5URJ,5URJ,6QV3,8RO0,8RO0,4BGD,4BGD,8ALZ


Conserved Protein Domain Family
Sec63

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pfam02889: Sec63 (This model is not part of the current CDD release)
Sec63 Brl domain
This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Statistics
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PSSM-Id: 515258
Aligned: 90 rows
Threshold Bit Score: 168.922
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5URJ_A        591 TELGRIASHYYITNDTVQTYNQLLKPTL-SEIELFRVFSLSSEFKNITVREEEKLELQKLL-ER---------------- 652  human
O60072       1619 TTLGRIVSYYYLFHTTIRNFVQKITENA-EFDLALQLLAEASEFDDLAIRHNEDLINIEIN-KS---------------- 1680 Schizosacchar...
WP_020445466  487 TALGRLASRFYLRLDTARGFHDLATREQiDDAGILRAVATAVEFDDVAARSDEADAVDAVLgER---------------- 550  Salinarchaeum...
Q6BM64        480 TEYGDVMTKYYILYPTMRNIIRSKAGN--TLLDVLTIFSRSSEFSEFSIKYNEKKLYKAINlSPyi-------------- 543  Debaryomyces ...
8_pfamImport    2 LEPGRLMTKYYLKFGTMKHIMQT--PLNcSLEDALHIICRSEEIAWIQLRRNEKKFLNDINmDK---------------- 63  
Q5D892        535 EEPGRLMTKYYLKFETMKYIINT--PTSySLDEALHIVCHAEEISWIQLRRNEKKTLNDVNaDK---------------- 596  thale cress
A2PYH4        778 TEAGRLMAWYYITFETVKKFYT-ISGKE-TLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNkDPnri-----------ti 844  human
A2RUV5        647 TETGKLMALYYIAFNTAKLFHT-IRGTE-TLAELVSLISSCSEFSDVQLRANERRVLNTLNkDKnrv-----------ti 713  tropical claw...
XP_001704428 2045 TPLGEIVSRYYIRTRSGALINTWLTGEThTLQSYLDMLVRCEEFQEIPIRHNEDRDSALLL-QKylwdgkrefsgaliry 2123
B6DMK2        542 LEPGRLMTKFYLKFDTMKLIVKA--SACcTLEDLLHIICHSAEITWIQLRRNEKKLLNEINaDK---------------- 603  Japanese rice
5URJ_A        653 -VPIPVk--------------eSIEEPSAKINVLLQAFI-SQLKLEG--------FALMADMVYVTQSAGRLMRAIFEIV 708  human
O60072       1681 -LKYSAacl-----------nlPMVDAHVKAFILTQAHM-ARLKLPV--------DDYVTDTSTVLDQVIRIIQSYIDVS 1739 Schizosacchar...
WP_020445466  551 -At-------------------DLPDGQRKVLAILQAAVaGTTP-----------NSLRSDAWIIRQNALRMLAALGAVL 599  Salinarchaeum...
Q6BM64        544 rFPLHSt---------------EFQDSD-KVMLLLQYEL-CGLDFPNspelmklyYSFEGDKCYVFKQASRIIRCMIDVF 606  Debaryomyces ...
8_pfamImport   64 -----DgqlrfhilgdkgkrkrRIQTREEKIFVLANDCLtGNPSVHD--------LSLTQDANAICSNGCRIAKCMKEYF 130 
Q5D892        597 -----EgrlrfhindnkgkrkkRIQTREEKLFVLANDWLtGDPSVHD--------LSMTQDANSICSNGSRIARCMKEYF 663  thale cress
A2PYH4        845 rFPMEg----------------RIKTREMKVNCLIQAQL-GCIPIQD--------FALTQDTAKIFRHGSRITRWLSDFV 899  human
A2RUV5        714 rYPMEg----------------KIKTKEMKVNCLIQAHL-GCILVQD--------FSLTQDISKIFRHGTRLAKCLSEFL 768  tropical claw...
XP_001704428 2124 nMPDDI----------------TCTEPSFKAHILLQAQL-VRSSLQGafe--lpvVDYWLDLVTIIDAAIRITVATVEIA 2184
B6DMK2        604 -----EgrlwfhvvgangkrkkRIQTREEKIFILANDCLtGDPLVHD--------LSLNQEMNSICSNGCRVAKCMREYF 670  Japanese rice
5URJ_A        709 LNRGW-AQLTDKTLNLCKMIDKRMW-QSMCPLRQFRKLPEEVVKKIEKKNFP--Fe------------rLYDLNHNEIGE 772  human
O60072       1740 AELGY-SHVCLQYISLMQCLKQACY-PSEIYRASLPGLNASSEKEARDYLNKf----------------aGNKTDELYQM 1801 Schizosacchar...
WP_020445466  600 GEFAG-PAAANECRRLEARIEHGVG-PDAAALTAIEGVGEGRARSLAQAGFEspAe-------------IAAATPATVAA 664  Salinarchaeum...
Q6BM64        607 RYKKD-CVSLLNTLRFSRCVAGRCWeNSVTELKQLDGIDEECIKKLRKNNISgfAe------------aKYLSQLQLEYF 673  Debaryomyces ...
8_pfamImport  131 IYKKS-YKGALNSILLSKCLLQKLWdDSPYLLKQLPGIGMVTAKALHSMGIVsfEa------------lAEADPRRIEIV 197 
Q5D892        664 IYKKN-YKGTLSSTLLAKSLYQKLWdDSPYLLKQLPGIGMVTAKALHSMGVRsfEa------------lAEADPRRIEIV 730  thale cress
A2PYH4        900 AAQEKkFAVLLNSLILAKCFRCKLWeNSLHVSKQLEKIGITLSNAIVNAGLTsfKk------------iEETDARELELI 967  human
A2RUV5        769 ALQENkFSAFLNALILTKCFKSKLWeNSSHISKQLEKIGVTLANAMVNAGLTtfKk------------iEDTNARELELI 836  tropical claw...
XP_001704428 2185 LAKRLsRSIVQTVVQLSQGLVQGLW-PNMEPMLSISSLRNALQSNKKTFQKLsaNgistlqqlvdefhkLGRKQLTEFLG 2263
B6DMK2        671 IYKKN-YKSAISSMLLAKCLHQKLWeSSPFLLKQLPGIGIVTAKALKTAGIDsfEs------------lATADARKIESV 737  Japanese rice
5URJ_A        773 LIRMPKMGKTIHKYVH-L-FPKLEL-SVHL------------QPITRSTLK-----VELTIT--------------PDFQ 818  human
O60072       1802 LCNDPNVFDIESLVNSlIsYPKMNI-----------------EVSQSSSDK-----LLLYLRrlnqplnpdfyifaPLFP 1859 Schizosacchar...
WP_020445466  665 AGVGDGVAERIVDAAA-D-LPRIEIeWGDLpdsipagdrdfsEATIHNRGDgaqagVRVTVN--------------GVEM 728  Salinarchaeum...
Q6BM64        674 LGIEPGTGKNIAQSLQ-S-LPKFKInATLA------------SNKVRTDLEtleisLIVSIGidnmer---gnskiK--- 733  Debaryomyces ...
8_pfamImport  198 TGRKYPFGNHIKESLS-SlPPKVELkIEEI------------ECQRQGKSK-----IVLILTrlsqs-----fqsiK--- 251 
Q5D892        731 TGRKYPFGNTIKESLS-SlPPKVEIkVEEV------------DCQKQGISK-----LAVTLSrvsqp-----lqstK--- 784  thale cress
A2PYH4        968 LNRHPPFGTQIKETVM-Y-LPKYELkVEQI------------TRYSDTTAE-----ILVTVIlrnfeql-qtkrtaSD-- 1025 human
A2RUV5        837 VNRHPPFGNQIKESVA-H-LPKYEIkFQQL------------AKYRATTAE-----VVLTVLltnfkql-qkkrtaPD-- 894  tropical claw...
XP_001704428 2264 KHQLLSGIQRKELCEElMkYPNLII-RATItri-------nrPANIPDKSKhtgkfVCVIISlkhvss--iqaspfPQQF 2333
B6DMK2        738 TGRNYPFGDSIKSYLP-SlGPKIDInIEDA------------G-NRQGKST-----IIVTLTrlsqa-----vgssK--- 790  Japanese rice
5URJ_A        819 WDEKV-HGSSEAFWILVE--DVDSEVILHHEY---FLLkAKyaqd----ehlITFFVPVFEPlppqYFIRVVSDRWLSCE 888  human
O60072       1860 KPQ------SEGFFVLII--DSETQELFAIRR---ASFaGRrnddsirlslrISMDI-PPTCrnrnVKVMVVCDGYPLIY 1927 Schizosacchar...
WP_020445466  729 TADETyLSDATTVPLALFgaDADE----------------------------LELAVEVVFPe---LPLQPIEDR----- 772  Salinarchaeum...
Q6BM64        734 ---------HNFINTIIG---LSTGELLDFRRiaiLELvEGni-------nsFRLTANVTDRqq-kIHCHILSEDMVNID 793  Debaryomyces ...
8_pfamImport  252 ---------RYYADMVVG--LEEDNLILFHEKi------SRvdefsspysttILLSTP-QQGkl-tVKADLIFEEYIGID 312 
Q5D892        785 ---------RHYADLIVG--SEEENLIHFHEKi-------RmedfsspysvtVLLERPHQQTkv-tVKADLIFEEYIGID 845  thale cress
A2PYH4       1026 ---------SHYVTLIIG--DADNQVVYLHKIt------DSvllkagswakkIAVKRALKSEd---LSINLISSEFVGLD 1085 human
A2RUV5        895 ---------SHFVMLVIG--DDDNQAIFKQKIm------DSslfktgswtrkIEIKRASKSTn---VCLNLISSEYVGLD 954  tropical claw...
XP_001704428 2334 SSEVYkKSKPHTWFLVLS--ESETDTVIDYKRlsgFAReRS-----------QEFIIPFVSS----LCISALSDCFLGMD 2396
B6DMK2        791 ---------QNYADMVVG--SEEDNAILFHEKiktqefs-------spysvkLYVPCP-PNAra-tLKVDVIFEEYVGLD 850  Japanese rice
5URJ_A        889 TQLPVS 894  human
O60072       1928 EHKIVl 1933 Schizosaccharomyces pombe 972h-
WP_020445466  773 RTVAVE 778  Salinarchaeum sp. Harcht-Bsk1
Q6BM64        794 ARYVLS 799  Debaryomyces hansenii
8_pfamImport  313 LHQKLL 318 
Q5D892        846 LHETLL 851  thale cress
A2PYH4       1086 IQQKLT 1091 human
A2RUV5        955 IQQSFN 960  tropical clawed frog
XP_001704428 2397 KEITID 2402
B6DMK2        851 IHKKHV 856  Japanese rice
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