3DDU,1VZ3,3IUM,1YR2


Conserved Protein Domain Family
Peptidase_S9_N

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pfam02897: Peptidase_S9_N 
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Prolyl oligopeptidase, N-terminal beta-propeller domain
This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.
Statistics
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PSSM-Id: 397164
Aligned: 30 rows
Threshold Bit Score: 355.462
Threshold Setting Gi: 2499852
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DDU_A         6 PDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTK-----AFVEAQNKITVPFLEQCP-IRGLYKERMTELYDYPKYSCHF 79  human
Q9SX53         7 PPVAKKVEHVMEMFGDVRVDNYYWLRDDSRTNPDm---lSYLREENHYTDFVMSGTKqFENQLFAEIRGRIKEDDISAPL 83  thale cress
Q9XYH4        27 YVEGEDRGPNPMNPPRYREDPYFWMRDDDRKDPAv---iEHLNKEKVYFQARSADIAqLRDDIYAEHISHINEDDMSAPY 103 Leishmania major
XP_011780577  20 KVEGEDRGANPMDPPRRRVDPLFWLRDDNRADPEv---lAHLHLEKDYYEKRAVDIKdLAETIYQEHISHIEETDMSAPY 96  Trypanosoma bru...
Q94795        18 YVEGENRGNNAMNPPRRRNDPLFWLRDDSRKNPEv---iAHLKLEQAYFEERTADIKdFSETIFKEYFSHIKETDISAPY 94  Trypanosoma cruzi
Q9ZDP6         3 PPIANKQNYSFEIHKQTIKDDYNWLRDPNWPNVEedkilDYLKAENKYTENFFLNLKkDKKKIFEELKGRIKLDDESVYI 82  Rickettsia prow...
Q59536         4 PIAKRIPH-PHELHGDVREDDYYWLKDRDNTEVI-----QYLEEENRYYHEIMRPLQeQTEQIYESMVDRVPDSEMKVPV 77  Moraxella lacunata
P24555         3 PKAARIPHAM-TLHGDTRIDNYYWLRDDTRSQPEv---lDYLQQENSYGHRVMASQQaLQDRILKEIIDRIPQREVSAPY 78  Escherichia col...
O07834        29 PDVAKKPHVVKAPHGAERNDEYYWLRDDKRENKEm---lAYLNAENAYTDAVMAPLKpLEDKLYDEVVARIKQDDASVPY 105 Pseudoxanthomon...
P55656         8 PPLPRSERRIRVLHNDVTIDSYGWLRDREDPDVL-----AYLEAENHYADEVTSYVAeLKADLIAEIEKRDSCDGAPPPF 82  Sinorhizobium f...
3DDU_A        80 KKGKRYFYFYNTGLQNQRVLYVQ-------D----SL--EG----EARVFLDPNILSDDGT-VALRGYA-FSEDGEYFAY 140 human
Q9SX53        84 RKGPYYYYEKNLQGKEYIQHCRRlitdnkaEpsvyDTmpTGpdapPEHVILDENTKAQEHDyYRIGAFK-ASPDHKLVAY 162 thale cress
Q9XYH4       104 VYGKYRYYTREVKGKPYKIYCRVf-----tD----KEpgDVa---AEEVIIDVNQVAEGKAfCDVMEVKpAPPEHDLVAF 171 Leishmania major
XP_011780577  97 VYDRFLYYTRDVKGLSYKLHCRV-------Pa--gKTpgEGe---DEEIVLDENKLAEGKSfCVVGCVApAPPEHALVAY 164 Trypanosoma bru...
Q94795        95 RYDGYTYYTREVEGLSYKIHCRV-------Pl--gMTpgKSe---DEQVILDENKLAEGKSfCMVHEVKpAPPDHNLVAY 162 Trypanosoma cruzi
Q9ZDP6        83 KKKDYYYYQRVERDKNYPIYCRK------------HNsiEA----TEEVILDVNLLASKGSfTDIGEIA-MSPDQNLMAY 145 Rickettsia prow...
Q59536        78 QHGQFFYYSRLDKNKQYPIYARK-------QaasrALlqDA----TEEVVLDLNELAEEDDyLSVTVQR-MTTDHSRLAY 145 Moraxella lacunata
P24555        79 IKNGYRYRHIYEPGCEYAIYQRQ-------S----AFseEWd---EWETLLDANKRAAHSEfYSMGGMA-ITPDNTIMAL 143 Escherichia col...
O07834       106 RERGWWYYARFVTGKDYPVHARRkdgpgvdAvsiqAAnaAGdf-aGEQVLLDVNALGAGKDyYNVGDYE-VSQDNRLLAY 183 Pseudoxanthomon...
P55656        83 QVGFFFYFQKSQSGLLHSAWWRRp--------------vTGg---PEELVFDPNTLPGAEVfYSLGALE-PSDDGRYIAF 144 Sinorhizobium f...
3DDU_A       141 GLSASGSDWVTIKFMKVDGA-KELPDVLERVKFSc-MAWTHDgKGMFYNSYPqQDGKSDgtetstnlhqKLYYHVLGTDQ 218 human
Q9SX53       163 AEDTKGDEIYTVNVIDSEAL-KPVGQQLKGLTSY--LEWAGN-DALLYITMD-EILRPD----------KVWLHKLGTEQ 227 thale cress
Q9XYH4       172 SVDMSGNEVYTIEFKRISDPsQTIADKVSGTNGE--IVWGPDhTSLFYVTKD-ETLREN----------KVWRHVMGKLQ 238 Leishmania major
XP_011780577 165 SVDYCGDEVYSIRFVR-----DVVADKVEGTNGS--VVWGPNaECFFYITKD-ASKRDN----------KVWRHIIGQPQ 226 Trypanosoma bru...
Q94795       163 SVDYVGNEMYTIRFTD-----NAVTDVVEGTNGQ--ILWGPNaSCFFYITKD-AAERNY----------KIWRHIIGRPQ 224 Trypanosoma cruzi
Q9ZDP6       146 SVNFTGNEQYNIKIYNIKKQ-QYLSNEVKDVAPV--IIWHARlNGFFYITIN-ENQRWD----------RVIFHSLDRNI 211 Rickettsia prow...
Q59536       146 LENRDGTDRYTIYIKDLNTG-ELLSDRVPNVYIYgsMEWCRCgDYIFYTTVD-EHQRPC----------QLWRHRLGSDV 213 Moraxella lacunata
P24555       144 AEDFLSRRQYGIRFRNLETG-NWYPELLDNVEPS--FVWANDsWIFYYVRKHpVTLLPY----------QVWRHAIGTPA 210 Escherichia col...
O07834       184 ADDTNGRRQYTIRFKNLDTG-ELLPDTVTNAEPN--LVWSDDgRTLFYVDKDpETLLSK----------RVKAHVLGTPA 250 Pseudoxanthomon...
P55656       145 SFDLIGNERYELRVRDMTNG-R---EIWRDPSRAgrLVWAADnRTLFFTRERaDRRQHD----------RVVRLDVETGR 210 Sinorhizobium f...
3DDU_A       219 SEDILCAEfPDEPKWMGGAELSDDGRYVLLSIREGCd-------pVNRLWYCDLQQESsgiagilKWVKLIDN-FEG-EY 289 human
Q9SX53       228 SSDVCLYH-EKDDMFSLELHASESHKYLFVASESKT---------TRFVFSLDVSKTQ-------DGLRVLTPrVDGiDS 290 thale cress
Q9XYH4       239 SEDVCLYE-EHNPLFSAFMYKAADTNTLCIGSQSPE---------TAEVHLLDLRKGNa-----hNTLEIVRPrEKGvRY 303 Leishmania major
XP_011780577 227 SEDVCLYT-DDDPLFSVGVGRSGDGKTLIICSMSSE---------TSESHLLDLRKGVk-----hNTLEMVRPrEKGvRY 291 Trypanosoma bru...
Q94795       225 SEDVCLYT-ENDLLFSTAMAISGDGNTLIIGSGSFE---------TTESHLLDLRKGNg-----hTTLEMVRPrERGvRY 289 Trypanosoma cruzi
Q9ZDP6       212 TQDKLIFE-VKNPIHFISCKRSASHEYIFINSGDHN---------ENEIYVISMQDDS-------FTPKLVRVaENKvFY 274 Rickettsia prow...
Q59536       214 ESDELIFE-EKDDTFTLFISKSQSGKFIFVYSSSKT---------TSEIHMIDTDSPL-------SPLQLVDErRDGiLY 276 Moraxella lacunata
P24555       211 SQDKLIYE-EKDDTYYVSLHKTTSKHYVVIHLASAT---------TSEVRLLDAEMADa------EPFVFLPRrKDH-EY 273 Escherichia col...
O07834       251 SQDALVYE-EEDDSFYMGIGRSRDDKFICISVESTV---------SSEMRCTPAASPg-------VFTVLAPReRDV-EY 312 Pseudoxanthomon...
P55656       211 SE--VVFEeVNERLALV-VRRSGSGAYLFIDVIITSdmssriqraAAEVWCLPAERPTd------MWRRILAReLGH-EI 280 Sinorhizobium f...
3DDU_A       290 DYVTNeGTVFTFKTN-RHSPNYRVINIDFTDPEESkwkV-LVPEHEKDVLEwIACVRSNFLVLCYLHDVKNTLQLHDlTT 367 human
Q9SX53       291 SVSHR-GNHFFIQRRsTEFYNSELIACPVDDTSKT---TvLLPHRESVKIQ-EIQLFRDHLAVFERENGLQKITVHRlPA 365 thale cress
Q9XYH4       304 DVQMHgTSHLVILTNeGGAVNHKLLIAPRGQPSdw--sHvLVDHSEDVFME-SIAVRSNYLVVAGRRAGLTRIWTMMaDS 380 Leishmania major
XP_011780577 292 TVEMHgTDTLIVLTNkDKCVNGKVVLTKRSAPTdw--gTvLIPHDDKVTID-DVAVFAKFAVLSGRRDGLTRVWTVRlGP 368 Trypanosoma bru...
Q94795       290 DVELHgTETLLILTNkDNCMNGKVVSATRNTPSdw--eNvIVPHSEDVFIG-EIGVFAKFVVLSGRRGGITRVWAMPvGS 366 Trypanosoma cruzi
Q9ZDP6       275 EVEHN-GDFFYIKTN-YKAKNFHIVKVPINNFENAnwnDiYIQEEQDKYLK-SFDVTKNYLILNYRYNGLPLIKIKQfQD 351 Rickettsia prow...
Q59536       277 DVEHWe-DDLLILTN-EGALNFQLLRCPLNDLss---kVnVVEYNEERYLQ-EMYPFRDKLLIAGRENGLTQIWVVHdGE 350 Moraxella lacunata
P24555       274 SLDHYq-HRFYLRSN-RHGKNFGLYRTRMRDEQqw--eE-LIPPRENIMLE-GFTLFTDWLVVEERQRGLTSLRQINrKT 347 Escherichia col...
O07834       313 QADHL-GDRWVIRTNaDGATNFKIVTAPTDSTSRKdwkD-WVAHRDDVFVE-GFELFDGFSVVAERANALESLRVIKaDG 389 Pseudoxanthomon...
P55656       281 YAEHW-GNEFLFRVN-DTGPNLRLVRTAIDDTSPSrwqE-VVPHRAGITLE-EIHVLEEHVIVLEREGIQPRLVAHH-RN 355 Sinorhizobium f...
3DDU_A       368 GA-----------LLKIFPLd-vGSIVGYSGQKKDTeIFYQFTSFLSPGIIYHCDLTKEELEPRVFR 422 human
Q9SX53       366 EGqpleglqggrnVSFVDPV---YSVDSTESEFSSRvLRFKYCSMKTPPSVYDYDMDSGTSVVKKID 429 thale cress
Q9XYH4       381 QDgvfqagtglreVVMEEPIftvHLVESQMLEYEEPtFRMEYSSLATPNTWFDVSPQDTLAPLVKVR 447 Leishmania major
XP_011780577 369 DNlfssa--tlkeLHFDEPVftaHVVCSQMKTYDASlLRLRYSSMTTPTVWYDEDVLSGERKVVKAR 433 Trypanosoma brucei gambiense...
Q94795       367 DGlfrsg-afvqeVSFDEPVftaFPVFSHMKMYDTEtLRVSYTSMSTPTTWFDLHVVNGTRTIVKVR 432 Trypanosoma cruzi
Q9ZDP6       352 QHe----------NIIHFPDv-sFQANSFSTNFEEDnIRIDYSSLARPNTTYSYDFDKNKLTILKDQ 407 Rickettsia prowazekii
Q59536       351 LQq----------ISWDEPLytvAVLSEQS--YDTNeVLIQYESLLTPKTTFGLNLQTGEKQCLQVA 405 Moraxella lacunata
P24555       348 REv----------IGIAFDDpayVTWIAYNPEPETArLRYGYSSMTTPDTLFELDMDTGERRVLKQT 404 Escherichia coli K-12
O07834       390 SSd---------yVKADESAysmGLSANPETGTDW--LRYSYTSMTTPATTYEINTKTGERRQLKQQ 445 Pseudoxanthomonas mexicana
P55656       356 GRvgpsivpvehsCTVTVGLsagGSYSCARHPYRVSaLTYKICSFVTPDIFIQHDLLTDKskvlyrt 422 Sinorhizobium fredii NGR234
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