsk---pwEGISVEELSNKY--SKMtpgydqfKNIMESVICMfDS-FAIP 220  Clostridium s...
WP_005426151   91 ----------------qpgiGCWLMKQYPDfvdgygewSGYYGKYGVm-------------------------NGPQFMD 129  Blautia obeum
Q8A3J9        106 ------------------------------------flKENIKKYDLICGIGDDA------------------------- 124  Bacteroides t...
EDO60733      118 --------------------NPNFSyd---------ylKPEQELYGIISGIGSDA------------------------- 143 
6VXC_G        178 PGHTVCG-DTIYKKGFLDLKKDIEARLKELDflndldaynkka---dleamaiacdaMVILGKRYAEKARQMAEEet--d 251  Clostridioide...
WP_006069341  155 LSGMYLDyNKLIDNGIGGMRRLIGDKLDSArachdtkaial------hesflgcfdiVEKVIDHHIKLCAKELEVtt--d 226  Vibrio medite...
WP_011966617  157 LSGMMLDyPKLLDKGIGGLRSDLQEKLKEQpdnnfyka------------giqcldiFVDCASHLQQDAREQMASa---n 221  Parabacteroid...
Q2HBR9        485 MGHIVPGyDLLVRDGLKKMITDIKDKLAKVSdpasatasfy-------esciislegVQGYLRNWAKIAQRAAIAagmta 557  Chaetomium gl...
Q8XZ58        623 VGHVVPGyEALLTHGIRGVSRQIDEAQQALAatdpqraeavap---fyagsrlalrgLAEYLEGLAGTAHDTAQAlpqdq 699  Ralstonia sol...
EDO62661      121 RGHITWDwTKILRLGTEGLKAQYENALhsakdleaehf---------yrgvlialeaLEDWNDQHVAYLRKMGKQ----- 186 
2YAJ_C        221 QGREVINyYMPLQYGFDGIIKLCDEKIAEVMgeagddgdfgmsrgyyyaamkeitkgLSAWCENYSKRAKYLASIet--d 298  Clostridium s...
WP_005426151  130 AAHHYANcETILKYGLSGIIRHARMRLEEKDltdhqqdfl--------kcmidvcrsLQRISERFAEKAEEMLKTeh--d 199  Blautia obeum
Q8A3J9        125 --HFAPDyEIGVKLGWNGLIKKIEHYQSMHHseeqqhfys---------lhlrvirsVQGWIQRHIDQAYRMAASat--d 191  Bacteroides t...
EDO60733      144 --HFGGDyQLGLSLGWGGLLEKLAFYRKKHPehaefyda-----------eelvirgIQNWISRAIAEGERMAEAer--h 208 
6VXC_G        252 EAKKKDLLLIAETCDVVPAHK-PETYHQAIQMYWFV-HIGVTTELNIwDAFTPGRLDQHLNPFYERDVENGILDRDRAQE 329  Clostridioide...
WP_006069341  227 LTRKHQMNDLIDALNAIRNDK-PQTFLQGIQLSWLY-SLCS-------GVVNFGRMDDYLGDLLVADLETGRITERQAIN 297  Vibrio medite...
WP_011966617  222 MKRQKELERICQALENIKEKK-PGTFHEAMQLFWLF-ALLA-------GVINYGRLDDYLGPYLVADLKSGRLTDEEAYR 292  Parabacteroid...
Q2HBR9        558 PDDVANMKDVEARMNRLADDA-PESFQDAVQLIYSF-HCCLHLVGEL---TPFGRLDQILYPYLSK---GGGTTLEHAQE 629  Chaetomium gl...
Q8XZ58        700 KIERTNLAEMEARLRRLASGAvPETVLDALQLVLAC-HATLHLCGEP---VAVGRLDRLIRPFQEKAP----LGETQLQE 771  Ralstonia sol...
EDO62661      187 --------ELADLCQHVPRHP-ARGFKEAIQSFFMQ-YLAVFYENPF-GGNGPGQFDKYLWPYLKKDLENGSCTLEEAEE 255 
2YAJ_C        299 SEIKANYEKIEEVMGNIAHKK-PANFWEAIQMTLCC-HFGVVNEDPQ-SGLSIGRLGQVLQPFYEKDVEDGIMTDEEVIE 375  Clostridium s...
WP_005426151  200 EEHVKALKMIAVTARRIPSEP-AETFYEAMCAIWFTrEMCNALDGLGfAVI--GHLDRILISYYERDLKNNRITPDEAQE 276  Blautia obeum
Q8A3J9        192 DCSKNNLLEIAKVNESIINDA-PTTLREACQWIIWY-HLASRTYN---RDGAGGQIDTLLAPFYEKDLAEGRIDKETAVY 266  Bacteroides t...
EDO60733      209 PVLKENLRQMARVNRNILNGA-PKTMREACQWVCWF-NMASRTYN---RDGAGFQLDEVLKRYYDADLEAGRITRDEAVF 283 
6VXC_G        330 LLECLWVKFNNQPAPPKVGITL-----------------KESStYTdFANINTGGIN----PDGQDGVNEVSYIILDVMD 388  Clostridioide...
WP_006069341  298 YIRSHYRLIEARKTTV-------------------------------NGRVVVGGLG----RRNPETADVYCKLAIQAVR 342  Vibrio medite...
WP_011966617  293 YIHSLWTMIENRRTTV-------------------------------NGRIIVGGKG----RKHPKEADVFLHIAMKVAK 337  Parabacteroid...
Q2HBR9        630 IIDCLWVKIGENAFVNRAFIYDyvtygttavcglggnfpQGGGiNQwVQQITVGGYKatdsATPECGANAVTMLCLKAAR 709  Chaetomium gl...
Q8XZ58        772 AIDCFWLKLGEKTLLNRIFIDDrqelgnlamgnragpypKGQSvNQwIQQVTVGGLN----ADGSWEYSDVTLACLRASS 847  Ralstonia sol...
EDO62661      256 LVEELFIRLDERVSANDLW----------------------------NEMIITGGTH----RDGSSAVSPLSKIMVDAIM 303 
2YAJ_C        376 LLELYRIKITCIECFASAGVSG-----------------GVLSgNT-FNNLSLGGQN----YDGLSAVTPLEYLIVEAGM 433  Clostridium s...
WP_005426151  277 LIDCFVSMTDARWNLEAD---------------------LPGGtNA---DIIIGGCD----KNGDIVYNDISRMIINSYK 328  Blautia obeum
Q8A3J9        267 YLACFLLNDPVYWQ--------------------------------------LGGPD----ESGKDQTSPLSFLILEAAD 304  Bacteroides t...
EDO60733      284 YIACLLLNDPHYYQ--------------------------------------IGGTD----ENGEPLLSEFSYMVLEGAD 321 
6VXC_G        389 EMKLIQPSSNVQISKKTP----QKFLKRACEISRKg-WGQPAFYNTEAIVQelm------------------eagKTiED 445  Clostridioide...
WP_006069341  343 ENKDTEPQFTLRIYKGMN----QGVYQDALEAIGEg-LTYPILYNDDVNVPavmn-----------------smqISeQD 400  Vibrio medite...
WP_011966617  338 NCRYVEPQFTLRFDKETS----EEIWDEALDALGAg-ATYPTLYNDDVNVPavmy-----------------gmrVDeKT 395  Parabacteroid...
Q2HBR9        710 RIPVNAPTLSLRVHKDIP----HEYLDEAAKGILSg-GAQPILYNDDKLCPalkds--------------atanvVDlKW 770  Chaetomium gl...
Q8XZ58        848 RLPFNAPVLSLRVSRDMPsawrKRLLAEAARGQLSg-GASPILLNDDKIIPalsssgiaigprasadeaarwnaaVRrED 926  Ralstonia sol...
EDO62661      304 KLNITHPTVYMRVPKDAD----EEYVKLCAKYLKYg-NNRAQIYYDPNVIRalte-----------------tdgVRpED 361 
2YAJ_C        434 RNQTPQPTLSVLYDEKTP----EDFLMKAASCTKLg-LGYPAWMNNQTGMNfmmrn--------------ygpegMDlHD 494  Clostridium s...
WP_005426151  329 KYHFANPKLQVRISAKHP----DEFLLQVGELAGMg-LNVLSIFNDDVIIPanq------------------kqgKSlED 385  Blautia obeum
Q8A3J9        305 KI-NTSLNLTVRVFDGLN----KDLFRKSVEYLVKnkNGWPRFSGDKALVEgfm------------------kngFSaQL 361  Bacteroides t...
EDO60733      322 KL-DSACNITVRVDKNID----RKFLHKAVDYLFKnkNGWPRFSGDEALNRgfm------------------rlgYPeSL 378 
6VXC_G        446 arLGGTSGCVET--G-------------CFGKEAYVL---TGYMNI--PKILELTLNNGydPISKKQIG-----I--ET- 497  Clostridioide...
WP_006069341  401 aqHYVPFGCGEF--V-------------LSGKSVGTP---NTCINI--LKILNISLTGGtdFWDGQNKS-----G----- 450  Vibrio medite...
WP_011966617  396 aeQYVPFGCTEF--V-------------IQGQSTGTP---NICINL--LKLLTIYMNDGidPIDGKRKS-----G--PV- 447  Parabacteroid...
Q2HBR9        771 srDYAADGCYEP--M-------------LAGASEFTF------NNVapLLALEQTLNEGstY---GEAGpeqlrGlkQTf 826  Chaetomium gl...
Q8XZ58        927 ahDYACDGCYEP--Q-------------FVGANWFHL----GGVTL--LQMLEVALNQGrqMQSAGPVDlfgknV--SF- 982  Ralstonia sol...
EDO62661      362 atEYGVGGCLEI--G-------------IQGMNDDLLq--CAWVNM--PLMLELAITGGysLSERKQVDs----A--GI- 415 
2YAJ_C        495 arAWCLGGCLESapGcflpleyngkvtmIPGGASPTCgtgVHFIGM--PKVLELVLTNGldKRTGKQVY-----P--PH- 564  Clostridium s...
WP_005426151  386 crLYVAGGCQEI----------------CLSNEVNSRa--YTYLNL--VQMLNGSLYPEywNDIFKRDG-----F--EF- 437  Blautia obeum
Q8A3J9        362 arRRIAVGCNWM--S-------------LPGLEYTMNd--LVKINM--AKVFEVSYTEMmnEQ----------------- 405  Bacteroides t...
EDO60733      379 arRRIAVGCHWM--S-------------LPGLEYCLNd--CVKINS--AKVFEVALDEMmsQE----------------- 422 
6VXC_G        498 GDP--R--NFQSYEELFEAFKKQLHYMIDIKIEGNAVIENICAKHMPCPLMSTIVDDCIEKGKDYQRggaryn-tryiqg 572  Clostridioide...
WP_006069341  451 GTSllQpeQVTSFDDVIKNYKDLLDFYIELTSKAQAFSYQVMNQEVGFLFTSILTDDCIGRSKALLDggvykl-ggtnet 529  Vibrio medite...
WP_011966617  448 SLK--KleEYQTFEEFYDGYKALLDYYLDLSVKAQYHSYEVMNQHVSFLFTSLLTDDCIARGKALLDggvryl-ggtnet 524  Parabacteroid...
Q2HBR9        827 RSK--PakEFKSFEDLKDTFVKQLEWLVVQCYNTMLDGYGNLANVCPSPLLSVLIQGCVEKGRDLTNggskfh-imaplc 903  Chaetomium gl...
Q8XZ58        983 RSQ--PasAIASYAELEEVFFKHLEWTFARQMEGTVADFGRMEGVCPSPLLNLFIHDCLAKGRDIYAggaryn-vfgpcf 1059 Ralstonia sol...
EDO62661      416 PLP--GlaQHNTFESFYKNYLDFTDRLVGISFSMIERQSIHDEKYRPAYLISSMIDDCLERGRHMHAggaryh-dysmtp 492 
2YAJ_C        565 NK------KLDSYETMVNQWKEYMELTTDVVNRCNNIQMDIWRKYNMPAVNSLLKPDCFKKGKHIGTmgarynscinfes 638  Clostridium s...
WP_005426151  438 LPA--A--NASDFEEFYHIVIENYRNELNFFVKKYNEYGSWWKIINPSLFFSATMPSCTETAKDVSEggavyn-tdnfaa 512  Blautia obeum
Q8A3J9        406 --------KDHSTSRLWMLFNEHLAKAVQTSADGIRHHLKFQKYNEPELLLNLLSHGPLEKGKDVSDggaeyy-nlaidg 476  Bacteroides t...
EDO60733      423 --------GPYSTERLWELYQKHMARAVEVTAEGVAFHLKYQQYNEPELMLNLISHGPVEKGLDMTCggamyy-nmcmdg 493 
6VXC_G        573 VGIGTITDSLTAIKYnv--fdKKKFDMDTlLKALDANFEGYeailn------------------------lvsnkTPKYG 626  Clostridioide...
WP_006069341  530 YGNTNAYDSLAAIKKvi--feDKKYSYSElIQALRVNFDGYdrmky-------------------------dlinAPKFG 582  Vibrio medite...
WP_011966617  525 YGNINTSDSLWVIRDlv--fnQKKYTLRQlNDAMLANFNGYealrk-------------------------dclnCDKYG 577  Parabacteroid...
Q2HBR9        904 VGMSNTIDSLYAIQKlvfddeTARVTLQElVKCLICDWGHNmiepyenqlsgtadas---erglryselrnaalaLPKWG 980  Chaetomium gl...
Q8XZ58       1060 TSLANTINALWAIRVmcfdqaTAITTLSElVQALLCNWGENmidplvhptvlagdatrvsqaatrfrqlrsialsLPRWG 1139 Ralstonia sol...
EDO62661      493 LGIPNVIDGLYAIRTav--fdQHICTAEElVSAMRADFKGYerlqr-------------------------qlraIPKYG 545 
2YAJ_C        639 CGTITFVNSLSSIKKnv--fdDSKFTIEEmTDAMLNNFGFKtayetevfspdfrest---dkstkyekifaacvnAPKYG 713  Clostridium s...
WP_005426151  513 AGAGTVIDSLYAIKKav--yeDKITTFGHlLKAMKEDFRDDeilrq------------------------yllhkVPKFC 566  Blautia obeum
Q8A3J9        477 AGLATVADSFAALEQri--elENKLSWNTlTEYLRNNFSGDggcrir-----------------------hllknSEKYG 531  Bacteroides t...
EDO60733      494 AAIATVADSFGALQQrv--eeEKRIDWQAlYHHLKTDFQDEggelvr-----------------------qmlshSPRYG 548 
6VXC_G        627 NDDDYADEIMQEIFNAYYN-EVTGRPT-V--CGGEYRVDMLPTTCHI-YFG 672  Clostridioides difficile 70-100-2010
WP_006069341  583 NDDAYVDDIAVEMHEYICN-------------GIKDSAAKVGMDSYL-VVI 619  Vibrio mediterranei
WP_011966617  578 NDLETADTMANDLYEFVAKgVRDRGIA-I---GMQY---FLIVISNN-QLN 620  Parabacteroides distasonis
Q2HBR9        981 SGDEEVNKLGDWLVQTCVDlCVKAIRH-P---NATIKAHLDNIKK---TYG 1024 Chaetomium globosum CBS 148.51
Q8XZ58       1140 RGNADIDRFGNEICQRVAGiAVQVMAQpRdgLADQYRRKAMAYGTPAhPFG 1190 Ralstonia solanacearum
EDO62661      546 QENDDADDFARTVVTDIAKmFVTRRNR-F---GGIFRPMVLTF-IYA-PLA 590 
2YAJ_C        714 NADKYADEIFKAYHYYIYD-MTHKFRS-Y--YGKPLYLCQISVSTHG-PQG 759  Clostridium scatologenes
WP_005426151  567 KDKD-ATEFGKKVMDDLAE-CLGGQAN-Y--RGGKFEPSLFAFYSYN-WFK 611  Blautia obeum
Q8A3J9        532 AAESLGEKWAIRIKETFTE-LVRLQSEpD--KRRIFIPGFFSWANTV-GFG 578  Bacteroides thetaiotaomicron
EDO60733      549 GGNTISDQWAVRISNSYSE-QVRAVSEkY--PGCEFIPGWFSWSNTI-VLG 595 
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